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Article: Changes in Inflammatory Cytokines After Chronic Hepatitis C Treatment Among People Living With HIV.

Karimi-Sari, Hamidreza / Piggott, Damani A / Scully, Eileen P / Ward, Kathleen / Sutcliffe, Catherine G / Sulkowski, Mark / Falade-Nwulia, Oluwaseun

Open forum infectious diseases

2024 Volume 11, Issue 1, Page(s) ofad623

Abstract: We aimed to evaluate the effect of hepatitis C virus cure on serum inflammatory markers among people with HIV. Among 127 people with HIV, serum alanine aminotransferase, soluble tumor necrosis factor receptor 1, and inflammatory index score were ... ...

Abstract	We aimed to evaluate the effect of hepatitis C virus cure on serum inflammatory markers among people with HIV. Among 127 people with HIV, serum alanine aminotransferase, soluble tumor necrosis factor receptor 1, and inflammatory index score were significantly lower at the 24-week time point in patients who achieved sustained virologic response as compared with those who did not.
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad623
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Article ; Online: Modelling the structure of Short Gastrulation and generation of a toolkit for studying its function in Drosophila.

Frampton, Sophie L / Sutcliffe, Catherine / Baldock, Clair / Ashe, Hilary L

Biology open

2022 Volume 11, Issue 6

Abstract: A BMP gradient is essential for patterning the dorsal-ventral axis of invertebrate and vertebrate embryos. The extracellular BMP binding protein Short Gastrulation (Sog) in Drosophila plays a key role in BMP gradient formation. In this study, we combine ... ...

Abstract	A BMP gradient is essential for patterning the dorsal-ventral axis of invertebrate and vertebrate embryos. The extracellular BMP binding protein Short Gastrulation (Sog) in Drosophila plays a key role in BMP gradient formation. In this study, we combine genome editing, structural and developmental approaches to study Sog function in Drosophila. We generate a sog knockout fly stock, which allows simple reintegration of altered versions of the sog coding sequence. As proof-of-principle, we test the requirement for two cysteine residues that were previously identified as targets for palmitoylation, which has been proposed to enhance Sog secretion. However, we show that the sogC27,28S mutant is viable with only very mild phenotypes, indicating that these residues and their potential modification are not critical for Sog secretion in vivo. Additionally, we use experimental negative stain EM imaging and hydrodynamic data to validate the AlphaFold structure prediction for Sog. The model suggests a more compact shape than the vertebrate ortholog Chordin and conformational flexibility between the C-terminal von Willebrand C domains. We discuss how this altered compactness may contribute to mechanistic differences in Sog and Chordin function during BMP gradient formation. This article has an associated First Person interview with the first author of the paper.
MeSH term(s)	Animals ; Bone Morphogenetic Proteins/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Gastrulation ; Humans ; Signal Transduction
Chemical Substances	Bone Morphogenetic Proteins ; Drosophila Proteins
Language	English
Publishing date	2022-06-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.059199
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Article ; Online: Is laboratory monitoring of ART essential worldwide?

Sutcliffe, Catherine G

The Lancet. Infectious diseases

2011 Volume 11, Issue 11, Page(s) 803–804

MeSH term(s)	Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Drug Monitoring ; Drug Resistance, Viral ; Female ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV-1/drug effects ; HIV-1/physiology ; Humans ; Male
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2011-11
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(11)70185-2
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Article ; Online: Dynamics of hunchback translation in real-time and at single-mRNA resolution in the Drosophila embryo.

Vinter, Daisy J / Hoppe, Caroline / Minchington, Thomas G / Sutcliffe, Catherine / Ashe, Hilary L

Development (Cambridge, England)

2021 Volume 148, Issue 18

Abstract: The Hunchback (Hb) transcription factor is crucial for anterior-posterior patterning of the Drosophila embryo. The maternal hb mRNA acts as a paradigm for translational regulation due to its repression in the posterior of the embryo. However, little is ... ...

