LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 706

Search options

  1. Article ; Online: Chaperone therapy for lysosomal and non-lysosomal protein misfolding diseases.

    Suzuki, Yoshiyuki

    Brain & development

    2023  Volume 45, Issue 5, Page(s) 251–259

    Abstract: Chaperone therapy was introduced first as a new molecular therapeutic approach to lysosomal diseases. In a recent article, I reviewed the development of chaperone therapy mainly for lysosomal diseases. Then, more data have been collected particularly on ... ...

    Abstract Chaperone therapy was introduced first as a new molecular therapeutic approach to lysosomal diseases. In a recent article, I reviewed the development of chaperone therapy mainly for lysosomal diseases. Then, more data have been collected particularly on non-lysosomal protein misfolding diseases. In this short review, I propose the concept of chaperone therapy to be classified into two different therapeutic approaches, for pH-dependent lysosomal, and pH-independent non-lysosomal protein misfolding diseases. The concept of lysosomal chaperone therapy is well established, but the non-lysosomal chaperone therapy is heterogeneous and to be investigated further for various individual diseases. As a whole, these two-types of new molecular therapeutic approaches will make an impact on the treatment of a wide range of pathological conditions caused by protein misfolding, not necessarily lysosomal but also many non-lysosomal diseases caused by gene mutations, metabolic diseases, malignancy, infectious diseases, and aging. The concept will open a completely new aspect of protein therapy in future.
    MeSH term(s) Humans ; Molecular Chaperones/metabolism ; Proteostasis Deficiencies/genetics ; Proteostasis Deficiencies/therapy ; Proteostasis Deficiencies/metabolism ; Mutation ; Lysosomes/metabolism
    Chemical Substances Molecular Chaperones
    Language English
    Publishing date 2023-03-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 604822-5
    ISSN 1872-7131 ; 0387-7604
    ISSN (online) 1872-7131
    ISSN 0387-7604
    DOI 10.1016/j.braindev.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1788: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Predicting Dominant Genotypes in Norovirus Seasons in Japan.

    Suzuki, Yoshiyuki

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 8

    Abstract: Human noroviruses are an etiological agent of acute gastroenteritis. Since multiple genotypes co-circulate every season changing their proportions, it may be desirable to develop multivalent vaccines by formulating genotype composition of seed strains to ...

    Abstract Human noroviruses are an etiological agent of acute gastroenteritis. Since multiple genotypes co-circulate every season changing their proportions, it may be desirable to develop multivalent vaccines by formulating genotype composition of seed strains to match that of dominant strains. Here, performances of the models for predicting dominant genotypes, defined as the two most prevalent genotypes, were evaluated using observed genotype frequencies in Japan and genomic sequences for GI and GII strains. In the null model, genotype proportions in the target season were predicted to be the same as those in the immediately preceding season. In the fitness model, genotype proportions were predicted taking into account the acquisition of novel P-types through recombination and genotype-specific proliferation efficiency, as well as herd immunity to VP1 assuming the duration (
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13081634
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Methods for making multiple alignment of genomic sequences for severe acute respiratory syndrome coronavirus 2.

    Suzuki, Yoshiyuki

    Meta gene

    2020  Volume 26, Page(s) 100785

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic. To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29 ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic. To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29.9 kb, which may be time consuming. Phylogenetic analysis of SARS-CoV-2 may be accelerated by making a multiple alignment of nucleotide sequences using the CPA (combining pairwise alignments) method, in which a pairwise alignment is made for a reference and each of other sequences, and the pairwise alignments are combined into a multiple alignment. Here it is shown from the analysis of 3729 genomic sequences for SARS-CoV-2 and outgroup strains that the CPA method can produce a multiple alignment with an elevated or a reduced number of variable sites depending on the reference compared to the OMA (ordinary multiple alignment) method, which was considered to be the most reliable. In particular, the topology of the phylogenetic tree constructed from the multiple alignment made using the CPA method adopting the outgroup sequence as the reference was considerably different from that using the OMA method, suggesting that the outgroup sequence may not be suitable as the reference in the CPA method.
    Keywords covid19
    Language English
    Publishing date 2020-08-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2743632-9
    ISSN 2214-5400
    ISSN 2214-5400
    DOI 10.1016/j.mgene.2020.100785
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Chaperone therapy for molecular pathology in lysosomal diseases.

