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Article ; Online: Comments on "Epidemiology of overall and early-onset serrated polyps versus conventional adenomas in a colonoscopy screening cohort".

Arai, Junya / Aoki, Tomonori / Hayakawa, Yoku / Niikura, Ryota / Suzuki, Nobumi / Fujishiro, Mitsuhiro

2023 Volume 152, Issue 11, Page(s) 2433–2435

MeSH term(s)	Humans ; Colonoscopy ; Colonic Polyps/diagnosis ; Colonic Polyps/epidemiology ; Adenoma/diagnosis ; Adenoma/epidemiology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology
Language	English
Publishing date	2023-02-11
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34445
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article: Clinicopathological Features of Gastric Cancer with Autoimmune Gastritis.

Arai, Junya / Niikura, Ryota / Hayakawa, Yoku / Suzuki, Nobumi / Hirata, Yoshihiro / Ushiku, Tetsuo / Fujishiro, Mitsuhiro

Biomedicines

2022 Volume 10, Issue 4

Abstract: Most gastric cancers develop in patients with chronic gastritis. Chronic gastritis can be classified into two major subtypes: Helicobacter pylori (H. pylori)-induced gastritis and autoimmune gastritis (AIG). Whereas H. pylori-related gastric cancers are ... ...

Abstract	Most gastric cancers develop in patients with chronic gastritis. Chronic gastritis can be classified into two major subtypes: Helicobacter pylori (H. pylori)-induced gastritis and autoimmune gastritis (AIG). Whereas H. pylori-related gastric cancers are more common and have been extensively investigated, the clinicopathological features of gastric cancer with autoimmune gastritis are unclear. Patients diagnosed with gastric cancer and hospitalized in the University Tokyo Hospital from 1998 to 2017 were enrolled. Diagnosis of autoimmune gastritis was based on positivity for serum anti-parietal cell antibody (APCA). We evaluated mucin expression and immune cell infiltration by immunohistochemical staining for MUC5AC, MUC6, PD-L1, CD3, CD11, Foxp3, and PD1. We also examined the presence of bacterial taxa that are reportedly enriched in AIG. Survival analyses of recurrence and 5-year mortality were also performed. In total, 261 patients (76 APCA-positive and 185 APCA-negative) were analyzed. Immunohistochemical staining in the matched cohort showed that AIG-related gastric cancer had higher MUC5AC expression (p = 0.0007) and MUC6 expression (p = 0.0007). Greater infiltration of CD3-positive (p = 0.001), Foxp3-positive (p < 0.001), and PD1-positive cells (p = 0.001); lesser infiltration of CD11b-positive (p = 0.005) cells; and a higher prevalence of Bacillus cereus (p = 0.006) were found in AIG-related gastric cancer patients. The cumulative incidences of gastric cancer recurrence were 2.99% at 2 years, 15.68% at 6 years, and 18.81% at 10 years in APCA-positive patients; they were 12.79% at 2 years, 21.35% at 6 years, and 31.85% at 10 years in APCA-negative patients. The cumulative incidences of mortality were 0% at 3 years and 0% at 5 years in APCA-positive patients; they were 1.52% at 3 years and 2.56% at 5 years in APCA-negative patients. We identified molecular differences between AIG and non-AIG gastric cancer. Differences in T-cell populations and the gastric microbiota may contribute to the pathogenesis of gastric cancers and potentially affect the response to immunotherapy.
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10040884
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Article ; Online: The Association between Diverticular Rebleeding and Early-Morning Blood Pressure and Surge: A Prospective Observational Trial.

Arai, Junya / Niikura, Ryota / Yamada, Atsuo / Aoki, Tomonori / Suzuki, Nobumi / Tsuji, Yosuke / Hayakawa, Yoku / Kawai, Takashi / Fujishiro, Mitsuhiro

Digestion

2023 Volume 104, Issue 5, Page(s) 400–408

Abstract: Introduction: Colonic diverticular bleeding is the major cause of lower gastrointestinal bleeding. Hypertension is a major risk factor for diverticular rebleeding. Direct evidence of an association between actual 24-h blood pressure (BP) and rebleeding ... ...

