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Article ; Online: Brief Insight into the Physiological Perspective of Renin-Angiotensin-Aldosterone-System as a Gateway in Pathogenesis of COVID-19

Debasish Paul / Dipak Kumar Dhar / Susmita Dutta

International Journal of Research and Review 7(7) 157-160

2020

Abstract: The world is facing an unprecedented crisis due to “COVID-19” pandemic and the number of cases are constantly soaring. ACE2 is ubiquitously present in different organs including nasal epithelium, conducting airways and alveolar epithelium. It is found ... ...

Abstract	The world is facing an unprecedented crisis due to “COVID-19” pandemic and the number of cases are constantly soaring. ACE2 is ubiquitously present in different organs including nasal epithelium, conducting airways and alveolar epithelium. It is found that S-protein of SARS-CoV-2 activated by TMPRSS2 targets ACE2 for gaining entry into host cells. Eventually the downregulation of ACE-2 occurs, either directly because of viral binding and endocytosis or indirectly because of cell lysis or ADAM17 activity. This results in homeostatic disruption of ACE/ACE2 system balance and the activity of activator pathways of Renin-Angiotensin-Aldosterone-System (ACE/angiotensin II/AT1R pathway) remains uninhibited by inhibitor pathways (angiotensin-(1-7)/ACE-2/MasR pathway). This will flare up immune response, destroy the alveolar type II pneumocyte and release pro inflammatory cytokines such as IL-6, TNF, etc. As a result “COVID-19” manifests as different symptoms of ranging from mild flu like to severe ARDS. This review highlights further prospect of studies on ACE2 or S-protein as a therapeutic agent or target.
Keywords	COVID-19 ; SARS-CoV-2 ; ACE2 ; Renin-Angiotensin-Aldosterone-System ; TMPRSS2 ; ADAM17 ; covid19
Subject code	570
Publishing date	2020-07-31
Publishing country	eu
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Experiment, modeling and optimization of liquid phase adsorption of Cu(II) using dried and carbonized biomass of Lyngbya majuscula

Kushwaha, Deepika / Susmita Dutta

Appl Water Sci. 2017 May, v. 7, no. 2

2017

Abstract: The present work aims at evaluation of the potential of cyanobacterial biomass to remove Cu(II) from simulated wastewater. Both dried and carbonized forms of Lyngbya majuscula, a cyanobacterial strain, have been used for such purpose. The influences of ... ...

Abstract	The present work aims at evaluation of the potential of cyanobacterial biomass to remove Cu(II) from simulated wastewater. Both dried and carbonized forms of Lyngbya majuscula, a cyanobacterial strain, have been used for such purpose. The influences of different experimental parameters viz., initial Cu(II) concentration, solution pH and adsorbent dose have been examined on sorption of Cu(II). Kinetic and equilibrium studies on Cu(II) removal from simulated wastewater have been done using both dried and carbonized biomass individually. Pseudo-second-order model and Langmuir isotherm have been found to fit most satisfactorily to the kinetic and equilibrium data, respectively. Maximum 87.99 and 99.15Â % of Cu(II) removal have been achieved with initial Cu(II) concentration of 10 and 25Â mg/L for dried and carbonized algae, respectively, at an adsorbent dose of 10Â g/L for 20Â min of contact time and optimum pH 6. To optimize the removal process, Response Surface Methodology has been employed using both the dried and carbonized biomass. Removal with initial Cu(II) concentration of 20Â mg/L, with 0.25Â g adsorbent dose in 50Â mL solution at pH 6 has been found to be optimum with both the adsorbents. This is the first ever attempt to make a comparative study on Cu(II) removal using both dried algal biomass and its activated carbon. Furthermore, regeneration of matrix was attempted and more than 70% and 80% of the adsorbent has been regenerated successfully in the case of dried and carbonized biomass respectively upto the 3rd cycle of regeneration study.
Keywords	Moorea producens ; activated carbon ; adsorbents ; adsorption ; algae ; biomass ; copper ; liquids ; models ; pH ; response surface methodology ; sorption isotherms ; wastewater
Language	English
Dates of publication	2017-05
Size	p. 935-949.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2594789-8
ISSN	2190-5495 ; 2190-5487
ISSN (online)	2190-5495
ISSN	2190-5487
DOI	10.1007/s13201-015-0304-0
Database	NAL-Catalogue (AGRICOLA)

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Article: Application of RSM and ANN for optimization and modeling of biosorption of chromium(VI) using cyanobacterial biomass

Sen, Sushovan / Somnath Nandi / Susmita Dutta

Applied water science. 2018 Sept., v. 8, no. 5

2018

Abstract: Proper treatment of heavy metal ions present in wastewaters is a major concern. With extensive usage in various industries, Cr(VI) contamination has become threatening for the environment. Biosorption is a favorable technique for heavy metals removal. In ...

