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  1. Article ; Online: Multistep Biooxidation of 5-(Hydroxymethyl)furfural to 2,5-Furandicarboxylic Acid with H

    Swoboda, Alexander / Zwölfer, Silvie / Duhović, Zerina / Bürgler, Moritz / Ebner, Katharina / Glieder, Anton / Kroutil, Wolfgang

    ChemSusChem

    2024  , Page(s) e202400156

    Abstract: 5-(Hydroxymethyl)furfural (HMF) is a key platform chemical derived from renewable biomass sources, holding great potential as starting material for the synthesis of valuable compounds, thereby replacing petrochemical-derived counterparts. Among these ... ...

    Abstract 5-(Hydroxymethyl)furfural (HMF) is a key platform chemical derived from renewable biomass sources, holding great potential as starting material for the synthesis of valuable compounds, thereby replacing petrochemical-derived counterparts. Among these valorised compounds, 2,5-furandicarboxylic acid (FDCA) has emerged as a versatile building block. Here we demonstrate the biocatalytic synthesis of FDCA from HMF via a one-pot three-step oxidative cascade performed via two operative steps under mild reaction conditions employing two unspecific peroxygenases (UPOs) using hydrogen peroxide as the only oxidant. The challenge of HMF oxidation by UPOs is the chemoselectivity of the first step, as one of the two possible oxidation products is only a poor substrate for further oxidation. The unspecific peroxygenase from Marasmius oreades (MorUPO) was found to oxidize 100 mM of HMF to 5-formyl-2-furoic acid (FFCA) with 95 % chemoselectivity. In the sequential one-pot cascade employing MorUPO (TON up to 13535) and the UPO from Agrocybe aegerita (AaeUPO, TON up to 7079), 100 mM of HMF were oxidized to FDCA reaching up to 99 % conversion and yielding 861 mg isolated pure crystalline FDCA, presenting the first example of a gram scale biocatalytic synthesis of FDCA involving UPOs.
    Language English
    Publishing date 2024-04-03
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202400156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Das Kostenmanagement für unsichere Zeiten rüsten

    Swoboda, Alexander M

    CFO aktuell : Zeitschrift für Finance & Controlling Vol. 8, No. 2 , p. 64-67

    Enterprise Product Costing als umfassender Ansatz

    2014  Volume 8, Issue 2, Page(s) 64–67

    Author's details Alexander M. Swoboda
    Language German
    Size graph. Darst.
    Publisher Linde
    Publishing place Wien
    Document type Article
    ZDB-ID 2296327-3
    ISSN 1993-2960
    Database ECONomics Information System

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  3. Article: Structural and biochemical studies enlighten the unspecific peroxygenase from Hypoxylon sp. EC38 as an efficient oxidative biocatalyst.

    Rotilio, Laura / Swoboda, Alexander / Ebner, Katharina / Rinnofner, Claudia / Glieder, Anton / Kroutil, Wolfgang / Mattevi, Andrea

    ACS catalysis

    2021  Volume 11, Issue 18, Page(s) 11511–11525

    Abstract: Unspecific peroxygenases (UPO) are glycosylated fungal enzymes that can selectively oxidize C-H bonds. UPOs employ hydrogen peroxide as oxygen donor and reductant. With such an easy-to-handle co-substrate and without the need of a reducing agent, UPOs ... ...

    Abstract Unspecific peroxygenases (UPO) are glycosylated fungal enzymes that can selectively oxidize C-H bonds. UPOs employ hydrogen peroxide as oxygen donor and reductant. With such an easy-to-handle co-substrate and without the need of a reducing agent, UPOs are emerging as convenient oxidative biocatalysts. Here, an unspecific peroxygenase from
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 2155-5435
    ISSN 2155-5435
    DOI 10.1021/acscatal.1c03065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: International Trade and Money

    Connolly, Michael B / Swoboda, Alexander K

    (Routledge Library Editions: International Finance Ser)

    2018  

    Abstract: Cover -- Half Title Page -- Title Page -- Copyright Page -- Original Title Page -- Original Copyright Page -- Contents -- Editors' Preface -- Part I: Introduction -- 1. The Need for a Reconsideration of the Theory of International Trade -- Part II: ... ...

