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Article ; Online: Cardiac magnetic resonance assessment of athletic myocardial fibrosis; Benign bystander or malignant marker?

Javed, Wasim / Malhotra, Aneil / Swoboda, Peter

2023 Volume 394, Page(s) 131382

Abstract: The benefits of exercise are irrefutable with a well-established dose-dependent relationship between exercise intensity and reduction in cardiovascular disease. Differentiating the physiological adaptation to exercise, termed the "athlete's heart" from ... ...

Abstract	The benefits of exercise are irrefutable with a well-established dose-dependent relationship between exercise intensity and reduction in cardiovascular disease. Differentiating the physiological adaptation to exercise, termed the "athlete's heart" from cardiomyopathies, has been advanced by the advent of more sophisticated imaging modalities such as cardiac magnetic resonance imaging (CMR). Myocardial fibrosis on CMR is a mutual finding amongst seemingly healthy endurance athletes and individuals with cardiomyopathy. As a substrate for arrhythmias, fibrosis is traditionally associated with increased cardiovascular risk. In this article, we discuss the aetiologies, distribution and potential implications of myocardial fibrosis in athletes.
MeSH term(s)	Humans ; Predictive Value of Tests ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/pathology ; Magnetic Resonance Imaging ; Sports/physiology ; Fibrosis ; Athletes ; Magnetic Resonance Spectroscopy
Language	English
Publishing date	2023-09-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131382
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Book ; Thesis: Methodenvergleich zwischen der Tetracain-Tropfanästhesie kombiniert mit intraokular injizierten Tetracain und der Retrobulbäranästhesie mit Mepivacain bei der Phakoemulsifikation mit limbusparallelen Stufenschnitt

Swoboda, Peter Josef

eine prospektive Untersuchung an der Augenklinik am Marienplatz München

2003

Author's details	vorgelegt von Peter Josef Swoboda
Language	German
Size	50 Bl. : graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 2003
HBZ-ID	HT013938479
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Article: Human LUHMES and NES cells as models for studying primary cilia in neurons.

Coschiera, Andrea / Watts, Michelle Evelyn / Kere, Juha / Tammimies, Kristiina / Swoboda, Peter

Methods in cell biology

2023 Volume 176, Page(s) 27–41

Abstract: Primary cilia are antenna-like organelles emanating from the cell surface. They are involved in cell-to-cell communication and bidirectional signal transduction to/from the extracellular environment. During brain formation, cilia critically aid in ... ...

Abstract	Primary cilia are antenna-like organelles emanating from the cell surface. They are involved in cell-to-cell communication and bidirectional signal transduction to/from the extracellular environment. During brain formation, cilia critically aid in neurogenesis and maturation of neuronal structures such as axons, dendrites and synapses. Aberrations in cilia function can induce neuron differentiation defects and pathological consequences of varying severity, resulting in ciliopathies and likely a number of neurodevelopmental disorders. Despite the documented relevance of cilia for proper brain development, human neuronal models to recognize and study cilia biology are still scarce. We have established two types of cell models, Lund Human Mesencephalic (LUHMES) cells and neuroepithelial stem (NES) cells derived from induced pluripotent stem cells (iPSC), to investigate cilia biology in both proliferating neuronal progenitors/precursors and during the entire neuron differentiation and maturation process. We employ improved immunocytochemistry assays able to specifically detect cilia by confocal and super-resolution microscopy. We provide straightforward and robust methods to easily maintain cells in culture, for immunostaining and characterization of cilia orientation, anatomy and shape in human neurons across all stages of differentiation.
MeSH term(s)	Humans ; Cilia/physiology ; Neurons/metabolism ; Cell Differentiation ; Neurogenesis/physiology ; Induced Pluripotent Stem Cells
Language	English
Publishing date	2023-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0091-679X
ISSN	0091-679X
DOI	10.1016/bs.mcb.2022.12.012
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Article ; Online: Comparison of Stress-Rest and Stress-LGE Analysis Strategy in Patients Undergoing Stress Perfusion Cardiovascular Magnetic Resonance.

