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  1. Article ; Online: Harnessing metabolomics to better understand exercise-mediated substrate metabolism.

    Deane, Colleen S / Swann, Jonathan R

    Experimental physiology

    2023  Volume 108, Issue 6, Page(s) 797–798

    MeSH term(s) Metabolomics ; Exercise
    Language English
    Publishing date 2023-05-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.102: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The effects of a hydrolyzed protein diet on the plasma, fecal and urine metabolome in cats with chronic enteropathy.

    Kathrani, Aarti / Yen, Sandi / Hall, Edward J / Swann, Jonathan R

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19979

    Abstract: Hydrolyzed protein diets are extensively used to treat chronic enteropathy (CE) in cats. However, the biochemical effects of such a diet on feline CE have not been characterized. In this study an ... ...

    Abstract Hydrolyzed protein diets are extensively used to treat chronic enteropathy (CE) in cats. However, the biochemical effects of such a diet on feline CE have not been characterized. In this study an untargeted
    MeSH term(s) Cats ; Humans ; Animals ; Feces/chemistry ; Metabolome ; Metabolomics ; Diet/veterinary ; Inflammatory Bowel Diseases
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-47334-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Malnourished Microbes: Host-Microbiome Interactions in Child Undernutrition.

    Jones, Helen J / Bourke, Claire D / Swann, Jonathan R / Robertson, Ruairi C

    Annual review of nutrition

    2023  Volume 43, Page(s) 327–353

    Abstract: Childhood undernutrition is a major global health burden that is only partially resolved by nutritional interventions. Both chronic and acute forms of child undernutrition are characterized by derangements in multiple biological systems including ... ...

    Abstract Childhood undernutrition is a major global health burden that is only partially resolved by nutritional interventions. Both chronic and acute forms of child undernutrition are characterized by derangements in multiple biological systems including metabolism, immunity, and endocrine systems. A growing body of evidence supports a role of the gut microbiome in mediating these pathways influencing early life growth. Observational studies report alterations in the gut microbiome of undernourished children, while preclinical studies suggest that this can trigger intestinal enteropathy, alter host metabolism, and disrupt immune-mediated resistance against enteropathogens, each of which contribute to poor early life growth. Here, we compile evidence from preclinical and clinical studies and describe the emerging pathophysiological pathways by which the early life gut microbiome influences host metabolism, immunity, intestinal function, endocrine regulation, and other pathways contributing to child undernutrition. We discuss emerging microbiome-directed therapies and consider future research directions to identify and target microbiome-sensitive pathways in child undernutrition.
    MeSH term(s) Child ; Humans ; Child Nutrition Disorders ; Defecation ; Gastrointestinal Microbiome ; Malnutrition ; Microbiota ; Observational Studies as Topic
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 406980-8
    ISSN 1545-4312 ; 0199-9885
    ISSN (online) 1545-4312
    ISSN 0199-9885
    DOI 10.1146/annurev-nutr-061121-091234
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1786: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Targeting microbial metabolites to treat autism.

    Diaz Heijtz, Rochellys / Gressens, Pierre / Swann, Jonathan R

    Nature medicine

    2022  Volume 28, Issue 3, Page(s) 448–450

    MeSH term(s) Animals ; Anxiety ; Autism Spectrum Disorder/therapy ; Autistic Disorder ; Brain/metabolism ; Gastrointestinal Microbiome ; Mice
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01711-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  5. Article ; Online: The effect of a hydrolyzed protein diet on the fecal microbiota in cats with chronic enteropathy.

    Kathrani, Aarti / Yen, Sandi / Swann, Jonathan R / Hall, Edward J

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 2746

    Abstract: The effect of a hydrolyzed protein diet on the fecal microbiota has not been studied in feline chronic enteropathy (CE). Our study aimed to (1) compare the fecal microbiota of cats with CE to control cats with no gastrointestinal signs and (2) determine ... ...