Abstract	The Hunchback (Hb) transcription factor is crucial for anterior-posterior patterning of the Drosophila embryo. The maternal hb mRNA acts as a paradigm for translational regulation due to its repression in the posterior of the embryo. However, little is known about the translatability of zygotically transcribed hb mRNAs. Here, we adapt the SunTag system, developed for imaging translation at single-mRNA resolution in tissue culture cells, to the Drosophila embryo to study the translation dynamics of zygotic hb mRNAs. Using single-molecule imaging in fixed and live embryos, we provide evidence for translational repression of zygotic SunTag-hb mRNAs. Whereas the proportion of SunTag-hb mRNAs translated is initially uniform, translation declines from the anterior over time until it becomes restricted to a posterior band in the expression domain. We discuss how regulated hb mRNA translation may help establish the sharp Hb expression boundary, which is a model for precision and noise during developmental patterning. Overall, our data show how use of the SunTag method on fixed and live embryos is a powerful combination for elucidating spatiotemporal regulation of mRNA translation in Drosophila.
MeSH term(s)	Animals ; Body Patterning/genetics ; DNA-Binding Proteins/genetics ; Drosophila/genetics ; Drosophila Proteins/genetics ; Embryo, Nonmammalian/physiology ; Gene Expression Regulation, Developmental/genetics ; Morphogenesis/genetics ; Protein Biosynthesis/genetics ; RNA, Messenger, Stored/genetics ; Transcription Factors/genetics ; Zygote/physiology
Chemical Substances	DNA-Binding Proteins ; Drosophila Proteins ; RNA, Messenger, Stored ; Transcription Factors ; hb protein, Drosophila
Language	English
Publishing date	2021-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.196121
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Article: Influenza A and D Viruses in Non-Human Mammalian Hosts in Africa: A Systematic Review and Meta-Analysis

Kalonda, Annie / Phonera, Marvin / Saasa, Ngonda / Kajihara, Masahiro / Sutcliffe, Catherine G. / Sawa, Hirofumi / Takada, Ayato / Simulundu, Edgar

Viruses. 2021 Dec. 02, v. 13, no. 12

2021

Abstract: We conducted a systematic review and meta-analysis to investigate the prevalence and current knowledge of influenza A virus (IAV) and influenza D virus (IDV) in non-human mammalian hosts in Africa. PubMed, Google Scholar, Wiley Online Library and World ... ...

Abstract	We conducted a systematic review and meta-analysis to investigate the prevalence and current knowledge of influenza A virus (IAV) and influenza D virus (IDV) in non-human mammalian hosts in Africa. PubMed, Google Scholar, Wiley Online Library and World Organisation for Animal Health (OIE-WAHIS) were searched for studies on IAV and IDV from 2000 to 2020. Pooled prevalence and seroprevalences were estimated using the quality effects meta-analysis model. The estimated pooled prevalence and seroprevalence of IAV in pigs in Africa was 1.6% (95% CI: 0–5%) and 14.9% (95% CI: 5–28%), respectively. The seroprevalence of IDV was 87.2% (95% CI: 24–100%) in camels, 9.3% (95% CI: 0–24%) in cattle, 2.2% (95% CI: 0–4%) in small ruminants and 0.0% (95% CI: 0–2%) in pigs. In pigs, H1N1 and H1N1pdm09 IAVs were commonly detected. Notably, the highly pathogenic H5N1 virus was also detected in pigs. Other subtypes detected serologically and/or virologically included H3N8 and H7N7 in equids, H1N1, and H3N8 and H5N1 in dogs and cats. Furthermore, various wildlife animals were exposed to different IAV subtypes. For prudent mitigation of influenza epizootics and possible human infections, influenza surveillance efforts in Africa should not neglect non-human mammalian hosts. The impact of IAV and IDV in non-human mammalian hosts in Africa deserves further investigation.
Keywords	Equidae ; Influenza A virus ; World Organization for Animal Health ; cattle ; humans ; influenza ; meta-analysis ; models ; monitoring ; seroprevalence ; systematic review ; viruses ; wildlife ; Africa
Language	English
Dates of publication	2021-1202
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13122411
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The downside of success: confirmation of HIV infection in early treated children.

Sutcliffe, Catherine G / Moss, William J

The Lancet. Infectious diseases

2015 Volume 15, Issue 7, Page(s) 751–752

MeSH term(s)	Anti-HIV Agents/therapeutic use ; Female ; HIV Antibodies/blood ; HIV Seronegativity/drug effects ; HIV Seropositivity/drug therapy ; HIV Seropositivity/immunology ; HIV-1/immunology ; HIV-2/immunology ; Humans ; Male
Chemical Substances	Anti-HIV Agents ; HIV Antibodies
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(15)00086-9
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Article ; Online: Streptococcus pneumoniae

Cella, Eleonora / Sutcliffe, Catherine G / Grant, Lindsay R / Tso, Carol / Weatherholtz, Robert C / Littlepage, Shea / Becenti, Ladonna / Jubair, Mohammad / Simons, Brenna C / Harker-Jones, Marcella / Reid, Raymond / Yazzie, Del / Santosham, Mathuram / O'Brien, Katherine L / Hammitt, Laura L / Azarian, Taj

Microbial genomics

2024 Volume 10, Issue 3

Abstract: Background. ...

