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Article ; Online: Horizontal and vertical microchamber platforms for evaluation of the paracellular permeability of an epithelial cell monolayer.

Kida, Ryuya / Tsugane, Mamiko / Suzuki, Hiroaki

2024 Volume 24, Issue 3, Page(s) 572–583

Abstract: Epithelial cells serve as a barrier by tightly adhering to each other and contribute to the homeostasis of living organisms by controlling substance permeation. Therefore, evaluation of the barrier function is important in pharmaceutical development ... ...

Abstract	Epithelial cells serve as a barrier by tightly adhering to each other and contribute to the homeostasis of living organisms by controlling substance permeation. Therefore, evaluation of the barrier function is important in pharmaceutical development processes. However, the widely used Transwell-based assays require the development of the defect-free epithelial cell monolayer above several tens of mm
MeSH term(s)	Reproducibility of Results ; Epithelial Cells/metabolism ; Permeability
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d3lc00855j
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Article: Use of bispectral index for detection of partial cerebral hypoperfusion during cervical spine surgery: A case report.

Suzuki, Hiroaki / Doi, Kazuki / Asai, Takashi

Saudi journal of anaesthesia

2024 Volume 18, Issue 2, Page(s) 280–282

Abstract: The BIS value may decrease by cerebral hypoperfusion. We report a case in which the BIS value suddenly decreased during cervical spine surgery, which led us to find cervical screws compressing the vertebral arteries. In a 79-year-old man undergoing ... ...

Abstract	The BIS value may decrease by cerebral hypoperfusion. We report a case in which the BIS value suddenly decreased during cervical spine surgery, which led us to find cervical screws compressing the vertebral arteries. In a 79-year-old man undergoing cervical spine surgery, the BIS suddenly decreased from about 40 to 10-20, about 4 h after the start of surgery. Intraoperative 3-dementional computed tomography indicated that both the two tips of cervical screws inserted in the 6th cervical vertebra were within bilateral transverse foramens. These cervical screws were removed, and the BIS increased immediately. The cervical screws were re-inserted again thorough the same vertebra into the bilateral transverse foramens, and the BIS decreased immediately. Postoperatively, cerebral hypoperfusion due to compression of bilateral vertebral arteries by two cervical screws was identified. The BIS may be a useful to detect cerebral hypoperfusion due to compression of the vertebral artery by a cervical screw.
Language	English
Publishing date	2024-03-14
Publishing country	India
Document type	Case Reports
ZDB-ID	2562174-9
ISSN	0975-3125 ; 1658-354X
ISSN (online)	0975-3125
ISSN	1658-354X
DOI	10.4103/sja.sja_761_23
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Article ; Online: Simple manual roller pump-driven valve-free microfluidic solution exchange system for urgent bioassay.

Biswas, Gokul Chandra / Suzuki, Hiroaki

RSC advances

2022 Volume 12, Issue 5, Page(s) 2938–2946

Abstract: We introduce a simple-to-use manual roller pump (MRP)-driven and valve-free microfluidic system for sequential solution exchange, followed by a bioassay to detect protein. The polydimethylsiloxane (PDMS)/glass-based disposable device comprises a reaction ...

Abstract	We introduce a simple-to-use manual roller pump (MRP)-driven and valve-free microfluidic system for sequential solution exchange, followed by a bioassay to detect protein. The polydimethylsiloxane (PDMS)/glass-based disposable device comprises a reaction chamber, multiple micro-flow channels (μFCs), and air vents. The practical solution exchange was realized by sequential injection and withdrawal of several solutions into and from the reaction chamber through constricted μFCs by utilizing changing air pressure of an MRP when a small cylindrical roller was pressed and rolled over a soft silicone tube using a finger. Furthermore, we investigated the effect of surface hydrophobicity on solution exchange. A sandwich fluorescence-based immunoassay to detect human interleukin 2 (IL-2) was performed using this simple microfluidic scheme to demonstrate its suitability for analytical bioassays. The system allowed quick IL-2 detection in 20 min in a pre-functionalized device with a detection limit of 80 pg mL
Language	English
Publishing date	2022-01-21
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra08052k
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Article: Simple manual roller pump-driven valve-free microfluidic solution exchange system for urgent bioassay

