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  1. AU="Svanberg Frisinger, Frida"
  2. AU="Iyappan, Petchi"
  3. AU="Naomi Nakagata"
  4. AU="Marianne A. van der Sande"
  5. AU="Reno, Chiara"

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  1. Article: In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in

    Svanberg Frisinger, Frida / Jana, Bimal / Donadio, Stefano / Guardabassi, Luca

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: Novel antimicrobials interfering with pathogen-specific targets can minimize the risk of perturbations of the gut microbiota (dysbiosis) during therapy. We employed an in silico approach to identify essential proteins ... ...

    Abstract Novel antimicrobials interfering with pathogen-specific targets can minimize the risk of perturbations of the gut microbiota (dysbiosis) during therapy. We employed an in silico approach to identify essential proteins in
    Language English
    Publishing date 2021-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10060632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Impact of the Gram-Negative-Selective Inhibitor MAC13243 on In Vitro Simulated Gut Microbiota.

    Svanberg Frisinger, Frida / Pirolo, Mattia / Ng, Duncan Y K / Mao, Xiaotian / Nielsen, Dennis Sandris / Guardabassi, Luca

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 6

    Abstract: New Gram-negative-selective antimicrobials are desirable to avoid perturbations in the gut microbiota leading to antibiotic-induced dysbiosis. We investigated the impact of a prototype drug (MAC13243) interfering with the Gram-negative outer membrane ... ...

    Abstract New Gram-negative-selective antimicrobials are desirable to avoid perturbations in the gut microbiota leading to antibiotic-induced dysbiosis. We investigated the impact of a prototype drug (MAC13243) interfering with the Gram-negative outer membrane protein LolA on the faecal microbiota. Faecal suspensions from two healthy human donors were exposed to MAC13243 (16, 32, or 64 mg/L) using an in vitro gut model (CoMiniGut). Samples collected 0, 4, and 8 h after exposure were subjected to viable cell counts, 16S rRNA gene quantification and V3-V4 sequencing using the Illumina MiSeq platform. MAC13243 exhibited concentration-dependent killing of coliforms in both donors after 8 h. Concentrations of ≤32 mg/L reduced the growth of aerobic bacteria without influencing the microbiota composition and diversity. An expansion of Firmicutes at the expense of Bacteroidetes and Actinobacteria was observed in the faecal microbiota from one donor following exposure to 64 mg/L of MAC13242. At all concentrations tested, MAC13243 did not lead to the proliferation of
    Language English
    Publishing date 2022-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15060731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An Endogenous Staphylococcus aureus CRISPR-Cas System Limits Phage Proliferation and Is Efficiently Excised from the Genome as Part of the SCC

    Mikkelsen, Kasper / Bowring, Janine Zara / Ng, Yong Kai / Svanberg Frisinger, Frida / Maglegaard, Julie Kjærsgaard / Li, Qiuchun / Sieber, Raphael N / Petersen, Andreas / Andersen, Paal Skytt / Rostøl, Jakob T / Høyland-Kroghsbo, Nina Molin / Ingmer, Hanne

    Microbiology spectrum

    2023  Volume 11, Issue 4, Page(s) e0127723

    Abstract: CRISPR-Cas is an adaptive immune system that allows bacteria to inactivate mobile genetic elements. Approximately 50% of bacteria harbor CRISPR-Cas; however, in the human pathogen Staphylococcus aureus, CRISPR-Cas loci are less common and often studied ... ...

    Abstract CRISPR-Cas is an adaptive immune system that allows bacteria to inactivate mobile genetic elements. Approximately 50% of bacteria harbor CRISPR-Cas; however, in the human pathogen Staphylococcus aureus, CRISPR-Cas loci are less common and often studied in heterologous systems. We analyzed the prevalence of CRISPR-Cas in genomes of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in Denmark. Only 2.9% of the strains carried CRISPR-Cas systems, but for strains of sequence type ST630, over half were positive. All CRISPR-Cas loci were type III-A and located within the staphylococcal cassette chromosome
    MeSH term(s) Humans ; Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/genetics ; CRISPR-Cas Systems ; Bacteriophages/genetics ; Staphylococcus/genetics ; Staphylococcal Infections/microbiology ; Chromosomes ; Cell Proliferation ; Chromosomes, Bacterial
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01277-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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