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Article ; Online: 3D bioprinting and its innovative approach for biomedical applications

Swikriti Tripathi / Subham Shekhar Mandal / Sudepta Bauri / Pralay Maiti

MedComm, Vol 4, Iss 1, Pp n/a-n/a (2023)

2023

Abstract: Abstract 3D bioprinting or additive manufacturing is an emerging innovative technology revolutionizing the field of biomedical applications by combining engineering, manufacturing, art, education, and medicine. This process involved incorporating the ... ...

Abstract	Abstract 3D bioprinting or additive manufacturing is an emerging innovative technology revolutionizing the field of biomedical applications by combining engineering, manufacturing, art, education, and medicine. This process involved incorporating the cells with biocompatible materials to design the required tissue or organ model in situ for various in vivo applications. Conventional 3D printing is involved in constructing the model without incorporating any living components, thereby limiting its use in several recent biological applications. However, this uses additional biological complexities, including material choice, cell types, and their growth and differentiation factors. This state‐of‐the‐art technology consciously summarizes different methods used in bioprinting and their importance and setbacks. It also elaborates on the concept of bioinks and their utility. Biomedical applications such as cancer therapy, tissue engineering, bone regeneration, and wound healing involving 3D printing have gained much attention in recent years. This article aims to provide a comprehensive review of all the aspects associated with 3D bioprinting, from material selection, technology, and fabrication to applications in the biomedical fields. Attempts have been made to highlight each element in detail, along with the associated available reports from recent literature. This review focuses on providing a single platform for cancer and tissue engineering applications associated with 3D bioprinting in the biomedical field.
Keywords	3D bioprinting ; bioprinting technology ; cancer therapy ; fabrication strategy ; tissue engineering ; Medicine ; R
Subject code	670
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Photochemical Oximesulfonylation of Alkenes Using Sulfonyl-Oxime-Ethers as Bifunctional Reagents.

Dey, Jayanta / Banerjee, Nayan / Daw, Swikriti / Guin, Joyram

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 44, Page(s) e202312384

Abstract: Utilization of oxime ethers as bifunctional reagents remains unknown. Herein, we present a mechanistically distinct strategy that enables oximesulfonylation of olefins using sulfonyl-oxime-ethers as bifunctional reagents under metal-free photochemical ... ...

Abstract	Utilization of oxime ethers as bifunctional reagents remains unknown. Herein, we present a mechanistically distinct strategy that enables oximesulfonylation of olefins using sulfonyl-oxime-ethers as bifunctional reagents under metal-free photochemical conditions. Via concomitant C-S and C-C bond formation, the process permits incorporation of oxime and sulfonyl groups into olefins in a complete atom-economic fashion, providing rapid access to multi-functionalized β-sulfonyl oxime ethers with good yields and stereoselectivity. The method is amenable to functionalization of complex bioactive molecules and is shown to be scalable. A radical chain mechanism initiated via photochemical Hydrogen Atom Transfer (HAT) mediated N-O bond cleavage is suggested for the process, based on our results on mechanistic investigations.
Language	English
Publishing date	2023-09-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202312384
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design and synthesis of neoteric benzylidene amino-benzimidazole scaffolds for antioxidant and anti-inflammatory activity.

Swikriti / Babbar, Ritchu / Saini, Deepika / Rawat, Ravi / Chigurupati, Sridevi / Felemban, Shatha G / Vargas-De-La-Cruz, Celia / Behl, Tapan

Future medicinal chemistry

2023

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2023-0058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Traumatic Brain Injury among Patients Admitted in Neurosurgical Unit in a Tertiary Care Centre

Ajit Shrestha / Nimesh Paudel / Ganesh Adhikari / Swikriti Shrestha / Sandesh Lamichhane / Subash Subedi / Neelam Jaishwal

Journal of Nepal Medical Association, Vol 61, Iss

A Descriptive Cross-sectional Study

2023 Volume 262

Abstract: Introduction: Traumatic brain injuries are one of the leading causes of mortality, morbidity, and economic burden in context to Nepal. Non-contrast computed tomography is used for rapid diagnosis and repeat computed tomography helps to detect the ... ...

