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  1. AU="Suzanne Fischer"
  2. AU="Aboelata, Noha"
  3. AU="Chiang, Sarah N"
  4. AU="Wessel, Kristin M"
  5. AU="Wilson, Jenna M"
  6. AU="Goines, Paula"
  7. AU=Ippolito Mariachiara AU=Ippolito Mariachiara
  8. AU="Jose Chauca"
  9. AU="Asih, Puji B S"
  10. AU="Dsane-Selby, Lydia"
  11. AU="Tolossa, Tadesse"
  12. AU="Erdal Bedir"

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  1. Artikel ; Online: Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

    Suzanne Fischer / David Creytens / Sofie De Geyter / Elly De Vlieghere / Piet Pattyn / Sarah‐Lee Bekaert / Kaat Durinck / Nadine Van Roy / An Hendrix / Lore Lapeire / Gwen Sys / Olivier De Wever

    Clinical and Translational Medicine, Vol 13, Iss 6, Pp n/a-n/a (2023)

    2023  

    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Serum Calcification Propensity T50 Associates with Disease Severity in Patients with Pseudoxanthoma Elasticum

    Lukas Nollet / Matthias Van Gils / Suzanne Fischer / Laurence Campens / Swapna Karthik / Andreas Pasch / Julie De Zaeytijd / Bart P. Leroy / Daniel Devos / Tine De Backer / Paul J. Coucke / Olivier M. Vanakker

    Journal of Clinical Medicine, Vol 11, Iss 13, p

    2022  Band 3727

    Abstract: Pseudoxanthoma elasticum (PXE) is a currently intractable genetic disorder characterized by progressive ectopic calcification in the skin, eyes and arteries. Therapeutic trials in PXE are severely hampered by the lack of reliable biomarkers. Serum ... ...

    Abstract Pseudoxanthoma elasticum (PXE) is a currently intractable genetic disorder characterized by progressive ectopic calcification in the skin, eyes and arteries. Therapeutic trials in PXE are severely hampered by the lack of reliable biomarkers. Serum calcification propensity T50 is a blood test measuring the functional anticalcifying buffer capacity of serum. Here, we evaluated T50 in PXE patients aiming to investigate its determinants and suitability as a potential biomarker for disease severity. Fifty-seven PXE patients were included in this cross-sectional study, and demographic, clinical, imaging and biochemical data were collected from medical health records. PXE severity was assessed using Phenodex scores. T50 was measured using a validated, nephelometry-based assay. Multivariate models were then created to investigate T50 determinants and associations with disease severity. In short, the mean age of patients was 45.2 years, 68.4% was female and mean serum T50 was 347 min. Multivariate regression analysis identified serum fetuin-A ( p < 0.001), phosphorus ( p = 0.007) and magnesium levels ( p = 0.034) as significant determinants of T50, while no correlations were identified with serum calcium, eGFR, plasma PPi levels or the ABCC6 genotype. After correction for covariates, T50 was found to be an independent determinant of ocular ( p = 0.013), vascular ( p = 0.013) and overall disease severity ( p = 0.016) in PXE. To conclude, shorter serum T50—indicative of a higher calcification propensity—was associated with a more severe phenotype in PXE patients. This study indicates, for the first time, that serum T50 might be a clinically relevant biomarker in PXE and may thus be of importance to future therapeutic trials.
    Schlagwörter pseudoxanthoma elasticum ; PXE ; ectopic calcification ; biomarker ; genetics ; rare diseases ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

    Juan L Mendoza / Suzanne Fischer / Marvin H Gee / Lilian H Lam / Simon Brackenridge / Fiona M Powrie / Michael Birnbaum / Andrew J McMichael / K Christopher Garcia / Geraldine M Gillespie

    eLife, Vol

    2020  Band 9

    Abstract: T cell cross-reactivity ensures that diverse pathogen-derived epitopes encountered during a lifetime are recognized by the available TCR repertoire. A feature of cross-reactivity where previous exposure to one microbe can alter immunity to subsequent, ... ...

    Abstract T cell cross-reactivity ensures that diverse pathogen-derived epitopes encountered during a lifetime are recognized by the available TCR repertoire. A feature of cross-reactivity where previous exposure to one microbe can alter immunity to subsequent, non-related pathogens has been mainly explored for viruses. Yet cross-reactivity to additional microbes is important to consider, especially in HIV infection where gut-intestinal barrier dysfunction could facilitate T cell exposure to commensal/pathogenic microbes. Here we evaluated the cross-reactivity of a ‘public’, HIV-specific, CD8 T cell-derived TCR (AGA1 TCR) using MHC class I yeast display technology. Via screening of MHC-restricted libraries comprising ~2×108 sequence-diverse peptides, AGA1 TCR specificity was mapped to a central peptide di-motif. Using the top TCR-enriched library peptides to probe the non-redundant protein database, bacterial peptides that elicited functional responses by AGA1-expressing T cells were identified. The possibility that in context-specific settings, MHC class I proteins presenting microbial peptides influence virus-specific T cell populations in vivo is discussed.
    Schlagwörter HIV ; sporosarcina newyorkensis ; CD8 T cells ; MHC ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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