Biswas, Gokul Chandra / Suzuki, Hiroaki

RSC advances. 2022 Jan. 21, v. 12, no. 5

2022

Abstract	We introduce a simple-to-use manual roller pump (MRP)-driven and valve-free microfluidic system for sequential solution exchange, followed by a bioassay to detect protein. The polydimethylsiloxane (PDMS)/glass-based disposable device comprises a reaction chamber, multiple micro-flow channels (μFCs), and air vents. The practical solution exchange was realized by sequential injection and withdrawal of several solutions into and from the reaction chamber through constricted μFCs by utilizing changing air pressure of an MRP when a small cylindrical roller was pressed and rolled over a soft silicone tube using a finger. Furthermore, we investigated the effect of surface hydrophobicity on solution exchange. A sandwich fluorescence-based immunoassay to detect human interleukin 2 (IL-2) was performed using this simple microfluidic scheme to demonstrate its suitability for analytical bioassays. The system allowed quick IL-2 detection in 20 min in a pre-functionalized device with a detection limit of 80 pg mL⁻¹ and a range of 125 pg mL⁻¹ to 2.0 ng mL⁻¹. We have thus developed a microfluidic scheme that non-experts can efficiently perform and that can be the fundamental module for low-cost bioassays necessary for emergencies and situations where resources are constrained.
Keywords	air ; atmospheric pressure ; bioassays ; detection limit ; humans ; hydrophobicity ; immunoassays ; interleukin-2 ; polydimethylsiloxane
Language	English
Dates of publication	2022-0121
Size	p. 2938-2946.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d1ra08052k
Database	NAL-Catalogue (AGRICOLA)

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Article: Pneumatic Microballoons for Active Control of the Vibration-Induced Flow.

Sato, Taku / Kaneko, Kanji / Hayakawa, Takeshi / Suzuki, Hiroaki

Micromachines

2023 Volume 14, Issue 11

Abstract: Vibration-induced flow (VIF), in which a mean flow is induced around a microstructure by applying periodic vibrations, is increasingly used as an active flow-control technique at the microscale. In this study, we have developed a microdevice that ... ...

Abstract	Vibration-induced flow (VIF), in which a mean flow is induced around a microstructure by applying periodic vibrations, is increasingly used as an active flow-control technique at the microscale. In this study, we have developed a microdevice that actively controls the VIF patterns using elastic membrane protrusions (microballoons) actuated by pneumatic pressure. This device enables on-demand spatial and temporal fluid manipulation using a single device that cannot be achieved using a conventional fixed-structure arrangement. We successfully demonstrated that the device achieved displacements of up to 38 µm using the device within a pressure range of 0 to 30 kPa, indicating the suitability of the device for microfluidic applications. Using this active microballoon array, we demonstrated that the device can actively manipulate the flow field and induce swirling flows. Furthermore, we achieved selective actuation of the microballoon using this system. By applying air pressure from a multi-input channel system through a connection tube, the microballoons corresponding to each air channel can be selectively actuated. This enabled precise control of the flow field and periodic switching of the flow patterns using a single chip. In summary, the proposed microdevice provides active control of VIF patterns and has potential applications in advanced microfluidics, such as fluid mixing and particle manipulation.
Language	English
Publishing date	2023-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14112010
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Article ; Online: Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis.

Yamazaki, Daichi / Osaki, Yoshinori / Suzuki, Hiroaki / Shimano, Hitoshi

BMJ case reports

2023 Volume 16, Issue 3

Abstract: We report a rare case of takotsubo cardiomyopathy caused by subacute thyroiditis in a man in his 50s. He went to the doctor with complaints of loss of appetite, diarrhoea, chills and general malaise. He had consciousness disturbance, thyrotoxicosis and ... ...