    Abstract The effect of a hydrolyzed protein diet on the fecal microbiota has not been studied in feline chronic enteropathy (CE). Our study aimed to (1) compare the fecal microbiota of cats with CE to control cats with no gastrointestinal signs and (2) determine the effect of a hydrolyzed protein diet on the fecal microbiota of cats with CE and whether this differs between dietary responders and non-responders. The fecal microbiome of cats with CE (n = 36) showed decreased α-diversity in terms of genus richness (P = 0.04) and increased β-diversity in terms of Bray-Curtis Dissimilarity (P < 0.001) compared to control cats (n = 14). Clostridium was the only genera significantly over-represented in cats with CE compared to control cats (adjusted P < 0.1). After 6-weeks of feeding the diet, fifteen cats were classified as responders and 18 as non-responders, based on clinical signs. At the genus level, α-diversity was increased in non-responders versus responders at diagnosis, but decreased after dietary intervention in both groups (P < 0.05). At the family level, non-responders became increasingly dissimilar after dietary intervention (P = 0.012). In general, the abundance of bacteria decreased with feeding a hydrolyzed diet, with the genera most significantly affected being more frequently observed in non-responders. Bifidobacterium was the only genus that increased significantly in abundance post-diet and this effect was observed in both responders and non-responders. Both Oscillibacter and Desulfovibrionaceae_unclassified were most abundant in non-responders at diagnosis but were rarely observed post diet in neither responders nor non-responders. Cats with CE had similar microbiota changes to those described in human inflammatory bowel disease. Whether the presence of Oscillibacter and Desulfovibrionaceae_unclassified are indicators of non-response to the diet at diagnosis requires further investigation. Despite the hydrolyzed diet reducing α-diversity in all cats with CE, this did not resolve gastrointestinal signs in some cats. However, responders metabolized the diet in a similar manner, reflected by sustained β-diversity, while the microbiome of non-responders became increasingly dissimilar compared to diagnosis at the family level. Therefore, the microbiome may not be as tightly regulated in cats with CE that are non-responders and therefore, these cats would require additional therapy for remission of clinical signs.
    MeSH term(s) Animal Feed ; Animals ; Bacteria/classification ; Bacteria/isolation & purification ; Cats ; Feces/microbiology ; Female ; Inflammatory Bowel Diseases/microbiology ; Male ; Protein Hydrolysates/pharmacology
    Chemical Substances Protein Hydrolysates
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06576-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microbe-Immune Crosstalk: Evidence That T Cells Influence the Development of the Brain Metabolome.

    Caspani, Giorgia / Green, Miranda / Swann, Jonathan R / Foster, Jane A

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Cross-talk between the immune system and the brain is essential to neuronal development, neuronal excitability, neuroplasticity, and neurotransmission. Gut microbiota are essential to immune system development and immune function; hence, it is essential ... ...

    Abstract Cross-talk between the immune system and the brain is essential to neuronal development, neuronal excitability, neuroplasticity, and neurotransmission. Gut microbiota are essential to immune system development and immune function; hence, it is essential to consider more broadly the microbiota-immune-brain axis in neurodevelopment. The gut, brain, and microbial metabolomes obtained from C57Bl/6 and T-cell-deficient mice across four developmental timepoints (postnatal day 17, 24, 28, and 84) were studied by
    MeSH term(s) Animals ; Brain ; Gastrointestinal Microbiome/physiology ; Metabolome/genetics ; Mice ; RNA, Ribosomal, 16S/genetics ; T-Lymphocytes
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063259
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  7. Article ; Online: Modeling Enteropathy or Diarrhea with the Top Bacterial and Protozoal Pathogens: Differential Determinants of Outcomes.

    Guerrant, Richard L / Bolick, David T / Swann, Jonathan R

    ACS infectious diseases

    2021  Volume 7, Issue 5, Page(s) 1020–1031

    Abstract: Developing effective therapeutics or preventive interventions for important health threats is greatly enhanced whenever accessible models can enable the assessment of clinically important outcomes. While no non-human model is ever perfect, ... ...