Abstract	Proper treatment of heavy metal ions present in wastewaters is a major concern. With extensive usage in various industries, Cr(VI) contamination has become threatening for the environment. Biosorption is a favorable technique for heavy metals removal. In the present study, dried cyanobacterial consortium of Dinophysis caudata and Dinophysis acuminata were used to assess its biosorption capability. The surface texture and morphology of the biosorbent were obtained through scanning electron microscopy. The presence of different chemical bonds, namely hydroxyl, C–H and C–N, was confirmed through FTIR study. Pseudo-second-order Mckay-Ho model was found to perform best to fit the kinetic data. Temkin adsorption isotherm model fit best to the equilibrium data. Response surface methodology (RSM) was employed to optimize Cr(VI) abatement. Effect of initial concentration (IC) of metal ion, temperature, pH variation and amount of adsorbent (AD) were studied during batch study. Maximum Cr(VI) abatement after 5 min contact time was 80.77% for an IC of Cr(VI) of 25 mg/L, at pH 11 and 45 °C with the AD of 2.5 g/L. The optimum removal conditions as shown by RSM study were IC of Cr(VI): 15 mg/L, AD: 1 g/L, pH: 11, and the removal was predicted as 81.72%. Artificial neural network-based model was further developed based on experimental points which indicated that the model can predict abatement of Cr(VI) for various operating conditions with reasonably high accuracy.
Keywords	adsorbents ; biomass ; biosorbents ; biosorption ; chemical bonding ; chromium ; Dinophysis acuminata ; Dinophysis caudata ; Fourier transform infrared spectroscopy ; heavy metals ; industry ; metal ions ; neural networks ; pH ; response surface methodology ; scanning electron microscopy ; sorption isotherms ; temperature ; texture ; wastewater
Language	English
Dates of publication	2018-09
Size	p. 148.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2594789-8
ISSN	2190-5495 ; 2190-5487
ISSN (online)	2190-5495
ISSN	2190-5487
DOI	10.1007/s13201-018-0790-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In silico analysis of altered expression of long non-coding RNA in SARS-CoV-2 infected cells and their possible regulation by STAT1, STAT3 and interferon regulatory factors

Sayantan Laha / Chinmay Saha / Susmita Dutta / Madhurima Basu / Raghunath Chatterjee / Sujoy Ghosh / Nitai P. Bhattacharyya

Heliyon, Vol 7, Iss 3, Pp e06395- (2021)

2021

Abstract: Altered expression of long noncoding RNA (lncRNA), longer than 200 nucleotides without potential for coding protein, has been observed in diverse human diseases including viral diseases. It is largely unknown whether lncRNA would deregulate in SARS-CoV-2 ...

Abstract	Altered expression of long noncoding RNA (lncRNA), longer than 200 nucleotides without potential for coding protein, has been observed in diverse human diseases including viral diseases. It is largely unknown whether lncRNA would deregulate in SARS-CoV-2 infection, causing ongoing pandemic COVID-19. To identify, if lncRNA was deregulated in SARS-CoV-2 infected cells, we analyzed in silico the data in GSE147507. It was revealed that expression of 20 lncRNA like MALAT1, NEAT1 was increased and 4 lncRNA like PART1, TP53TG1 was decreased in at least two independent cell lines infected with SARS-CoV-2. Expression of NEAT1 was also increased in lungs tissue of COVID-19 patients. The deregulated lncRNA could interact with more than 2800 genes/proteins and 422 microRNAs as revealed from the database that catalogs experimentally determined interactions. Analysis with the interacting gene/protein partners of deregulated lncRNAs revealed that these genes/proteins were associated with many pathways related to viral infection, inflammation and immune functions. To find out whether these lncRNAs could be regulated by STATs and interferon regulatory factors (IRFs), we used ChIPBase v2.0 that catalogs experimentally determined binding from ChIP-seq data. It was revealed that any one of the transcription factors IRF1, IRF4, STAT1, STAT3 and STAT5A had experimentally determined binding at regions within -5kb to +1kb of the deregulated lncRNAs in at least 2 independent cell lines/conditions. Our analysis revealed that several lncRNAs could be regulated by IRF1, IRF4 STAT1 and STAT3 in response to SARS-CoV-2 infection and lncRNAs might be involved in antiviral response. However, these in silico observations are necessary to be validated experimentally.
Keywords	Long non-coding RNA ; NEAT1 ; MALAT1 ; Interferon regulatory factors ; SARS-CoV-2 ; COVID-19 ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	570
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Critical Review on Occurrence of Fluoride and Its Removal through Adsorption with an Emphasis on Natural Minerals

