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  1. Article: Advantages of Long-Wavelength Photosensitizer

    Plotnikova, Ekaterina / Nemtsova, Elena / Abakumov, Maxim / Suvorov, Nikita / Pankratov, Andrey / Shegai, Peter / Kaprin, Andrey

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 12

    Abstract: This research presents a novel synthetic photosensitizer for the photodynamic therapy (PDT) of malignant tumors: meso-tetra(3-pyridyl) bacteriochlorin, which absorbs at 747 nm (in the long-wavelength region of the spectrum) and is stable when stored in ... ...

    Abstract This research presents a novel synthetic photosensitizer for the photodynamic therapy (PDT) of malignant tumors: meso-tetra(3-pyridyl) bacteriochlorin, which absorbs at 747 nm (in the long-wavelength region of the spectrum) and is stable when stored in the dark. H
    Language English
    Publishing date 2023-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16121708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Development of a Dosage form for a Photoswitchable Local Anesthetic Ethercaine.

    Noev, Alexey / Morozova, Natalia / Suvorov, Nikita / Vasil'ev, Yuriy / Pankratov, Andrei / Grin, Mikhail

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 10

    Abstract: The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body. A possible way to increase the selectivity of the action ... ...

    Abstract The toxicity of local anesthetics is a serious problem, given their widespread use. One of the main causes of the side effects of local anesthetics is their non-selectivity of action in the body. A possible way to increase the selectivity of the action of drugs is to use the photopharmacology approach. Previously, we described the light-controlled local anesthetic ethercaine, the biological effect of which can be controlled using light, thereby increasing its selectivity of action. An important limitation of ethercaine was its low solubility in water, limiting the potential of this compound. In this work, we developed a dosage form of ethercaine, which allowed us to increase its solubility from 0.6% to 2% or more. The resulting 1% solution of ethercaine hydrochloride in 4% Kolliphor ELP had high biological activity on the surface anesthesia model, while demonstrating low acute toxicity in mice with intravenous administration (4-5 times less than that of lidocaine).
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16101398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy.

    Suvorov, Nikita / Pogorilyy, Viktor / Diachkova, Ekaterina / Vasil'ev, Yuri / Mironov, Andrey / Grin, Mikhail

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this ... ...

    Abstract The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.
    MeSH term(s) Amino Acid Sequence ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cations ; Chlorophyll/chemistry ; Chlorophyll/pharmacology ; Photochemotherapy ; Porphyrins/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Cations ; Porphyrins ; Chlorophyll (1406-65-1) ; chlorin (2683-84-3)
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Advantages of combined photodynamic therapy in the treatment of oncological diseases.

    Grin, Mikhail / Suvorov, Nikita / Ostroverkhov, Petr / Pogorilyy, Viktor / Kirin, Nikita / Popov, Alexander / Sazonova, Anna / Filonenko, Elena

    Biophysical reviews

    2022  Volume 14, Issue 4, Page(s) 941–963

    Abstract: When conducting combined therapy of malignant neoplasms, treatment methods with various mechanisms of antitumor effects are used, while an additive or even synergistic effect can be realized. Combination treatment regimens are aimed at increasing the ... ...

    Abstract When conducting combined therapy of malignant neoplasms, treatment methods with various mechanisms of antitumor effects are used, while an additive or even synergistic effect can be realized. Combination treatment regimens are aimed at increasing the efficiency and, above all, at the complete eradication of the tumor, which can be achieved either by suppressing the survival mechanisms in PDT-resistant tumor cells or by pre-attenuation of tumor cells so that they become more susceptible to subsequent PDT. Photodynamic therapy is an approved medical technology for the treatment of various malignant neoplasms, and several precancerous and non-cancer diseases. To date, numerous data have been published on the combined use of PDT with traditional and innovative methods of treatment. This review considers research in this area in recent years.
    Language English
    Publishing date 2022-06-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-022-00962-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review.