Abstract	Background.
MeSH term(s)	Child ; Adult ; Humans ; Streptococcus pneumoniae ; Vaccines, Conjugate ; Serogroup ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Incidence
Chemical Substances	Vaccines, Conjugate ; Pneumococcal Vaccines
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2835258-0
ISSN	2057-5858 ; 2057-5858
ISSN (online)	2057-5858
ISSN	2057-5858
DOI	10.1099/mgen.0.001196
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Article ; Online: The Evolving Pediatric HIV Epidemic in Rural Southern Zambia: The Beneficial Impact of Advances in Prevention and Treatment at a District Hospital From 2007 to 2019.

Sutcliffe, Catherine G / Moyo, Nkumbula / Hamahuwa, Mutinta / Mutanga, Jane N / van Dijk, Janneke H / Hamangaba, Francis / Schue, Jessica L / Thuma, Philip E / Moss, William J

The Pediatric infectious disease journal

2023 Volume 42, Issue 6, Page(s) 489–495

Abstract: Background: Remarkable progress has been made in expanding access to services addressing the pediatric HIV epidemic, including programs to prevent mother-to-child transmission, early diagnosis and treatment for children living with HIV. Few long-term ... ...

Abstract	Background: Remarkable progress has been made in expanding access to services addressing the pediatric HIV epidemic, including programs to prevent mother-to-child transmission, early diagnosis and treatment for children living with HIV. Few long-term data are available from rural sub-Saharan Africa to assess implementation and impact of national guidelines. Methods: Results from 3 cross-sectional studies and 1 cohort study conducted at Macha Hospital in Southern Province, Zambia from 2007 to 2019 were summarized. For infant diagnosis, maternal antiretroviral treatment, infant test results and turnaround times for results were evaluated by year. For pediatric HIV care, the number and age of children initiating care and treatment, and treatment outcomes within 12 months were evaluated by year. Results: Receipt of maternal combination antiretroviral treatment increased from 51.6% in 2010-2012 to 93.4% in 2019, and the proportion of infants testing positive decreased from 12.4% to 4.0%. Turnaround times for results returning to clinic varied but were shorter when labs consistently used a text messaging system. The proportion of mothers receiving results was higher when a text message intervention was piloted. The number of children living with HIV enrolled into care and the proportion initiating treatment with severe immunosuppression and dying within 12 months decreased over time. Conclusions: These studies demonstrate the long-term beneficial impact of implementing a strong HIV prevention and treatment program. While expansion and decentralization brought challenges, the program succeeded in decreasing the rate of mother-to-child transmission and ensuring that children living with HIV benefit from access to life-saving treatment.
MeSH term(s)	Infant ; Child ; Humans ; Female ; Cohort Studies ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Zambia/epidemiology ; Cross-Sectional Studies ; Hospitals, District ; Infectious Disease Transmission, Vertical/prevention & control ; Anti-Retroviral Agents/therapeutic use
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003873
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Article ; Online: Respiratory viruses in rural Zambia during the second year of the COVID-19 pandemic.

Sutcliffe, Catherine G / Hamahuwa, Mutinta / Miller, Evan / Sinywimaanzi, Pamela / Hardick, Justin / Morales, Juliet / Munachoonga, Passwell / Monze, Mwaka / Manabe, Yukari C / Fenstermacher, Katherine Z J / Rothman, Richard E / Pekosz, Andrew / Thuma, Philip E / Simulundu, Edgar

IJID regions

2023 Volume 8, Page(s) 90–94

Abstract: Objectives: Limited data on respiratory infections are available from sub-Saharan Africa during the COVID-19 pandemic. The objective of this study was to evaluate the burden of respiratory viruses in rural Zambia from 2019-2021.: Methods: ... ...

