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  1. Article ; Online: Diabetes-Specific Complete Smoothie Formulas Improve Postprandial Glycemic Response in Obese Type 2 Diabetic Individuals: A Randomized Crossover Trial.

    Mongkolsucharitkul, Pichanun / Pinsawas, Bonggochpass / Surawit, Apinya / Pongkunakorn, Tanyaporn / Manosan, Thamonwan / Ophakas, Suphawan / Suta, Sophida / Pumeiam, Sureeporn / Mayurasakorn, Korapat

    Nutrients

    2024  Volume 16, Issue 3

    Abstract: This study aimed to compare newly developed diabetes-specific complete smoothie formulas with a standard diabetes-specific nutritional formula (DSNF) regarding their effects on glucose homeostasis, insulin levels, and lipid metabolism in obese type 2 ... ...

    Abstract This study aimed to compare newly developed diabetes-specific complete smoothie formulas with a standard diabetes-specific nutritional formula (DSNF) regarding their effects on glucose homeostasis, insulin levels, and lipid metabolism in obese type 2 diabetes (T2DM) patients. We conducted a randomized, double-blind, crossover study with 41 obese T2DM participants to compare two developed diabetes-specific complete smoothie formulas, a soy-based regular smoothie (SM) and a smoothie with modified carbohydrate content (SMMC), with the standard DSNF, Glucerna. Glycemic and insulin responses were assessed after the participants randomly consumed 300 kilocalories of each formulation on three separate days with a 7-day gap between. Postprandial effects on glycemic control, insulin levels, and lipid metabolism were measured. SMMC resulted in a significantly lower glucose area under the curve (AUC
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/metabolism ; Cross-Over Studies ; Fatty Acids, Nonesterified ; Insulin/metabolism ; Obesity/complications ; Glucose ; Postprandial Period/physiology ; Blood Glucose/metabolism
    Chemical Substances Fatty Acids, Nonesterified ; Insulin ; Glucose (IY9XDZ35W2) ; Blood Glucose
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16030395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Factors influencing optimal diabetes care and clinical outcomes in Thai patients with type 2 diabetes mellitus: a multilevel modelling analysis.

    Surawit, Apinya / Pongkunakorn, Tanyaporn / Manosan, Thamonwan / Mongkolsucharitkul, Pichanun / Chamnan, Parinya / Suvarnabhumi, Krishna / Puangpet, Thanapat / Suta, Sophida / Pumeiam, Sureeporn / Pinsawas, Bonggochpass / Ophakas, Suphawan / Pisitpornsuk, Sananon / Utchin, Chalita / Mayurasakorn, Korapat

    BMJ open

    2024  Volume 14, Issue 5, Page(s) e079415

    Abstract: Background: Increasing levels of poor glycaemic control among Thai patients with type 2 diabetes mellitus (T2DM) motivated us to compare T2DM care between urban and suburban primary care units (PCUs), to identify gaps in care, and to identify ... ...

    Abstract Background: Increasing levels of poor glycaemic control among Thai patients with type 2 diabetes mellitus (T2DM) motivated us to compare T2DM care between urban and suburban primary care units (PCUs), to identify gaps in care, and to identify significant factors that may influence strategies to enhance the quality of care and clinical outcomes in this population.
    Methods: We conducted a cross-sectional study involving 2160 patients with T2DM treated at four Thai PCUs from 2019 to 2021, comprising one urban and three suburban facilities. Using mixed effects logistic regression, we compared care factors between urban and suburban PCUs.
    Results: Patients attending suburban PCUs were significantly more likely to undergo eye (adjusted OR (AOR): 1.83, 95% CI 1.35 to 1.72), foot (AOR: 1.61, 95% CI 0.65 to 4.59) and HbA
    Conclusion: This highlights the necessity for targeted interventions to bridge urban-suburban care gaps, optimise drug prescriptions and implement comprehensive care strategies for improved glycaemic control, DR prevention and CKD progression mitigation among in Thai patients with T2DM. The value of the clinical target aggregate (ABC) and the process of care aggregate (FAACE) was also conclusively demonstrated.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/therapy ; Male ; Female ; Thailand ; Cross-Sectional Studies ; Middle Aged ; Aged ; Primary Health Care ; Glycated Hemoglobin/analysis ; Multilevel Analysis ; Blood Pressure ; Diabetic Retinopathy/therapy ; Diabetic Retinopathy/epidemiology ; Quality of Health Care ; Logistic Models ; Suburban Population ; Glycemic Control ; Cholesterol, LDL/blood ; Urban Population/statistics & numerical data ; Adult ; Southeast Asian People
    Chemical Substances Glycated Hemoglobin ; Cholesterol, LDL
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-079415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Validation of a Thai semiquantitative food frequency questionnaire (semi-FFQ) for people at risk of metabolic syndrome.

