LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Article: Are Analogue or Digital Clocks Friendlier for People Living with Dementia?

    Koreki, Akihiro / Kusudo, Keisuke / Suzuki, Hisaomi / Nozaki, Shoko / Onaya, Mitsumoto / Bowes, Alison / Sado, Mitsuhiro

    Dementia and geriatric cognitive disorders extra

    2021  Volume 11, Issue 3, Page(s) 207–212

    Abstract: Background: In ageing population, it is desirable to reduce the impact of cognitive decline on daily life. While various types of dementia-friendly environments have been proposed, the question still remains regarding whether analogue or digital clocks ... ...

    Abstract Background: In ageing population, it is desirable to reduce the impact of cognitive decline on daily life. While various types of dementia-friendly environments have been proposed, the question still remains regarding whether analogue or digital clocks are friendlier for people with dementia.
    Methods: In clinical practice, we normally use our original clock reading test (10 analogue and 10 digital clocks) to assess patients' ability to read a clock. In the present study, a retrospective medical record survey was conducted. Fifty-five participants who had done the test were identified. The result of the test was compared between analogue and digital clocks. Additionally, to assess specific ability to read analogue clocks, an "analogue-digital gap" was defined as the difference between patients' performance for analogue and digital clocks. Univariate and multivariate analyses were conducted to detect significant factors associated with reading ability specific to analogue clocks.
    Results: The analogue clock proved less readable than the digital clock, even after adjusting for MMSE total score (
    Conclusions: In the present study, the digital clock was friendlier than the analogue clock for patients with dementia. Compared to the digital clock, reading analogue clocks might require more widespread cognition, such as working memory and visuospatial processing. While our finding was a general tendency, and individual assessment is necessary, it might help the development of personalized environmental adjustments.
    Language English
    Publishing date 2021-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2621464-7
    ISSN 1664-5464
    ISSN 1664-5464
    DOI 10.1159/000518350
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Risk of Nonalcoholic Fatty Liver Disease in Patients With Schizophrenia Treated With Antipsychotic Drugs: A Cross-sectional Study.

    Koreki, Akihiro / Mori, Hiroko / Nozaki, Shoko / Koizumi, Teruki / Suzuki, Hisaomi / Onaya, Mitsumoto

    Journal of clinical psychopharmacology

    2021  Volume 41, Issue 4, Page(s) 474–477

    Abstract: Background: Although the prevalence of metabolic syndrome in patients with schizophrenia is higher than the prevalence in the general population, little is known regarding nonalcoholic fatty liver disease (NAFLD) in patients with schizophrenia.: ... ...

    Abstract Background: Although the prevalence of metabolic syndrome in patients with schizophrenia is higher than the prevalence in the general population, little is known regarding nonalcoholic fatty liver disease (NAFLD) in patients with schizophrenia.
    Procedures: We analyzed the medical records of patients with schizophrenia/schizoaffective disorder (N = 253) who received an abdominal echography.
    Results: In total, 108 patients (42.7%) showed NAFLD on abdominal echography. Of these, 13 patients (12.0%) showed signs of fibrosis on abdominal echography. In terms of age distribution, NAFLD was more prevalent in younger patients, particularly in female patients. We also found that body mass index, the total dose of antipsychotic drugs that carry a risk of metabolic syndrome, and the total dose of antipsychotic drugs that carry a risk of hyperprolactinemia were significantly associated with NAFLD (P < 0.001, 0.049, and 0.041, respectively). In our exploratory analysis, we found that signs of fibrosis in NAFLD were more highly associated with female patients (P = 0.023). Importantly, the risk in younger female patients may be specific to patients with schizophrenia compared with the general population.
    Conclusions: Considering that antipsychotic drugs were associated with the development of NAFLD, early detection and management of NAFLD should be conducted in patients with schizophrenia.
    MeSH term(s) Adult ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Dose-Response Relationship, Drug ; Early Diagnosis ; Female ; Humans ; Japan/epidemiology ; Liver Cirrhosis/diagnostic imaging ; Male ; Medical Records/statistics & numerical data ; Middle Aged ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/prevention & control ; Prevalence ; Risk Assessment/methods ; Risk Factors ; Schizophrenia/drug therapy ; Schizophrenia/epidemiology ; Sex Factors ; Ultrasonography/methods ; Ultrasonography/statistics & numerical data
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001421
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: In vivo

    Kubota, Manabu / Endo, Hironobu / Takahata, Keisuke / Tagai, Kenji / Suzuki, Hisaomi / Onaya, Mitsumoto / Sano, Yasunori / Yamamoto, Yasuharu / Kurose, Shin / Matsuoka, Kiwamu / Seki, Chie / Shinotoh, Hitoshi / Kawamura, Kazunori / Zhang, Ming-Rong / Takado, Yuhei / Shimada, Hitoshi / Higuchi, Makoto

    Brain communications

    2024  Volume 6, Issue 2, Page(s) fcae075

    Abstract: Frontotemporal dementia refers to a group of neurodegenerative disorders with diverse clinical and neuropathological features. ...