Biswas, Gargi / Manjari Kumari / Kalyan Adhikari / Susmita Dutta

Curr Pollution Rep. 2017 June, v. 3, no. 2

2017

Abstract: Being the most reactive of all chemical elements and the lightest member of halogen group, fluorine is found in the environment as fluoride. Both natural and anthropogenic activities are responsible for fluoride contamination in groundwater. Fluoride has ...

Abstract	Being the most reactive of all chemical elements and the lightest member of halogen group, fluorine is found in the environment as fluoride. Both natural and anthropogenic activities are responsible for fluoride contamination in groundwater. Fluoride has dual effect on human health. While lower concentration (<0.5 mg/L) is responsible for dental fluorosis, higher concentration (>1.5 mg/L) leads to skeletal fluorosis and even death. The present review paper is aimed at providing detailed occurrence of fluoride pollution around the globe and in India. Among the different defluoridation techniques to remove excess fluoride from contaminated drinking water at both community and domestic levels, adsorption is found to be very effective due to its technical feasibility, simple characteristics and comparative low-cost nature. Various adsorbents have been tested for their ability to treat fluoride contaminated water, viz., activated carbon, activated alumina, soil, clay and a variety of waste materials. Since fluoride pollution of drinking water is a major concern of poor people as they cannot afford to spend on purification of water, usage of low-cost natural mineral (natural mineral) as adsorbent for fluoride removal is one of the most essential issues in modern era. The present review bestows a detailed discussion on natural mineral as adsorbent used in defluoridation process with special emphasis on soil and low-cost clay minerals.
Keywords	adsorbents ; adsorption ; aluminum oxide ; anthropogenic activities ; carbon ; clay ; clay minerals ; defluoridation ; drinking water ; fluorides ; fluorine ; groundwater contamination ; soil ; wastes ; India
Language	English
Dates of publication	2017-06
Size	p. 104-119.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ISSN	2198-6592
DOI	10.1007/s40726-017-0054-8
Database	NAL-Catalogue (AGRICOLA)

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Article: A comparative study of removal of fluoride from contaminated water using shale collected from different coal mines in India

Biswas, Gargi / Manjari Dutta / Susmita Dutta / Kalyan Adhikari

Environmental science and pollution research international. 2016 May, v. 23, no. 10

2016

Abstract: Low-cost water defluoridation technique is one of the most important issues throughout the world. In the present study, shale, a coal mine waste, is employed as novel and low-cost adsorbent to abate fluoride from simulated solution. Shale samples were ... ...

