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  1. Article ; Online: [No title information]

    Deeg, Susanne / Boettcher, Michael / Svoboda, Daniel

    Klinische Padiatrie

    2022  

    Title translation Case report: 2-jähriger Junge mit viertgradiger Avulsionsverletzung der Hand durch Einklemmung in ein Förderband.
    Language German
    Publishing date 2022-09-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/a-1768-0873
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  2. Article: [No title information]

    Deeg, Susanne / Boettcher, Michael / Svoboda, Daniel

    Klinische Pädiatrie

    2022  Volume 235, Issue 01, Page(s) 45–47

    Language German
    Publishing date 2022-09-09
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/a-1768-0873
    Database Thieme publisher's database

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  3. Article ; Online: Muscle hypertrophy and neuroplasticity in the small bowel in short bowel syndrome.

    Khasanov, Rasul / Svoboda, Daniel / Tapia-Laliena, María Ángeles / Kohl, Martina / Maas-Omlor, Silke / Hagl, Cornelia Irene / Wessel, Lucas M / Schäfer, Karl-Herbert

    Histochemistry and cell biology

    2023  Volume 160, Issue 5, Page(s) 391–405

    Abstract: Short bowel syndrome (SBS) is a severe, life-threatening condition and one of the leading causes of intestinal failure in children. Here we were interested in changes in muscle layers and especially in the myenteric plexus of the enteric nervous system ( ... ...

    Abstract Short bowel syndrome (SBS) is a severe, life-threatening condition and one of the leading causes of intestinal failure in children. Here we were interested in changes in muscle layers and especially in the myenteric plexus of the enteric nervous system (ENS) of the small bowel in the context of intestinal adaptation. Twelve rats underwent a massive resection of the small intestine to induce SBS. Sham laparotomy without small bowel transection was performed in 10 rats. Two weeks after surgery, the remaining jejunum and ileum were harvested and studied. Samples of human small bowel were obtained from patients who underwent resection of small bowel segments due to a medical indication. Morphological changes in the muscle layers and the expression of nestin, a marker for neuronal plasticity, were studied. Following SBS, muscle tissue increases significantly in both parts of the small bowel, i.e., jejunum and ileum. The leading pathophysiological mechanism of these changes is hypertrophy. Additionally, we observed an increased nestin expression in the myenteric plexus in the remaining bowel with SBS. Our human data also showed that in patients with SBS, the proportion of stem cells in the myenteric plexus had risen by more than twofold. Our findings suggest that the ENS is tightly connected to changes in intestinal muscle layers and is critically involved in the process of intestinal adaptation to SBS.
    MeSH term(s) Child ; Rats ; Humans ; Animals ; Short Bowel Syndrome/etiology ; Short Bowel Syndrome/metabolism ; Nestin ; Rats, Sprague-Dawley ; Ileum/metabolism ; Ileum/surgery ; Disease Models, Animal ; Neuronal Plasticity
    Chemical Substances Nestin
    Language English
    Publishing date 2023-07-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-023-02214-4
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  4. Article ; Online: Case report: Infant with a Fast-growing Soft Tissue Tumor on the Thumb, Revealing a PLAG1-positive Connatal Lipoblastoma.

    Deeg, Susanne / Wessel, Lucas / Martel, Richard / Porubsky, Stefan / Svoboda, Daniel

    Klinische Padiatrie

    2020  Volume 232, Issue 6, Page(s) 285–288

    Abstract: At the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 months had no diagnostic specificity. By a ... ...

    Title translation Fallbericht: Säugling mit einem schnell-wachsenden Weichteiltumor am Daumen, histologisch konnatales PLAG1-positives Lipoblastom.
    Abstract At the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 months had no diagnostic specificity. By a biopsy at the age of 5 months malignancy could be excluded. Finally at the age of 16 months the tumor which had meanwhile grown to a monstrous size (5 cm of diameter) could be entirely removed by microsurgical technique maintaining the integrity of all intrinsic structures. The diagnosis of myxoid lipoblastoma was confirmed. According to literature, Lipoblastomas often present as connatal rapid growing soft tissue tumors and are benign. Total removal is essential for avoiding a local recurrence.
    MeSH term(s) Biopsy ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Infant ; Liposarcoma, Myxoid/genetics ; Liposarcoma, Myxoid/pathology ; Liposarcoma, Myxoid/surgery ; Magnetic Resonance Imaging ; Neoplasm Recurrence, Local ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/surgery ; Thumb/diagnostic imaging ; Transcription Factors ; Treatment Outcome
    Chemical Substances DNA-Binding Proteins ; PLAG1 protein, human ; Transcription Factors
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/a-1159-7532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Fallbericht: Säugling mit einem schnell-wachsenden Weichteiltumor am Daumen, histologisch konnatales PLAG1-positives Lipoblastom./ Case report: Infant with a Fast-growing Soft Tissue Tumor on the Thumb, Revealing a PLAG1-positive Connatal Lipoblastoma

