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  1. Article ; Online: Microangiopathy, lomustine, and karyomegalic mesangial cells.

    Alrohaibani, Alaaeddin / Swetnam, Leah A / Andeen, Nicole K

    Kidney international

    2020  Volume 98, Issue 2, Page(s) 517

    MeSH term(s) Brain Neoplasms ; Humans ; Lomustine ; Mesangial Cells
    Chemical Substances Lomustine (7BRF0Z81KG)
    Keywords covid19
    Language English
    Publishing date 2020-04-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Diverse Spectrum of Immune Complex- and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma.

    Andeen, Nicole K / Abdulameer, Shahad / Charu, Vivek / Zuckerman, Jonathan E / Troxell, Megan / Kambham, Neeraja / Alpers, Charles E / Najafian, Behzad / Nicosia, Roberto F / Smith, Kelly D / Kung, Vanderlene L / Avasare, Rupali S / Vallurupalli, Anusha / Jefferson, J Ashley / Hecox, Douglas / Swetnam, Leah / Yamashita, Michifumi / Lin, Mercury / Bissonnette, Mei Lin /
    Akilesh, Shreeram / Hou, Jean

    Kidney international reports

    2021  Volume 7, Issue 3, Page(s) 568–579

    Abstract: Introduction: There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL).: Methods: We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL.: ... ...

    Abstract Introduction: There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL).
    Methods: We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL.
    Results: A total of 30 patients with MCL and kidney biopsies were identified, with a median age of 67 (range 48-87) years, 73% of whom were men. A total of 20 patients had active MCL at the time of biopsy, of whom 14 (70%) presented with acute kidney injury (AKI), proteinuria and/or hematuria, and biopsy findings potentially attributable to lymphoma. Of the 14, 11 had immune complex (IC) or complement-mediated (C3) disease including proliferative glomerulonephritis (GN) with monotypic Ig deposits (PGNMID [2]), C3GN, (2), secondary membranous nephropathy (MN [3]), tubular basement membrane (TBM) deposits (2), and modest lupus-like GN (2). Lymphomatous infiltration was present in 8 of the 20 patients, 5 with coincident IC or C3 lesions. A total of 6 patients with available follow-up were treated for MCL, all with clinical remission of GN (2 PGNMID, 2 C3GN, and 2 MN).
    Conclusion: MCL is associated with diverse monoclonal and polyclonal glomerular and extra-glomerular IC and C3 disease. For patients with active MCL and kidney dysfunction requiring biopsy, 70% had findings due or potentially due to lymphoma, including 55% with IC or C3 disease and 40% had lymphomatous kidney infiltration. IC and C3GN in the setting of active MCL was responsive to lymphoma-directed therapy.
    Language English
    Publishing date 2021-12-27
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.12.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A large outbreak of hepatitis B virus infections associated with frequent injections at a physician's office.

    Samandari, Taraz / Malakmadze, Naile / Balter, Sharon / Perz, Joseph F / Khristova, Marina / Swetnam, Leah / Bornschlegel, Katherine / Phillips, Michael S / Poshni, Iqbal A / Nautiyal, Preeti / Nainan, Omana V / Bell, Beth P / Williams, Ian T

    Infection control and hospital epidemiology

    2005  Volume 26, Issue 9, Page(s) 745–750

    Abstract: Objectives: To determine whether hepatitis B virus (HBV) transmission occurred among patients visiting a physician's office and to evaluate potential transmission mechanisms.: Design: Serologic survey, retrospective cohort study, and observation of ... ...

    Abstract Objectives: To determine whether hepatitis B virus (HBV) transmission occurred among patients visiting a physician's office and to evaluate potential transmission mechanisms.
    Design: Serologic survey, retrospective cohort study, and observation of infection control practices.
    Setting: Private medical office.
    Patients: Those visiting the office between March 1 and December 26, 2001.
    Results: We identified 38 patients with acute HBV infection occurring between February 2000 and February 2002. The cohort study, limited to the 10 months before outbreak detection, included 91 patients with serologic test results and available charts representing 18 case-patients and 73 susceptible patients. Overall, 67 patients (74%) received at least one injection during the observation period. Case-patients received a median of 14 injections (range, 2-25) versus 2 injections (range, 0-17) for susceptible patients (P < .001). Acute infections occurred among 18 (27%) of 67 who received at least one injection versus none of 24 who received no injections (RR, 13.6; CI95, 2.4-undefined). Risk of infection increased 5.2-fold (CI95, 0.6-47.3) for those with 3 to 6 injections and 20.0-fold (CI95, 2.8-143.5) for those with more than 6 injections. Typically, injections consisted of doses of atropine, dexamethasone, vitamin B12, or a combination of these mixed in one syringe. HBV DNA genetic sequences of 24 patients with acute infection and 4 patients with chronic infection were identical in the 1,500-bp region examined. Medical staff were seronegative for HBV infection markers. The same surface was used for storing multidose vials, preparing injections, and dismantling used injection equipment.
    Conclusion: Administration of unnecessary injections combined with failure to separate clean from contaminated areas and follow safe injection practices likely resulted in patient-to-patient HBV transmission in a private physician's office.
    MeSH term(s) Aged ; Aged, 80 and over ; Analysis of Variance ; Cross Infection/epidemiology ; Disease Outbreaks ; Female ; Hepatitis B/epidemiology ; Humans ; Infection Control/organization & administration ; Injections ; Logistic Models ; Male ; Middle Aged ; New York City/epidemiology ; Physicians' Offices/statistics & numerical data ; Retrospective Studies
    Language English
    Publishing date 2005-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0899-823X ; 0195-9417
    ISSN (online) 1559-6834
    ISSN 0899-823X ; 0195-9417
    DOI 10.1086/502612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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