    Sologova, Diana / Petukhova, Marina / Podoplelova, Polina / Davletshin, Dinislam / Firsova, Anna / Grishin, Andrey / Grin, Mikhail / Suvorov, Nikita / Vasil'ev, Yuriy / Dydykin, Sergey / Rysanova, Elena / Shchelkova, Victoria / Tarasenko, Svetlana / Diachkova, Ekaterina

    Dentistry journal

    2023  Volume 11, Issue 8

    Abstract: Background: The complex traditional treatment of inflammation diseases in oral cavity includes the prescription of antibiotic and antiseptic therapy. This systematic review aims to evaluate the effect of photodynamic therapy as a part of management of ... ...

    Abstract Background: The complex traditional treatment of inflammation diseases in oral cavity includes the prescription of antibiotic and antiseptic therapy. This systematic review aims to evaluate the effect of photodynamic therapy as a part of management of inflammatory diseases in oral cavity; Methods: The study is presented in accordance with the preferred reporting points for systematic reviews and meta-analyses (PRISMA). This systematic review was conducted using electronic databases such as Medline PubMed, Scopus and the Cochrane Central Register of Controlled Trials. All the studies in this systematic review, were randomized, the risk of bias 2 (ROB 2) were assessed; Results: Considering the inclusion and exclusion criteria, we included 10 randomized clinical trials, published up to 2023 investigating the application of photodynamic therapy as a part of management of inflammatory diseases in oral cavity. The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx.
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681351-8
    ISSN 2304-6767 ; 2304-6767
    ISSN (online) 2304-6767
    ISSN 2304-6767
    DOI 10.3390/dj11080192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The First Selenoanhydride in the Series of Chlorophyll a Derivatives, Its Stability and Photoinduced Cytotoxicity.

    Pogorilyy, Viktor / Plyutinskaya, Anna / Suvorov, Nikita / Diachkova, Ekaterina / Vasil'ev, Yuriy / Pankratov, Andrei / Mironov, Andrey / Grin, Mikhail

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 23

    Abstract: In this work, we obtained the first selenium-containing chlorin with a chalcogen atom in exlocycle E. It was shown that the spectral properties were preserved in the target compound and the stability increased at two different pH values, in comparison ... ...

    Abstract In this work, we obtained the first selenium-containing chlorin with a chalcogen atom in exlocycle E. It was shown that the spectral properties were preserved in the target compound and the stability increased at two different pH values, in comparison with the starting purpurin-18. The derivatives have sufficiently high fluorescence and singlet oxygen quantum yields. The photoinduced cytotoxicity of sulfur- and selenium-anhydrides of chlorin p
    MeSH term(s) Animals ; Cell Line, Tumor ; Chlorophyll A/analogs & derivatives ; Chlorophyll A/pharmacology ; Mice ; Organoselenium Compounds/chemistry ; Organoselenium Compounds/pharmacology ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Porphyrins/chemistry ; Porphyrins/pharmacology ; Sarcoma/drug therapy
    Chemical Substances Organoselenium Compounds ; Photosensitizing Agents ; Porphyrins ; chlorin (2683-84-3) ; Chlorophyll A (YF5Q9EJC8Y)
    Language English
    Publishing date 2021-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26237298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Novel Photoswitchable Azobenzene-Containing Local Anesthetic Ethercaine with Light-Controlled Biological Activity In Vivo.

    Noev, Alexey / Kuznetsov, Nikita / Korenev, Georgiy / Morozova, Natalia / Vasil'ev, Yuriy / Suvorov, Nikita / Diachkova, Ekaterina / Usachev, Maksim / Pankratov, Andrei / Grin, Mikhail

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: Pain is a common symptom that impairs the quality of life for people around the world. Local anesthetics widely used for pain relief have a number of side effects, which makes the development of both new drugs and new ways to control their activity ... ...

