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Article ; Online: Binaural Listening with Head Rotation Helps Persons with Blindness Perceive Narrow Obstacles.

Miura, Takahiro / Okochi, Naoyuki / Suzuki, Junya / Ifukube, Tohru

International journal of environmental research and public health

2023 Volume 20, Issue 8

Abstract: Orientation and mobility (O&M) are important abilities that people with visual impairments use in their independent performance of daily activities. In orientation, people with total blindness pinpoint nonsounding objects and sounding objects. The ... ...

Abstract	Orientation and mobility (O&M) are important abilities that people with visual impairments use in their independent performance of daily activities. In orientation, people with total blindness pinpoint nonsounding objects and sounding objects. The ability to perceive nonsounding objects is called
MeSH term(s)	Humans ; Auditory Perception ; Hearing ; Movement ; Blindness
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20085573
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Article ; Online: Site-Specific O-Glycosylation Analysis by Liquid Chromatography-Mass Spectrometry with Electron-Transfer/Higher-Energy Collisional Dissociation.

Hashii, Noritaka / Suzuki, Junya

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2271, Page(s) 169–178

Abstract: O-glycosylation is a major post-translational modification of proteins. Accurate and detailed analysis to reveal O-glycosylation patterns at each site (site-specific O-glycosylation analysis) is essential to deeply understand glycoprotein function. ... ...

Abstract	O-glycosylation is a major post-translational modification of proteins. Accurate and detailed analysis to reveal O-glycosylation patterns at each site (site-specific O-glycosylation analysis) is essential to deeply understand glycoprotein function. Recent reports also demonstrated that unintended O-glycosylation occurs on therapeutic fusion glycoproteins; therefore, it is increasingly important to perform detailed and exhaustive O-glycosylation analysis during the development of therapeutic glycoproteins. Here, we describe a method of in-depth site-specific O-glycosylation analysis by liquid chromatography-mass spectrometry using electron-transfer/higher-energy collisional dissociation (EThcD) and database analysis.
MeSH term(s)	Chromatography, Reverse-Phase ; Glycoproteins/analysis ; Glycosylation ; Protein Processing, Post-Translational ; Research Design ; Tandem Mass Spectrometry ; Workflow
Chemical Substances	Glycoproteins
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1241-5_12
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Article ; Online: Recovery of the Japanese orthopedic association back pain evaluation questionnaire score and walking ability following lumbar spinal stenosis surgery.

Takenaka, Hiroto / Kamiya, Mitsuhiro / Sugiura, Hideshi / Nishihama, Kasuri / Suzuki, Junya / Hanamura, Shuntaro

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2024

Abstract: Purpose: We investigated the recovery of the Japanese orthopedic association back pain evaluation questionnaire (JOABPEQ) scores and 6 min walk distance (6MWD) in patients after surgery for lumbar spinal stenosis and identified the items among 25 ... ...

Abstract	Purpose: We investigated the recovery of the Japanese orthopedic association back pain evaluation questionnaire (JOABPEQ) scores and 6 min walk distance (6MWD) in patients after surgery for lumbar spinal stenosis and identified the items among 25 questions of JOABPEQ that showed recovery. Methods: A total of 227 patients (average age 71.5 years; SD: 7.5; 121 men) were included from a single center. The outcome measures were JOABPEQ, visual analog scale (VAS), and 6MWD and obtained preoperatively and at 1, 3, 6, and 12 months postoperatively. Mixed-model repeated measures were used to compare the variables at each time point between the surgery groups. Results: The JOABPEQ, VAS, and 6MWD scores generally improved at 1 month postoperatively compared with those obtained preoperatively, and some parameters further improved at 3 months. However, improvement in the lumbar spine dysfunction item of JOABPEQ was delayed, showing improvement at 3 months postoperatively for decompression surgery (average score: pre, 64.6; 3 months, 78.5) and 6 months postoperatively for fusion surgery (average score: Pre, 64.3; 6 months, 77.1). Responses to the individual JOABPEQ questions generally improved after surgery. No significant changes in lumbar spine dysfunction occurred in the fusion group. Conclusion: Our results demonstrated the early postoperative recovery course of JOABPEQ and 6MWD. In the fusion group, significant changes in lumbar spine dysfunction started at 6 months postoperatively. These findings could help medical staff explain postoperative recovery to patients after lumbar spinal stenosis surgery and in their decision making regarding surgery.
Language	English
Publishing date	2024-04-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-024-08238-1
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Article ; Online: Chronic circadian rhythm disorder induces heart failure with preserved ejection fraction-like phenotype through the Clock-sGC-cGMP-PKG1 signaling pathway.