Swoboda, Peter P / Matthews, Gareth D K / Garg, Pankaj / Plein, Sven / Greenwood, John P

Circulation. Cardiovascular imaging

2023 Volume 16, Issue 12, Page(s) e014765

Abstract: Background: Stress perfusion cardiovascular magnetic resonance can be performed without rest perfusion for the quantification of ischemia burden. However, the optimal method of analysis is uncertain.: Methods: We identified 666 patients from CE-MARC ( ...

Abstract	Background: Stress perfusion cardiovascular magnetic resonance can be performed without rest perfusion for the quantification of ischemia burden. However, the optimal method of analysis is uncertain. Methods: We identified 666 patients from CE-MARC (Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease) with complete stress perfusion, rest perfusion, late gadolinium enhancement (LGE), and quantitative coronary angiography data. For each segment of the 16-segment model, perfusion was visually graded during stress and rest imaging, with infarct transmurality assessed from LGE imaging. In the stress-LGE analysis, a segment was defined as ischemic if it had a subendocardial perfusion defect with no infarction. Rest perfusion was not used in this analysis. We compared the diagnostic accuracy of stress-LGE analysis against quantitative coronary angiography and the stress-rest method validated in the original CE-MARC analysis. The diagnostic accuracy of the stress-LGE method was evaluated with different thresholds of infarct transmurality used to define whether an infarcted segment had peri-infarct ischemia. Results: The optimal stress-LGE analysis classified all segments with a stress perfusion defect as ischemic unless they had >75% infarct transmurality (area under the curve, 0.843; sensitivity, 75.6%; specificity, 93.1%; Conclusions: In this analysis of CE-MARC, the optimum definition of inducible ischemia was the presence of a stress-induced perfusion defect without transmural infarction. This definition improved the diagnostic accuracy compared with the stress-rest analysis validated in the original study. The absence of ischemia by either analysis strategy conferred a favorable long-term prognosis.
MeSH term(s)	Humans ; Contrast Media ; Predictive Value of Tests ; Gadolinium ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Ischemia ; Perfusion ; Infarction ; Magnetic Resonance Imaging, Cine/methods ; Myocardial Perfusion Imaging/methods
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2435045-X
ISSN	1942-0080 ; 1941-9651
ISSN (online)	1942-0080
ISSN	1941-9651
DOI	10.1161/CIRCIMAGING.123.014765
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Article: The Role of Cardiovascular Magnetic Resonance in Sports Cardiology; Current Utility and Future Perspectives.

Androulakis, Emmanuel / Swoboda, Peter P

Current treatment options in cardiovascular medicine

2018 Volume 20, Issue 10, Page(s) 86

Abstract: Purpose of review: Cardiovascular magnetic resonance (CMR) is frequently used in the investigation of suspected cardiac disease in athletes. In this review, we discuss how CMR can be used in athletes with suspected cardiomyopathy with particular ... ...

Abstract	Purpose of review: Cardiovascular magnetic resonance (CMR) is frequently used in the investigation of suspected cardiac disease in athletes. In this review, we discuss how CMR can be used in athletes with suspected cardiomyopathy with particular reference to volumetric analysis and tissue characterization. We also discuss the finding of non-ischaemic fibrosis in athletes describing its prevalence, distribution and clinical importance. Recent findings: The strengths of CMR include high spatial resolution, unrestricted imaging planes and lack of ionizing radiation. Regular physical exercise leads to cardiac remodeling that in certain situations can be clinically challenging to differentiate from various cardiomyopathies. Thorough morphological assessment by CMR is fundamental to ensuring accurate diagnosis. Developments in tissue characterization by late gadolinium enhancement and T1 mapping have the potential to be powerful additional tools in this challenging clinical situation. Using late gadolinium enhancement, it is also possible to detect non-ischaemic fibrosis in athletes who do not have overt cardiomyopathy. The mechanisms of this fibrosis are unclear; however, it does appear to be clinically important. We also review data on the prevalence of non-ischaemic fibrosis in athletes. CMR is a powerful tool to aid in the diagnosis of cardiomyopathy in athletes. It may also have a future role in assessing fibrosis related to long-term participation in sport.
Language	English
Publishing date	2018-08-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057337-6
ISSN	1534-3189 ; 1092-8464
ISSN (online)	1534-3189
ISSN	1092-8464
DOI	10.1007/s11936-018-0679-y
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Zs.A 5529: Show issues

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Article ; Online: Heart failure in Diabetic patients.