Abstract	We report a rare case of takotsubo cardiomyopathy caused by subacute thyroiditis in a man in his 50s. He went to the doctor with complaints of loss of appetite, diarrhoea, chills and general malaise. He had consciousness disturbance, thyrotoxicosis and thyroid-stimulating hormone (TSH) suppression. Thyroglobulin and C reactive protein levels in the blood were elevated, but TSH receptor antibody, thyroid-stimulating antibody, antithyroglobulin antibody and antithyroid peroxidase antibody were not. We began treatment with prednisolone and propranolol after he was diagnosed with thyroid storm caused by subacute thyroiditis. The ECG revealed inverted T waves on the fifth day after admission. He was newly diagnosed with takotsubo cardiomyopathy on the day. A large thrombus was detected in the left ventricle, requiring anticoagulation therapy. Thus, even if there are no findings of takotsubo cardiomyopathy or thrombus at the onset of thyroid storm, appropriate monitoring is required because they can develop during the treatment course.
MeSH term(s)	Humans ; Male ; Heart Ventricles/diagnostic imaging ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/drug therapy ; Takotsubo Cardiomyopathy/etiology ; Thrombosis/diagnostic imaging ; Thrombosis/drug therapy ; Thyroid Crisis/complications ; Thyroiditis/complications ; Thyroiditis/diagnosis ; Thyroiditis, Subacute/diagnosis ; Thyrotoxicosis/complications ; Thyrotropin ; Middle Aged
Chemical Substances	Thyrotropin (9002-71-5)
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-250540
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Article ; Online: Successful One-Lung Ventilation With a Double Bronchial Blocker Technique in a Patient With Bronchial Anomaly and Tracheal Stenosis Caused by Kommerell Diverticulum.

Suzuki, Hiroaki / Fujishiro, Asuka / Arai, Takero

Journal of cardiothoracic and vascular anesthesia

2023 Volume 37, Issue 12, Page(s) 2607–2610

MeSH term(s)	Humans ; One-Lung Ventilation/methods ; Tracheal Stenosis/complications ; Tracheal Stenosis/diagnostic imaging ; Bronchi/diagnostic imaging ; Bronchi/surgery ; Bronchoscopy ; Diverticulum/complications ; Diverticulum/diagnostic imaging ; Diverticulum/surgery ; Intubation, Intratracheal/methods ; Respiration, Artificial
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2023.09.007
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 31: Show issues

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Article ; Online: Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA.

Suzuki, Hiroaki / Matsuoka, Masaaki

Journal of neurochemistry

2021 Volume 158, Issue 3, Page(s) 753–765

Abstract: A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Unconventional translation of the hexanucleotide repeat expansion generates ... ...

Abstract	A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Unconventional translation of the hexanucleotide repeat expansion generates five dipeptide repeat proteins (DPRs). The molecular mechanism underlying the DPR-linked neurotoxicity is under investigation. In this study, using cell-based models, we show that poly-proline-arginine DPR (poly-PR), the most neurotoxic DPR in vitro, binds to adenosine deaminase acting on RNA (ADAR)1p110 and ADAR2 and inhibits their RNA editing activity. We further show that poly-PR impairs cellular stress response that is mediated by ADAR1p110. These results together suggest that the poly-PR-mediated inhibition of the ADAR activity contributes to C9-ALS/FTD-linked neurotoxicity.
MeSH term(s)	Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Animals ; Arginine/genetics ; Arginine/metabolism ; C9orf72 Protein/genetics ; C9orf72 Protein/metabolism ; Dipeptides/genetics ; Dipeptides/metabolism ; HeLa Cells ; Humans ; Mice ; Neurons/metabolism ; Proline/genetics ; Proline/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Chemical Substances	C9orf72 Protein ; C9orf72 protein, mouse ; Dipeptides ; RNA-Binding Proteins ; Arginine (94ZLA3W45F) ; Proline (9DLQ4CIU6V) ; ADAR1 protein, mouse (EC 3.5.4.4) ; ADAR2 protein, mouse (EC 3.5.4.4) ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2021-06-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.15445
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Ui II Zs.170: Show issues

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Article ; Online: [Nationwide Questionnaire Survey on Disaster Power Outage Countermeasures in the Radiology Departments of Hospitals].

