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  1. AU="Suthaharan, Praveen"
  2. AU=Freeman Alexandra F
  3. AU="Szabo, Gergo"

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  1. Artikel ; Online: Assumed shared belief about conspiracy theories in social networks protects paranoid individuals against distress.

    Suthaharan, Praveen / Corlett, Philip R

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 6084

    Abstract: Paranoia is the belief that others intend you harm. It is related to conspiracy theories, wherein those others represent an organized faction, coordinating the harm against self and others, and violating societal norms. Current psychological studies of ... ...

    Abstract Paranoia is the belief that others intend you harm. It is related to conspiracy theories, wherein those others represent an organized faction, coordinating the harm against self and others, and violating societal norms. Current psychological studies of paranoid conspiracy theorizing focus either on the individual or their broader social network. Likewise, theories of belief formation and updating often contain individual level processes as well as broader interpersonal and organizational factors. Here we examine paranoia and conspiracy theorizing in terms of individual behavioral predictors (performance on a probabilistic reversal learning task which assays belief updating) as well as social sensing: we ask participants to report the features of their social network, including whether their friends and acquaintances share their paranoid conspiratorial beliefs. We find that people who believe paranoid conspiracy theories expect more volatility during the task. They also assume that members of their social network share their paranoid beliefs. Critically, those participants with larger social networks and greater assumed shared belief tend to harbor their conspiratorial beliefs with less emotional distress and expect less volatility in the task. This is evidence that, like political and religious beliefs, conspiracy theories may flourish under a sacred canopy of belief consensus. These data suggest that friends and acquaintances may serve as sources of credulity and moving between them may sustain conspiracy beliefs when there is detraction. This hybrid individual/social account may shed light on clinical paranoia and persecutory delusion, wherein disability is defined normatively, and social supports are fewer.
    Mesh-Begriff(e) Humans ; Delusions ; Paranoid Disorders
    Sprache Englisch
    Erscheinungsdatum 2023-04-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33305-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Relationships between cognitive biases, decision-making, and delusions.

    Sheffield, Julia M / Smith, Ryan / Suthaharan, Praveen / Leptourgos, Pantelis / Corlett, Philip R

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 9485

    Abstract: Multiple measures of decision-making under uncertainty (e.g. jumping to conclusions (JTC), bias against disconfirmatory evidence (BADE), win-switch behavior, random exploration) have been associated with delusional thinking in independent studies. Yet, ... ...

    Abstract Multiple measures of decision-making under uncertainty (e.g. jumping to conclusions (JTC), bias against disconfirmatory evidence (BADE), win-switch behavior, random exploration) have been associated with delusional thinking in independent studies. Yet, it is unknown whether these variables explain shared or unique variance in delusional thinking, and whether these relationships are specific to paranoia or delusional ideation more broadly. Additionally, the underlying computational mechanisms require further investigation. To investigate these questions, task and self-report data were collected in 88 individuals (46 healthy controls, 42 schizophrenia-spectrum) and included measures of cognitive biases and behavior on probabilistic reversal learning and explore/exploit tasks. Of those, only win-switch rate significantly differed between groups. In regression, reversal learning performance, random exploration, and poor evidence integration during BADE showed significant, independent associations with paranoia. Only self-reported JTC was associated with delusional ideation, controlling for paranoia. Computational parameters increased the proportion of variance explained in paranoia. Overall, decision-making influenced by strong volatility and variability is specifically associated with paranoia, whereas self-reported hasty decision-making is specifically associated with other themes of delusional ideation. These aspects of decision-making under uncertainty may therefore represent distinct cognitive processes that, together, have the potential to worsen delusional thinking across the psychosis spectrum.
    Mesh-Begriff(e) Humans ; Delusions ; Thinking ; Psychotic Disorders ; Decision Making ; Bias ; Cognition
    Sprache Englisch
    Erscheinungsdatum 2023-06-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36526-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Belief Updating and Paranoia in Individuals With Schizophrenia.