Abstract	Introduction: Traumatic brain injuries are one of the leading causes of mortality, morbidity, and economic burden in context to Nepal. Non-contrast computed tomography is used for rapid diagnosis and repeat computed tomography helps to detect the progression and complications of cerebral injury. The aim of this study was to find out the prevalence of traumatic brain injury among patients admitted in the neurosurgical unit in a tertiary care centre. Methods: This descriptive cross-sectional study was conducted among patients admitted to the neurosurgery unit in the tertiary care centre from 1 August 2019 to 29 August 2020. Ethical approval was taken from Institutional Review Committee (Reference number: CMC-IRC/075/076-156). Convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated. Results: Among 350 patients admitted in the neurosurgical unit, the prevalence of traumatic brain injury was 140 (40%) (34.87-45.13, 95% Confidence Interval). Change in management was required among 28 (20%) when computed tomography was done within 12-24 hours. Among them, 27 (19.29%) underwent surgical intervention after a repeat computed tomography scan. Conclusions: The prevalence of traumatic brain injury was found to be higher than similar studies done in similar settings.
Keywords	contusion ; craniotomy ; traumatic brain injury ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nepal Medical Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Traumatic Brain Injury among Patients Admitted in Neurosurgical Unit in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

Shrestha, Ajit / Paudel, Nimesh / Adhikari, Ganesh / Shrestha, Swikriti / Lamichhane, Sandesh / Subedi, Subash / Jaishwal, Neelam

JNMA; journal of the Nepal Medical Association

2023 Volume 61, Issue 262, Page(s) 514–518

Abstract	Introduction: Traumatic brain injuries are one of the leading causes of mortality, morbidity, and economic burden in context to Nepal. Non-contrast computed tomography is used for rapid diagnosis and repeat computed tomography helps to detect the progression and complications of cerebral injury. The aim of this study was to find out the prevalence of traumatic brain injury among patients admitted in the neurosurgical unit in a tertiary care centre. Methods: This descriptive cross-sectional study was conducted among patients admitted to the neurosurgery unit in the tertiary care centre from 1 August 2019 to 29 August 2020. Ethical approval was taken from Institutional Review Committee (Reference number: CMC-IRC/075/076-156). Convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated. Results: Among 350 patients admitted in the neurosurgical unit, the prevalence of traumatic brain injury was 140 (40%) (34.87-45.13, 95% Confidence Interval). Change in management was required among 28 (20%) when computed tomography was done within 12-24 hours. Among them, 27 (19.29%) underwent surgical intervention after a repeat computed tomography scan. Conclusions: The prevalence of traumatic brain injury was found to be higher than similar studies done in similar settings. Keywords: contusion; craniotomy; traumatic brain injury.
MeSH term(s)	Humans ; Tertiary Care Centers ; Cross-Sectional Studies ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries, Traumatic/surgery ; Hospitalization ; Contusions
Language	English
Publishing date	2023-06-01
Publishing country	Nepal
Document type	Journal Article
ZDB-ID	2209910-4
ISSN	1815-672X ; 0028-2715
ISSN (online)	1815-672X
ISSN	0028-2715
DOI	10.31729/jnma.8197
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Article ; Online: 3D bioprinting and its innovative approach for biomedical applications.

Tripathi, Swikriti / Mandal, Subham Shekhar / Bauri, Sudepta / Maiti, Pralay

MedComm

2022 Volume 4, Issue 1, Page(s) e194

Abstract: 3D bioprinting or additive manufacturing is an emerging innovative technology revolutionizing the field of biomedical applications by combining engineering, manufacturing, art, education, and medicine. This process involved incorporating the cells with ... ...

