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Artikel ; Online: Proximal Tubular Deposits and an Abnormal MRI of the Kidneys with Chronic Hemolytic Anemia.

Toishi, Takumi / Suzuki, Tomo

Kidney360

2023 Band 4, Heft 5, Seite(n) 711–712

Mesh-Begriff(e)	Humans ; Kidney/diagnostic imaging ; Anemia, Hemolytic/diagnostic imaging ; Magnetic Resonance Imaging
Sprache	Englisch
Erscheinungsdatum	2023-05-25
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000000000000086
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Resuming automated peritoneal dialysis after laparoscopic peritoneal wall anchoring for peritoneal dialysis catheter fixation.

Matsunami, Masatoshi / Suzuki, Tomo / Suzuki, Koichiro / Kuji, Hiroshi

Journal of nephrology

2024

Sprache	Englisch
Erscheinungsdatum	2024-03-21
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-024-01917-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Inflamed Obstructive Meibomian Gland Dysfunction Causes Ocular Surface Inflammation.

Suzuki, Tomo

Investigative ophthalmology & visual science

2018 Band 59, Heft 14, Seite(n) DES94–DES101

Abstract: Meibomian gland dysfunction (MGD) is one of the primary causes of evaporative dry eye. Stagnation of meibum induces an unstable tear film, thus resulting in shortened tear film breakup time and superficial punctate keratopathy (SPK) in the lower cornea ... ...

Abstract	Meibomian gland dysfunction (MGD) is one of the primary causes of evaporative dry eye. Stagnation of meibum induces an unstable tear film, thus resulting in shortened tear film breakup time and superficial punctate keratopathy (SPK) in the lower cornea and punctate staining of lower bulbar conjunctiva. MGD is sometimes accompanied with inflammation (termed "meibomitis") via the proliferation of bacteria in the meibomian gland and eyelash area. Meibomitis is strongly related to ocular surface inflammation such as corneal cellular infiltrates and neovascularization, SPK, and conjunctivitis. It is difficult to differentiate SPK caused by dry eye from that caused by meibomitis. When clinicians are unaware of the existence of meibomitis, and only aware of SPK on the cornea, they often try to treat SPK as it is caused by dry eye using dry eye-specific eyedrops or even using punctual plugs when conservative therapy is ineffective. However, even when intensive dry eye therapy is applied, it may be unsuccessful until SPK caused by meibomitis is recognized and treated with systemic antimicrobial agents. Hence, the tear secreting glands, including the meibomian glands, and the ocular surface should be clinically considered as one unit (i.e., the meibomian gland and ocular surface [MOS]) when considering the pathophysiology and treatment of ocular surface inflammatory diseases (i.e., corneal epithelial damage). Following this clinical pathway, a treatment focusing on meibomian gland inflammation may be a more reasonable approach for meibomitis-related or associated keratoconjunctivitis to more effectively treat this ocular surface disease.
Mesh-Begriff(e)	Anti-Bacterial Agents/administration & dosage ; Blepharitis/complications ; Blepharitis/drug therapy ; Blepharitis/physiopathology ; Corneal Neovascularization/drug therapy ; Corneal Neovascularization/etiology ; Corneal Neovascularization/physiopathology ; Humans ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/physiopathology ; Keratoconjunctivitis/drug therapy ; Keratoconjunctivitis/etiology ; Keratoconjunctivitis/physiopathology ; Lubricant Eye Drops/administration & dosage ; Meibomian Glands/pathology
Chemische Substanzen	Anti-Bacterial Agents ; Lubricant Eye Drops
Sprache	Englisch
Erscheinungsdatum	2018-11-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.17-23345
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Renal perivasculitis induced by sulfasalazine.

Akao, Satoshi / Akao, Kei / Rokutanda, Ryo / Suzuki, Tomo

Journal of nephrology

2023

Sprache	Englisch
Erscheinungsdatum	2023-11-28
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01820-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of Aging on Human Meibum.

Butovich, Igor A / Suzuki, Tomo

Investigative ophthalmology & visual science

2021 Band 62, Heft 12, Seite(n) 23

Abstract: Purpose: The purpose of this study was to determine if aging affects meibum lipid composition in non-meibomian gland dysfunction (MGD)/non-dry eye (DE) population. Aging has been repeatedly linked to pathological changes in various tissues and organs, ... ...