    Sheffield, Julia M / Suthaharan, Praveen / Leptourgos, Pantelis / Corlett, Philip R

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2022  Band 7, Heft 11, Seite(n) 1149–1157

    Abstract: Background: Persecutory delusions are among the most common delusions in schizophrenia and represent the extreme end of the paranoia continuum. Paranoia is accompanied by significant worry and distress. Identifying cognitive mechanisms underlying ... ...

    Abstract Background: Persecutory delusions are among the most common delusions in schizophrenia and represent the extreme end of the paranoia continuum. Paranoia is accompanied by significant worry and distress. Identifying cognitive mechanisms underlying paranoia is critical for advancing treatment. We hypothesized that aberrant belief updating, which is related to paranoia in human and animal models, would also contribute to persecutory beliefs in individuals with schizophrenia.
    Methods: Belief updating was assessed in 42 participants with schizophrenia and 44 healthy control participants using a 3-option probabilistic reversal learning task. Hierarchical Gaussian Filter was used to estimate computational parameters of belief updating. Paranoia was measured using the Positive and Negative Syndrome Scale and the revised Green et al. Paranoid Thoughts Scale. Unusual thought content was measured with the Psychosis Symptom Rating Scale and the Peters et al. Delusions Inventory. Worry was measured using the Dunn Worry Questionnaire.
    Results: Paranoia was significantly associated with elevated win-switch rate and prior beliefs about volatility both in schizophrenia and across the whole sample. These relationships were specific to paranoia and did not extend to unusual thought content or measures of anxiety. We observed a significant indirect effect of paranoia on the relationship between prior beliefs about volatility and worry.
    Conclusions: This work provides evidence that relationships between belief updating parameters and paranoia extend to schizophrenia, may be specific to persecutory beliefs, and contribute to theoretical models implicating worry in the maintenance of persecutory delusions.
    Mesh-Begriff(e) Humans ; Paranoid Disorders/diagnosis ; Paranoid Disorders/psychology ; Paranoid Disorders/therapy ; Schizophrenia/complications ; Schizophrenia/diagnosis ; Delusions ; Anxiety/psychology ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2022-04-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2022.03.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Relating Glutamate, Conditioned, and Clinical Hallucinations via 1H-MR Spectroscopy.

    Leptourgos, Pantelis / Bansal, Sonia / Dutterer, Jenna / Culbreth, Adam / Powers, Albert / Suthaharan, Praveen / Kenney, Joshua / Erickson, Molly / Waltz, James / Wijtenburg, S Andrea / Gaston, Frank / Rowland, Laura M / Gold, James / Corlett, Philip

    Schizophrenia bulletin

    2022  Band 48, Heft 4, Seite(n) 912–920

    Abstract: Background and hypothesis: Hallucinations may be driven by an excessive influence of prior expectations on current experience. Initial work has supported that contention and implicated the anterior insula in the weighting of prior beliefs.: Study ... ...

    Abstract Background and hypothesis: Hallucinations may be driven by an excessive influence of prior expectations on current experience. Initial work has supported that contention and implicated the anterior insula in the weighting of prior beliefs.
    Study design: Here we induce hallucinated tones by associating tones with the presentation of a visual cue. We find that people with schizophrenia who hear voices are more prone to the effect and using computational modeling we show they overweight their prior beliefs. In the same participants, we also measured glutamate levels in anterior insula, anterior cingulate, dorsolateral prefrontal, and auditory cortices, using magnetic resonance spectroscopy.
    Study results: We found a negative relationship between prior-overweighting and glutamate levels in the insula that was not present for any of the other voxels or parameters.
    Conclusions: Through computational psychiatry, we bridge a pathophysiological theory of psychosis (glutamate hypofunction) with a cognitive model of hallucinations (prior-overweighting) with implications for the development of new treatments for hallucinations.
    Mesh-Begriff(e) Glutamic Acid ; Hallucinations/diagnostic imaging ; Hallucinations/etiology ; Humans ; Magnetic Resonance Spectroscopy ; Psychotic Disorders/complications ; Schizophrenia
    Chemische Substanzen Glutamic Acid (3KX376GY7L)
    Sprache Englisch
    Erscheinungsdatum 2022-02-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbac006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Paranoia as a deficit in non-social belief updating.