Abstract	3D bioprinting or additive manufacturing is an emerging innovative technology revolutionizing the field of biomedical applications by combining engineering, manufacturing, art, education, and medicine. This process involved incorporating the cells with biocompatible materials to design the required tissue or organ model in situ for various in vivo applications. Conventional 3D printing is involved in constructing the model without incorporating any living components, thereby limiting its use in several recent biological applications. However, this uses additional biological complexities, including material choice, cell types, and their growth and differentiation factors. This state-of-the-art technology consciously summarizes different methods used in bioprinting and their importance and setbacks. It also elaborates on the concept of bioinks and their utility. Biomedical applications such as cancer therapy, tissue engineering, bone regeneration, and wound healing involving 3D printing have gained much attention in recent years. This article aims to provide a comprehensive review of all the aspects associated with 3D bioprinting, from material selection, technology, and fabrication to applications in the biomedical fields. Attempts have been made to highlight each element in detail, along with the associated available reports from recent literature. This review focuses on providing a single platform for cancer and tissue engineering applications associated with 3D bioprinting in the biomedical field.
Language	English
Publishing date	2022-12-24
Publishing country	China
Document type	Journal Article ; Review
ISSN	2688-2663
ISSN (online)	2688-2663
DOI	10.1002/mco2.194
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Article: Ventricular tachycardia storm after accidental poisoning of delphinium species: a rare case report.

Shrestha, Swikriti / Thapa, Shovit / Hussain, Asraf / Lamichhane, Sandesh / Subedi, Subash / Kc, Sujata / Kandel, Narayan / Pant, Kailash

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 5, Page(s) 3052–3055

Abstract: Introduction: Delphinium: Case presentation: Here, the authors present an 80-year-old male with incessant ventricular tachycardia after ingestion of this herb. The sinus rhythm was restored after electrical cardioversion and aggressive intravenous ... ...

Abstract	Introduction: Delphinium Case presentation: Here, the authors present an 80-year-old male with incessant ventricular tachycardia after ingestion of this herb. The sinus rhythm was restored after electrical cardioversion and aggressive intravenous antiarrhythmics. Clinical discussion: To the best knowledge of the authors, no case of a ventricular storm following ingestion of Conclusion: This report aims to present the rare case using theoretical concepts from the discipline and to share our approach in the hope of achieving a better understanding of similar cases.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001892
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Article ; Online: Methemoglobinemia due to Hemolysis Secondary to Infection in a Child: A Case Report.

Parajuli, Biraj / Shrestha, Swikriti / Lamichhane, Sandesh / Subedi, Subash / K C, Sujata

JNMA; journal of the Nepal Medical Association

2022 Volume 60, Issue 254, Page(s) 906–908

Abstract: Methemoglobinemia is a rare condition characterised by hypoxic state manifesting as headache, nausea, fatigue, and confusion. We report a 2-year-old boy presenting with fever and cough for 7 days with an episode of hypoxia as the saturation declined and ... ...

Abstract	Methemoglobinemia is a rare condition characterised by hypoxic state manifesting as headache, nausea, fatigue, and confusion. We report a 2-year-old boy presenting with fever and cough for 7 days with an episode of hypoxia as the saturation declined and did not improve on face mask oxygenation. On further evaluation, acute intravascular hemolysis was established following decreased haemoglobin level, increased levels of lactate dehydrogenase, and unconjugated bilirubin in the setting of documented infection. Assessment of arterial blood gas showed a significantly raised saturation gap and detection of methemoglobin confirmed the diagnosis. He was managed conservatively with packed red blood cells transfusion following which hypoxia was corrected. Methemoglobinemia as a result of hemolysis can be a non-cardio-respiratory cause of hypoxia and inciting aetiology needs to be addressed. Keywords: case reports; hemolysis; hypoxia; infection; methemoglobinemia.
MeSH term(s)	Child, Preschool ; Humans ; Male ; Blood Gas Analysis ; Fever ; Hemolysis ; Hypoxia/therapy ; Hypoxia/complications ; Methemoglobinemia/diagnosis ; Methemoglobinemia/etiology ; Methemoglobinemia/therapy ; Infections/complications
Language	English
Publishing date	2022-10-01
Publishing country	Nepal
Document type	Case Reports
ZDB-ID	2209910-4
ISSN	1815-672X ; 0028-2715
ISSN (online)	1815-672X
ISSN	0028-2715
DOI	10.31729/jnma.7874
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Article: Kawasaki disease - often a diagnostic dilemma in pediatric population: a case report.

