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Article ; Online: Detection of Macrolide and/or Fluoroquinolone Resistance Genes in

Ljubin-Sternak, Sunčanica / Meštrović, Tomislav / Marijan, Tatjana / Anušić, Maja / Šuto, Sandra / Vraneš, Jasmina

2024 Volume 15, Issue 4

Abstract: Mycoplasma ... ...

Abstract	Mycoplasma genitalium
MeSH term(s)	Mycoplasma genitalium/genetics ; Mycoplasma genitalium/drug effects ; Mycoplasma genitalium/isolation & purification ; Humans ; Male ; Fluoroquinolones/pharmacology ; Fluoroquinolones/therapeutic use ; Croatia/epidemiology ; Macrolides/pharmacology ; Macrolides/therapeutic use ; Adult ; Mycoplasma Infections/microbiology ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/drug therapy ; Mycoplasma Infections/urine ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial/genetics ; Middle Aged ; Young Adult ; RNA, Ribosomal, 23S/genetics ; Adolescent ; Urethritis/microbiology ; Urethritis/epidemiology ; Urethritis/drug therapy ; Microbial Sensitivity Tests
Chemical Substances	Fluoroquinolones ; Macrolides ; Anti-Bacterial Agents ; RNA, Ribosomal, 23S
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes15040470
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Article ; Online: Incidence of severe infection in patients with rheumatoid arthritis taking biologic agents: a systematic review.

Makimoto, Kiyoko / Konno, Rie / Kinoshita, Atsushi / Kanzaki, Hatsumi / Suto, Shunji

JBI evidence synthesis

2023 Volume 21, Issue 5, Page(s) 835–885

Abstract: Objective: The objective of this review was to estimate the population-based incidence and determine the types of severe infection and deaths experienced by patients with rheumatoid arthritis taking biologic agents.: Introduction: Since the late ... ...

Abstract	Objective: The objective of this review was to estimate the population-based incidence and determine the types of severe infection and deaths experienced by patients with rheumatoid arthritis taking biologic agents. Introduction: Since the late 1990s, various biologic and synthetic drugs have been developed to treat rheumatoid arthritis. In recent years, the incidence of severe infection in patients with rheumatoid arthritis in Western nations has been determined by observational studies; however, no systematic review has been conducted on this topic. Inclusion criteria: The following inclusion criteria were considered: i) observational studies on patients with rheumatoid arthritis treated with biologic agents; ii) studies reporting the number of severe infections requiring hospitalization for treatment; iii) studies reporting person-years of observation data; and iv) studies based on rheumatoid arthritis registries, medical records from rheumatology centers, or insurance claim databases. Methods: PubMed, CINAHL, Embase, and Web of Science were searched to identify published studies. The reference lists of all studies selected for critical appraisal were screened for additional studies. Unpublished studies were searched on MedNar and OpenGrey databases. All the searches were updated on December 6, 2021. After removing the duplicates, 2 independent reviewers screened titles and abstracts against the inclusion criteria and then assessed full texts against the criteria. Two reviewers independently appraised the study and outcome levels for methodological quality using the critical appraisal instrument for cohort studies from JBI. Two reviewers extracted the relevant information related to severe infection and drugs. Results: Fifty-two studies from 21 countries reported severe infection rates associated with using 8 biologic agents, plus nonbiologic disease-modifying antirheumatic drugs. In total, 18,428 infections with 395,065 person-years of biologic drug exposure were included in the analysis. Thirty-five studies included infections in outpatients receiving intravenous antibiotic therapy. Fifteen studies reported the first episode of infection, and the remaining studies did not specify either the first or all of the episodes of infection. Inclusion of viral infection and/or opportunistic infection varied among studies. Fifteen studies reported the site of infection; respiratory, skin/soft tissue, urinary tract, and sepsis/bacteremia were commonly reported. Ten studies reported the case fatality rates, ranging from 2.5% to 22.2%. Meta-analysis was conducted for 8 biologic agents and conventional disease-modifying antirheumatic drugs. The infection rate varied from 0.9 to 18.1/100 person-years. The meta-analysis revealed an infection rate of 5.0/100 person-years (95% CI 3.8-6.7) among patients receiving tumor necrosis factor inhibitors (heterogeneity 98.2%). The meta-analysis for the other 3 biologic agents revealed a point estimate of 5.5 to 8.7/100 person-years with high heterogeneity. Sensitivity analysis indicated that registry-based studies were less likely to have very low or very high infection rates compared with other data sources. The definition of infection, the patient composition of the cohorts, and the type of databases appeared to be the primary sources of clinical and methodological heterogeneity. Conclusions: Due to high statistical heterogeneity, the meta-analysis was not suited to estimating a summary measure of the infection rate. Developing standardized data collection is necessary to compare infection rates across studies. Systematic review registration number: PROSPERO CRD42020175137.
MeSH term(s)	Humans ; Biological Factors/adverse effects ; Incidence ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Antirheumatic Agents/adverse effects ; Cohort Studies
Chemical Substances	Biological Factors ; Antirheumatic Agents
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2689-8381
ISSN (online)	2689-8381
DOI	10.11124/JBIES-22-00048
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Article ; Online: Periodic corner holes on the Si(111)-7×7 surface can trap silver atoms.