    Abstract Developing effective therapeutics or preventive interventions for important health threats is greatly enhanced whenever accessible models can enable the assessment of clinically important outcomes. While no non-human model is ever perfect, inexpensive
    MeSH term(s) Animals ; Cryptosporidiosis ; Cryptosporidium ; Diarrhea ; Escherichia coli ; Mice ; Shigella
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.0c00831
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  8. Article: Developmental Signatures of Microbiota-Derived Metabolites in the Mouse Brain.

    Swann, Jonathan R / Spitzer, Sonia O / Diaz Heijtz, Rochellys

    Metabolites

    2020  Volume 10, Issue 5

    Abstract: The gut microbiome is recognized to exert a wide-ranging influence on host health and disease, including brain development and behavior. Commensal bacteria can produce bioactive molecules that enter the circulation and impact host physiology and ... ...

    Abstract The gut microbiome is recognized to exert a wide-ranging influence on host health and disease, including brain development and behavior. Commensal bacteria can produce bioactive molecules that enter the circulation and impact host physiology and homeostasis. However, little is known about the potential for these metabolites to cross the blood-brain barrier and enter the developing brain under normal physiological conditions. In this study, we used a liquid chromatography-mass spectrometry-based metabolomic approach to characterize the developmental profiles of microbial-derived metabolites in the forebrains of mice across three key postnatal developmental stages, co-occurring with the maturation of the gut microbiota. We demonstrate that direct metabolites of the gut microbiome (e.g., imidazole propionate) or products of the combinatorial metabolism between the microbiome and host (e.g., 3-indoxyl-sulfate, trimethylamine-
    Language English
    Publishing date 2020-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo10050172
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  9. Article: Utilising Pancreatic Exocrine Insufficiency in the Detection of Resectable Pancreatic Ductal Adenocarcinoma.

    McDonnell, Declan / Afolabi, Paul R / Wilding, Sam / Griffiths, Gareth O / Swann, Jonathan R / Byrne, Christopher D / Hamady, Zaed Z

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed late, leading to a high mortality rate. Early detection facilitates better treatment options. The aim of this UK-based case-control study was to determine whether two validated tests for ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed late, leading to a high mortality rate. Early detection facilitates better treatment options. The aim of this UK-based case-control study was to determine whether two validated tests for pancreatic exocrine insufficiency (PEI), namely, the
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245756
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  10. Article: Metabolic phenotyping of malnutrition during the first 1000 days of life

    Mayneris-Perxachs, Jordi / Swann, Jonathan R

    European journal of nutrition. 2019 Apr., v. 58, no. 3

    2019  

    Abstract: Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously ... ...

    Abstract Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously measures a diverse range of low molecular weight metabolites in a sample providing a comprehensive assessment of the individual’s biochemical status. There are a growing number of studies applying such approaches to characterize the metabolic derangements induced by various forms of early-life malnutrition. This includes acute and chronic undernutrition and specific micronutrient deficiencies. Collectively, these studies highlight the diverse and dynamic metabolic disruptions resulting from various forms of nutritional deficiencies. Perturbations were observed in many pathways including those involved in energy, amino acid, and bile acid metabolism, the metabolic interactions between the gut microbiota and the host, and changes in metabolites associated with gut health. The information gleaned from such studies provides novel insights into the mechanisms linking malnutrition with developmental impairments and assists in the elucidation of candidate biomarkers to identify individuals at risk of developmental shortfalls. As the metabolic profile represents a snapshot of the biochemical status of an individual at a given time, there is great potential to use this information to tailor interventional strategies specifically to the metabolic needs of the individual.
    Keywords amino acids ; at-risk population ; bile acids ; biomarkers ; cognitive development ; digestive system ; energy metabolism ; intestinal microorganisms ; malnutrition ; metabolites ; metabolomics ; molecular weight ; nutrient deficiencies ; phenotype
    Language English
    Dates of publication 2019-04
    Size p. 909-930.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note Review
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-018-1679-0
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2281: Show issues

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