Subedi, Subash / Shrestha, Swikriti / Khatri Chhetri, Sujata / Lamichhane, Sandesh / Dhakal, Swastika / Dahal, Pravakar / Baniya, Shubha / Pokhrel, Santosh

Annals of medicine and surgery (2012)

2023 Volume 85, Issue 5, Page(s) 2037–2040

Abstract: Kawasaki disease (KD) is the most common cause of childhood vasculitis affecting small- and medium-sized arteries. The cause of this disease is unknown with an overall prevalence of 0.10% making this a rare entity.: Case presentation: Here the authors ...

Abstract	Kawasaki disease (KD) is the most common cause of childhood vasculitis affecting small- and medium-sized arteries. The cause of this disease is unknown with an overall prevalence of 0.10% making this a rare entity. Case presentation: Here the authors present an index case of a 2-year-old child presenting with a persistent high-grade fever of more than 5 days and a 3-day history of bilateral swelling of hands and feet along with cervical lymphadenopathy. On the subsequent day of admission, the child developed mucocutaneous symptoms and cervical lymphadenopathy. The diagnosis of KD was made, and it was successfully treated with intravenous immunoglobulin and aspirin. Clinical discussion: Timely diagnosis and early treatment of KD are challenging due to the lack of definitive diagnostic tests. Watchful waiting for symptoms may be necessary before a diagnosis can be made because not all clinical symptoms are present simultaneously as in the index case. Conclusions: This case highlights considering KD as a differential diagnosis of nonresolving fever in children with mucocutaneous findings. Intravenous immunoglobulin along with aspirin is the mainstay of therapy and should be started as early as possible to prevent detrimental cardiac complications. There is a high tendency of diagnostic dilemmas due to a wide array of nonspecific presentations thus healthcare providers must be more vigilant of this entity.
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000000472
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Article ; Online: Mosquito Olfactory Response Ensemble enables pattern discovery by curating a behavioral and electrophysiological response database

Abhishek Gupta / Swikriti S. Singh / Aarush M. Mittal / Pranjul Singh / Shefali Goyal / Karthikeyan R. Kannan / Arjit K. Gupta / Nitin Gupta

iScience, Vol 25, Iss 3, Pp 103938- (2022)

2022

Abstract: Summary: Many experimental studies have examined behavioral and electrophysiological responses of mosquitoes to odors. However, the differences across studies in data collection, processing, and reporting make it difficult to perform large-scale analyses ...

Abstract	Summary: Many experimental studies have examined behavioral and electrophysiological responses of mosquitoes to odors. However, the differences across studies in data collection, processing, and reporting make it difficult to perform large-scale analyses combining data from multiple studies. Here we extract and standardize data for 12 mosquito species, along with Drosophila melanogaster for comparison, from over 170 studies and curate the Mosquito Olfactory Response Ensemble (MORE), publicly available at https://neuralsystems.github.io/MORE. We demonstrate the ability of MORE in generating biological insights by finding patterns across studies. Our analyses reveal that ORs are tuned to specific ranges of several physicochemical properties of odorants; the empty-neuron recording technique for measuring OR responses is more sensitive than the Xenopus oocyte technique; there are systematic differences in the behavioral preferences reported by different types of assays; and odorants tend to become less attractive or more aversive at higher concentrations.
Keywords	Biological sciences ; Computer science applications ; Entomology ; Neuroscience ; Science ; Q
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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