    Abstract Frontotemporal dementia refers to a group of neurodegenerative disorders with diverse clinical and neuropathological features.
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcae075
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia.

    Kubota, Manabu / Takahata, Keisuke / Matsuoka, Kiwamu / Sano, Yasunori / Yamamoto, Yasuharu / Tagai, Kenji / Tarumi, Ryosuke / Suzuki, Hisaomi / Kurose, Shin / Nakajima, Shinichiro / Shiwaku, Hiroki / Seki, Chie / Kawamura, Kazunori / Zhang, Ming-Rong / Takahashi, Hidehiko / Takado, Yuhei / Higuchi, Makoto

    Schizophrenia bulletin

    2022  Volume 49, Issue 3, Page(s) 688–696

    Abstract: Background and hypothesis: Phosphodiesterase 10A (PDE10A) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. Therapeutic PDE10A inhibition effects on schizophrenia have been ... ...

    Abstract Background and hypothesis: Phosphodiesterase 10A (PDE10A) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. Therapeutic PDE10A inhibition effects on schizophrenia have been reported previously, but the status of this molecule in the living patients with schizophrenia remains elusive. Therefore, this study aimed to investigate the central PDE10A status in patients with schizophrenia and examine its relationship with psychopathology, cognition, and corticostriatal glutamate levels.
    Study design: This study included 27 patients with schizophrenia, with 5 antipsychotic-free cases, and 27 healthy controls. Positron emission tomography with [18F]MNI-659, a specific PDE10A radioligand, was employed to quantify PDE10A availability by measuring non-displaceable binding potential (BPND) of the ligand in the limbic, executive, and sensorimotor striatal functional subregions, and in the pallidum. BPND estimates were compared between patients and controls while controlling for age and gender. BPND correlations were examined with behavioral and clinical measures, along with regional glutamate levels quantified by the magnetic resonance spectroscopy.
    Study results: Multivariate analysis of covariance demonstrated a significant main effect of diagnosis on BPND (p = .03). A posthoc test showed a trend-level higher sensorimotor striatal BPND in patients, although it did not survive multiple comparison corrections. BPND in controls in this subregion was significantly and negatively correlated with the Tower of London scores, a cognitive subtest. Striatal or dorsolateral prefrontal glutamate levels did not correlate significantly with BPND in either group.
    Conclusions: The results suggest altered striatal PDE10A availability and associated local neural dysfunctions in patients with schizophrenia.
    MeSH term(s) Humans ; Schizophrenia/diagnostic imaging ; Phosphoric Diester Hydrolases/metabolism ; Positron-Emission Tomography/methods ; Basal Ganglia ; Glutamates
    Chemical Substances Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Glutamates ; PDE10A protein, human (EC 3.1.4.-)
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbac181
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Impact of the COVID-19 pandemic on patients with mental health problems and the differences among diagnostic categories.

    Mashima, Yuki / Koizumi, Teruki / Minegishi, Shunta / Miyakoshi, Megumi / Okada, Mai / Ogyu, Kamiyu / Kusudo, Keisuke / Kiyohara, Masataka / Kitada, Shinobu / Koyanagi, Kazuhiro / Suzuki, Hisaomi / Nozaki, Shoko / Oda, Akihiko / Hirai, Shinji / Nakane, Jun / Onaya, Mitsumoto / Oda, Tatsuro / Koreki, Akihiro

    The International journal of social psychiatry

    2022  Volume 68, Issue 5, Page(s) 969–980

    Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in a total upending of our daily lives. While anxiety and depression were frequently reported among the general population, the pandemic's impact on patients with mental health ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in a total upending of our daily lives. While anxiety and depression were frequently reported among the general population, the pandemic's impact on patients with mental health problems remains unknown.
    Methods: A cross-sectional questionnaire survey involving 1,166 patients was conducted at one psychiatric hospital and one mental health clinic.
    Results: Symptom deterioration was reported in 23% to 34% of the patients and 9% to 20% reported increase in drug dosage. No significant differences were reported in these items among diagnostic categories. Patients with
    Conclusion: One third of patients reported symptom deterioration during the pandemic, which was associated with stress and daily life changes. Patients with good adaptability to environmental changes might resilient against symptom deterioration. Providing continuous support to help patients manage their daily life in this COVID-19 era may minimize the risk of symptom deterioration.
    MeSH term(s) Anxiety/epidemiology ; Anxiety/psychology ; COVID-19/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/psychology ; Humans ; Mental Health ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 3062-4
    ISSN 1741-2854 ; 0020-7640
    ISSN (online) 1741-2854
    ISSN 0020-7640
    DOI 10.1177/00207640221097509
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies.