Che, Yiyang / Shimizu, Yuuki / Hayashi, Takumi / Suzuki, Junya / Pu, Zhongyue / Tsuzuki, Kazuhito / Narita, Shingo / Shibata, Rei / Murohara, Toyoaki

Scientific reports

2024 Volume 14, Issue 1, Page(s) 10777

Abstract: Emerging evidence has documented that circadian rhythm disorders could be related to cardiovascular diseases. However, there is limited knowledge on the direct adverse effects of circadian misalignment on the heart. This study aimed to investigate the ... ...

Abstract	Emerging evidence has documented that circadian rhythm disorders could be related to cardiovascular diseases. However, there is limited knowledge on the direct adverse effects of circadian misalignment on the heart. This study aimed to investigate the effect of chronic circadian rhythm disorder on heart homeostasis in a mouse model of consistent jetlag. The jetlag model was induced in mice by a serial 8-h phase advance of the light cycle using a light-controlled isolation box every 4 days for up to 3 months. Herein, we demonstrated for the first time that chronic circadian rhythm disorder established in the mouse jetlag model could lead to HFpEF-like phenotype such as cardiac hypertrophy, cardiac fibrosis, and cardiac diastolic dysfunction, following the attenuation of the Clock-sGC-cGMP-PKG1 signaling. In addition, clock gene knock down in cardiomyocytes induced hypertrophy via decreased sGC-cGMP-PKG signaling pathway. Furthermore, treatment with an sGC-activator riociguat directly attenuated the adverse effects of jetlag model-induced cardiac hypertrophy, cardiac fibrosis, and cardiac diastolic dysfunction. Our data suggest that circadian rhythm disruption could induce HFpEF-like phenotype through downregulation of the clock-sGC-cGMP-PKG1 signaling pathway. sGC could be one of the molecular targets against circadian rhythm disorder-related heart disease.
MeSH term(s)	Animals ; Signal Transduction ; Mice ; Heart Failure/metabolism ; Heart Failure/etiology ; Heart Failure/physiopathology ; Cyclic GMP/metabolism ; Soluble Guanylyl Cyclase/metabolism ; CLOCK Proteins/metabolism ; CLOCK Proteins/genetics ; Male ; Disease Models, Animal ; Phenotype ; Cyclic GMP-Dependent Protein Kinase Type I/metabolism ; Cyclic GMP-Dependent Protein Kinase Type I/genetics ; Myocytes, Cardiac/metabolism ; Circadian Rhythm/physiology ; Mice, Inbred C57BL ; Chronobiology Disorders/metabolism ; Stroke Volume
Chemical Substances	Cyclic GMP (H2D2X058MU) ; Soluble Guanylyl Cyclase (EC 4.6.1.2) ; CLOCK Proteins (EC 2.3.1.48) ; Cyclic GMP-Dependent Protein Kinase Type I (EC 2.7.11.12) ; Clock protein, mouse (EC 2.3.1.48)
Language	English
Publishing date	2024-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-61710-2
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Article ; Online: Minimal Clinically Important Difference of the 6-Minute Walk Distance in Patients Undergoing Lumbar Spinal Canal Stenosis Surgery: 12 Months Follow-Up.