Osiecki, Jacek R / Suto, Shozo / Chutia, Arunabhiram

Nature communications

2022 Volume 13, Issue 1, Page(s) 2973

Abstract: Advancement in nanotechnology to a large extent depends on the ability to manipulate materials at the atomistic level, including positioning single atoms on the active sites of the surfaces of interest, promoting strong chemical bonding. Here, we report ... ...

Abstract	Advancement in nanotechnology to a large extent depends on the ability to manipulate materials at the atomistic level, including positioning single atoms on the active sites of the surfaces of interest, promoting strong chemical bonding. Here, we report a long-time confinement of a single Ag atom inside a corner hole (CH) of the technologically relevant Si(111)-7×7 surface, which has comparable size as a fullerene C
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-29768-6
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Article: Essential hyaluronan structure for binding with hyaluronan-binding protein (HABP) determined by glycotechnological approach

Suto, Shinichiro / Kakizaki, Ikuko / Tatara, Yota / Endo, Masahiko

Carbohydrate polymers. 2021 Jan. 01, v. 251

2021

Abstract: Hyaluronan specifically binds to aggrecan globular domain 1, which is often referred to as just hyaluronan binding protein (HABP), however, the hyaluronan carbohydrate structure recognized by HABP had not been studied in detail. The aim of the present ... ...

Abstract	Hyaluronan specifically binds to aggrecan globular domain 1, which is often referred to as just hyaluronan binding protein (HABP), however, the hyaluronan carbohydrate structure recognized by HABP had not been studied in detail. The aim of the present study was to investigate the important structure of hyaluronan for binding to HABP. We prepared hybrid oligosaccharides from hyaluronan and chondroitin, with or without modification of the reducing or non-reducing terminus, as tools to determine the preferred structure of hyaluronan for binding to the HABP by a competitive ELISA-like method. The non-reducing terminal structure was critical, especially, the glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) of the hyaluronan-unit are essential for complete HABP binding activity, and for any HABP binding activity, respectively. It is possible to replace GlcUAβ-1-3GlcNAc of the internal disaccharide units with GlcUAβ-1-3N-acetylgalactosamine (GalNAc), if the chain length is decasaccharide or larger.
Keywords	N-acetylglucosamine ; carbohydrate structure ; chondroitin ; glucuronic acid ; hyaluronic acid ; oligosaccharides
Language	English
Dates of publication	2021-0101
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.116989
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Article ; Online: Culturally Congruent Health Activities for the Prevention of Functional Disabilities Among Older Adults in Japan's Forest Communities.