    Suzuki, Yoshiyuki

    Brain & development

    2020  Volume 43, Issue 1, Page(s) 45–54

    Abstract: In lysosomal diseases, enzyme deficiency is caused by misfolding of mutant enzyme protein with abnormal steric structure that is expressed by gene mutation. Chaperone therapy is a new molecular therapeutic approach primarily for lysosomal diseases. The ... ...

    Abstract In lysosomal diseases, enzyme deficiency is caused by misfolding of mutant enzyme protein with abnormal steric structure that is expressed by gene mutation. Chaperone therapy is a new molecular therapeutic approach primarily for lysosomal diseases. The misfolded mutant enzyme is digested rapidly or aggregated to induce endoplasmic reticulum stress. As a result, the catalytic activity is lost. The following sequence of events results in chaperone therapy to achieve correction of molecular pathology. An orally administered low molecular competitive inhibitor (chaperone) is absorbed into the bloodstream and reaches the target cells and tissues. The mutant enzyme is stabilized by the chaperone and subjected to normal enzyme proteinfolding (proteostasis). The first chaperone drug was developed for Fabry disease and is currently available in medical practice. At present three types of chaperones are available: competitive chaperone with enzyme inhibitory bioactivity (exogenous), non-competitive (or allosteric) chaperone without inhibitory bioactivity (exogenous), and molecular chaperone (heat shock protein; endogenous). The third endogenous chaperone would be directed to overexpression or activated by an exogenous low-molecular inducer. This new molecular therapeutic approach, utilizing the three types of chaperone, is expected to apply to a variety of diseases, genetic or non-genetic, and neurological or non-neurological, in addition to lysosomal diseases.
    MeSH term(s) Endoplasmic Reticulum Stress/physiology ; Fabry Disease/drug therapy ; Gangliosidosis, GM1/drug therapy ; Humans ; Lysosomal Storage Diseases/metabolism ; Lysosomal Storage Diseases/physiopathology ; Lysosomal Storage Diseases/therapy ; Lysosomes/metabolism ; Molecular Chaperones/metabolism ; Molecular Chaperones/therapeutic use ; Proteostasis Deficiencies/metabolism ; Proteostasis Deficiencies/physiopathology ; Proteostasis Deficiencies/therapy
    Chemical Substances Molecular Chaperones
    Language English
    Publishing date 2020-07-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 604822-5
    ISSN 1872-7131 ; 0387-7604
    ISSN (online) 1872-7131
    ISSN 0387-7604
    DOI 10.1016/j.braindev.2020.06.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1788: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Methods for making multiple alignment of genomic sequences for severe acute respiratory syndrome coronavirus 2

    Suzuki, Yoshiyuki

    Meta Gene

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29 9 ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a pandemic To monitor the global transmission pattern of SARS-CoV-2, it is required to constantly update the phylogenetic tree of genomic sequences with 29 9 kb, which may be time consuming Phylogenetic analysis of SARS-CoV-2 may be accelerated by making a multiple alignment of nucleotide sequences using the CPA (combining pairwise alignments) method, in which a pairwise alignment is made for a reference and each of other sequences, and the pairwise alignments are combined into a multiple alignment Here it is shown from the analysis of 3729 genomic sequences for SARS-CoV-2 and outgroup strains that the CPA method can produce a multiple alignment with an elevated or a reduced number of variable sites depending on the reference compared to the OMA (ordinary multiple alignment) method, which was considered to be the most reliable In particular, the topology of the phylogenetic tree constructed from the multiple alignment made using the CPA method adopting the outgroup sequence as the reference was considerably different from that using the OMA method, suggesting that the outgroup sequence may not be suitable as the reference in the CPA method
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #720653
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Co-evolution in a putative bundling signal of bluetongue and epizootic hemorrhagic disease viruses.

    Suzuki, Yoshiyuki

    Genes & genetic systems

    2017  Volume 91, Issue 5, Page(s) 283–288

    Abstract: Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) possess a genome of 10 segmented RNAs (S1-S10), one copy of each of which is considered to be packaged in a virion. This selective packaging is thought to be mediated by supramolecular ...