Abstract	Introduction: Colonic diverticular bleeding is the major cause of lower gastrointestinal bleeding. Hypertension is a major risk factor for diverticular rebleeding. Direct evidence of an association between actual 24-h blood pressure (BP) and rebleeding is lacking. Therefore, we analyzed the association between 24-h BP and diverticular rebleeding. Methods: We performed a prospective observational cohort trial involving hospitalized patients with colonic diverticular bleeding. We performed 24-h BP measurements (ambulatory BP monitoring [ABPM]) in the patients. The primary outcome was diverticular rebleeding. We evaluated the 24-h BP difference and the morning and pre-awaking BP surge between rebleeding and non-rebleeding patients. Morning BP surge was defined as early-morning systolic BP minus the lowest night systolic BP >45 mm Hg (highest quartile of morning BP surge). The pre-awaking BP surge was defined as the difference between morning BP and pre-awaking BP. Results: Of 47 patients, 17 were excluded, leaving 30 who underwent ABPM. Of the 30 patients, 4 (13.33%) had rebleeding. The mean 24-h systolic and diastolic BP were 125.05 and 76.19 mm Hg in rebleeding patients and 129.98 and 81.77 mm Hg in non-rebleeding patients, respectively. Systolic BP at 5:00 (difference -23.53 mm Hg, p = 0.031) and 11:30 (difference -31.48 mm Hg, p = 0.006) was significantly lower in rebleeding patients than in non-rebleeding patients. Diastolic BP at 2:30 (difference -17.75 mm Hg, p = 0.023) and 5:00 (difference -16.12 mm Hg, p = 0.043) was significantly lower in rebleeding patients than in non-rebleeding patients. A morning surge was observed in one rebleeding patient and no non-rebleeding patients. The pre-awaking surge was significantly higher in rebleeding patients (28.44 mm Hg) than in non-rebleeding patients (9.30 mm Hg) (p = 0.015). Conclusion: Lower BP in the early-morning and a higher pre-awaking surge were risk factors for diverticular rebleeding. A 24-h ABPM can identify these BP findings and reduce the risk of rebleeding by enabling interventions in patients with diverticular bleeding.
MeSH term(s)	Humans ; Blood Pressure/physiology ; Prospective Studies ; Circadian Rhythm ; Hypertension/complications ; Diverticular Diseases
Language	English
Publishing date	2023-07-05
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	1712-7
ISSN	1421-9867 ; 0012-2823
ISSN (online)	1421-9867
ISSN	0012-2823
DOI	10.1159/000531099
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Article ; Online: Upper gastrointestinal involvement of Behçet's disease in Japan: endoscopic findings and clinical features.

Murakami, Keita / Arai, Junya / Ihara, Sozaburo / Tsuchida, Yumi / Shoda, Hirofumi / Tsuboi, Mayo / Kurokawa, Ken / Shiomi, Chihiro / Suzuki, Nobumi / Hayakawa, Yoku / Fujio, Keishi / Fujishiro, Mitsuhiro

Journal of gastroenterology and hepatology

2024 Volume 39, Issue 4, Page(s) 708–715

Abstract: Aim: Behçet's disease (BD) can involve any gastrointestinal (GI) tract site. We analyzed the characteristics, risk factors, and treatment responses to upper GI (UGI) involvement in patients with BD.: Methods: This retrospective cohort study analyzed ... ...