Swoboda, Peter P / Plein, Sven

European heart journal

2018 Volume 39, Issue 20, Page(s) 1755–1757

Language	English
Publishing date	2018-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehy201
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Nottingham Ischaemic Cardiovascular Magnetic Resonance resource (NotIs CMR): a prospective paired clinical and imaging scar database-protocol.

Jathanna, Nikesh / Strachan, Kevin / Erhayiem, Bara / Kamaruddin, Hazlyna / Swoboda, Peter / Auer, Dorothee / Chen, Xin / Jamil-Copley, Shahnaz

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2023 Volume 25, Issue 1, Page(s) 69

Abstract: Introduction: Research utilising artificial intelligence (AI) and cardiovascular magnetic resonance (CMR) is rapidly evolving with various objectives, however AI model development, generalisation and performance may be hindered by availability of robust ...

Abstract	Introduction: Research utilising artificial intelligence (AI) and cardiovascular magnetic resonance (CMR) is rapidly evolving with various objectives, however AI model development, generalisation and performance may be hindered by availability of robust training datasets including contrast enhanced images. Methods: NotIs CMR is a large UK, prospective, multicentre, observational cohort study to guide the development of a biventricular AI scar model. Patients with ischaemic heart disease undergoing clinically indicated contrast-enhanced cardiac magnetic resonance imaging will be recruited at Nottingham University Hospitals NHS Trust and Mid-Yorkshire Hospital NHS Trust. Baseline assessment will include cardiac magnetic resonance imaging, demographic data, medical history, electrocardiographic and serum biomarkers. Participants will undergo monitoring for a minimum of 5 years to document any major cardiovascular adverse events. The main objectives include (1) AI training, validation and testing to improve the performance, applicability and adaptability of an AI biventricular scar segmentation model being developed by the authors and (2) develop a curated, disease-specific imaging database to support future research and collaborations and, (3) to explore associations in clinical outcome for future risk prediction modelling studies. Conclusion: NotIs CMR will collect and curate disease-specific, paired imaging and clinical datasets to develop an AI biventricular scar model whilst providing a database to support future research and collaboration in Artificial Intelligence and ischaemic heart disease.
MeSH term(s)	Humans ; Cicatrix/diagnostic imaging ; Cicatrix/etiology ; Cicatrix/pathology ; Artificial Intelligence ; Prospective Studies ; Contrast Media ; Predictive Value of Tests ; Magnetic Resonance Imaging/methods ; Myocardial Ischemia/diagnostic imaging ; Coronary Artery Disease ; Magnetic Resonance Spectroscopy ; Magnetic Resonance Imaging, Cine ; Observational Studies as Topic
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-023-00978-1
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Article ; Online: Cardiac Magnetic Resonance Left Ventricular Filling Pressure Is Associated with NT-proBNP in Patients with New Onset Heart Failure.

Assadi, Hosamadin / Matthews, Gareth / Chambers, Bradley / Grafton-Clarke, Ciaran / Shabi, Mubien / Plein, Sven / Swoboda, Peter P / Garg, Pankaj

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 11

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Natriuretic Peptide, Brain ; Heart Failure ; Magnetic Resonance Imaging ; Stroke Volume/physiology ; Prognosis ; Magnetic Resonance Spectroscopy ; Biomarkers
Chemical Substances	pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Biomarkers
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59111924
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Article ; Online: Primary cilia promote the differentiation of human neurons through the WNT signaling pathway.

Coschiera, Andrea / Yoshihara, Masahito / Lauter, Gilbert / Ezer, Sini / Pucci, Mariangela / Li, Haonan / Kavšek, Alan / Riedel, Christian G / Kere, Juha / Swoboda, Peter

BMC biology

2024 Volume 22, Issue 1, Page(s) 48

Abstract: Background: Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell's immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of ciliary signaling ... ...

