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  1. Article ; Online: Vegetative plaque on the left superior eyelid.

    Wikholm, Colin G / Thakker, Sach / Bakhshi, Pegah R / Swigost, Adam J / Moshell, Alan / Cardis, Michael A

    Skin health and disease

    2023  Volume 3, Issue 5, Page(s) e277

    Abstract: Herein we present case report of a 73-year-old female who developed a rapidly growing, ulcerated lesion on her left superior eyelid. Despite treatment for suspected infection, symptoms only marginally improved. Physical examination revealed a diffusely ... ...

    Abstract Herein we present case report of a 73-year-old female who developed a rapidly growing, ulcerated lesion on her left superior eyelid. Despite treatment for suspected infection, symptoms only marginally improved. Physical examination revealed a diffusely ulcerated multinodular tumour with overlying haemorrhagic and serosanguineous exudate. A shave biopsy led to a diagnosis of primary cutaneous anaplastic large cell lymphoma (pcALCL), a rare CD30+ lymphoproliferative disorder. The patient had no extracutaneous involvement on PET-CT and her prognosis is good given the indolent nature of pcALCL. Differential diagnoses included merkel cell carcinoma, periocular sebaceous carcinoma, lymphomatoid papulosis, and extranodal natural killer/T cell lymphoma. Prognosis for pcALCL is generally good. Treatment recommendation for pcALCL is surgical excision with negative margins for localised disease, while intravenous brentuximab vedotin is suggested for widespread, relapsed, and refractory disease.
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Case Reports
    ISSN 2690-442X
    ISSN (online) 2690-442X
    DOI 10.1002/ski2.277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case series of hydroxychloroquine exacerbating the dermatomyositis rash.

    Rypka, Katelyn / Buonomo, Michele / Buechler, Connor / Benolken, Molly / Swigost, Adam / Konstantinov, Nikifor / Gaddis, Kevin / Goldfarb, Noah

    Dermatology online journal

    2023  Volume 29, Issue 5

    Abstract: Hydroxychloroquine (HCQ) is an antimalarial agent that is commonly used in the management of rheumatic skin disease. Few reports exist documenting exacerbation of dermatomyositis (DM) related to HCQ. Herein, we describe three adult patients with ... ...

    Abstract Hydroxychloroquine (HCQ) is an antimalarial agent that is commonly used in the management of rheumatic skin disease. Few reports exist documenting exacerbation of dermatomyositis (DM) related to HCQ. Herein, we describe three adult patients with worsening DM cutaneous disease after starting HCQ and resolution or improvement with cessation. The time to exacerbation ranged from two weeks to nine months after the initiation of HCQ 400mg/day. Two of the three patients had antibodies to transcription intermediary factor 1γ (TIF1γ) and the other had antibodies to anti-nuclear matrix protein 2 (NXP2). After discontinuation of HCQ, the time to improvement or resolution of cutaneous symptoms ranged from six weeks to six months. Hydroxychloroquine may be associated with worsening cutaneous features in DM. In patients who are not improving despite escalation of immunosuppressive medications, or are worsening, we recommend a trial of discontinuing HCQ.
    MeSH term(s) Adult ; Humans ; Hydroxychloroquine/adverse effects ; Dermatomyositis/chemically induced ; Dermatomyositis/drug therapy ; Dermatomyositis/diagnosis ; Retrospective Studies ; Exanthema
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2023-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    DOI 10.5070/D329562407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multiple Squamous Neoplasms Arising in a Red Tattoo After Laser Tattoo Removal.

    Swigost, Adam / Farah, Ronda S / Canova, Erica / Goldfarb, Noah

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2019  Volume 46, Issue 7, Page(s) 970–973

    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Humans ; Laser Therapy ; Male ; Middle Aged ; Postoperative Complications/pathology ; Skin Neoplasms/pathology ; Tattooing
    Language English
    Publishing date 2019-07-15
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000002031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A novel irinotecan-lipiodol nanoemulsion for intravascular administration: pharmacokinetics and biodistribution in the normal and tumor bearing rat liver.

    Melancon, Marites P / Yevich, Steven / Avritscher, Rony / Swigost, Adam / Lu, Linfeng / Tian, Li / Damasco, Jossana A / Dixon, Katherine / Cortes, Andrea C / Munoz, Nina M / Liang, Dong / Liu, David / Tam, Alda L

    Drug delivery

    2021  Volume 28, Issue 1, Page(s) 240–251

    Abstract: Colorectal cancer is one of the most common cancers in the United States and treatment options are limited for patients who develop liver metastases. Several chemotherapeutic regimens have been used for transvascular liver-directed therapy in the ... ...