Abstract	Aim: Behçet's disease (BD) can involve any gastrointestinal (GI) tract site. We analyzed the characteristics, risk factors, and treatment responses to upper GI (UGI) involvement in patients with BD. Methods: This retrospective cohort study analyzed UGI findings in 101 patients with BD who underwent endoscopy between April 2005 and December 2022 at the University of Tokyo Hospital. The patients were divided into two groups based on the presence or absence of UGI findings. Patient backgrounds, clinical symptoms, colonoscopy (CS) findings, and blood test findings were compared between the groups. Results: In total, 18.8% (19/101) of the patients had UGI lesions. The prevalence rates in the esophagus, stomach, and duodenum were 6.9%, 6.9%, and 8.9%, respectively. Of these 19 patients, BD treatment were intensified in 10 (52.6%) patients after esophagogastroduodenoscopy (EGD), and all showed improvement in symptoms or endoscopic findings. In the multivariate analysis, symptoms (OR: 37.1, P < 0.001), CRP > 1 mg/dL (OR: 11.0, P = 0.01), and CS findings (OR: 5.16, P = 0.04) were independent predictors of UGI involvement in BD patients. The prediction model for UGI involvement using these three factors was highly accurate, with an AUC of 0.899 on the ROC curve. In the subgroup analysis of intestinal BD, symptoms (OR: 12.8, P = 0.01) and ESR > 20 mm/h (OR: 11.5, P = 0.007) were independent predictors. Conclusions: EGD should be conducted in BD patients with high CRP, GI symptoms, and lower GI involvement, which leads to better management of BD in terms of improving symptoms and endoscopic findings.
MeSH term(s)	Humans ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Behcet Syndrome/epidemiology ; Retrospective Studies ; Japan/epidemiology ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/diagnosis ; Endoscopy, Gastrointestinal
Language	English
Publishing date	2024-01-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16479
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 299: Show issues

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Article ; Online: Mouse Model for Cholangiocarcinoma from Peribiliary Glands.

Nakagawa, Hayato / Suzuki, Nobumi / Koike, Kazuhiko

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1905, Page(s) 237–245

Abstract: A good mouse model is mandatory for elucidating carcinogenic mechanisms and identifying the cellular origin of cancer. Although the lack of an appropriate mouse model has hampered investigation of extrahepatic cholangiocarcinoma (ECC), we recently ... ...

Abstract	A good mouse model is mandatory for elucidating carcinogenic mechanisms and identifying the cellular origin of cancer. Although the lack of an appropriate mouse model has hampered investigation of extrahepatic cholangiocarcinoma (ECC), we recently established a novel mouse model of biliary injury-related ECC by ductal cell-specific activation of Kras and deletion of transforming growth factor (TGF) β receptor type 2 and E-cadherin. Using this mouse model, we identified that peribiliary glands, which are considered a biliary epithelial stem cell niche, are potential cellular origins of ECC. Furthermore, we established an extrahepatic biliary organoid-derived xenograft cholangiocarcinoma (CC) model by lentiviral induction of Cre in organoids. This organoid system recreated the in vivo conditions and facilitated analysis of carcinogenesis. In this chapter, we describe the protocol used to establish our mouse model of ECC derived from peribiliary glands and our extrahepatic biliary organoid-derived xenograft model of CC.
MeSH term(s)	Animals ; Bile Duct Neoplasms/genetics ; Cholangiocarcinoma/genetics ; Disease Models, Animal ; Humans ; Mice ; Organoids/cytology ; Proto-Oncogene Proteins p21(ras)/genetics ; Receptor, Transforming Growth Factor-beta Type II/genetics ; Stem Cell Niche
Chemical Substances	Receptor, Transforming Growth Factor-beta Type II (EC 2.7.11.30) ; Tgfbr2 protein, mouse (EC 2.7.11.30) ; Kras2 protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2018-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8961-4_21
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Article ; Online: Risk and preventive factors of early-onset colorectal neoplasms: endoscopic and histological database analysis.