Takenaka, Hiroto / Kamiya, Mitsuhiro / Sugiura, Hideshi / Nishihama, Kasuri / Suzuki, Junya / Hanamura, Shuntaro

Spine

2022 Volume 48, Issue 8, Page(s) 559–566

Abstract: Study design: Retrospective review of prospectively collected data.: Objective: We evaluated the responsiveness of the 6-minute walk distance (6MWD) and determined the threshold of the minimal clinically important difference (MCID) in patients who ... ...

Abstract	Study design: Retrospective review of prospectively collected data. Objective: We evaluated the responsiveness of the 6-minute walk distance (6MWD) and determined the threshold of the minimal clinically important difference (MCID) in patients who underwent lumbar spinal stenosis (LSS) surgery. Summary of background data: Little evidence exists on the MCID of 6MWD after LSS surgery. The 6MWD is an objective gait assessment that can be measured quickly. Materials and methods: In total, 126 patients (74 men; average age, 72.2 ± 6.5 yr) were included and assessed preoperatively and at 12 months postoperatively. We used the Oswestry Disability Index (ODI), as an anchor to calculate the MCID for the 6MWD and measured internal and external responsiveness of the 6MWD. The external responsiveness was assessed in 2 ways: (1) One based on the anchoring questionnaire and (2) another based on the scale distribution. The anchor-based approach was evaluated using the Spearman rank correlation coefficient and receiver-operating characteristic curve. The distribution-based approach was evaluated using the minimal detectable change. Results: The ODI scores and 6MWD for each anchor significantly improved postoperatively. The change in the 6MWD was significantly correlated with change in the ODI (6 mo, r = -0.45; 12 mo, r = -0.49). The receiver-operating characteristic analysis demonstrated good discriminative properties for the 6MWD using the ODI anchor (6 mo, 0.72; 12 mo, 0.78). The cutoff values for 6MWD were 102.3 and 57.5 at 6 and 12 months, respectively. In the distribution-based approach, the minimal detectable change for the 6MWD was 95.7 m. Conclusions: We validated both the internal and external responsiveness of the 6MWD using the ODI and estimated the MCID in the 6MWD for patients undergoing LSS surgery. However, there was lower validity for the MCID among those participants with the high walking ability and low disability at baseline.
MeSH term(s)	Male ; Humans ; Aged ; Spinal Stenosis/surgery ; Follow-Up Studies ; Minimal Clinically Important Difference ; Constriction, Pathologic ; Walking ; Surveys and Questionnaires ; Spinal Canal ; Treatment Outcome ; Lumbar Vertebrae/surgery
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000004566
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Zs.A 1305: Show issues

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Article ; Online: Antiphospholipid antibody positivity and the thrombotic risk in Japanese patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.

Suzuki, Junya / Furuta, Shunsuke / Sugiyama, Takahiro / Iwamoto, Taro / Ikeda, Kei / Suzuki, Kotaro / Nakajima, Hiroshi

Modern rheumatology

2022 Volume 33, Issue 2, Page(s) 346–351

Abstract: Objectives: It has been reported that 21.0-51.7% of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) patients were antiphospholipid antibody (aPL)-positive. However, the clinical significance of aPL positivity in AAV is not fully ... ...

Abstract	Objectives: It has been reported that 21.0-51.7% of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) patients were antiphospholipid antibody (aPL)-positive. However, the clinical significance of aPL positivity in AAV is not fully understood. Methods: We retrospectively assessed patients with AAV diagnosed from 2013 to 2020 at our hospital. Positivity of aPL was defined as positivity of anti-cardiolipin antibody, anti-cardiolipin β2 glycoprotein 1 complex antibody, and/or lupus anticoagulant at least one time during the follow-up periods. The thrombotic risk of aPL positivity was examined by multivariate analyses with the Cox regression model. Results: A total of 93 patients with a median age of 71.9 years were included in the study. The median follow-up period was 35.4 months. Thirty-one patients (33.3%) were aPL-positive. Twenty-two thrombotic events occurred in 17 patients (18.3%). Thrombotic events occurred more frequently in aPL-positive patients than in aPL-negative patients (P = 0.011). Multivariate analyses with two different models identified aPL positivity as a thrombotic risk factor (hazard ratios 4.302 and 5.956, 95% confidence intervals 1.546-11.968 and 1.940-18.281, respectively). Conclusions: The proportion of aPL-positive patients was 33.3%, and aPL positivity increased the thrombotic risk in Japanese patients with AAV.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; East Asian People ; Antibodies, Antiphospholipid ; Antiphospholipid Syndrome/complications ; Thrombosis/diagnosis ; Thrombosis/etiology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Risk Factors
Chemical Substances	Antibodies, Antiphospholipid
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1093/mr/roac031
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Zs.B 2982: Show issues

