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  1. Article ; Online: A Novel CT Score Reveals More About Air Trapping in Asthma.

    Svenningsen, Sarah / Kirby, Miranda

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202312-2284ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chest CT Findings 1 Year after COVID-19: Another Piece of the Post-Pandemic Puzzle.

    Parraga, Grace / Svenningsen, Sarah

    Radiology

    2023  Volume 308, Issue 1, Page(s) e231502

    MeSH term(s) Humans ; COVID-19 ; Pandemics ; Thorax ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.231502
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  3. Article ; Online: Imaging in Asthma-Chronic Obstructive Pulmonary Disease Overlap.

    Svenningsen, Sarah / Kirby, Miranda

    Immunology and allergy clinics of North America

    2022  Volume 42, Issue 3, Page(s) 601–614

    Abstract: The purpose of this article is to review the imaging features in patients defined by researchers as having asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO), highlight the existing imaging studies investigating patients with ACO when ... ...

    Abstract The purpose of this article is to review the imaging features in patients defined by researchers as having asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO), highlight the existing imaging studies investigating patients with ACO when compared with those with asthma and COPD alone, and, finally, discuss some remaining gaps in the understanding of ACO that imaging may help resolve.
    MeSH term(s) Asthma/diagnosis ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2022.04.003
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  4. Article ; Online: Persistent Airway Plugs: A Call for Clinical Recognition and Novel Therapies.

    Svenningsen, Sarah / Nair, Parameswaran

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 9, Page(s) 977–978

    MeSH term(s) Asthma ; Humans ; Lung ; Mucus
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202201-0147ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals.

    Venegas Garrido, Carmen / Mukherjee, Manali / Svenningsen, Sarah / Nair, Parameswaran

    Allergology international : official journal of the Japanese Society of Allergology

    2024  

    Abstract: Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by specialized cells ...

    Abstract Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by specialized cells within the airway epithelium both in normal conditions and in response to various stimuli. Their relative proportions are correlated with specific inflammatory responses and disease mechanisms. The dysregulation of mucin expression is implicated in numerous respiratory diseases, including asthma, COPD, and cystic fibrosis, where the pathogenic role of mucus has been extensively described yet often overlooked. In airway diseases, excessive mucus production or impaired mucus clearance leads to mucus plugging, with secondary airway occlusion that contribute to airflow obstruction, asthma severity and poor control. Eosinophils and Charcot Leyden crystals in sputum contribute to the mucus burden and tenacity. Mucin may also contribute to eosinophil survival. Other mechanisms, including eosinophil-independent IL-13 release, mast-cell activation and non-type-2 (T2) cytokines, are also likely to participate in mucus pathobiology. An accurate assessment of mucus and its clinical and functional consequences require a thorough approach that includes evaluation of cellular predominance in sputum, airway cytokines and other inflammatory markers, mucus characteristics and composition and structural and functional impact measured by advanced lung imaging. This review, illustrated with clinical scenarios, provides an overview of current methods to assess mucus and its relevance to the choice of biologics to treat patients with severe asthma.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2024.03.001
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  6. Article ; Online: There is more to severe asthma associated with obesity than inflammation.

    Svenningsen, Sarah / Nair, Parameswaran

    Respirology (Carlton, Vic.)

    2021  Volume 26, Issue 4, Page(s) 288–289

    MeSH term(s) Asthma/epidemiology ; Asthma/etiology ; Humans ; Inflammation ; Obesity/complications ; Obesity/epidemiology
    Language English
    Publishing date 2021-02-09
    Publishing country Australia
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14012
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  7. Article ; Online: Sampling pattern discrepancy in the application of compressed sensing hyperpolarized xenon-129 lung MRI.

    Tavakkoli, Mitra / Svenningsen, Sarah / Friedlander, Yonni / Konyer, Norman B / Nair, Parameswaran / Noseworthy, Michael D

    NMR in biomedicine

    2024  , Page(s) e5121

    Abstract: Although hyperpolarized (HP) ...

    Abstract Although hyperpolarized (HP)
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.5121
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  8. Article ; Online: More Data about

    Kooner, Harkiran K / McIntosh, Marrissa J / Matheson, Alexander M / Svenningsen, Sarah / Parraga, Grace

    Radiology

    2023  Volume 307, Issue 4, Page(s) e230479

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Magnetic Resonance Imaging ; Lung ; Xenon Isotopes
    Chemical Substances Xenon Isotopes
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.230479
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  9. Article ; Online: Specific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal Breathing

    Capaldi, Dante P I / Konyer, Norman B / Kjarsgaard, Melanie / Dvorkin-Gheva, Anna / Dandurand, Ronald J / Nair, Parameswaran / Svenningsen, Sarah

    Radiology. Cardiothoracic imaging

    2024  Volume 5, Issue 6, Page(s) e230054

    Abstract: Purpose To determine if proton ( ...

    Abstract Purpose To determine if proton (
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Protons ; Prospective Studies ; Asthma/diagnostic imaging ; Inflammation ; Biomarkers ; Magnetic Resonance Imaging/methods
    Chemical Substances Protons ; Biomarkers
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2638-6135
    ISSN (online) 2638-6135
    DOI 10.1148/ryct.230054
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  10. Article ; Online: Response.

    Svenningsen, Sarah / Nair, Parameswaran

    Chest

    2019  Volume 156, Issue 4, Page(s) 808–809

    MeSH term(s) Asthma ; Humans ; Magnetic Resonance Imaging ; Mucus ; Respiratory System ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-10-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.06.002
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