    Nirdnoy, Nattvara / Sranacharoenpong, Kitti / Surawit, Apinya / Pinsawas, Bonggochpass / Mongkolsucharitkul, Pichanun / Pongkunakorn, Tanyaporn / Manosan, Thamonwan / Ophakas, Suphawan / Suta, Sophida / Pumeiam, Sureeporn / Mayurasakorn, Korapat

    Journal of health, population, and nutrition

    2023  Volume 42, Issue 1, Page(s) 13

    Abstract: Background: Food frequency questionnaires (FFQ) are a useful dietary assessment tool to determine relationships between diet and non-communicable diseases (NCDs). Our purpose was to validate a semiquantitative FFQ (semi-FFQ) for Thais at risk of ... ...

    Abstract Background: Food frequency questionnaires (FFQ) are a useful dietary assessment tool to determine relationships between diet and non-communicable diseases (NCDs). Our purpose was to validate a semiquantitative FFQ (semi-FFQ) for Thais at risk of metabolic syndrome (MS).
    Methods: The researchers identified 345 men and women aged 30-65 years who were eligible for the study. Ninety-four participants were finally enrolled (54 in a "urine-collection not-required" group and 40 in a "urine collection" group). They were asked to maintain a 4-day food record for 4 weeks and partook in a semi-FFQ interview during week 4. Urine samples and biochemical results related to MS were collected. Validation results were associated with three primary nutrients for MS (sugar, fat, and sodium) and biochemical results (blood glucose, lipid profiles, blood pressure, and 24-h urine sodium).
    Results: The biomarker level of each key MS nutrient significantly increased commensurate with rises in semi-FFQ estimated intakes. Correlation coefficients (r) were as follows: fasting blood glucose, r = 0.221 (fruits) and r = 0.229 (desserts); triglycerides, r = 0.112 (a la carte-dishes); low-density lipoprotein cholesterol, r = 0.205 (rice-with-topping dishes); systolic blood pressure, r = 0.272 (snacks) and r = 0.190 (a la carte dishes). Fasting blood glucose was a significant biomarker associated with the development of metabolic syndrome (OR 1.42, 95% CI 1.12-1.81). We also found that fat (OR 1.28, 95% CI 1.09-1.89), sodium (OR 1.98, 95% CI 1.05-1.95) and energy (OR 1.09, 95% CI 1.01-1.17) from an a la carte meal were significantly associated with the development of metabolic syndrome.
    Conclusions: Thai food has a unique characteristic since it often pairs various ingredients and seasoning in one menu. This semi-FFQ is a tool that offers relatively valid ranking for intake of energy, nutrients, single foods, and mixed dishes based on Thai menus associated with a risk for developing metabolic syndrome and NCDs. Using this tool could help identify unhealthy dietary patterns and help develop recommendations for people at risk with the goal of preventing NCDs.
    MeSH term(s) Female ; Humans ; Male ; Biomarkers ; Blood Glucose ; Diet ; Diet Records ; Diet Surveys ; Energy Intake ; Metabolic Syndrome ; Reproducibility of Results ; Sodium ; Southeast Asian People ; Surveys and Questionnaires ; Thailand
    Chemical Substances Biomarkers ; Blood Glucose ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-02-23
    Publishing country Bangladesh
    Document type Journal Article ; Validation Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2025045-9
    ISSN 2072-1315 ; 1606-0997
    ISSN (online) 2072-1315
    ISSN 1606-0997
    DOI 10.1186/s41043-023-00353-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Influence of Prolonged Whole Egg Supplementation on Insulin-like Growth Factor 1 and Short-Chain Fatty Acids Product: Implications for Human Health and Gut Microbiota.