Irie, Yasuko / Hohashi, Naohiro / Suto, Shunji / Fujimoto, Yu

Journal of transcultural nursing : official journal of the Transcultural Nursing Society

2021 Volume 33, Issue 1, Page(s) 16–25

Abstract: Introduction: In Japan's forest areas, cultural capital and older adults play key roles in helping to sustain the community. The purpose was to explore cultural values/beliefs related to culturally congruent health activities among older adults in ... ...

Abstract	Introduction: In Japan's forest areas, cultural capital and older adults play key roles in helping to sustain the community. The purpose was to explore cultural values/beliefs related to culturally congruent health activities among older adults in forest communities. Method: The qualitative ethnonursing research method was used. Data were collected through fieldwork and key informants' interviews ( Results: Findings included two universal cultural values/beliefs, which were "community identity as a community member" and "our cohesion and connection as community members." Additionally, two diverse cultural values/beliefs were found: "gender-based differences" and "differences between those having experience working outside the forest community and those without this experience." These were related to community-based health activities. Discussion: These values/beliefs were suggested to develop a multilayered network around health activities in order to prevent functional disabilities among older adults.
MeSH term(s)	Aged ; Forests ; Humans ; Japan
Language	English
Publishing date	2021-08-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1291524-5
ISSN	1552-7832 ; 1043-6596
ISSN (online)	1552-7832
ISSN	1043-6596
DOI	10.1177/10436596211042072
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Article ; Online: Essential hyaluronan structure for binding with hyaluronan-binding protein (HABP) determined by glycotechnological approach.

Suto, Shinichiro / Kakizaki, Ikuko / Tatara, Yota / Endo, Masahiko

Carbohydrate polymers

2020 Volume 251, Page(s) 116989

Abstract	Hyaluronan specifically binds to aggrecan globular domain 1, which is often referred to as just hyaluronan binding protein (HABP), however, the hyaluronan carbohydrate structure recognized by HABP had not been studied in detail. The aim of the present study was to investigate the important structure of hyaluronan for binding to HABP. We prepared hybrid oligosaccharides from hyaluronan and chondroitin, with or without modification of the reducing or non-reducing terminus, as tools to determine the preferred structure of hyaluronan for binding to the HABP by a competitive ELISA-like method. The non-reducing terminal structure was critical, especially, the glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) of the hyaluronan-unit are essential for complete HABP binding activity, and for any HABP binding activity, respectively. It is possible to replace GlcUAβ-1-3GlcNAc of the internal disaccharide units with GlcUAβ-1-3N-acetylgalactosamine (GalNAc), if the chain length is decasaccharide or larger.
MeSH term(s)	Aggrecans/chemistry ; Aggrecans/metabolism ; Animals ; Binding Sites ; Carbohydrate Sequence ; Cell Adhesion Molecules/chemistry ; Cell Adhesion Molecules/metabolism ; Chondroitin/chemistry ; Chondroitin/metabolism ; Glycosylation ; Humans ; Hyaluronan Receptors/chemistry ; Hyaluronan Receptors/metabolism ; Hyaluronic Acid/chemistry ; Hyaluronic Acid/metabolism ; Oligosaccharides/chemistry ; Oligosaccharides/metabolism ; Protein Binding
Chemical Substances	Aggrecans ; Cell Adhesion Molecules ; Hyaluronan Receptors ; Oligosaccharides ; Hyaluronic Acid (9004-61-9) ; Chondroitin (9007-27-6)
Language	English
Publishing date	2020-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2020.116989
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Article ; Online: Factors associated with EMS on-scene time and its regional difference in road traffic injuries: a population-based observational study.

Ito, Shingo / Asai, Hideki / Kawai, Yasuyuki / Suto, Shunji / Ohta, Sachiko / Fukushima, Hidetada

BMC emergency medicine

2022 Volume 22, Issue 1, Page(s) 160

Abstract: Background: The outcome of road traffic injury (RTI) is determined by duration of prehospital time, patient's demographics, and the type of injury and its mechanism. During the emergency medical service (EMS) prehospital time interval, on-scene time ... ...

