Article ; Online: Efficacy of Cochleated Amphotericin B in Mouse and Human Mucocutaneous Candidiasis.
Antimicrobial agents and chemotherapy
2022 Volume 66, Issue 7, Page(s) e0030822
Abstract: Candida albicans causes debilitating, often azole-resistant, infections in patients with chronic mucocutaneous candidiasis (CMC). Amphotericin B (AMB) resistance is rare, but AMB use is limited by parenteral administration and nephrotoxicity. In this ... ...
| Abstract | Candida albicans causes debilitating, often azole-resistant, infections in patients with chronic mucocutaneous candidiasis (CMC). Amphotericin B (AMB) resistance is rare, but AMB use is limited by parenteral administration and nephrotoxicity. In this study, we evaluated cochleated AMB (CAMB), a new oral AMB formulation, in mouse models of oropharyngeal candidiasis (OPC) and vulvovaginal candidiasis (VVC) and in patients with azole-resistant CMC. OPC and VVC were modeled in |
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| MeSH term(s) | Amphotericin B/adverse effects ; Animals ; Antifungal Agents/adverse effects ; Azoles ; Candida albicans ; Candidiasis/drug therapy ; Candidiasis, Chronic Mucocutaneous/drug therapy ; Candidiasis, Oral/drug therapy ; Candidiasis, Vulvovaginal/drug therapy ; Female ; Humans ; Mice | ||||||||||
| Chemical Substances | Antifungal Agents ; Azoles ; Amphotericin B (7XU7A7DROE) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2022-06-14 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural | ||||||||||
| ZDB-ID | 217602-6 | ||||||||||
| ISSN | 1098-6596 ; 0066-4804 | ||||||||||
| ISSN (online) | 1098-6596 | ||||||||||
| ISSN | 0066-4804 | ||||||||||
| DOI | 10.1128/aac.00308-22 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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