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Article ; Online: Immunogenicity and influence on disease activity of recombinant zoster vaccine in patients with rheumatoid arthritis treated with DMARDs.

Kojima, Shotaro / Iwamoto, Taro / Kobayashi, Yoshihisa / Kato, Manami / Takizawa, Fumiyoshi / Ida, Tomoaki / Suzuki, Junya / Toda, Yosuke / Miyachi, Kazusa / Iwata, Arifumi / Furuta, Shunsuke / Ikeda, Kei / Nakajima, Hiroshi

RMD open

2024 Volume 10, Issue 1

Abstract: Objectives: This study aimed to determine the immunogenicity and the influence on disease activity of an adjuvanted recombinant varicella-zoster virus (VZV) subunit vaccine (RZV) in patients with rheumatoid arthritis (RA) treated with disease-modifying ... ...

Abstract	Objectives: This study aimed to determine the immunogenicity and the influence on disease activity of an adjuvanted recombinant varicella-zoster virus (VZV) subunit vaccine (RZV) in patients with rheumatoid arthritis (RA) treated with disease-modifying antirheumatic drugs (DMARDs). Methods: This prospective longitudinal study enrolled 53 patients with RA (aged ≥50 years) treated with DMARDs (conventional synthetic (cs)DMARDs 20, biological (b)DMARDs 23 and targeted synthetic (ts)DMARDs 10) and 10 control individuals. The participants received two intramuscular RZV 2 months apart. VZV-specific CD4 Results: VZV-specific CMI and HI significantly increased in the three DMARDs-treated patients with RA after RZV administration compared with the corresponding prevaccination values (p<0.001-0.014), and the magnitudes and fold-increases of those responses were not significantly different among the three DMARDs-treated patients with RA. Furthermore, the vaccine response rates of CMI and HI were not significantly different between csDMARDs-treated patients and b-DMARDs or ts-DMARDs-treated patients. Meanwhile, no significant increases in disease activity indices or adverse events were observed in these patients during the 6-month follow-up period after the first vaccination. RZV-induced RA flares occurred in two patients (3.8%) but were mild and controllable. Conclusion: RZV is robustly immunogenic and has a clinically acceptable safety profile in elderly patients with RA receiving DMARDs.
MeSH term(s)	Aged ; Humans ; Herpes Zoster Vaccine/adverse effects ; Prospective Studies ; Longitudinal Studies ; Herpes Zoster/epidemiology ; Herpes Zoster/etiology ; Herpes Zoster/prevention & control ; Arthritis, Rheumatoid ; Antirheumatic Agents/adverse effects ; Herpesvirus 3, Human ; Vaccines, Synthetic/adverse effects
Chemical Substances	Herpes Zoster Vaccine ; Antirheumatic Agents ; Vaccines, Synthetic
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2023-003902
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Article ; Online: Role of Epiregulin on Lipopolysaccharide-Induced Hepatocarcinogenesis as a Mediator via EGFR Signaling in the Cancer Microenvironment.