Abstract	Low-cost water defluoridation technique is one of the most important issues throughout the world. In the present study, shale, a coal mine waste, is employed as novel and low-cost adsorbent to abate fluoride from simulated solution. Shale samples were collected from Mahabir colliery (MBS) and Sonepur Bazari colliery (SBS) of Raniganj coalfield in West Bengal, India, and used to remove fluoride. To increase the adsorption efficiency, shale samples were heat activated at a higher temperature and samples obtained at 550Â Â°C are denoted as heat-activated Mahabir colliery shale (HAMBSâââ) and heat-activated Sonepur Bazari colliery shale (HASBSâââ), respectively. To prove the fluoride adsorption onto different shale samples and ascertain its mechanism, natural shale samples, heat-activated shale samples, and their fluoride-loaded forms were characterized using scanning electron microscopy, energy dispersive X-ray analysis, X-ray diffraction study, and Fourier transform infrared spectroscopy. The effect of different parameters such as pH, adsorbent dose, size of particles, and initial concentration of fluoride was investigated during fluoride removal in a batch contactor. Lower pH shows better adsorption in batch study, but it is acidic in nature and not suitable for direct consumption. However, increase of pH of the solution from 3.2 to 6.8 and 7.2 during fluoride removal process with HAMBSâââ and HASBSâââ, respectively, confirms the applicability of the treated water for domestic purposes. HAMBSâââ and HASBSâââ show maximum removal of 88.3 and 88.5Â %, respectively, at initial fluoride concentration of 10Â mg/L, pHÂ 3, and adsorbent dose of 70Â g/L.
Keywords	Fourier transform infrared spectroscopy ; X-ray diffraction ; adsorbents ; adsorption ; coal ; defluoridation ; energy-dispersive X-ray analysis ; fluorides ; heat ; pH ; scanning electron microscopy ; shale ; temperature ; wastes ; water pollution ; India
Language	English
Dates of publication	2016-05
Size	p. 9418-9431.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-015-5815-6
Database	NAL-Catalogue (AGRICOLA)

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Article: Evaluation of fluoride bioremediation and production of biomolecules by living cyanobacteria under fluoride stress condition

Biswas, Gargi / Sohini Guha Thakurta / Jitamanyu Chakrabarty / Kalyan Adhikari / Susmita Dutta

Ecotoxicology and environmental safety. 2018 Feb., v. 148

2018

Abstract: Application of microalgae for defluoridation has gained interest in recent years. In the present study, bioremediation of fluoride using living cyanobacteria, Starria zimbabweensis, collected from wastewater of coke-oven effluent treatment plant, ... ...

Abstract	Application of microalgae for defluoridation has gained interest in recent years. In the present study, bioremediation of fluoride using living cyanobacteria, Starria zimbabweensis, collected from wastewater of coke-oven effluent treatment plant, Durgapur, India, has been investigated. Initially, the cyanobacterial strain was grown in BG11 medium at 25Â°C, 45Î¼mol/m2/s irradiation in 18h: 6h light:dark cycle in an algal incubator. Samples were withdrawn after 2 days interval and analyzed for its dry biomass and lipid content. Optimum inoculum size of 10% and age of 16th day were assessed based on maximum dry biomass (9.307 Â± 0.01g/L) and lipid (244.05 Â± 0.02mg/L) production. SEM-EDX and FTIR studies of both native and fluoride treated biomass were done to emphasize the changes. During kinetic study of defluoridation, initial fluoride concentration was varied in the range of 10â50mg/L. Maximum fluoride removal (66.6 Â± 0.11%) and dry biomass (18.19 Â± 0.12g/L) were obtained at 10mg/L fluoride concentration using 10% of 16th day's inoculum. Biomass and lipid content were found to increase 2 and 4 folds, respectively under fluoride stress condition. Furthermore, chlorophyll, carbohydrate and protein content of the biomass were also compared between control and fluoride contaminated conditions. Fatty Acid Methyl Ester (FAME) analysis was done using Gas Chromatography (GC) to compare the lipid profile of native and fluoride loaded strain.
Keywords	Cyanobacteria ; Fourier transform infrared spectroscopy ; biomass ; bioremediation ; chlorophyll ; defluoridation ; energy-dispersive X-ray analysis ; fatty acid methyl esters ; fluorides ; gas chromatography ; inoculum ; irradiation ; lipid content ; lipids ; microalgae ; protein content ; scanning electron microscopy ; wastewater ; India
Language	English
Dates of publication	2018-02
Size	p. 26-36.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2017.10.019
Database	NAL-Catalogue (AGRICOLA)

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Article: Sequestration of carbon dioxide and production of biomolecules using cyanobacteria

Upendar, Ganta / Abhishek Dutta / Jitamanyu Chakrabarty / Kartik Chandra Ghanta / Sunita Singh / Susmita Dutta

Journal of environmental management. 2018 July 15, v. 218

2018

Abstract: A cyanobacterial strain, Synechococcus sp. NIT18, has been applied to sequester CO2 using sodium carbonate as inorganic carbon source due to its efficiency of CO2 bioconversion and high biomass production. The biomass obtained is used for the extraction ... ...