Abstract	Background: The outcome of road traffic injury (RTI) is determined by duration of prehospital time, patient's demographics, and the type of injury and its mechanism. During the emergency medical service (EMS) prehospital time interval, on-scene time should be minimized for early treatment. This study aimed to examine the factors influencing on-scene EMS time among RTI patients. Methods: We evaluated 19,141 cases of traffic trauma recorded between April 2014 and March 2020 in the EMS database of the Nara Wide Area Fire Department and the prehospital database of the emergency Medical Alliance for Total Coordination of Healthcare (e-MATCH). To examine the association of the number of EMS phone calls until hospital acceptance, age ≥65 years, high-risk injury, vital signs, holiday, and nighttime (0:00-8:00) with on-scene time, a generalized linear mixed model with random effects for four study regions was conducted. Results: EMS phone calls were the biggest factor, accounting for 5.69 minutes per call, and high-risk injury accounted for an additional 2.78 minutes. Holiday, nighttime, and age ≥65 years were also associated with increased on-scene time, but there were no significant vital sign variables for on-scene time, except for the level of consciousness. Regional differences were also noted based on random effects, with a maximum difference of 2 minutes among regions. Conclusions: The number of EMS phone calls until hospital acceptance was the most significant influencing factor in reducing on-scene time, and high-risk injury accounted for up to an additional 2.78 minutes. Considering these factors, including regional differences, can help improve the regional EMS policies and outcomes of RTI patients.
MeSH term(s)	Aged ; Databases, Factual ; Emergency Medical Services ; Hospitals ; Humans ; Research ; Time Factors
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2050431-7
ISSN	1471-227X ; 1471-227X
ISSN (online)	1471-227X
ISSN	1471-227X
DOI	10.1186/s12873-022-00718-1
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Article: [Gastric varices treated by balloon-occluded retrograde transvenous obliteration following oxaliplatin-based chemotherapy for gastric cancer].

Igarashi, Shohei / Munakata, Masaki / Suto, Sho / Miyashiro, Kaede / Satake, Miwa / Shimaya, Koji / Hanabata, Norihiro / Kanazawa, Kosuke / Numao, Hiroshi / Sakuraba, Hirotake

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

2023 Volume 120, Issue 5, Page(s) 433–440

Abstract: A 78-year-old female patient with stomach cancer (with hepatic metastasis and peritoneal dissemination) had received eight courses of an S-1 and oxaliplatin regimen as palliative chemotherapy. Computed tomography revealed liver deformities and incidental ...

Abstract	A 78-year-old female patient with stomach cancer (with hepatic metastasis and peritoneal dissemination) had received eight courses of an S-1 and oxaliplatin regimen as palliative chemotherapy. Computed tomography revealed liver deformities and incidental gastric varices. Esophagogastroduodenoscopy confirmed the findings of gastric varices in the cardia and fornix. It was suspected that oxaliplatin-based chemotherapy had induced non-variceal portal hypertension in the patient-similar to that which is seen in patients with colon cancer who are treated with oxaliplatin-based chemotherapy. We had chosen balloon-occluded retrograde transvenous obliteration (BRTO) for the preventive treatment of gastric varices because the patient had a gastro-renal shunt, which enabled access to the gastric varices via the vena cava. Our patient had undergone BRTO, which resulted in the endoscopic disappearance of gastric varices. Currently, the patient is continuing chemotherapy without bleeding from gastric varices. Our case suggests that patients with gastric cancer treated with oxaliplatin-based chemotherapy require careful follow-up for portal hypertension.
MeSH term(s)	Female ; Humans ; Aged ; Esophageal and Gastric Varices/diagnostic imaging ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/therapy ; Stomach Neoplasms/therapy ; Stomach Neoplasms/complications ; Oxaliplatin ; Balloon Occlusion ; Hypertension, Portal/complications ; Treatment Outcome ; Gastrointestinal Hemorrhage/therapy
Chemical Substances	Oxaliplatin (04ZR38536J)
Language	Japanese
Publishing date	2023-05-15
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	708695-7
ISSN	1349-7693 ; 0446-6586
ISSN (online)	1349-7693
ISSN	0446-6586
DOI	10.11405/nisshoshi.120.433
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Zs.MO 477: Show issues

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Article ; Online: Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy.