    Deeg, Susanne / Wessel, Lucas / Martel, Richard / Porubsky, Stefan / Svoboda, Daniel

    Klin. paediatr

    Abstract: At the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 months had no diagnostic specificity. By a ... ...

    Abstract At the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 months had no diagnostic specificity. By a biopsy at the age of 5 months malignancy could be excluded. Finally at the age of 16 months the tumor which had meanwhile grown to a monstrous size (5 cm of diameter) could be entirely removed by microsurgical technique maintaining the integrity of all intrinsic structures. The diagnosis of myxoid lipoblastoma was confirmed. According to literature, Lipoblastomas often present as connatal rapid growing soft tissue tumors and are benign. Total removal is essential for avoiding a local recurrence.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32937669
    Database COVID19

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  6. Article: [No title information]

    Deeg, Susanne / Wessel, Lucas / Martel, Richard / Porubsky, Stefan / Svoboda, Daniel

    Klinische Pädiatrie

    2020  Volume 232, Issue 06, Page(s) 285–288

    Abstract: At the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 ... ...

    Abstract At the age of 4 months, an infant was presented to us with a nodular subcutaneous tumor on the right thumb measuring 2cm, already seen prenatally via ultrasound. An MRI in sedation performed at the age of 4.5 months had no diagnostic specificity. By a biopsy at the age of 5 months malignancy could be excluded. Finally at the age of 16 months the tumor which had meanwhile grown to a monstrous size (5 cm of diameter) could be entirely removed by microsurgical technique maintaining the integrity of all intrinsic structures. The diagnosis of myxoid lipoblastoma was confirmed. According to literature, Lipoblastomas often present as connatal rapid growing soft tissue tumors and are benign. Total removal is essential for avoiding a local recurrence.
    Keywords tumor ; hand ; lipoblastoma ; myxoid ; connatal ; Kinderchirurgie ; Hand ; Weichteiltumor ; Lipoblastom ; konnatal
    Language English
    Publishing date 2020-09-16
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/a-1159-7532
    Database Thieme publisher's database

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  7. Book ; Online ; Thesis: Neuroimmunomodulation in Heilungsprozessen chronischer Wunden

    Svoboda, Daniel

    Auswirkungen gepulster Elektrostimulation auf die Mastzellfunktion in chronischen venösen Beinulcera

    2002  

    Author's details vorgelegt von Daniel Svoboda
    Language German
    Size Online-Ressource
    Edition [Elektronische Ressource]
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Tübingen, 2002
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Comparison of long-term outcomes between open and laparoscopic Thal fundoplication in children.

    Kubiak, Rainer / Böhm-Sturm, Elena / Svoboda, Daniel / Wessel, Lucas M

    Journal of pediatric surgery

    2014  Volume 49, Issue 7, Page(s) 1069–1074

    Abstract: Objectives: In recent years laparoscopic fundoplication is increasingly performed in pediatric surgery. The aim of this study was to compare the long-term outcomes between open and laparoscopic Thal fundoplication in children.: Methods: This ... ...

