Article ; Online: The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity.
2022 Volume 110, Issue 21, Page(s) 3597–3626
Abstract: The sympathetic nervous system maintains metabolic homeostasis by orchestrating the activity of organs such as the pancreas, liver, and white and brown adipose tissues. From the first renderings by Thomas Willis to contemporary techniques for ... ...
| Abstract | The sympathetic nervous system maintains metabolic homeostasis by orchestrating the activity of organs such as the pancreas, liver, and white and brown adipose tissues. From the first renderings by Thomas Willis to contemporary techniques for visualization, tracing, and functional probing of axonal arborizations within organs, our understanding of the sympathetic nervous system has started to grow beyond classical models. In the present review, we outline the evolution of these findings and provide updated neuroanatomical maps of sympathetic innervation. We offer an autonomic framework for the neuroendocrine loop of leptin action, and we discuss the role of immune cells in regulating sympathetic terminals and metabolism. We highlight potential anti-obesity therapeutic approaches that emerge from the modern appreciation of SNS as a neural network vis a vis the historical fear of sympathomimetic pharmacology, while shifting focus from post- to pre-synaptic targeting. Finally, we critically appraise the field and where it needs to go. |
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| MeSH term(s) | Humans ; Neuroimmunomodulation ; Sympathetic Nervous System/metabolism ; Obesity ; Adipose Tissue, Brown/metabolism ; Homeostasis |
| Language | English |
| Publishing date | 2022-11-07 |
| Publishing country | United States |
| Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 808167-0 |
| ISSN | 1097-4199 ; 0896-6273 |
| ISSN (online) | 1097-4199 |
| ISSN | 0896-6273 |
| DOI | 10.1016/j.neuron.2022.10.017 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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