Sada, Nagisa / Suto, Shogo / Suzuki, Mana / Usui, Shoichiro / Inoue, Tsuyoshi

Epilepsia

2020 Volume 61, Issue 5, Page(s) e37–e42

Abstract: The ketogenic diet treatment is effective for drug-resistant epilepsy. Because its antiepileptic effect is associated with lactate dehydrogenase (LDH), drug development is possible by targeting LDH enzymes. Seizures in rodent models are suppressed by ... ...

Abstract	The ketogenic diet treatment is effective for drug-resistant epilepsy. Because its antiepileptic effect is associated with lactate dehydrogenase (LDH), drug development is possible by targeting LDH enzymes. Seizures in rodent models are suppressed by inhibiting LDH; however, it remains unclear whether LDH in the brain is changed by seizures. In the present study, we examined the expression of LDH subunits (LDHA and LDHB) in a chronic model of temporal lobe epilepsy, in which seizures were induced by the microinjection of kainate into the mouse hippocampus. Using Western blot analyses, we found that LDHA expression was increased in the hippocampus of the chronic seizure model, whereas LDHB expression was not. Lactate levels in the hippocampus were also increased in this seizure model, suggesting elevated LDH enzymatic activities. Furthermore, the inhibition of LDHA suppressed spontaneous paroxysmal discharges in vivo in the chronic seizure model. In conclusion, our results show that chronic seizures increase LDHA, and conversely, the inhibition of LDHA suppresses seizures, which supports LDHA as a molecular target for the development of new antiepileptic drugs.
MeSH term(s)	Animals ; Blotting, Western ; Disease Models, Animal ; Epilepsy, Temporal Lobe/enzymology ; Epilepsy, Temporal Lobe/metabolism ; Hippocampus/drug effects ; Hippocampus/enzymology ; Injections, Intraventricular ; Kainic Acid/pharmacology ; L-Lactate Dehydrogenase/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Seizures/chemically induced ; Up-Regulation
Chemical Substances	L-Lactate Dehydrogenase (EC 1.1.1.27) ; Kainic Acid (SIV03811UC)
Language	English
Publishing date	2020-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.16488
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Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Multi-Touch Tabletop System Using Infrared Image Recognition for User Position Identification.

Suto, Shota / Watanabe, Toshiya / Shibusawa, Susumu / Kamada, Masaru

Sensors (Basel, Switzerland)

2018 Volume 18, Issue 5

Abstract: A tabletop system can facilitate multi-user collaboration in a variety of settings, including small meetings, group work, and education and training exercises. The ability to identify the users touching the table and their positions can promote ... ...

Abstract	A tabletop system can facilitate multi-user collaboration in a variety of settings, including small meetings, group work, and education and training exercises. The ability to identify the users touching the table and their positions can promote collaborative work among participants, so methods have been studied that involve attaching sensors to the table, chairs, or to the users themselves. An effective method of recognizing user actions without placing a burden on the user would be some type of visual process, so the development of a method that processes multi-touch gestures by visual means is desired. This paper describes the development of a multi-touch tabletop system using infrared image recognition for user position identification and presents the results of touch-gesture recognition experiments and a system-usability evaluation. Using an inexpensive FTIR touch panel and infrared light, this system picks up the touch areas and the shadow area of the user's hand by an infrared camera to establish an association between the hand and table touch points and estimate the position of the user touching the table. The multi-touch gestures prepared for this system include an operation to change the direction of an object to face the user and a copy operation in which two users generate duplicates of an object. The system-usability evaluation revealed that prior learning was easy and that system operations could be easily performed.
Language	English
Publishing date	2018-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s18051559
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