    Abstract Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) possess a genome of 10 segmented RNAs (S1-S10), one copy of each of which is considered to be packaged in a virion. This selective packaging is thought to be mediated by supramolecular complex formation of the 10 RNAs, through intermolecular base pairing of complementary nucleotide sequences termed the bundling signal. Here, the whole genomic sequences of BTV and EHDV isolates were analyzed to identify co-evolving pairs of complementary nucleotide sequences within and between genomic segments. One co-evolving pair was identified within S5 and another between S5 and S10. The co-evolving pair between S5 and S10, consisting of six bases in each segment, was a candidate for a bundling signal and was identical to one of two putative bundling signals reported in a previous experimental study, validating the effectiveness of the method used in the present study. The six bases in S10 were confirmed to be located in a loop at the end of a stable stem. Although the six bases in S5 were located in a loop at the end of a stem of only four bases long, the complementary nucleotide sequences constituting this stem were, remarkably, the co-evolving pair within S5. These results highlight the importance not only of loops but also of stems in the intermolecular base pairing of bundling signals.
    MeSH term(s) Base Sequence ; Biological Evolution ; Bluetongue virus/genetics ; Hemorrhagic Disease Virus, Epizootic/genetics ; Phylogeny ; RNA, Viral/genetics ; Sequence Analysis, DNA
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2017-04-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1323536-9
    ISSN 1880-5779 ; 1341-7568
    ISSN (online) 1880-5779
    ISSN 1341-7568
    DOI 10.1266/ggs.16-00035
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3466: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin by docking simulation.

    Suzuki, Yoshiyuki

    Microbiology and immunology

    2017  Volume 61, Issue 5, Page(s) 185–189

    Abstract: Predicting susceptibility of various species to a virus assists assessment of risk of interspecies transmission. Evaluation of receptor functionality may be useful in screening for susceptibility. In this study, docking simulation was conducted for ... ...

    Abstract Predicting susceptibility of various species to a virus assists assessment of risk of interspecies transmission. Evaluation of receptor functionality may be useful in screening for susceptibility. In this study, docking simulation was conducted for measles virus hemagglutinin (MV-H) and immunoglobulin-like variable domain of signaling lymphocyte activation molecule (SLAM-V). It was observed that the docking scores for MV-H and SLAM-V correlated with the activity of SLAM as an MV receptor. These results suggest that the receptor functionality may be predicted from the docking scores of virion surface proteins and cellular receptor molecules.
    MeSH term(s) Animals ; Cats ; Cattle ; Dogs ; Hemagglutinins, Viral/immunology ; Humans ; Lymphocyte Activation/immunology ; Measles/transmission ; Measles/veterinary ; Measles/virology ; Measles virus/immunology ; Mice ; Molecular Docking Simulation ; Receptors, Virus/metabolism ; Sigmodontinae/virology ; Signaling Lymphocytic Activation Molecule Family/metabolism
    Chemical Substances Hemagglutinins, Viral ; Receptors, Virus ; Signaling Lymphocytic Activation Molecule Family
    Keywords covid19
    Language English
    Publishing date 2017-05-31
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 224792-6
    ISSN 1348-0421 ; 0385-5600
    ISSN (online) 1348-0421
    ISSN 0385-5600
    DOI 10.1111/1348-0421.12484
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: [Novel therapeutic drugs GSK548470 (Tenofovir)].

    Suzuki, Yoshiyuki

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 9, Page(s) 448–452

    MeSH term(s) Antiviral Agents/therapeutic use ; Clinical Trials, Phase III as Topic ; DNA, Viral/genetics ; Hepatitis B/drug therapy ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Humans ; Tenofovir/therapeutic use
    Chemical Substances Antiviral Agents ; DNA, Viral ; Tenofovir (99YXE507IL)
    Language Japanese
    Publishing date 2015-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: [Management of hepatitis B virus marker].

    Suzuki, Yoshiyuki

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 9, Page(s) 501–505

    MeSH term(s) Biomarkers/blood ; DNA, Viral/genetics ; Hepatitis B/diagnosis ; Hepatitis B/immunology ; Hepatitis B Antibodies/immunology ; Hepatitis B Antigens/immunology ; Hepatitis B virus/genetics ; Hepatitis B virus/immunology ; Humans
    Chemical Substances Biomarkers ; DNA, Viral ; Hepatitis B Antibodies ; Hepatitis B Antigens
    Language Japanese
    Publishing date 2015-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: [Management of hepatitis C virus marker].

    Suzuki, Yoshiyuki

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 9, Page(s) 225–229

    MeSH term(s) Biomarkers/analysis ; Drug Resistance, Viral ; Hepacivirus/genetics ; Hepacivirus/immunology ; Hepatitis Antibodies/immunology ; Hepatitis C/diagnosis ; Humans ; RNA, Viral/genetics
    Chemical Substances Biomarkers ; Hepatitis Antibodies ; RNA, Viral
    Language Japanese
    Publishing date 2015-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top