    Abstract Pain is a common symptom that impairs the quality of life for people around the world. Local anesthetics widely used for pain relief have a number of side effects, which makes the development of both new drugs and new ways to control their activity particularly important. Photopharmacology makes it possible to reduce the side effects of an anesthetic and control its biological activity in the body. The purpose of this work was to create a new light-controlled local anesthetic and study its biological activity in animals. A compound with a simple scheme of synthesis was chosen to shift the UV-Vis absorption band towards the visible range of the spectrum and was synthesized for the first time. Some computer calculations were performed to make sure that the aforementioned changes would not lead to loss of biological activity. The micellar form of the new compound was prepared, and in vivo biological studies were carried out in rabbits. The existence of a local anesthetic effect, which disappeared almost completely on irradiation with light (λ = 395 nm), was shown using the surface anesthesia model. Moreover, the possibility of multiple reversible changes in the biological activity of ethercaine under the action of light was demonstrated. The latter compound manifests no local irritating effect, either. The data obtained indicate the prospects for the development of new compounds based on azobenzene for light-controlled local anesthesia.
    MeSH term(s) Anesthesia, Local ; Anesthetics, Local/pharmacology ; Animals ; Azo Compounds ; Humans ; Pain ; Quality of Life ; Rabbits
    Chemical Substances Anesthetics, Local ; Azo Compounds ; azobenzene (F0U1H6UG5C)
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tin Carboxylate Complexes of Natural Bacteriochlorin for Combined Photodynamic and Chemotherapy of Cancer è.

    Tikhonov, Sergey / Ostroverkhov, Petr / Suvorov, Nikita / Mironov, Andrey / Efimova, Yulia / Plutinskaya, Anna / Pankratov, Andrei / Ignatova, Anastasia / Feofanov, Alexey / Diachkova, Ekaterina / Vasil'ev, Yuriy / Grin, Mikhail

    International journal of molecular sciences

    2021  Volume 22, Issue 24

    Abstract: Photodynamic therapy (PDT) is currently one of the most promising methods of cancer treatment. However, this method has some limitations, including a small depth of penetration into biological tissues, the low selectivity of accumulation, and hypoxia of ... ...

    Abstract Photodynamic therapy (PDT) is currently one of the most promising methods of cancer treatment. However, this method has some limitations, including a small depth of penetration into biological tissues, the low selectivity of accumulation, and hypoxia of the tumor tissues. These disadvantages can be overcome by combining PDT with other methods of treatment, such as radiation therapy, neutron capture therapy, chemotherapy, etc. In this work, potential drugs were obtained for the first time, the molecules of which contain both photodynamic and chemotherapeutic pharmacophores. A derivative of natural bacteriochlorophyll a with a tin IV complex, which has chemotherapeutic activity, acts as an agent for PDT. This work presents an original method for obtaining agents of combined action, the structure of which is confirmed by various physicochemical methods of analysis. The method of molecular modeling was used to investigate the binding of the proposed drugs to DNA. In vitro biological tests were carried out on several lines of tumor cells: Hela, A549, S37, MCF7, and PC-3. It was shown that the proposed conjugates of binary action for some cell lines had a dark cytotoxicity that was significantly higher (8-10 times) than the corresponding metal complexes of amino acids, which was explained by the targeted chemotherapeutic action of the tin (IV) complex due to chlorin. The greatest increase in efficiency relative to the initial dipropoxy-BPI was found for the conjugate with lysine as a chelator of the tin cation relative to cell lines, with the following results: S-37 increased 3-fold, MCF-7 3-fold, and Hela 2.4-fold. The intracellular distribution of the obtained agents was also studied by confocal microscopy and showed a diffuse granular distribution with predominant accumulation in the near nuclear region.
    MeSH term(s) A549 Cells ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; HeLa Cells ; Humans ; MCF-7 Cells ; Neoplasms/drug therapy ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Porphyrins/chemistry ; Porphyrins/pharmacology ; Tin/chemistry ; Tin/pharmacology
    Chemical Substances Coordination Complexes ; Photosensitizing Agents ; Porphyrins ; bacteriochlorin ; Tin (7440-31-5)
    Language English
    Publishing date 2021-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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