    Suta, Sophida / Ophakas, Suphawan / Manosan, Thamonwan / Honwichit, Orranich / Charoensiddhi, Suvimol / Surawit, Apinya / Pongkunakorn, Tanyaporn / Pumeiam, Sureeporn / Mongkolsucharitkul, Pichanun / Pinsawas, Bonggochpass / Sutheeworapong, Sawannee / Puangsombat, Patcha / Khoomrung, Sakda / Mayurasakorn, Korapat

    Nutrients

    2023  Volume 15, Issue 22

    Abstract: The gut microbiota exert a profound influence on human health and metabolism, with microbial metabolites playing a pivotal role in shaping host physiology. This study investigated the impact of prolonged egg supplementation on insulin-like growth factor ... ...

    Abstract The gut microbiota exert a profound influence on human health and metabolism, with microbial metabolites playing a pivotal role in shaping host physiology. This study investigated the impact of prolonged egg supplementation on insulin-like growth factor 1 (IGF-1) and circulating short-chain fatty acids (SCFAs). In a subset of a cluster-randomized trial, participants aged 8-14 years were randomly assigned into three groups: (1) Whole Egg (WE)-consuming 10 additional eggs per week [
    MeSH term(s) Humans ; Acetates ; Dietary Supplements ; Fatty Acids, Volatile/metabolism ; Gastrointestinal Microbiome ; Insulin-Like Growth Factor I ; Child ; Adolescent
    Chemical Substances Acetates ; Fatty Acids, Volatile ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15224804
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  5. Article ; Online: Prolonged Egg Supplement Advances Growing Child's Growth and Gut Microbiota.

    Suta, Sophida / Surawit, Apinya / Mongkolsucharitkul, Pichanun / Pinsawas, Bonggochpass / Manosan, Thamonwan / Ophakas, Suphawan / Pongkunakorn, Tanyaporn / Pumeiam, Sureeporn / Sranacharoenpong, Kitti / Sutheeworapong, Sawannee / Poungsombat, Patcha / Khoomrung, Sakda / Akarasereenont, Pravit / Thaipisuttikul, Iyarit / Suktitipat, Bhoom / Mayurasakorn, Korapat

    Nutrients

    2023  Volume 15, Issue 5

    Abstract: Protein-energy malnutrition still impacts children's growth and development. We investigated the prolonged effects of egg supplementation on growth and microbiota in primary school children. For this study, 8-14-year-old students (51.5% F) in six rural ... ...

    Abstract Protein-energy malnutrition still impacts children's growth and development. We investigated the prolonged effects of egg supplementation on growth and microbiota in primary school children. For this study, 8-14-year-old students (51.5% F) in six rural schools in Thailand were randomly assigned into three groups: (1) whole egg (WE), consuming 10 additional eggs/week (
    MeSH term(s) Adolescent ; Child ; Humans ; Body Weight ; Dietary Supplements ; Eggs ; Gastrointestinal Microbiome ; Lipoproteins
    Chemical Substances Lipoproteins
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15051143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Immune Response after SARS-CoV-2 Infection with Residual Post-COVID Symptoms.

    Pongkunakorn, Tanyaporn / Manosan, Thamonwan / Surawit, Apinya / Ophakas, Suphawan / Mongkolsucharitkul, Pichanun / Pumeiam, Sureeporn / Suta, Sophida / Pinsawas, Bonggochpass / Sookrung, Nitat / Saelim, Nawannaporn / Mahasongkram, Kodchakorn / Prangtaworn, Pannathee / Tungtrongchitr, Anchalee / Tangjittipokin, Watip / Mangmee, Suthee / Boonnak, Kobporn / Narkdontri, Tassanee / Teerawattanapong, Nipaporn / Wanitphadeedecha, Rungsima /
    Mayurasakorn, Korapat

    Vaccines

    2023  Volume 11, Issue 9

    Abstract: Many patients develop post-acute COVID syndrome (long COVID (LC)). We compared the immune response of LC and individuals with post-COVID full recovery (HC) during the Omicron pandemic. Two hundred ninety-two patients with confirmed COVID infections from ... ...