    Abstract Colorectal cancer is one of the most common cancers in the United States and treatment options are limited for patients who develop liver metastases. Several chemotherapeutic regimens have been used for transvascular liver-directed therapy in the treatment of colorectal liver metastases without clear evidence of superiority of one therapy over another. We describe the development of a novel nanoemulsion through combining irinotecan (IRI), a first line systemic agent used for the treatment of colon cancer, with lipiodol, an oily contrast medium derived from poppy seed oil, and evaluated its pharmacokinetic and biodistribution profile as a function of portal venous chemoembolization (PVCE) versus transarterial chemoembolization (TACE) delivery. The Tessari technique was used to create a stable emulsion (20 mg IRI mixed with 2 mL lipiodol) with resultant particle size ranging from 28.9 nm to 56.4 nm. Pharmacokinetic profile established through venous sampling in Buffalo rats demonstrate that the area under the curve (AUC
    MeSH term(s) Animals ; Cell Line, Tumor ; Chemoembolization, Therapeutic/methods ; Colorectal Neoplasms/pathology ; Drug Carriers ; Emulsions/pharmacokinetics ; Ethiodized Oil/pharmacokinetics ; Hepatic Artery ; In Vitro Techniques ; Irinotecan/administration & dosage ; Irinotecan/pharmacokinetics ; Liver/metabolism ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Nanostructures ; Portal Vein ; Prodrugs/administration & dosage ; Prodrugs/pharmacokinetics ; Rats ; Topoisomerase I Inhibitors/administration & dosage ; Topoisomerase I Inhibitors/pharmacokinetics
    Chemical Substances Drug Carriers ; Emulsions ; Prodrugs ; Topoisomerase I Inhibitors ; Irinotecan (7673326042) ; Ethiodized Oil (8008-53-5)
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1213261-5
    ISSN 1521-0464 ; 1071-7544
    ISSN (online) 1521-0464
    ISSN 1071-7544
    DOI 10.1080/10717544.2020.1869863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Amyloid precursor protein expression modulates intestine immune phenotype.

    Puig, Kendra L / Swigost, Adam J / Zhou, Xudong / Sens, Mary Ann / Combs, Colin K

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

    2011  Volume 7, Issue 1, Page(s) 215–230

    Abstract: Amyloid precursor protein (APP) is widely expressed across many tissue and cell types. Proteolytic processing of the protein gives rise to a plethora of protein fragments with varied biological activities. Although a large amount of data has been ... ...

    Abstract Amyloid precursor protein (APP) is widely expressed across many tissue and cell types. Proteolytic processing of the protein gives rise to a plethora of protein fragments with varied biological activities. Although a large amount of data has been generated describing the metabolism of the protein in neurons, its role in regulating the phenotype of other cells remains unclear. Based upon prior work demonstrating that APP regulates the activation phenotype of monocytic lineage cells, we hypothesized that APP can regulate macrophage activation phenotype in tissues other than brain. Ileums of the small intestines from C57BL6/J wild type and APP(-/-) mice were compared as a representative tissue normally associated with abundant macrophage infiltration. APP(-/-) intestines demonstrated diminished CD68 immunoreactivity compared to wild type mice. This correlated with significantly less cyclooxygenase-2 (cox-2), CD68, CD40, CD11c, and βIII-tubulin protein levels. Peritoneal macrophages from APP(-/-) mice demonstrated decreased in vitro migratory ability compared to wild type cells and diminished basal KC cytokine secretion. Whereas, APP(-/-) intestinal macrophages had an increase in basal KC cytokine secretion compared to wild type cells. Conversely, there was a significant decrease in multiple cytokine levels in APP(-/-) compared to wild type ileums. Finally, APP(-/-) mice demonstrated impaired absorption and increased motility compared to wild type mice. These data demonstrate the APP expression regulates immune cell secretions and phenotype and intestinal function. This data set describes a novel function for this protein or its metabolites that may be relevant not only for Alzheimer's disease but a range of immune-related disorders.
    MeSH term(s) Amyloid beta-Protein Precursor/immunology ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Blotting, Western ; Cytokines/biosynthesis ; Ileum/immunology ; Ileum/metabolism ; Immunohistochemistry ; Macrophage Activation/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phenotype
    Chemical Substances Amyloid beta-Protein Precursor ; Cytokines
    Language English
    Publishing date 2011-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-011-9327-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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