Abstract	Purpose: The purpose of this study was to determine if aging affects meibum lipid composition in non-meibomian gland dysfunction (MGD)/non-dry eye (DE) population. Aging has been repeatedly linked to pathological changes in various tissues and organs, including the onset of MGD and DE, in a number of clinical and population-wide surveys. Both conditions have been associated with abnormal meibum secretion and composition, among other factors. However, the chemical basis for such a connection has not been established yet. Methods: To identify and characterize possible changes in the meibum and meibogenesis with aging, lipidomic analyses of meibum samples collected from human subjects of two age groups - young (29 ± 5 years, n = 21) and elderly (68 ± 7 years, n = 29) - with similar male to female ratios in each group were conducted. Intact lipid species from major lipid groups of meibum (such as wax esters, cholesteryl esters, free cholesterol, triacylglycerols, etc.) were compared using lipidome-wide untargeted (such as Principal Component Analysis) and targeted (such as Orthogonal Projections to Latent Structures Discriminant Analysis) approaches, along with focused analyses of specific lipid species in liquid-chromatography mass spectrometry (LC-MS) and tandem mass spectrometry (MS-MS) experiments. Results: Extremely high similarities of meibum lipids in the two age groups were observed, with only minor changes in the individual lipid species. The magnitude of the intergroup variability for tested lipid species was comparable to the intragroup variability for the same meibum components. No statistically significant differences in the lipid esterification, elongation, and unsaturation patterns were observed. Conclusions: Chronological aging itself seems to have only minor effect on meibogenesis in healthy, non-MGD/non-DE subjects.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Aging/physiology ; Cholesterol Esters/metabolism ; Chromatography, Liquid ; Female ; Humans ; Lipid Metabolism/physiology ; Male ; Mass Spectrometry ; Meibomian Glands/metabolism ; Middle Aged ; Principal Component Analysis ; Tears/metabolism ; Triglycerides/metabolism ; Young Adult
Chemische Substanzen	Cholesterol Esters ; Triglycerides
Sprache	Englisch
Erscheinungsdatum	2021-09-07
Erscheinungsland	United States
Dokumenttyp	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.62.12.23
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Immunosuppressive therapy with tacrolimus is a potential drug candidate for the prevention of unexplained or preeclamptic stillbirths with Th1-dominant immune states: a case series of five patients.

Hisano, Michi / Nakagawa, Koji / Suzuki, Tomo / Sugiyama, Rikikazu / Yamaguchi, Koushi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2023 Band 36, Heft 2, Seite(n) 2258254

Abstract: Some of obstetrical complications such as unexplained pregnancy loss and preeclampsia (PE) are associated with maternal-fetal immune abnormalities, leading to uteroplacental dysfunction, insufficient fetal immune tolerance, or fetal rejection. ... ...

Abstract	Some of obstetrical complications such as unexplained pregnancy loss and preeclampsia (PE) are associated with maternal-fetal immune abnormalities, leading to uteroplacental dysfunction, insufficient fetal immune tolerance, or fetal rejection. Immunosuppressants with calcineurin inhibitors could be useful for the prevention of these complications by modulating the cellular immune balance by directly inhibiting activated T-helper (Th) 1 and natural killer (NK)/NKT cells. We present our experience with the immunosuppressant tacrolimus in five pregnant women who had a previous pregnancy history of unexplained or preeclamptic stillbirth. Th1 and Th2 cell populations and NK cell activities in peripheral blood were measured as clinical parameters during pregnancy. Case 1-3 achieved suppressions of predominant Th1 immunity and live births without pregnancy-related complications. In case 4, increased tacrolimus dose after a miscarriage resulted in her first live birth; however, she developed PE and severe fetal growth restriction with elevated Th1/Th2 cell ratios at 26 weeks of gestation. Case 5 had a previous history of early onset PE and the hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and an emergency cesarean section was needed for maternal safety at 20 weeks of gestation. The course of the next pregnancy was stable under tacrolimus treatment; however, the HELLP syndrome recurred after PE at 33 weeks of gestation. Although an imbalance in the Th1/Th2 cell ratio was not observed during pregnancy, NK cell activity was markedly elevated before delivery. In conclusion, tacrolimus is a potential drug candidate for the prevention of unexplained or preeclamptic stillbirth with Th1-dominant immune states.
Mesh-Begriff(e)	Humans ; Female ; Pregnancy ; Tacrolimus/therapeutic use ; Stillbirth ; Pre-Eclampsia/drug therapy ; Pre-Eclampsia/prevention & control ; Pharmaceutical Preparations ; Cesarean Section ; Immunosuppression Therapy ; Immunosuppressive Agents/therapeutic use ; Abortion, Spontaneous ; HELLP Syndrome/drug therapy ; HELLP Syndrome/prevention & control
Chemische Substanzen	Tacrolimus (WM0HAQ4WNM) ; Pharmaceutical Preparations ; Immunosuppressive Agents
Sprache	Englisch
Erscheinungsdatum	2023-09-13
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2023.2258254
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Humoral response after a fourth "booster" dose of coronavirus disease 2019 vaccination and outcome of Japan's seventh wave of coronavirus disease 2019 infections in hemodialysis patients: A single-center experience.

