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  1. Article ; Online: Correction: Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines.

    Saadeh, Haythem A / Sweidan, Kamal A / Mubarak, Mohammad S

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 13

    Abstract: The author wishes to make the following correction to this paper [ ... ]. ...

    Abstract The author wishes to make the following correction to this paper [...].
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27134306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines.

    Saadeh, Haythem A / Sweidan, Kamal A / Mubarak, Mohammad S

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 18

    Abstract: Compounds containing the 8-hydroxyquinoline (8-HQ) ...

    Abstract Compounds containing the 8-hydroxyquinoline (8-HQ)
    MeSH term(s) Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/pharmacology ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Chemistry Techniques, Synthetic/methods ; Humans ; Oxyquinoline/chemical synthesis ; Oxyquinoline/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Antiviral Agents ; Oxyquinoline (5UTX5635HP)
    Keywords covid19
    Language English
    Publishing date 2020-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25184321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines

    Saadeh, Haythem A. / Sweidan, Kamal A. / Mubarak, Mohammad S.

    Molecules

    Abstract: Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects The chemistry and biology of this group have attracted the attention of chemists, ... ...

    Abstract Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects The chemistry and biology of this group have attracted the attention of chemists, medicinal chemists, and professionals in health sciences A number of prescribed drugs incorporate this group, and numerous 8-HQ- based molecules can be used to develop potent lead compounds with good efficacy and low toxicity This review focusses on the recent advances in the synthesis of 8-HQ derivatives with different pharmacological properties, including anticancer, antiviral, and antibacterial activities For this purpose, recent relevant references were searched in different known databases and search engines, such as MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Cochrane, Scientific Information Database (SID), SciFinder, and Institute for Scientific Information (ISI) Web of Knowledge This review article provides a literature overview of the various synthetic strategies and biological activities of 8-HQ derivatives and covers the recent related literature Taken together, compounds containing the 8-HQ moiety have huge therapeutic value and can act as potential building blocks for various pharmacologically active scaffolds In addition, several described compounds in this review could act leads for the development of drugs against numerous diseases including cancer
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #790351
    Database COVID19

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  4. Article ; Online: Molecular Modeling, Synthesis and Biological Evaluation of

    Sabbah, Dima A / Hasan, Shaima' E / Abu Khalaf, Reema / Bardaweel, Sanaa K / Hajjo, Rima / Alqaisi, Khalid M / Sweidan, Kamal A / Al-Zuheiri, Aya M

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 22

    Abstract: The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design. Twenty one derivatives ... ...

    Abstract The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design. Twenty one derivatives of
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Caco-2 Cells ; Gene Expression Regulation, Neoplastic/drug effects ; HCT116 Cells ; Humans ; Inhibitory Concentration 50 ; Models, Molecular ; Molecular Docking Simulation ; Phosphatidylinositol 3-Kinases/chemistry ; Phosphatidylinositol 3-Kinases/metabolism ; Principal Component Analysis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Quinolones/pharmacology
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Quinolones
    Language English
    Publishing date 2020-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25225348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Synthesis and in Vivo Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats.

    Jasim, Suhair H / Abu Sheikha, Ghassan M / Abuzaid, Haneen M / Al-Qirim, Tariq M / Shattat, Ghassan F / Sabbah, Dima A / Ata, Samah A / Ala, Samah A / Aboumair, Mustafa S / Sweidan, Kamal A / Bkhaitan, Majdi M

    Chemical & pharmaceutical bulletin

    2018  Volume 66, Issue 10, Page(s) 953–958

    Abstract: A new series of imidazole-5-carboxamide derivatives were prepared and tested for their anti-hyperlipidemic activity in Triton-WR-1339-induced hyperlipidemic Wistar rats. The purpose of this research was to improve benzophenone carboxamides water ... ...

    Abstract A new series of imidazole-5-carboxamide derivatives were prepared and tested for their anti-hyperlipidemic activity in Triton-WR-1339-induced hyperlipidemic Wistar rats. The purpose of this research was to improve benzophenone carboxamides water solubility maintaining at the same time the antihyperlipidemic activity. Compounds 4, 6, 10, and 11 were synthesized through a coupling reaction between imidazoles-5-carbonyl chloride and amino benzophenones. The tested animals (n=48) were divided into six groups: the first group (hyperlipidemic control group; HCG) received an intraperitoneal injection (i.p.) of (300 mg/kg) Triton WR-1339. The second group received i.p. injection of Triton WR-1339 followed by an intra-gastric administration of bezafibrate (100 mg/kg) (bezafibrate; BF). The third, fourth, fifth, and sixth groups received i.p. injection of Triton WR-1339 followed by an intra-gastric administration of (30 mg/kg) of compounds 4, 6, 10, and 11, respectively. At a dose of 30 mg/kg body weight compounds 4, 6, 10, and 11 significantly (p<0.0001) decreased the plasma level of triglyceride (TG), low-density lipoprotein (LDL) and total cholesterol (TC) levels after 18 h of treatment. Additionally, compounds 4, 6, 11 and bezafibrate (100 mg/kg) significantly (p<0.0001) increased the plasma level of high-density lipoprotein (HDL) levels, which is known for its preventive role against atherogenesis. These results demonstrate the possibility of pharmacokinetic properties improvement maintaining the biological and pharmacological profile of these compounds.
    MeSH term(s) Animals ; Hyperlipidemias/chemically induced ; Hyperlipidemias/drug therapy ; Hypolipidemic Agents/chemical synthesis ; Hypolipidemic Agents/chemistry ; Hypolipidemic Agents/therapeutic use ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Imidazoles/therapeutic use ; Intubation, Gastrointestinal ; Lipids/chemistry ; Lipoproteins, HDL/blood ; Male ; Molecular Structure ; Polyethylene Glycols/administration & dosage ; Rats ; Rats, Wistar ; Solubility
    Chemical Substances Hypolipidemic Agents ; Imidazoles ; Lipids ; Lipoproteins, HDL ; Polyethylene Glycols (3WJQ0SDW1A) ; tyloxapol (Y27PUL9H56)
    Language English
    Publishing date 2018-08-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c18-00346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 770: Show issues Location:
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