    Reed, Erin J / Uddenberg, Stefan / Suthaharan, Praveen / Mathys, Christoph D / Taylor, Jane R / Groman, Stephanie Mary / Corlett, Philip R

    eLife

    2020  Band 9

    Abstract: Paranoia is the belief that harm is intended by others. It may arise from selective pressures to infer and avoid social threats, particularly in ambiguous or changing circumstances. We propose that uncertainty may be sufficient to elicit learning ... ...

    Abstract Paranoia is the belief that harm is intended by others. It may arise from selective pressures to infer and avoid social threats, particularly in ambiguous or changing circumstances. We propose that uncertainty may be sufficient to elicit learning differences in paranoid individuals, without social threat. We used reversal learning behavior and computational modeling to estimate belief updating across individuals with and without mental illness, online participants, and rats chronically exposed to methamphetamine, an elicitor of paranoia in humans. Paranoia is associated with a stronger prior on volatility, accompanied by elevated sensitivity to perceived changes in the task environment. Methamphetamine exposure in rats recapitulates this impaired uncertainty-driven belief updating and rigid anticipation of a volatile environment. Our work provides evidence of fundamental, domain-general learning differences in paranoid individuals. This paradigm enables further assessment of the interplay between uncertainty and belief-updating across individuals and species.
    Mesh-Begriff(e) Adult ; Animals ; Case-Control Studies ; Cluster Analysis ; Female ; Humans ; Male ; Methamphetamine ; Models, Psychological ; Paranoid Disorders/psychology ; Rats, Long-Evans ; Reversal Learning ; Uncertainty
    Chemische Substanzen Methamphetamine (44RAL3456C)
    Sprache Englisch
    Erscheinungsdatum 2020-05-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.56345
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Paranoia and belief updating during the COVID-19 crisis.

    Suthaharan, Praveen / Reed, Erin J / Leptourgos, Pantelis / Kenney, Joshua G / Uddenberg, Stefan / Mathys, Christoph D / Litman, Leib / Robinson, Jonathan / Moss, Aaron J / Taylor, Jane R / Groman, Stephanie M / Corlett, Philip R

    Nature human behaviour

    2021  Band 5, Heft 9, Seite(n) 1190–1202

    Abstract: The COVID-19 pandemic has made the world seem less predictable. Such crises can lead people to feel that others are a threat. Here, we show that the initial phase of the pandemic in 2020 increased individuals' paranoia and made their belief updating more ...

    Abstract The COVID-19 pandemic has made the world seem less predictable. Such crises can lead people to feel that others are a threat. Here, we show that the initial phase of the pandemic in 2020 increased individuals' paranoia and made their belief updating more erratic. A proactive lockdown made people's belief updating less capricious. However, state-mandated mask-wearing increased paranoia and induced more erratic behaviour. This was most evident in states where adherence to mask-wearing rules was poor but where rule following is typically more common. Computational analyses of participant behaviour suggested that people with higher paranoia expected the task to be more unstable. People who were more paranoid endorsed conspiracies about mask-wearing and potential vaccines and the QAnon conspiracy theories. These beliefs were associated with erratic task behaviour and changed priors. Taken together, we found that real-world uncertainty increases paranoia and influences laboratory task behaviour.
    Mesh-Begriff(e) Attitude to Health ; COVID-19/psychology ; Culture ; Health Policy ; Humans ; Infection Control ; Masks ; Pandemics ; Paranoid Disorders/psychology
    Sprache Englisch
    Erscheinungsdatum 2021-07-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-021-01176-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Paranoia and belief updating during a crisis.