    Abstract Many patients develop post-acute COVID syndrome (long COVID (LC)). We compared the immune response of LC and individuals with post-COVID full recovery (HC) during the Omicron pandemic. Two hundred ninety-two patients with confirmed COVID infections from January to May 2022 were enrolled. We observed anti-SARS-CoV-2 receptor-binding domain immunoglobulin G, surrogate virus neutralization test, T cell subsets, and neutralizing antibodies against Wuhan, BA.1, and BA.5 viruses (NeuT). NeuT was markedly reduced against BA.1 and BA.5 in HC and LC groups, while antibodies were more sustained with three doses and an updated booster shot than ≤2-dose vaccinations. The viral neutralization ability declined at >84-days after COVID-19 onset (PC) in both groups. PD1-expressed central and effector memory CD4
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11091413
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  7. Article ; Online: Immune response after SARS-CoV-2 infection with residual post COVID symptoms

    Pongkunakorn, Tanyaporn / Manosan, Thamonwan / Surawit, Apinya / Ophakas, Suphawan / Mongkolsucharitkul, Pichanun / Pumiem, Sureeporn / Suta, Sophida / Pinsawas, Bonggochpass / Sookrung, Nitat / Saelim, Nawannaporn / Mahasongkram, Kodchakorn / Prangtaworn, Pannathee / Tungtrongchitr, Anchalee / Tangjittipokin, Watip / Boonnak, Kobporn / Narkdontri, Tassanee / Teerawattanapong, Nipaporn / Jongkaewwattana, Anan / Mayurasakorn, Korapat

    medRxiv

    Abstract: BACKGROUND In a number of patients, post-acute COVID syndrome develops after acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Long COVID [LC]). Here, we examined the immune responses and clinical characteristics of ... ...

    Abstract BACKGROUND In a number of patients, post-acute COVID syndrome develops after acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Long COVID [LC]). Here, we examined the immune responses and clinical characteristics of individuals with LC compared to age- and gender-matched healthy recovered COVID individuals (HC) during the Omicron pandemic. Immune responses following BNT162b2 (Pfizer) booster are also determined. METHODS This retrospective cohort study included 292 patients (LC, 158; HC, 134) confirmed to have SARS-CoV-2 infection from January to August 2022. We determined anti-SARS-CoV-2 receptor-binding domain immunoglobulin G (anti-RBD IgG), surrogate virus neutralization test (sVNT), T-cell subsets, and neutralization of wild-type, BA.1 and BA.5. A subset of patients was voluntarily recruited for booster vaccination with BNT162b2 vaccine and immunogenicity was assessed 4weeks after vaccination. RESULTS Cycle thresholds were higher in the HC group than in the LC group (20.7 vs. 19.7; P<0.039). Anti-RBD IgG was higher at ≤56 days after COVID-19 onset (PC) in 3-dose vaccines compared with 2-dose vaccines in the LC group (P=0.02) and after 57-84 days PC in 3-dose vaccines in the HC group (P<0.001). The sVNT in LC was significantly high against Wuhan and sVNT was 30% lower against the Omicron than the Wuhan. sVNT was relatively sustained in 3-dose vaccines than ≤ 2-dose vaccines. sVNT in the HC group reached its peak at 57-84 days PC as compared with the LC group. CONCLUSIONS These findings imply that LC produced increased neutralizing antibody responses than those with HC. During the Omicron pandemic, immunity after LC has still waned; therefore, a booster vaccine may be needed after 2-3 months from last infection. (ClinicalTrials.gov number, NCT05484700)
    Keywords covid19
    Language English
    Publishing date 2022-10-10
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.10.10.22280762
    Database COVID19

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