Abstract	Background: Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell's immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of ciliary signaling can lead to ciliopathies and certain neurodevelopmental disorders. In the developing brain cilia play well-documented roles for the expansion of the neural progenitor cell pool, while information about the roles of cilia during post-mitotic neuron differentiation and maturation is scarce. Results: We employed ciliated Lund Human Mesencephalic (LUHMES) cells in time course experiments to assess the impact of ciliary signaling on neuron differentiation. By comparing ciliated and non-ciliated neuronal precursor cells and neurons in wild type and in RFX2 -/- mutant neurons with altered cilia, we discovered an early-differentiation "ciliary time window" during which transient cilia promote axon outgrowth, branching and arborization. Experiments in neurons with IFT88 and IFT172 ciliary gene knockdowns, leading to shorter cilia, confirm these results. Cilia promote neuron differentiation by tipping WNT signaling toward the non-canonical pathway, in turn activating WNT pathway output genes implicated in cyto-architectural changes. Conclusions: We provide a mechanistic entry point into when and how ciliary signaling coordinates, promotes and translates into anatomical changes. We hypothesize that ciliary alterations causing neuron differentiation defects may result in "mild" impairments of brain development, possibly underpinning certain aspects of neurodevelopmental disorders.
MeSH term(s)	Humans ; Wnt Signaling Pathway ; Cilia/metabolism ; Neurons/physiology ; Cell Differentiation ; Neural Stem Cells/metabolism ; Cytoskeletal Proteins/metabolism ; Adaptor Proteins, Signal Transducing/metabolism
Chemical Substances	IFT172 protein, human ; Cytoskeletal Proteins ; Adaptor Proteins, Signal Transducing
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2133020-7
ISSN	1741-7007 ; 1741-7007
ISSN (online)	1741-7007
ISSN	1741-7007
DOI	10.1186/s12915-024-01845-w
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Article ; Online: Validation of Left Atrial Volume Correction for Single Plane Method on Four-Chamber Cine Cardiac MRI.

Assadi, Hosamadin / Sawh, Nicholas / Bailey, Ciara / Matthews, Gareth / Li, Rui / Grafton-Clarke, Ciaran / Mehmood, Zia / Kasmai, Bahman / Swoboda, Peter P / Swift, Andrew J / Geest, Rob J van der / Garg, Pankaj

Tomography (Ann Arbor, Mich.)

2024 Volume 10, Issue 4, Page(s) 459–470

Abstract: Background: Left atrial (LA) assessment is an important marker of adverse cardiovascular outcomes. Cardiovascular magnetic resonance (CMR) accurately quantifies LA volume and function based on biplane long-axis imaging. We aimed to validate single-plane- ...

Abstract	Background: Left atrial (LA) assessment is an important marker of adverse cardiovascular outcomes. Cardiovascular magnetic resonance (CMR) accurately quantifies LA volume and function based on biplane long-axis imaging. We aimed to validate single-plane-derived LA indices against the biplane method to simplify the post-processing of cine CMR. Methods: In this study, 100 patients from Leeds Teaching Hospitals were used as the derivation cohort. Bias correction for the single plane method was applied and subsequently validated in 79 subjects. Results: There were significant differences between the biplane and single plane mean LA maximum and minimum volumes and LA ejection fraction (EF) (all Conclusions: LA volumetric and functional assessment by the single plane method has a systematic bias compared to the biplane method. After bias correction, single plane LA volume and function are comparable to the biplane method.
MeSH term(s)	Humans ; Magnetic Resonance Imaging, Cine/methods ; Female ; Male ; Heart Atria/diagnostic imaging ; Middle Aged ; Aged ; Stroke Volume/physiology ; Reproducibility of Results ; Adult ; Image Interpretation, Computer-Assisted/methods
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Journal Article ; Validation Study ; Research Support, Non-U.S. Gov't
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography10040035
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