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  1. Article ; Online: Innate Immunity and Biomaterials at the Nexus

    Susan N. Christo / Kerrilyn R. Diener / Akash Bachhuka / Krasimir Vasilev / John D. Hayball

    BioMed Research International, Vol

    Friends or Foes

    2015  Volume 2015

    Abstract: Biomaterial implants are an established part of medical practice, encompassing a broad range of devices that widely differ in function and structural composition. However, one common property amongst biomaterials is the induction of the foreign body ... ...

    Abstract Biomaterial implants are an established part of medical practice, encompassing a broad range of devices that widely differ in function and structural composition. However, one common property amongst biomaterials is the induction of the foreign body response: an acute sterile inflammatory reaction which overlaps with tissue vascularisation and remodelling and ultimately fibrotic encapsulation of the biomaterial to prevent further interaction with host tissue. Severity and clinical manifestation of the biomaterial-induced foreign body response are different for each biomaterial, with cases of incompatibility often associated with loss of function. However, unravelling the mechanisms that progress to the formation of the fibrotic capsule highlights the tightly intertwined nature of immunological responses to a seemingly noncanonical “antigen.” In this review, we detail the pathways associated with the foreign body response and describe possible mechanisms of immune involvement that can be targeted. We also discuss methods of modulating the immune response by altering the physiochemical surface properties of the biomaterial prior to implantation. Developments in these areas are reliant on reproducible and effective animal models and may allow a “combined” immunomodulatory approach of adapting surface properties of biomaterials, as well as treating key immune pathways to ultimately reduce the negative consequences of biomaterial implantation.
    Keywords Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Hybrid core/shell microparticles and their use for understanding biological processes

    Bachhuka, Akash / Agnieszka Mierczynska / Alex Cavallaro / Jim Manavis / John D. Hayball / Kerrilyn R. Diener / Krasimir Vasilev / Louise E. Smith / Romeo Marian / Susan N. Christo

    Journal of colloid and interface science. 2015 Nov. 01, v. 457

    2015  

    Abstract: Hybrid micro and nanoparticles have become a topic of intense research in recent years. This is due to the special properties of these materials that open new avenues in advanced applications. Herein, we report a novel method for the generation of hybrid ...

    Abstract Hybrid micro and nanoparticles have become a topic of intense research in recent years. This is due to the special properties of these materials that open new avenues in advanced applications. Herein, we report a novel method for the generation of hybrid particles utilising plasma polymerization. Poly (methyl methacrylate) (PMMA) beads were first coated with a thin allylamine based plasma polymer layer. Gold nanoparticles of engineered size and surface structure were then attached in a controlled manner to the plasma polymer coated beads. To generate uniform chemistry on the outermost surface and to preserve the nanotopography, we deposited a 5–10nm thin layer of Acpp. We demonstrated that these particles can be utilized in in vivo models to interrogate important biological phenomena. Specifically, we used them in mice to study the inflammatory and foreign body responses to surface nanotopography. The data strongly indicates that surface nanotopography and chemistry can modulate collagen production and the number of adhering immune cells. The method for generating hybrid particles reported here is solvent free and can open new opportunities in fields such as tissue engineering, drug delivery, biosensors, and regenerative medicine.
    Keywords biological properties and phenomena ; biosensors ; collagen ; drugs ; medicine ; methodology ; mice ; microparticles ; models ; nanogold ; nanoparticles ; polymerization ; polymethylmethacrylate ; solvents ; tissue engineering
    Language English
    Dates of publication 2015-1101
    Size p. 9-17.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2015.06.040
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Substrate independent silver nanoparticle based antibacterial coatings

    Taheri, Shima / Alex Cavallaro / John D. Hayball / Krasimir Vasilev / Louise E. Smith / Mary Barton / Peter Majewski / Susan N. Christo

    Biomaterials. 2014 May, v. 35, no. 16

    2014  

    Abstract: Infections arising from bacterial adhesion and colonization on medical device surfaces are a significant healthcare problem. Silver based antibacterial coatings have attracted a great deal of attention as a potential solution. This paper reports on the ... ...

    Abstract Infections arising from bacterial adhesion and colonization on medical device surfaces are a significant healthcare problem. Silver based antibacterial coatings have attracted a great deal of attention as a potential solution. This paper reports on the development of a silver nanoparticles based antibacterial surface that can be applied to any type of material surface. The silver nanoparticles were surface engineered with a monolayer of 2-mercaptosuccinic acid, which facilitates the immobilization of the nanoparticles to the solid surface, and also reduces the rate of oxidation of the nanoparticles, extending the lifetime of the coatings. The coatings had excellent antibacterial efficacy against three clinically significant pathogenic bacteria i.e. Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa. Studies with primary human fibroblast cells showed that the coatings had no cytotoxicity in vitro. Innate immune studies in cultures of primary macrophages demonstrated that the coatings do not significantly alter the level of expression of pro-inflammatory cytokines or the adhesion and viability of these cells. Collectively, these coatings have an optimal combination of properties that make them attractive for deposition on medical device surfaces such as wound dressings, catheters and implants.
    Keywords antibacterial properties ; bacteria ; bacterial adhesion ; catheters ; coatings ; cytokines ; cytotoxicity ; fibroblasts ; health services ; humans ; macrophages ; nanoparticles ; nanosilver ; oxidation ; Pseudomonas aeruginosa ; Staphylococcus aureus ; Staphylococcus epidermidis ; viability
    Language English
    Dates of publication 2014-05
    Size p. 4601-4609.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2014.02.033
    Database NAL-Catalogue (AGRICOLA)

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