Abstract	Objectives: Limited data on respiratory infections are available from sub-Saharan Africa during the COVID-19 pandemic. The objective of this study was to evaluate the burden of respiratory viruses in rural Zambia from 2019-2021. Methods: Surveillance was initiated at Macha Hospital in Zambia in December 2018. Each week, patients with respiratory symptoms were enrolled from the outpatient clinic. Nasopharyngeal samples were collected and tested for respiratory pathogens. The prevalence of respiratory symptoms and viruses in 2021 was compared to results from 2019 and 2020. Results: After seeing few cases of influenza virus and respiratory syncytial virus in 2020, a return to prepandemic levels was observed in 2021. Rhinovirus/enterovirus, parainfluenza virus 1-4, and adenovirus circulated from 2019 to 2021, while human metapneumovirus and human coronaviruses (HKU1, 229E, OC43, and NL63 subtypes) were observed sporadically. SARS-CoV-2 was observed consistently in 2021 after being first identified in December 2020. The proportion of participants with co-infections in 2021 (11.6%) was significantly higher than in 2019 (6.9%) or 2020 (7.7%). Conclusion: Declines in influenza virus and respiratory syncytial virus were reversed once public health measures were lifted. Respiratory viruses contributed to a significant burden of respiratory infections in 2021. This study provides important information about respiratory viruses in this changing context and underrepresented region.
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article
ISSN	2772-7076
ISSN (online)	2772-7076
DOI	10.1016/j.ijregi.2023.07.003
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Article ; Online: Cost-effectiveness of point-of-care versus centralised, laboratory-based nucleic acid testing for diagnosis of HIV in infants: a systematic review of modelling studies.

le Roux, Stanzi M / Odayar, Jasantha / Sutcliffe, Catherine G / Salvatore, Phillip P / de Broucker, Gatien / Dowdy, David / McCann, Nicole C / Frank, Simone C / Ciaranello, Andrea L / Myer, Landon / Vojnov, Lara

The lancet. HIV

2023 Volume 10, Issue 5, Page(s) e320–e331

Abstract: Background: Point-of-care (POC) nucleic acid testing for diagnosis of HIV in infants facilitates earlier initiation of antiretroviral therapy (ART) than with centralised (standard-of-care, SOC) testing, but can be more expensive. We evaluated cost- ... ...

Abstract	Background: Point-of-care (POC) nucleic acid testing for diagnosis of HIV in infants facilitates earlier initiation of antiretroviral therapy (ART) than with centralised (standard-of-care, SOC) testing, but can be more expensive. We evaluated cost-effectiveness data from mathematical models comparing POC with SOC to provide global policy guidance. Methods: In this systematic review of modelling studies, we searched PubMed, MEDLINE, Embase, the National Health Service Economic Evaluation Database, Econlit, and conference abstracts, combining terms for "HIV" + "infant"/"early infant diagnosis" + "point-of-care" + "cost-effectiveness" + "mathematical models", without restrictions from database inception to July 15, 2022. We selected reports of mathematical cost-effectiveness models comparing POC with SOC for HIV diagnosis in infants younger than 18 months. Titles and abstracts were independently reviewed, with full-text review for qualifying articles. We extracted data on health and economic outcomes and incremental cost-effectiveness ratios (ICERs) for narrative synthesis. The primary outcomes of interest were ICERs (comparing POC with SOC) for ART initiation and survival of children living with HIV. Findings: Our search identified 75 records through database search. 13 duplicates were excluded, leaving 62 non-duplicate articles. 57 records were excluded and five were reviewed in full text. One article was excluded as it was not a modelling study, and four qualifying studies were included in the review. These four reports were from two mathematical models from two independent modelling groups. Two reports used the Johns Hopkins model to compare POC with SOC for repeat early infant diagnosis testing in the first 6 months in sub-Saharan Africa (first report, simulation of 25 000 children) and Zambia (second report, simulation of 7500 children). In the base scenario, POC versus SOC increased probability of ART initiation within 60 days of testing from 19% to 82% (ICER per additional ART initiation range US$430-1097; 9-month cost horizon) in the first report; and from 28% to 81% in the second ($23-1609, 5-year cost horizon). Two reports compared POC with SOC for testing at 6 weeks in Zimbabwe using the Cost-Effectiveness of Preventing AIDS Complications-Paediatric model (simulation of 30 million children; lifetime horizon). POC increased life expectancy and was considered cost-effective compared with SOC (ICER $711-850 per year of life saved in HIV-exposed children). Results were robust throughout sensitivity and scenario analyses. In most scenarios, platform cost-sharing (co-use with other programmes) resulted in POC being cost-saving compared with SOC. Interpretation: Four reports from two different models suggest that POC is a cost-effective and potentially cost-saving strategy for upscaling of early infant testing compared with SOC. Funding: Bill & Melinda Gates Foundation, Unitaid, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, WHO, and Massachusetts General Hospital Research Scholars.
MeSH term(s)	Child ; Humans ; State Medicine ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Point-of-Care Systems ; Point-of-Care Testing ; Early Diagnosis ; Cost-Benefit Analysis ; Acquired Immunodeficiency Syndrome
Language	English
Publishing date	2023-05-05
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2352-3018
ISSN (online)	2352-3018
DOI	10.1016/S2352-3018(23)00029-2
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