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  1. AU="Sydenstricker, Agnes V"
  2. AU="Glazer, Peter M"
  3. AU="Zhang, Haocheng"
  4. AU="Low, Tze-Yi"
  5. AU="Ratemi, Haithm W"
  6. AU="Lee, Kristy"
  7. AU="Nénon, Q"
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  9. AU="Parodi, Jose F"
  10. AU="Kabata, Yudai"
  11. AU="Butler, Javed"
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  13. AU="Artin, Hewa"
  14. AU="Bardakov, V M"
  15. AU="Sakaguchi, Bungo"
  16. AU="Boo, Irene"
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  21. AU="Gümüş, Funda"
  22. AU=Bhowmik Deep AU=Bhowmik Deep
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  25. AU="Sonkhya, Nishi"
  26. AU="Vaz, André"
  27. AU="Rugo, Hope S"
  28. AU="Gupta, Sonia"
  29. AU="Molday, Robert S"
  30. AU="Yaodong Hu"
  31. AU=Gimenez-Mascarell Paula
  32. AU="Orlandi, D"
  33. AU="Takeishi, Yasuchika"
  34. AU="Kamath, Karthik Shantharam" AU="Kamath, Karthik Shantharam"
  35. AU="Innocente, Alessandra"
  36. AU="Xing, Lei"
  37. AU="Chen, Mingyu"
  38. AU="Riedl, Sophie"
  39. AU="Ding, Haiyan"
  40. AU=Hu Xiumei AU=Hu Xiumei
  41. AU="Simmonds, Peter"
  42. AU="Chaturvedi, Apeksha"
  43. AU="Madden, Wyatt"
  44. AU="Wald, Moshe"
  45. AU="Zalesak, J."
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  47. AU="Modak, Manisha A"
  48. AU="Ottolini, Matteo"
  49. AU="Douglas Hanahan"
  50. AU="Bieniaszewska, Maria"
  51. AU="Alovisi, Camilla"
  52. AU="Lijfering, Willem M."
  53. AU="Rademacher, Jessica"
  54. AU="Dartigues, Jean-François"
  55. AU="Denicola, Anthony J"
  56. AU="Zhang, Xuewei"
  57. AU="Li, Yanjiao"
  58. AU="Botelho Meireles de Souza, Guilherme"
  59. AU="Gong, Yu-Qing"
  60. AU="Eisch, J"
  61. AU=De Vito Eduardo L
  62. AU="Lowsky, Robert"
  63. AU="Lindner, M."
  64. AU="Mugnai, Giacomo"
  65. AU="Chollet-Krugler, Marylène"
  66. AU="Firsanov, Denis"
  67. AU="Jo, Dong-Gyu"
  68. AU="Greenland, John R"
  69. AU="J Natale"
  70. AU="Drost, Carolin Christina"
  71. AU="Silvera, Risset"
  72. AU="Zgubič, M"
  73. AU="Russo, Rosita"
  74. AU="Ruiz-Ortega, Marta"
  75. AU="T Talbot"
  76. AU="Emoto, Kasey C"
  77. AU="Moos, W H" AU="Moos, W H"
  78. AU=Singh Sweta AU=Singh Sweta
  79. AU="Pimentel, Mauricio"
  80. AU="Kim, Ji Hee"
  81. AU=Ross Jeffrey S
  82. AU=Malhotra Atul
  83. AU="Tiesler, Carla M T"
  84. AU="Merighi, Adalberto" AU="Merighi, Adalberto"

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  1. Artikel ; Online: Urine proteomics by mass spectrometry identifies proteins involved in key pathogenic pathways in patients with juvenile dermatomyositis.

    Morales, Melissa / Alayi, Tchilabalo D / Tawalbeh, Shefa M / Sydenstricker, Agnes V / Spathis, Rita / Kim, Hanna / Nagaraju, Kanneboyina / Hathout, Yetrib / Rider, Lisa G

    Rheumatology (Oxford, England)

    2023  Band 62, Heft 9, Seite(n) 3161–3168

    Abstract: Objectives: To identify and validate biomarkers in JDM patients using a multiplexing tandem mass tag urine proteome profiling approach.: Methods: First morning void urine samples were collected from JDM patients (n = 20) and healthy control subjects ( ...