Kubo, Takahiro / Nishimura, Norihisa / Kaji, Kosuke / Tomooka, Fumimasa / Shibamoto, Akihiko / Iwai, Satoshi / Suzuki, Junya / Kawaratani, Hideto / Namisaki, Tadashi / Akahane, Takemi / Yoshiji, Hitoshi

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: Lipopolysaccharides (LPSs) have been reported to be important factors in promoting the progression of hepatocellular carcinoma (HCC), but the corresponding molecular mechanisms remain to be elucidated. We hypothesize that epiregulin (EREG), an epidermal ... ...

Abstract	Lipopolysaccharides (LPSs) have been reported to be important factors in promoting the progression of hepatocellular carcinoma (HCC), but the corresponding molecular mechanisms remain to be elucidated. We hypothesize that epiregulin (EREG), an epidermal growth factor (EGF) family member derived from hepatic stellate cells (HSCs) and activated by LPS stimulation, is a crucial mediator of HCC progression with epidermal growth factor receptor (EGFR) expression in the tumor microenvironment. We used a mouse xenograft model of Huh7 cells mixed with half the number of LX-2 cells, with/without intraperitoneal LPS injection, to elucidate the role of EREG in LPS-induced HCC. In the mouse model, LPS administration significantly enlarged the size of xenografted tumors and elevated the expression of EREG in tumor tissues compared with those in negative controls. Moreover, CD34 immunostaining and the gene expressions of angiogenic markers by a reverse transcription polymerase chain reaction revealed higher vascularization, with increased interleukin-8 (IL-8) expression in the tumors of the mice group treated with LPS compared to those without LPS. Our data collectively suggested that EREG plays an important role in the cancer microenvironment under the influence of LPS to increase not only the tumor cell growth and migration/invasion of EGFR-positive HCC cells but also tumor neovascularization via IL-8 signaling.
MeSH term(s)	Epiregulin/metabolism ; Epiregulin/genetics ; Animals ; Tumor Microenvironment ; ErbB Receptors/metabolism ; ErbB Receptors/genetics ; Lipopolysaccharides ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms/chemically induced ; Liver Neoplasms/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/chemically induced ; Carcinoma, Hepatocellular/genetics ; Signal Transduction ; Mice ; Cell Line, Tumor ; Neovascularization, Pathologic/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Interleukin-8/metabolism ; Interleukin-8/genetics ; Cell Proliferation ; Male ; Hepatic Stellate Cells/metabolism ; Gene Expression Regulation, Neoplastic/drug effects
Chemical Substances	Epiregulin ; ErbB Receptors (EC 2.7.10.1) ; Lipopolysaccharides ; EREG protein, human ; Interleukin-8 ; EGFR protein, human (EC 2.7.10.1)
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084405
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Article ; Online: Responsiveness and Minimal Clinically Important Difference of the 6-minute Walk Distance in Patients Undergoing Lumbar Spinal Canal Stenosis Surgery.

Takenaka, Hiroto / Kamiya, Mitsuhiro / Sugiura, Hideshi / Nishihama, Kasuri / Ito, Atsuki / Suzuki, Junya / Hanamura, Shuntaro

Clinical spine surgery

2021 Volume 35, Issue 3, Page(s) E345–E350

Abstract: Study design: This was a retrospective review of prospectively collected data.: Objective: We aimed to evaluate the responsiveness of the 6-minute walk distance (6MWD) and determine the threshold of the minimal clinically important difference (MCID) ... ...