    Suthaharan, Praveen / Reed, Erin J / Leptourgos, Pantelis / Kenney, Joshua / Uddenberg, Stefan / Mathys, Christoph D / Litman, Leib / Robinson, Jonathan / Moss, Aaron J / Taylor, Jane R / Groman, Stephanie M / Corlett, Philip R

    Research square

    2021  

    Abstract: The 2019 coronavirus (COVID-19) pandemic has made the world seem unpredictable. During such crises we can experience concerns that others might be against us, culminating perhaps in paranoid conspiracy theories. Here, we investigate paranoia and belief ... ...

    Abstract The 2019 coronavirus (COVID-19) pandemic has made the world seem unpredictable. During such crises we can experience concerns that others might be against us, culminating perhaps in paranoid conspiracy theories. Here, we investigate paranoia and belief updating in an online sample (N=1,010) in the United States of America (U.S.A). We demonstrate the pandemic increased individuals' self-rated paranoia and rendered their task-based belief updating more erratic. Local lockdown and reopening policies, as well as culture more broadly, markedly influenced participants' belief-updating: an early and sustained lockdown rendered people's belief updating less capricious. Masks are clearly an effective public health measure against COVID-19. However, state-mandated mask wearing increased paranoia and induced more erratic behaviour. Remarkably, this was most evident in those states where adherence to mask wearing rules was poor but where rule following is typically more common. This paranoia may explain the lack of compliance with this simple and effective countermeasure. Computational analyses of participant behaviour suggested that people with higher paranoia expected the task to be more unstable, but at the same time predicted more rewards. In a follow-up study we found people who were more paranoid endorsed conspiracies about mask-wearing and potential vaccines - again, mask attitude and conspiratorial beliefs were associated with erratic task behaviour and changed priors. Future public health responses to the pandemic might leverage these observations, mollifying paranoia and increasing adherence by tempering people's expectations of other's behaviour, and the environment more broadly, and reinforcing compliance.
    Sprache Englisch
    Erscheinungsdatum 2021-01-18
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-145987/v1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch ; Online: Paranoia and Belief Updating During a Crisis

    Reed, Erin / Suthaharan, Praveen / Leptourgos, Pantelis / Kenney, Joshua / Uddenberg, Stefan / Mathys, Christoph / Taylor, Jane / Groman, Stephanie / Corlett, Philip R.

    2020  

    Abstract: The 2019 coronavirus (COVID-19) pandemic has made the world seem unpredictable. During such crises we can experience concerns that others might be against us, culminating perhaps in paranoid conspiracy theories. Here we demonstrate the pandemic directly ... ...

    Abstract The 2019 coronavirus (COVID-19) pandemic has made the world seem unpredictable. During such crises we can experience concerns that others might be against us, culminating perhaps in paranoid conspiracy theories. Here we demonstrate the pandemic directly increased individuals’ self-rated paranoia and rendered their task-based belief updating more erratic. In the United States of America (U.S.A.), local lockdown and reopening policies, as well as culture more broadly, markedly influenced participants’ belief-updating: An early and sustained lockdown rendered people’s belief updating less capricious. However, state-mandated mask wearing actually increased paranoia and induced more erratic behaviour. Remarkably, this was most evident in those states where adherence to mask wearing rules was poor but where rule following is typically more common. Computational analyses of participant behaviour suggested that more paranoid people expected the task to be more unstable, but at the same time predicted more rewards. Future public health responses could leverage these observations, perhaps by encouraging an expectation of stability (as we observed in lockdown), by advising people to focus less on others’ behaviour, or by punishing violations of the mask wearing mandate, creating and sustaining a social norm for mask wearing and thus mollifying paranoia.
    Schlagwörter covid19
    Verlag Center for Open Science
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    DOI 10.31234/osf.io/mtces
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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