    Abstract Objectives: To identify and validate biomarkers in JDM patients using a multiplexing tandem mass tag urine proteome profiling approach.
    Methods: First morning void urine samples were collected from JDM patients (n = 20) and healthy control subjects (n = 21) and processed for analysis using a standardized liquid chromatography-tandem mass spectrometry approach. Biomarkers with significantly altered levels were correlated with clinical measures of myositis disease activity and damage. A subset of candidate biomarkers was validated using commercially available ELISA kits.
    Results: In total, 2348 proteins were detected in the samples, with 275 proteins quantified across all samples. Among the differentially altered proteins, cathepsin D and galectin-3 binding protein were significantly increased in the urine of JDM patients (adjusted P < 0.05), supporting previous findings in myositis patients. These two candidate biomarkers were confirmed with ELISAs. Cathepsin D positively correlated with Myositis Damage Index (r = 0.57, P < 0.05) and negatively correlated with the Childhood Myositis Assessment Scale (r = -0.54, P < 0.05). We also identified novel JDM candidate biomarkers involved with key features of myositis, including extracellular matrix remodelling proteins.
    Conclusion: This study confirmed the presence of several proteins in the urine of JDM patients that were previously found to be elevated in the blood of myositis patients and identified novel candidate biomarkers that require validation. These results support the use of urine as a source for biomarker development in JDM.
    Mesh-Begriff(e) Humans ; Child ; Dermatomyositis ; Cathepsin D ; Proteomics ; Myositis ; Mass Spectrometry
    Chemische Substanzen Cathepsin D (EC 3.4.23.5)
    Sprache Englisch
    Erscheinungsdatum 2023-01-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Seasonal Variation in Detection of Haemosporidia in a Bird Community: A Comparison of Nested PCR and Microscopy.

    Reinoso-Pérez, María Teresa / Dhondt, Keila V / Dulcet, Holland / Katzenstein, Nina / Sydenstricker, Agnes V / Dhondt, André A

    Journal of wildlife diseases

    2023  Band 60, Heft 1, Seite(n) 105–115

    Abstract: In a 2-yr study on prevalence of Haemosporidia in an avian community in Ithaca, New York, USA, we tested the hypothesis that apparent seasonal variation in prevalence is influenced by the detection protocol. We confirmed a higher detection of ... ...

    Abstract In a 2-yr study on prevalence of Haemosporidia in an avian community in Ithaca, New York, USA, we tested the hypothesis that apparent seasonal variation in prevalence is influenced by the detection protocol. We confirmed a higher detection of Haemosporidia using a molecular diagnosis technique (PCR) than by microscopy; this further increased when the PCR test was triplicated. Microscopic examination and PCR techniques have different specificity and sensitivity and therefore different probabilities of detecting hemoparasites. Birds with chronic infections or sampled during winter often have very low parasitemia, and such infections may be missed by microscopy but detected by PCR. Haemosporidian prevalence was higher during the breeding season than during the nonbreeding season regardless of the method used. Detection of Leucocytozoon spp. infection from blood smears using microscopy was challenging.
    Mesh-Begriff(e) Animals ; Seasons ; Microscopy/veterinary ; Bird Diseases/parasitology ; Protozoan Infections, Animal/diagnosis ; Protozoan Infections, Animal/epidemiology ; Protozoan Infections, Animal/parasitology ; Haemosporida/genetics ; Birds/parasitology ; Polymerase Chain Reaction/veterinary ; Polymerase Chain Reaction/methods ; Prevalence ; Plasmodium/genetics ; Phylogeny
    Sprache Englisch
    Erscheinungsdatum 2023-10-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 410709-3
    ISSN 1943-3700 ; 0090-3558
    ISSN (online) 1943-3700
    ISSN 0090-3558
    DOI 10.7589/JWD-D-23-00023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Complex interactions between bacteria and haemosporidia in coinfected hosts: An experiment.

    Reinoso-Pérez, María Teresa / Dhondt, Keila V / Sydenstricker, Agnes V / Heylen, Dieter / Dhondt, André A

    Ecology and evolution

    2020  Band 10, Heft 12, Seite(n) 5801–5814

    Abstract: Hosts are typically coinfected by multiple parasite species whose interactions might be synergetic or antagonistic, producing unpredictable physiological and pathological impacts on the host. This study shows the interaction ... ...

    Abstract Hosts are typically coinfected by multiple parasite species whose interactions might be synergetic or antagonistic, producing unpredictable physiological and pathological impacts on the host. This study shows the interaction between
    Sprache Englisch
    Erscheinungsdatum 2020-04-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.6318
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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