Abstract	A cyanobacterial strain, Synechococcus sp. NIT18, has been applied to sequester CO2 using sodium carbonate as inorganic carbon source due to its efficiency of CO2 bioconversion and high biomass production. The biomass obtained is used for the extraction of biomolecules - protein, carbohydrate and lipid. The main objective of the study is to maximize the biomass and biomolecules production with CO2 sequestration using cyanobacterial strain cultivated under different concentrations of CO2 (5–20%), pH (7–11) and inoculum size (5–12.5%) within a statistical framework. Maximum sequestration of CO2 and maximum productivities of protein, carbohydrate and lipid are 71.02%, 4.9 mg/L/day, 6.7 mg/L/day and 1.6 mg/L/day respectively, at initial CO2 concentration: 10%, pH: 9 and inoculum size: 12.5%. Since flue gas contains 10–15% CO2 and the present strain is able to sequester CO2 in this range, the strain could be considered as a useful tool for CO2 mitigation for greener world.
Keywords	biomass production ; biotransformation ; carbohydrates ; carbon dioxide ; carbon sequestration ; flue gas ; inoculum ; inorganic carbon ; lipids ; pH ; sodium carbonate ; Synechococcus
Language	English
Dates of publication	2018-0715
Size	p. 234-244.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2018.04.031
Database	NAL-Catalogue (AGRICOLA)

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Article: Removal of Cr(VI) using a cyanobacterial consortium and assessment of biofuel production

Sen, Sushovan / Abhishek Dutta / Jitamanyu Chakrabarty / Sohini Guhathakurata / Somnath Nandi / Susmita Dutta

International biodeterioration & biodegradation. 2017 Apr., v. 119

2017

Abstract: The use of cyanobacteria for the removal of heavy metals from wastewater is gaining interest due to its lower cost of operation and being environmentally benign. As chromium (Cr(VI)) is potentially toxic and carcinogenic for humans, its removal from ... ...

Abstract	The use of cyanobacteria for the removal of heavy metals from wastewater is gaining interest due to its lower cost of operation and being environmentally benign. As chromium (Cr(VI)) is potentially toxic and carcinogenic for humans, its removal from water and wastewater is obligatory in order to avoid water pollution. In the present study, the capacity of a living cyanobacterial consortium consisting of Limnococcus limneticus and Leptolyngbya subtilis, collected from East Kolkata Wetland, a wetland of international importance, for removal of Cr(VI) is investigated at different operating conditions. Input variables such as initial concentration of Cr(VI), pH and inoculum size are varied using one factor at a time (OFAT) analysis in the range of 5–30 mg/L, 7–11 and 2–10%, respectively. An optimum removal of 50% is achieved after 12 days of inoculation with initial concentration of 15 mg/L Cr(VI) at pH 9 and with inoculum size 10%. Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS) studies have ascertained the uptake of Cr(VI) by the living consortium. Fourier Transform Infrared Spectroscopy (FTIR) study has revealed that the amine, phosphate and carbonyl groups are involved for binding vis-à-vis biosorption of Cr(VI). The increase in inoculum size improves the percentage removal of Cr(VI). To assess the possibility of biofuel production, the cells are harvested for their dry biomass and lipid content. An increase in both dry biomass and lipid content is observed when living consortium is grown in Cr(VI) contaminated simulated wastewater instead of BG-11 medium. A regression model is developed to predict the interactive effect of four input variables namely initial concentration of Cr(VI), initial solution pH, inoculum size and time with three output variables namely dry biomass, lipid content and percentage removal of Cr(VI). Finally, Response Surface Methodology (RSM) is employed to optimize the process conditions for removal of Cr(VI). The optimum condition obtained from RSM study is initial Cr(VI) concentration:10 mg/L, pH: 9, inoculum size: 4%, time: 9 days and the predicted percentage removal (51%) matches quite well with experimental one (52.7%).
Keywords	biofuels ; biomass ; biosorption ; chromium ; energy-dispersive X-ray analysis ; Fourier transform infrared spectroscopy ; fuel production ; heavy metals ; humans ; inoculum ; Leptolyngbya ; lipid content ; operating costs ; pH ; phosphates ; regression analysis ; response surface methodology ; scanning electron microscopy ; toxicity ; wastewater ; water pollution ; wetlands
Language	English
Dates of publication	2017-04
Size	p. 211-224.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0964-8305
DOI	10.1016/j.ibiod.2016.10.050
Database	NAL-Catalogue (AGRICOLA)

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