Arai, Junya / Aoki, Tomonori / Hayakawa, Yoku / Niikura, Ryota / Ishibashi, Rei / Suzuki, Nobumi / Tsuji, Yosuke / Yamada, Atsuo / Ushiku, Tetsuo / Fujishiro, Mitsuhiro

Journal of gastroenterology and hepatology

2022 Volume 38, Issue 2, Page(s) 259–268

Abstract: Background and aim: The incidence of early-onset colorectal neoplasms has been increasing in both Western and Eastern countries. However, the risks and preventive factors for these neoplasms in Eastern countries remain unclear.: Methods: The data of ... ...

Abstract	Background and aim: The incidence of early-onset colorectal neoplasms has been increasing in both Western and Eastern countries. However, the risks and preventive factors for these neoplasms in Eastern countries remain unclear. Methods: The data of 5580 patients who underwent colonoscopy between 2016 and 2021 were retrospectively evaluated. The primary outcome was advanced colorectal neoplasm (ACRN), defined as advanced adenomas (adenoma ≥10 mm, or with high-grade dysplasia or villous component) or adenocarcinoma. The clinical factors associated with ACRNs were determined for each age category (≤50 and >50 years), and the differences between the two categories were assessed. Odds ratios adjusted for age and sex were calculated. Results: Among 1001 patients (age ≤50 years), ACRN was found in 94 (9.4%). In this younger category, male sex (adjusted odds ratio [aOR]:2.34, 95% confidence interval [CI]:1.51-3.63) and a family history of colorectal cancer (aOR:2.14, 95% CI:1.17-3.89) were significantly associated with higher odds of developing ACRNs. ACRNs were detected in 726 (15.9%) of 4579 patients (age >50 years). In the older age category, smoking (aOR:1.32, 95% CI:1.08-1.63) was significantly associated with a higher risk of ACRNs. Exercise of >3.5 metabolic equivalent of task (METs) (aOR,0.80; 95% CI:0.67-0.96) was significantly associated with a lower risk of ACRNs. Conclusion: The development of early-onset ACRNs was primarily associated with congenital factors, whereas that of late-onset ACRNs was associated with acquired ones. Colonoscopy is recommended for young male patients, particularly for those with a family history of colorectal cancer.
MeSH term(s)	Humans ; Male ; Middle Aged ; Risk Factors ; Retrospective Studies ; Colonoscopy/adverse effects ; Adenoma/pathology ; Colorectal Neoplasms/pathology
Language	English
Publishing date	2022-11-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16045
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Efficacy of Early Video Capsule Endoscopy for Acute Overt Lower Gastrointestinal Bleeding with Colonic Diverticulosis: A Prospective Observational Study.

Aoki, Tomonori / Yamada, Atsuo / Niikura, Ryota / Nakada, Ayako / Suzuki, Nobumi / Hayakawa, Yoku / Hirata, Yoshihiro / Koike, Kazuhiko / Fujishiro, Mitsuhiro

Digestion

2022 Volume 103, Issue 5, Page(s) 367–377

Abstract: Background/aims: Although most patients with presumptive colonic diverticular bleeding (CDB) do not undergo a small bowel investigation in clinical practice, no prospective study supports this management. We evaluated the utility of early small bowel ... ...