    Series title Routledge Library Editions: International Finance Ser
    Abstract Cover -- Half Title Page -- Title Page -- Copyright Page -- Original Title Page -- Original Copyright Page -- Contents -- Editors' Preface -- Part I: Introduction -- 1. The Need for a Reconsideration of the Theory of International Trade -- Part II: International Trade -- 2. Customs Unions, Preferential Systems and World Welfare -- 3. The Theory of Immiserizing Growth: Further Applications -- 4. Induced Technical Change and the Transfer Mechanism -- 5. The Simple Analytics of Multi-National Firm Behaviour -- 6. Trends in Income Distribution in some Western Countries -- Part III: International Monetary Analysis -- 7. A Model for the Analysis of Official Intervention in the Foreign Exchange Markets -- 8. Money Supply Process and Monetary Policy in an Open Economy -- 9. An Analysis of Currency Devaluation in Developing Countries -- 10. Some Misconceptions on the Sharing of the Burden of Adjustment between Deficit and Surplus Countries -- 11. The Monetary Approach to Balance-of-Payments Theory -- 12. Adjustment, Policy, and Monetary Equilibrium ina Two-Country Model -- Index
    Language English
    Size 1 Online-Ressource (265 pages)
    Document type Book ; Online
    ISBN 9781138542242 ; 9781351043892 ; 9781138542242 ; 1138542245 ; 1351043897 ; 1138542245
    Database ECONomics Information System

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  5. Article ; Online: Enantioselective High-Throughput Assay Showcased for the Identification of (R)- as well as (S)-Selective Unspecific Peroxygenases for C-H Oxidation.

    Swoboda, Alexander / Pfeifenberger, Lukas Johannes / Duhović, Zerina / Bürgler, Moritz / Oroz-Guinea, Isabel / Bangert, Klara / Weißensteiner, Florian / Parigger, Lena / Ebner, Katharina / Glieder, Anton / Kroutil, Wolfgang

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 46, Page(s) e202312721

    Abstract: Identifying (bio)catalysts displaying high enantio-/stereoselectivity is a fundamental prerequisite for the advancement of asymmetric catalysis. Herein, a high-throughput, stereoselective screening assay is reported that gives information on ... ...

    Abstract Identifying (bio)catalysts displaying high enantio-/stereoselectivity is a fundamental prerequisite for the advancement of asymmetric catalysis. Herein, a high-throughput, stereoselective screening assay is reported that gives information on enantioselectivity, stereopreference and activity as showcased for peroxygenase-catalyzed hydroxylation. The assay is based on spectrophotometric analysis of the simultaneous formation of NAD(P)H from the alcohol dehydrogenase catalyzed enantioselective oxidation of the sec-alcohol product formed in the peroxygenase reaction. The assay was applied to investigate a library comprising 44 unspecific peroxygenases (UPOs) containing 25 UPOs not reported yet. Thereby, previously non-described wild-type UPOs displaying (S)- as well as (R)-stereoselectivity for the hydroxylation of representative model substrates were identified, reaching up to 98 % ee for the (R)- and 94 % ee for the (S)-enantiomer. Homology models with concomitant docking studies indicated the structural reason for the observed complementary stereopreference.
    MeSH term(s) Stereoisomerism ; Mixed Function Oxygenases/metabolism ; Oxidation-Reduction ; Catalysis
    Chemical Substances peroxygenase (EC 1.14.-) ; Mixed Function Oxygenases (EC 1.-)
    Language English
    Publishing date 2023-10-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202312721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The SNB's new monetary policy framework ten years on

    Swoboda, Alexander K

    Swiss journal of economics and statistics Vol. 146, No. 1 , p. 413-417

    panel discussion

    2010  Volume 146, Issue 1, Page(s) 413–417

    Author's details contribution by Alexander Swoboda
    Language English
    Size graph. Darst.
    Publisher Lang
    Publishing place Bern
    Document type Article
    ZDB-ID 200233-4
    ISSN 0303-9692
    Database ECONomics Information System

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  7. Book ; Online: The new international monetary system

    Swoboda, Alexander K / Wyplosz, Charles

    essays in honour of Alexander Swoboda

    (Routledge International Studies in Money and Banking)

    2010  

    Abstract: Brings together some of the key international people in the field of monetary policy, central banking and exchange rate regimes to discuss contemporary international monetary ... ...