Suzuki, Hiroaki / Morishima, Yoshiaki / Ota, Joji / Arai, Kazumasa / Sato, Hisaya / Ishikawa, Eiji

Nihon Hoshasen Gijutsu Gakkai zasshi

2024

Abstract: Purpose: To identify the countermeasures and current status of disaster power outages in the radiology departments of hospitals.: Methods: A web-based questionnaire survey of 600 hospitals nationwide was conducted. The questionnaire survey covered 34 ...

Abstract	Purpose: To identify the countermeasures and current status of disaster power outages in the radiology departments of hospitals. Methods: A web-based questionnaire survey of 600 hospitals nationwide was conducted. The questionnaire survey covered 34 items, including availability of power in the radiology department in the event of a disaster and the impact of power outages on medical equipment in the radiology department. Results: In all, 242 facilities (40.3%) responded to our survey. During power outages, 55.8%-68.2% of facilities were able to use CT, digital radiography, and angiography systems with their private generators. In 28.1%-40.7% of facilities, medical information systems were not available in all laboratories. In addition, power outages caused equipment malfunctions in 81.4% of facilities' radiology departments. Conclusion: We have identified the power supplied by private generators to the radiology department's medical equipment and medical information systems. Many medical equipment have malfunctioned due to power outages. Therefore, drills should be conducted to simulate various situations caused by power outages.
Language	Japanese
Publishing date	2024-04-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	2269092-X
ISSN	1881-4883 ; 0369-4305
ISSN (online)	1881-4883
ISSN	0369-4305
DOI	10.6009/jjrt.2024-1450
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Article ; Online: Measuring auditory event-related potentials at the external ear canal: A demonstrative study using a new electrode and error-feedback paradigm.

Arao, Hiroshi / Suwazono, Shugo / Kimura, Akio / Asano, Hirotoshi / Suzuki, Hiroaki

The European journal of neuroscience

2023 Volume 58, Issue 11, Page(s) 4310–4327

Abstract: Although ear canal electroencephalogram (EEG) recording has received interest from basic and applied research communities, evidence on how it can be implemented in practice is limited. The present study involving eight male participants including the ... ...

Abstract	Although ear canal electroencephalogram (EEG) recording has received interest from basic and applied research communities, evidence on how it can be implemented in practice is limited. The present study involving eight male participants including the authors presents the utility of our ear canal electrode and method by demonstrating both comparability of ear canal EEG to those at nearby sites and distinctiveness that ear canal event-related potentials (ERPs) could have. For this purpose, we used the balanced noncephalic electrode reference and an experimental paradigm with an error-feedback sound. Clear auditory ERPs were detected at the ear canal sites with a sufficiently low noise level comparable with those at conventional sites. The N1c, a temporal maximum subcomponent, spread over the bilateral temporal sites, including the ear canals and earlobes. While consecutive signals are generally highly similar between the ear canal and the earlobe, the N1c was larger at the ear canal than the earlobe, as demonstrated by the conventional frequentist and the hierarchical Bayesian modelling approaches. Although an evident caveat is that our sample was limited in terms of size and sex, the general capability indicates that the structure of our ear canal electrode provides EEG measurement that can be used in basic and applied settings. Our experimental method can also be an ERP-based test that conveniently assesses the capability of existing and future ear canal electrodes. The distinctive nature of the ERPs to the error-feedback sound may be utilized to examine the basic aspects of auditory ERPs and to test the processes involved in feedback-guided behaviour of participants.
MeSH term(s)	Humans ; Male ; Ear Canal ; Feedback ; Bayes Theorem ; Evoked Potentials ; Electrodes
Language	English
Publishing date	2023-10-24
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.16175
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