    Suzuki, Hisaomi / Ohgidani, Masahiro / Kuwano, Nobuki / Chrétien, Fabrice / Lorin de la Grandmaison, Geoffroy / Onaya, Mitsumoto / Tominaga, Itaru / Setoyama, Daiki / Kang, Dongchon / Mimura, Masaru / Kanba, Shigenobu / Kato, Takahiro A

    Frontiers in cellular neuroscience

    2019  Volume 13, Page(s) 31

    Abstract: Suicide is one of the most disastrous outcomes for psychiatric disorders. Recent advances in biological psychiatry have suggested a positive relationship between some specific brain abnormalities and specific symptoms in psychiatric disorders whose ... ...

    Abstract Suicide is one of the most disastrous outcomes for psychiatric disorders. Recent advances in biological psychiatry have suggested a positive relationship between some specific brain abnormalities and specific symptoms in psychiatric disorders whose organic bases were previously completely unknown. Microglia, immune cells in the brain, are regarded to play crucial roles in brain inflammation by releasing inflammatory mediators and are suggested to contribute to various psychiatric disorders such as depression and schizophrenia. Recently, activated microglia have been suggested to be one of the possible contributing cells to suicide and suicidal behaviors
    Language English
    Publishing date 2019-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2019.00031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Resting-state hyperperfusion in the whole brain: A case of malignant catatonia that improved with electric convulsion therapy.

    Kurose, Shin / Koreki, Akihiro / Funayama, Michitaka / Takahashi, Eriko / Kaji, Masataka / Ogyu, Kamiyu / Takasu, Shotaro / Koizumi, Teruki / Suzuki, Hisaomi / Onaya, Mitsumoto / Mimura, Masaru

    Schizophrenia research

    2019  Volume 210, Page(s) 287–288

    MeSH term(s) Brain/diagnostic imaging ; Brain/physiopathology ; Catatonia/etiology ; Catatonia/physiopathology ; Catatonia/therapy ; Cerebrovascular Circulation/physiology ; Electroconvulsive Therapy ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Schizophrenia/complications ; Schizophrenia/physiopathology ; Schizophrenia/therapy
    Language English
    Publishing date 2019-06-06
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2019.05.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies.

    Tagai, Kenji / Ono, Maiko / Kubota, Manabu / Kitamura, Soichiro / Takahata, Keisuke / Seki, Chie / Takado, Yuhei / Shinotoh, Hitoshi / Sano, Yasunori / Yamamoto, Yasuharu / Matsuoka, Kiwamu / Takuwa, Hiroyuki / Shimojo, Masafumi / Takahashi, Manami / Kawamura, Kazunori / Kikuchi, Tatsuya / Okada, Maki / Akiyama, Haruhiko / Suzuki, Hisaomi /
    Onaya, Mitsumoto / Takeda, Takahiro / Arai, Kimihito / Arai, Nobutaka / Araki, Nobuyuki / Saito, Yuko / Trojanowski, John Q / Lee, Virginia M Y / Mishra, Sushil K / Yamaguchi, Yoshiki / Kimura, Yasuyuki / Ichise, Masanori / Tomita, Yutaka / Zhang, Ming-Rong / Suhara, Tetsuya / Shigeta, Masahiro / Sahara, Naruhiko / Higuchi, Makoto / Shimada, Hitoshi

    Neuron

    2020  Volume 109, Issue 1, Page(s) 42–58.e8

    Abstract: A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar degeneration (FTLD) tau inclusions has been unsuccessful. Here, we ... ...

    Abstract A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau pathologies in Alzheimer's disease (AD), although sensitive detection of frontotemporal lobar degeneration (FTLD) tau inclusions has been unsuccessful. Here, we generated an imaging probe, PM-PBB3, for capturing diverse tau deposits. In vitro assays demonstrated the reactivity of this compound with tau pathologies in AD and FTLD. We could also utilize PM-PBB3 for optical/PET imaging of a living murine tauopathy model. A subsequent clinical PET study revealed increased binding of
    MeSH term(s) Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Animals ; Benzothiazoles/metabolism ; Carbon Radioisotopes/metabolism ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Positron-Emission Tomography/methods ; Tauopathies/diagnostic imaging ; Tauopathies/genetics ; Tauopathies/metabolism
    Chemical Substances Benzothiazoles ; Carbon Radioisotopes ; PBB3 compound
    Language English
    Publishing date 2020-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.09.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top