Matsunami, Masatoshi / Suzuki, Tomo / Kuji, Hiroshi

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

2022 Band 27, Heft 3, Seite(n) 597–598

Mesh-Begriff(e)	Humans ; Japan ; COVID-19 ; Vaccination ; Renal Dialysis
Sprache	Englisch
Erscheinungsdatum	2022-12-01
Erscheinungsland	Australia
Dokumenttyp	Letter
ZDB-ID	2119809-3
ISSN	1744-9987 ; 1091-6660 ; 1744-9979
ISSN (online)	1744-9987
ISSN	1091-6660 ; 1744-9979
DOI	10.1111/1744-9987.13953
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Artikel ; Online: PET/CT imaging of renal intravascular large B-cell lymphoma.

Narita, Kentaro / Suzuki, Tomo / Matsue, Kosei

Clinical and experimental nephrology

2022 Band 26, Heft 11, Seite(n) 1144–1145

Mesh-Begriff(e)	Fluorodeoxyglucose F18 ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Radiopharmaceuticals
Chemische Substanzen	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Sprache	Englisch
Erscheinungsdatum	2022-07-30
Erscheinungsland	Japan
Dokumenttyp	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-022-02257-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands.

Butovich, Igor A / Suzuki, Tomo

Experimental eye research

2020 Band 199, Seite(n) 108189

Abstract: Meibomian glands that are embedded in tarsal plates of human eyelids, and sebaceous glands found in the skin, including that of eyelids, are two related types of holocrine glands that produce lipid-rich secretions called meibum and sebum. Pervasive ... ...

Abstract	Meibomian glands that are embedded in tarsal plates of human eyelids, and sebaceous glands found in the skin, including that of eyelids, are two related types of holocrine glands that produce lipid-rich secretions called meibum and sebum. Pervasive ocular disorders, such as Meibomian gland dysfunction and dry eye, have been linked to changes in the lipid composition of meibum. However, in most described cases the changes were either small, or random, or insufficiently characterized on the molecular level. Here, we present results of comprehensive lipidomic analyses of meibum, tears and sebum of a patient whose secretions were highly abnormal (abnormal meibum, tears and sebum, or AMTS, patient). The lipidomes were characterized on the level of individual lipid species using ultra-high performance liquid chromatography and high resolution mass spectrometry. The major differences between the AMTS patient and normal age- and gender-matched subjects included, among others, severely diminished pools of normal meibomian lipids such as wax esters and cholesteryl esters in meibum and tears, a 2x increase in total cholesteryl esters to wax esters ratio, their skewed molecular profiles, a ~3x increase in free cholesterol to cholesteryl esters ratio, and, most importantly, a 20x to 30x increase in the triglicerides fraction over the norm. Sebum of the AMTS patient was also highly abnormal lacking major wax esters. Notably, the routine blood lipid panel test of the AMTS patient showed no abnormalities. The data imply that the AMTS patient had a severe, previously unreported, metabolic disorder that affected meibogenesis in Meibomian glands and sebogenesis in sebaceous glands. This is, to the best of our knowledge, a first observation of the condition that we have termed High Triglycerides/Low Waxes (HTLW) syndrome.
Mesh-Begriff(e)	Aged ; Dry Eye Syndromes/metabolism ; Female ; Homeostasis ; Humans ; Lipid Metabolism/physiology ; Male ; Mass Spectrometry ; Meibomian Glands/metabolism ; Sebaceous Glands/metabolism ; Tears/metabolism ; Triglycerides/metabolism
Chemische Substanzen	Triglycerides
Sprache	Englisch
Erscheinungsdatum	2020-08-15
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80122-7
ISSN	1096-0007 ; 0014-4835
ISSN (online)	1096-0007
ISSN	0014-4835
DOI	10.1016/j.exer.2020.108189
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Coronavirus Disease-19 in a patient with minimal change nephrotic syndrome undergoing rituximab monotherapy.

Suzuki, Tomo / Nagaoka, Kanako / Takahashi, Yoshinori / Osawa, Ryosuke / Hosokawa, Naoto

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2022 Band 32, Heft 5, Seite(n) 1505–1506

Mesh-Begriff(e)	COVID-19 ; Female ; Humans ; Immunologic Factors ; Male ; Nephrosis, Lipoid/complications ; Nephrosis, Lipoid/diagnosis ; Nephrosis, Lipoid/drug therapy ; Nephrotic Syndrome/diagnosis ; Nephrotic Syndrome/drug therapy ; Recurrence ; Rituximab/therapeutic use ; Treatment Outcome
Chemische Substanzen	Immunologic Factors ; Rituximab (4F4X42SYQ6)
Sprache	Englisch
Erscheinungsdatum	2022-05-09
Erscheinungsland	Saudi Arabia
Dokumenttyp	Letter
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.344780
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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