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  1. Artikel: Fgf8a

    Gebuijs, I G E / Raterman, S T / Metz, J R / Swanenberg, L / Zethof, J / Van den Bos, R / Carels, C E L / Wagener, F A D T G / Von den Hoff, J W

    Biology open

    2019  Band 8, Heft 9

    Abstract: Craniofacial development is tightly regulated and therefore highly vulnerable to disturbance by genetic and environmental factors. Fibroblast growth factors (FGFs) direct migration, proliferation and survival of cranial neural crest cells (CNCCs) forming ...

    Abstract Craniofacial development is tightly regulated and therefore highly vulnerable to disturbance by genetic and environmental factors. Fibroblast growth factors (FGFs) direct migration, proliferation and survival of cranial neural crest cells (CNCCs) forming the human face. In this study, we analyzed bone and cartilage formation in the head of five dpf
    Sprache Englisch
    Erscheinungsdatum 2019-09-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2632264-X
    ISSN 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.039834
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies.

    de Witte, Moniek A / Janssen, Anke / Nijssen, Klaartje / Karaiskaki, Froso / Swanenberg, Luuk / van Rhenen, Anna / Admiraal, Rick / van der Wagen, Lotte / Minnema, Monique C / Petersen, Eefke / Raymakers, Reinier A P / Westinga, Kasper / Straetemans, Trudy / Halkes, Constantijn J M / Boelens, Jaap-Jan / Kuball, Jürgen

    Blood advances

    2021  Band 5, Heft 1, Seite(n) 240–249

    Abstract: We conducted a multicenter prospective single-arm phase 1/2 study that assesses the outcome of αβ T-cell depleted allogeneic hematopoietic stem cell transplantation (allo-HSCT) of peripheral blood derived stem cells from matched related, or unrelated ... ...

    Abstract We conducted a multicenter prospective single-arm phase 1/2 study that assesses the outcome of αβ T-cell depleted allogeneic hematopoietic stem cell transplantation (allo-HSCT) of peripheral blood derived stem cells from matched related, or unrelated donors (10/10 and 9/10) in adults, with the incidence of acute graft-versus-host disease (aGVHD) as the primary end point at day 100. Thirty-five adults (median age, 59; range, 19-69 years) were enrolled. Conditioning consisted of antithymocyte globulin, busulfan, and fludarabine, followed by 28 days of mycophenolic acid after allo-HSCT. The minimal follow-up time was 24 months. The median number of infused CD34+ cells and αβ T cells were 6.1 × 106 and 16.3 × 103 cells per kg, respectively. The cumulative incidence (CI) of aGVHD grades 2-4 and 3-4 at day 100 was 26% and 14%. One secondary graft failure was observed. A prophylactic donor lymphocyte infusion (DLI) (1 × 105 CD3+ T cells per kg) was administered to 54% of the subjects, resulting in a CI of aGVHD grades 2-4 and 3-4 to 37% and 17% at 2 years. Immune monitoring revealed an early reconstitution of natural killer (NK) and γδ T cells. Cytomegalovirus reactivation associated with expansion of memory-like NK cells. The CI of relapse was 29%, and the nonrelapse mortality 32% at 2 years. The 2-year CI of chronic GVHD (cGVHD) was 23%, of which 17% was moderate. We conclude that only 26% of patients developed aGVHD 2-4 after αβ T-cell-depleted allo-HSCT within 100 days and was associated with a low incidence of cGVHD after 2 years. This trial was registered at www.trialregister.nl as #NL4767.
    Mesh-Begriff(e) Adult ; Graft vs Host Disease/etiology ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Middle Aged ; Neoplasm Recurrence, Local ; Prospective Studies ; T-Lymphocytes
    Sprache Englisch
    Erscheinungsdatum 2021-02-11
    Erscheinungsland United States
    Dokumenttyp Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2020002444
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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