Abstract	Study design: This was a retrospective review of prospectively collected data. Objective: We aimed to evaluate the responsiveness of the 6-minute walk distance (6MWD) and determine the threshold of the minimal clinically important difference (MCID) in the 6MWD in patients who underwent surgery for lumbar spinal canal stenosis (LSS) surgery. Summary of background data: The 6MWD rapidly and objectively assesses the walking distance in patients with LSS. To date, no study has assessed the MCID in the 6MWD in patients who underwent LSS surgery. Materials and methods: A total of 41 patients (16 women; average age: 69.4 y, SD: 7.8 y) were included and assessed preoperatively and at 6 months postoperatively. We evaluated the 6MWD and Oswestry Disability Index (ODI), which is a health-related patientrReported outcome, used as an anchor to calculate the MCID for in the 6MWD. We used 2 different approaches to examine the responsiveness of the 6MWD: internal and external responsiveness. The external responsiveness was assessed in 2 ways: one based on the anchoring questionnaire and the other based on the scale distribution of the scale. The anchor-based approach was evaluated using the Spearman rank correlation coefficient and the receiver operating characteristic curve. The distribution-based approach was evaluated using the minimal detectable change. Results: The ODI scores and 6MWD for each anchor significantly improved postoperatively. The correlation coefficient between changes in the 6MWD and ODI was r=-0.58. The area under the receiver operating characteristic curve for the ODI anchor was 0.70 (95% confidence interval: 0.52-0.89), and the cutoff value for the ODI anchor was 50 m (sensitivity=0.57, specificity=0.71). In the distribution-based approach, the minimal detectable change for the 6MWD was 105.9 m. Conclusions: Both the internal and the external responsiveness of the 6MWD were validated using the ODI. Therefore, the MCID in the 6MWD in patients undergoing LSS surgery ranges from 50 to 105.9 m. Level of evidence: Level III.
MeSH term(s)	Aged ; Constriction, Pathologic ; Female ; Humans ; Lumbar Vertebrae/surgery ; Minimal Clinically Important Difference ; Spinal Canal ; Spinal Stenosis/surgery ; Treatment Outcome ; Walking
Language	English
Publishing date	2021-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2849646-2
ISSN	2380-0194 ; 2380-0186
ISSN (online)	2380-0194
ISSN	2380-0186
DOI	10.1097/BSD.0000000000001196
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Article ; Online: Relationship between changes in physical function parameters and Roland-Morris disability questionnaire score after decompression surgery for lumbar spinal canal stenosis.

Takenaka, Hiroto / Sugiura, Hideshi / Kamiya, Mitsuhiro / Nishihama, Kasuri / Ito, Atsuki / Suzuki, Junya / Kawamura, Morio / Hanamura, Shuntaro

Nagoya journal of medical science

2022 Volume 84, Issue 3, Page(s) 570–579

Abstract: Although decompression surgery for lumbar spinal canal stenosis (LSS) improves leg symptoms, low back pain (LBP), and disability, the factors related to the improvement of subjective disability have not been studied sufficiently. The purpose of the study ...

Abstract	Although decompression surgery for lumbar spinal canal stenosis (LSS) improves leg symptoms, low back pain (LBP), and disability, the factors related to the improvement of subjective disability have not been studied sufficiently. The purpose of the study was to clarify the relationship between subjective disability and objective physical function parameters. A total of 51 patients who underwent decompression were included and evaluated preoperatively and 6 and 12 months postoperatively. Patient-reported outcomes related to activity limitation due to LBP were evaluated using Roland-Morris disability questionnaire (RDQ) and VAS (Visual Analog Scale). Physical function was assessed using 6-min walk distance (6MWD) and trunk muscle strength. Univariate analysis and multivariable linear regression analysis were performed to identify significant factors for RDQ score change. The 6- and 12-month postoperative RDQ scores, VAS scores, and trunk extensor strength significantly improved relative to the preoperative values. In the univariate analysis, age, changes in VAS (LBP, leg pain, and numbness) scores, and change in 6MWD were associated with the RDQ score change (
MeSH term(s)	Activities of Daily Living ; Constriction, Pathologic/surgery ; Decompression, Surgical/adverse effects ; Decompression, Surgical/methods ; Humans ; Lumbar Vertebrae/surgery ; Spinal Canal ; Spinal Stenosis/surgery ; Surveys and Questionnaires ; Treatment Outcome
Language	English
Publishing date	2022-10-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	193148-9
ISSN	2186-3326 ; 0027-7622
ISSN (online)	2186-3326
ISSN	0027-7622
DOI	10.18999/nagjms.84.3.570
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