Abstract	Background/aims: Although most patients with presumptive colonic diverticular bleeding (CDB) do not undergo a small bowel investigation in clinical practice, no prospective study supports this management. We evaluated the utility of early small bowel capsule endoscopy (CE) after negative colonoscopy results. Methods: This prospective study evaluated the diagnostic yield of early small bowel CE (≤3 days from visit) for consecutive patients with acute-onset hematochezia, when colonoscopy found colonic diverticulosis but did not identify the definite bleeding source (n = 51; presumptive CDB). As a matched control for comparing clinical outcomes, presumptive CDB patients without CE (n = 51) were retrospectively extracted. Results: On CE for the prospective cohort, the rates of total positive findings, P2 findings (high bleeding potential according to the P classification), and blood pooling in the colon were 57%, 12% (ulceration, 8%; angioectasia, 4%), and 24%, respectively. The rates of rebleeding within 30 and 365 days were 16% and 29% in the prospective cohort with CE, respectively, and were not significantly different from those in the retrospective cohort without CE (10% and 25%, respectively). In addition, thromboembolism and mortality within 30 and 365 days were not significantly different between those with and without CE. Conclusion: Early CE detected a suspected small bowel bleeding source in 12% of acute-onset presumptive CDB patients but did not significantly improve major clinical outcomes. Therefore, routine CE is unnecessary for presumptive CDB patients after colonoscopy (UMIN000026676).
MeSH term(s)	Capsule Endoscopy/methods ; Diverticulosis, Colonic/complications ; Diverticulosis, Colonic/diagnosis ; Endoscopy, Gastrointestinal ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Humans ; Intestine, Small/diagnostic imaging ; Retrospective Studies
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	1712-7
ISSN	1421-9867 ; 0012-2823
ISSN (online)	1421-9867
ISSN	0012-2823
DOI	10.1159/000525314
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Article ; Online: Association between postprandial hyperglycemia at clinic visits and all-cause and cancer mortality in patients with type 2 diabetes: A long-term historical cohort study in Japan.

Takao, Toshiko / Takahashi, Kazuyuki / Suka, Machi / Suzuki, Nobumi / Yanagisawa, Hiroyuki

Diabetes research and clinical practice

2019 Volume 148, Page(s) 152–159

Abstract: Aims: To evaluate the effect of postprandial hyperglycemia at clinic visits on all-cause and cancer mortality independent of glycated hemoglobin (HbA1c) levels in a real-world setting in Japanese patients with type 2 diabetes. We also investigated age ... ...

Abstract	Aims: To evaluate the effect of postprandial hyperglycemia at clinic visits on all-cause and cancer mortality independent of glycated hemoglobin (HbA1c) levels in a real-world setting in Japanese patients with type 2 diabetes. We also investigated age at death. Methods: This historical cohort study included 1582 patients with type 2 diabetes who first visited our clinic from 1995 to 1998 and continued visiting for at least 1 year. The patients were followed up through 2017. Blood glucose levels at 2 h ± 30 min post-breakfast (2h-PBBG) were measured in 926 patients during the first year. The first measurements of 2h-PBBG levels were used as a measure of postprandial hyperglycemia. Results: A total of 233 patients died. The average age at death (men/women) was 75.6/80.8 years. A total of 139 patients who had 2h-PBBG levels measured died, including 46 deaths from cancer. Multivariate Cox regression analysis showed that 2h-PBBG levels significantly predicted all-cause and cancer mortality independent of HbA1c levels. Conclusions: Postprandial hyperglycemia at clinic visits may be associated with all-cause and cancer mortality in patients with type 2 diabetes independent of HbA1c levels. As this is a small observational study, further studies are warranted to confirm our findings.
MeSH term(s)	Aged ; Aged, 80 and over ; Ambulatory Care/statistics & numerical data ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Cause of Death ; Cohort Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/mortality ; Female ; Glycated Hemoglobin A/analysis ; Glycated Hemoglobin A/metabolism ; Humans ; Hyperglycemia/blood ; Hyperglycemia/complications ; Hyperglycemia/mortality ; Japan/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Neoplasms/blood ; Neoplasms/complications ; Neoplasms/mortality ; Postprandial Period/physiology
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A
Language	English
Publishing date	2019-01-11
Publishing country	Ireland
Document type	Journal Article ; Observational Study
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2019.01.006
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Article ; Online: Severe obstructive colitis treated with repeated colonoscopic decompression.

Arai, Junya / Suzuki, Nobumi / Hayakawa, Yoku / Matzuzaki, Hiroyuki / Yokoyama, Yuichiro / Aoki, Tomonori / Ishibashi, Rei / Odawara, Nariaki / Ihara, Sozaburo / Tsuji, Yosuke / Ishihara, Soichiro / Fujishiro, Mitsuhiro

DEN open

2023 Volume 4, Issue 1, Page(s) e233

Abstract: Obstructive colitis is an acute condition caused by colorectal strictures and requires a combination of therapeutic strategies, including surgery, endoscopic interventions, and medications. Here, we describe the case of a 69-year-old man who developed ... ...