    Institution International Monetary Fund
    ebrary, Inc
    Author's details edited by Charles Wyplosz
    Series title Routledge International Studies in Money and Banking
    Abstract Brings together some of the key international people in the field of monetary policy, central banking and exchange rate regimes to discuss contemporary international monetary issues
    Keywords Foreign exchange rates ; International finance ; International liquidity
    Language English
    Size Online-Ressource (x, 185 p)
    Publisher Routledge
    Publishing place Abingdon, Oxon ;New York, NY
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9780203858394 ; 9780415560528 ; 0203858395 ; 0415560527
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Conference proceedings: The new international monetary system

    Swoboda, Alexander K / Wyplosz, Charles

    essays in honour of Alexander Swoboda

    (Routledge international studies in money and banking ; 57)

    2010  

    Institution International Monetary Fund
    Internationaler Währungsfonds
    Event/congress Conference (2008.05)
    Author's details ed. by Charles Wyplosz
    Series title Routledge international studies in money and banking ; 57
    Keywords Foreign exchange rates ; International finance ; International liquidity ; Notenbankpolitik ; Internationales Währungssystem ; Internationaler Finanzmarkt ; Wechselkurssystem ; Internationale Wirtschaftsbeziehungen ; Internationale Wirtschaftsorganisation ; Welt
    Language English
    Size X, 185 S., graph. Darst.
    Document type Book ; Conference proceedings
    Note Enth. 12 Beitr. ; Includes bibliographical references and index
    ISBN 0203858395 ; 0415560527 ; 9780203858394 ; 9780415560528
    Database ECONomics Information System

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  9. Article: Companion Animals as Models for Inhibition of STAT3 and STAT5.

    Kieslinger, Matthias / Swoboda, Alexander / Kramer, Nina / Pratscher, Barbara / Wolfesberger, Birgitt / Burgener, Iwan A

    Cancers

    2019  Volume 11, Issue 12

    Abstract: The use of transgenic mouse models has revolutionized the study of many human diseases. However, murine models are limited in their representation of spontaneously arising tumors and often lack key clinical signs and pathological changes. Thus, a closer ... ...

    Abstract The use of transgenic mouse models has revolutionized the study of many human diseases. However, murine models are limited in their representation of spontaneously arising tumors and often lack key clinical signs and pathological changes. Thus, a closer representation of complex human diseases is of high therapeutic relevance. Given the high failure rate of drugs at the clinical trial phase (i.e., around 90%), there is a critical need for additional clinically relevant animal models. Companion animals like cats and dogs display chronic inflammatory or neoplastic diseases that closely resemble the human counterpart. Cat and dog patients can also be treated with clinically approved inhibitors or, if ethics and drug safety studies allow, pilot studies can be conducted using, e.g., inhibitors of the evolutionary conserved JAK-STAT pathway. The incidence by which different types of cancers occur in companion animals as well as mechanisms of disease are unique between humans and companion animals, where one can learn from each other. Taking advantage of this situation, existing inhibitors of known oncogenic STAT3/5 or JAK kinase signaling pathways can be studied in the context of rare human diseases, benefitting both, the development of drugs for human use and their application in veterinary medicine.
    Language English
    Publishing date 2019-12-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11122035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Recurrent

    Kieslinger, Matthias / Swoboda, Alexander / Kramer, Nina / Freund, Patricia / Pratscher, Barbara / Neubauer, Heidi A / Steinborn, Ralf / Wolfesberger, Birgitt / Fuchs-Baumgartinger, Andrea / Moriggl, Richard / Burgener, Iwan A

    Cancers

    2021  Volume 13, Issue 20

    Abstract: Alimentary lymphomas arising from T cells are rare and aggressive malignancies in humans. In comparison, they represent the most common anatomical form of lymphoma in cats. Due to the low prevalence in humans, the underlying pathomechanism for these ... ...

    Abstract Alimentary lymphomas arising from T cells are rare and aggressive malignancies in humans. In comparison, they represent the most common anatomical form of lymphoma in cats. Due to the low prevalence in humans, the underlying pathomechanism for these diseases is poorly characterised, limiting experimental analysis and therapeutic exploration. To date, activating mutations of the JAK/STAT core cancer pathway and particularly the STAT5B oncoprotein have been identified in human enteropathy-associated T cell lymphoma. Here, we describe a high homology of human and feline STAT3 and STAT5B proteins and strong conservation at the genomic level. Analysis of 42 samples of feline T cell alimentary lymphoma reveals broad activation of STAT3 and STAT5B. Screening for known activating mutations in
    Language English
    Publishing date 2021-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13205238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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