    Abstract Objectives: In recent years laparoscopic fundoplication is increasingly performed in pediatric surgery. The aim of this study was to compare the long-term outcomes between open and laparoscopic Thal fundoplication in children.
    Methods: This retrospective study includes children who underwent a Thal fundoplication between 3/1997 and 7/2009. The minimum follow-up time to enter the study was 2 years; the overall median follow-up was 77 months (range, 29-176 months).
    Results: A total of 101 patients were included, of which 47 underwent an open and 54 a laparoscopic Thal. Intraoperative problems, early postoperative complications, time to establish enteral feeds and length of stay did not differ among both groups. The mean duration of surgery was significantly less in the open group (OPG) (108.0 (± 7.72) versus 144.1 (± 6.36) minutes; p=0.001) and this was mainly attributed to patients with neurological problems. Severe dysphagia requiring endoscopy was observed in 10 patients, but this did not differ significantly between groups (n=2 in the OPG vs. n=8 in the laparoscopic group (LAPG); p=0.10). Overall 12 patients (11.9%) (6 in each group) required a redo-fundoplication after a median of 18.7 months (range, 6-36 months). In the whole study group, 80 patients (79.2%) were classified as having surgical results being excellent, good or satisfactory and this did not differ significantly between groups.
    Conclusions: In the long-term open and laparoscopic Thal fundoplication have similarly good outcomes. The laparoscopic approach can be considered as an alternative, however there is not a clear superiority compared with the open counterpart.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Deglutition Disorders/etiology ; Enteral Nutrition ; Female ; Follow-Up Studies ; Fundoplication/adverse effects ; Fundoplication/methods ; Gastroesophageal Reflux/surgery ; Humans ; Infant ; Intraoperative Complications ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Length of Stay ; Male ; Operative Time ; Postoperative Complications ; Reoperation ; Retrospective Studies ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2014.02.077
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  9. Article ; Online: Elastic Stable Intramedullary Nailing (ESIN), Orthoss ® and Gravitational Platelet Separation - System (GPS ® )

    Wessel Lucas M / Svoboda Daniel / Rapp Marion / Kaiser Martin M

    BMC Musculoskeletal Disorders, Vol 12, Iss 1, p

    An effective method of treatment for pathologic fractures of bone cysts in children

    2011  Volume 45

    Abstract: Abstract Background The different treatment strategies for bone cysts in children are often associated with persistence and high recurrence rates of the lesions. The safety and clinical outcomes of a combined mechanical and biological treatment with ... ...

    Abstract Abstract Background The different treatment strategies for bone cysts in children are often associated with persistence and high recurrence rates of the lesions. The safety and clinical outcomes of a combined mechanical and biological treatment with elastic intramedullary nailing, artificial bone substitute and autologous platelet rich plasma are evaluated. Methods From 02/07 to 01/09 we offered all children with bone cysts the treatment combination of elastic intramedullary nailing (ESIN), artificial bone substitute (Orthoss ® ) and autologous platelet rich plasma, concentrated by the Gravitational Platelet Separation (GPS ® ) - System. All patients were reviewed radiologically for one year following the removal of the intramedullary nailing, which was possible because of cyst obliteration. Results A cohort of 12 children (4 girls, 8 boys) was recruited. The mean patient age was 11.4 years (range 7-15 years). The bone defects (ten humeral, two femoral) included eight juvenile and four aneurysmal bone cysts. Five patients suffered from persistent cysts following earlier unsuccessful treatment of humeral bone cyst after pathologic fracture; the other seven presented with acute pathologic fractures. No peri- or postoperative complications occurred. The radiographic findings showed a total resolution of the cysts in ten cases (Capanna Grade 1); in two cases a small residual cyst remained (Capanna Grade 2). The intramedullary nails were removed six to twelve months (mean 7.7) after the operation; in one case, a fourteen year old boy (Capanna Grade 2), required a further application of GPS ® and Orthoss ® to reach a total resolution of the cyst. At follow-up (20-41 months, mean 31.8 months) all patients showed very good functional results and had returned to sporting activity. No refracture occurred, no further procedure was necessary. Conclusions The combination of elastic intramedullary nailing, artificial bone substitute and autologous platelet rich plasma (GPS ® ) enhances the treatment of bone cysts in children, with no resulting complications.
    Keywords Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Diseases of the musculoskeletal system ; RC925-935
    Subject code 333 ; 616
    Language English
    Publishing date 2011-02-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Conference proceedings: C-PAM or no CPAM

    Adrian, Miriam / Nientiedt, Tobias / Wessel, Lucas M. / Svoboda, Daniel

    2016  , Page(s) 16dgch342

    Event/congress 133. Kongress der Deutschen Gesellschaft für Chirurgie; Berlin; Deutsche Gesellschaft für Chirurgie; 2016
    Keywords Medizin, Gesundheit
    Publishing date 2016-04-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/16dgch342
    Database German Medical Science

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