Abstract	Obstructive colitis is an acute condition caused by colorectal strictures and requires a combination of therapeutic strategies, including surgery, endoscopic interventions, and medications. Here, we describe the case of a 69-year-old man who developed severe obstructive colitis owing to diverticular stenosis of the sigmoid colon. We immediately performed endoscopic decompression to avoid perforation. The mucosa of the dilated colon appeared black, suggesting severe ischemia. We considered surgical total colectomy owing to the extensive colitis. However, considering the invasiveness of the emergent surgery, we adopted a conservative approach as enhanced computed tomography demonstrated colonic dilation with maintained blood flow in the deeper layer of the colonic wall and no signs of colonic necrosis, such as peritoneal irritation sign or elevation of deviation enzymes, were observed. Moreover, the patient preferred a conservative approach, and surgeons in our team agreed with this conservative approach. While relapses of colonic dilation occurred several times, antibiotic treatment and repeated endoscopic decompression successfully suppressed the dilation and systemic inflammation. The colonic mucosa healed gradually, and we performed a colostomy without resecting a large portion of the colorectum. In conclusion, severe obstructive colitis with maintained blood flow can be treated with endoscopic decompression instead of emergent resection for a wide portion of the colorectum. Moreover, endoscopic images of improved colitic mucosa obtained through repeated colorectal procedures are rare and noteworthy.
Language	English
Publishing date	2023-05-16
Publishing country	Australia
Document type	Case Reports
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.233
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Article ; Online: Association of probiotic use with nivolumab effectiveness against various cancers: A multicenter retrospective cohort study.

Arai, Junya / Niikura, Ryota / Hayakawa, Yoku / Suzuki, Nobumi / Honda, Tetsuro / Okamura, Takuma / Hasatani, Kenkei / Yoshida, Naohiro / Nishida, Tsutomu / Sumiyoshi, Tetsuya / Kiyotoki, Shu / Ikeya, Takashi / Arai, Masahiro / Boku, Narikazu / Fujishiro, Mitsuhiro

Cancer medicine

2023 Volume 12, Issue 16, Page(s) 16876–16880

Abstract: Background: Previous studies have revealed an association between probiotic use and effectiveness of immune checkpoint inhibitors in renal and lung cancers. However, little is known regarding other cancers, including gastrointestinal cancer.: Methods!# ...

Abstract	Background: Previous studies have revealed an association between probiotic use and effectiveness of immune checkpoint inhibitors in renal and lung cancers. However, little is known regarding other cancers, including gastrointestinal cancer. Methods: To address this issue, we conducted a multicenter retrospective cohort study and the duration of nivolumab treatment for various cancers was compared between probiotic users and non-users. Results and conclusions: In total, 488 patients who received nivolumab therapy were included. In all cancers, no significant differences in treatment duration of nivolumab were observed between probiotic users and non-users (median 62.0 vs. 56.0, hazard ratio = 1.02, p = 0.825), whereas probiotic use, compared with non-use, in patients with gastric cancer was significantly associated with a longer duration of nivolumab treatment (55.0 vs. 31.0 days, hazard ratio = 0.69, p = 0.039). In conclusion, probiotics may improve the response to nivolumab and potentially prolong progression-free survival in patients with gastric cancer.
MeSH term(s)	Humans ; Nivolumab/therapeutic use ; Stomach Neoplasms/drug therapy ; Retrospective Studies ; Antineoplastic Agents, Immunological/adverse effects ; Lung Neoplasms/drug therapy
Chemical Substances	Nivolumab (31YO63LBSN) ; Antineoplastic Agents, Immunological
Language	English
Publishing date	2023-07-08
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6313
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