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  1. Article: Safety and efficacy of minimally invasive percutaneous nephrolithotomy for infantile nephrolithiasis. Single centre experience from Pakistan.

    Ahmad, Tariq / Minallah, Nasrum / Khaliq, Nida / Rashid, Hania / Syed, Misbah / Almuradi, Moath Ahmad Abdullah

    Frontiers in pediatrics

    2023  Volume 10, Page(s) 1035964

    Abstract: Objective: To assess the efficacy and safety of mini-percutaneous nephrolithotomy (PCNL) for small renal stones 1-2 cm in size in infants less than one year.: Material and methods: This descriptive case series was conducted in the department of ... ...

    Abstract Objective: To assess the efficacy and safety of mini-percutaneous nephrolithotomy (PCNL) for small renal stones 1-2 cm in size in infants less than one year.
    Material and methods: This descriptive case series was conducted in the department of pediatric urology Institute of Kidney Diseases Peshawar, Pakistan, from March 2019 to March 2022. All the patients underwent mini-PCNL in prone position under GA with 14 Fr access sheath and 10 Fr nephroscope. Stone clearance was assessed by non-contrast CT KUB at 30th postoperative day. Patients with no residual fragments on the non-contrast CT KUB were defined as stone-free. Patients with residual fragments of any size were defined as procedure failure. Safety was determined in terms of intra and postoperative complications.
    Results: A total of 51 infants were included in the study. The mean age of patients was 9.6 + 1.8 (5-12 month). The mean stone size was 15.8 + 2.7 (10-21) mm in length and 12.3 + 2.2 (8-17) mm in width. PCNL mean operative time was 51.6 ± 7.1 (40-70) minutes. Complete stone clearance at one month was observed in 46 (90.2%) patients. Residual fragments were seen in 5(9.8%) patients with a mean size of 1.6 + 0.4 (0.9-2.0) mm. None of the patients required any additional procedure for clearance of stones. In 7 (13.7%) patients, some post-operative complications were observe, all were grade I complications, including fever in 5(9.8%) and transient hematuria in 2(3.9%) patients.
    Conclusion: Mini-PCNL is a safe and effective treatment for renal stones in infants measuring 1-2 cm with high SFR and an acceptable complication rate.
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.1035964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Kinetics and Mechanism of Paracetamol Oxidation by Chromium(VI) in Absence and Presence of Manganese(II) and Sodiumdodecyl Sulphate

    Mohammed Ilyas / Maqsood Ahmad Malik / Syed Misbah Zahoor Andrabi / Zaheer Khan

    Research Letters in Physical Chemistry, Vol

    2007  Volume 2007

    Abstract: The kinetics of paracetamol oxidation are first order each in [paracetamol] and [HClO4]. The kinetic study shows that the oxidation proceeds in two steps. The effects of anionic micelles of sodiumdodecyl sulphate (SDS) and complexing agents ( ... ...

    Abstract The kinetics of paracetamol oxidation are first order each in [paracetamol] and [HClO4]. The kinetic study shows that the oxidation proceeds in two steps. The effects of anionic micelles of sodiumdodecyl sulphate (SDS) and complexing agents (ethylenediammine tetraacetic acid (EDTA) and 2,2′-bipyridyl (bpy)) were also studied. Fast kinetic spectrophotometric method has been described for the determination of paracetamol. The method is based on the catalytic effect of manganese(II) on the oxidation of paracetamol by chromium(VI) in the presence of HClO4 (= 0.23 mol dm−3). Optimum reaction time is 4 to 6 minutes at a temperature of 30∘C. The addition of manganese(II) ions largely decreased the absorbance of chromium(VI) at 350 nm. This reaction can be utilized for the determination of paracetamol in drugs.
    Keywords Science ; Q ; Chemistry ; QD1-999 ; Physical and theoretical chemistry ; QD450-801
    Subject code 660
    Language English
    Publishing date 2007-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Kinetics and Mechanism of Paracetamol Oxidation by Chromium(VI) in Absence and Presence of Manganese(II) and Sodiumdodecyl Sulphate

    Maqsood Ahmad Malik / Mohammed Ilyas / Syed Misbah Zahoor Andrabi / Zaheer Khan

    Research Letters in Physical Chemistry, Vol

    2007  Volume 2007

    Abstract: The kinetics of paracetamol oxidation are first order each in [paracetamol] and [HClO4]. The kinetic study shows that the oxidation proceeds in two steps. The effects of anionic micelles of sodiumdodecyl sulphate (SDS) and complexing agents ( ... ...

    Abstract The kinetics of paracetamol oxidation are first order each in [paracetamol] and [HClO4]. The kinetic study shows that the oxidation proceeds in two steps. The effects of anionic micelles of sodiumdodecyl sulphate (SDS) and complexing agents (ethylenediammine tetraacetic acid (EDTA) and 2,2′-bipyridyl (bpy)) were also studied. Fast kinetic spectrophotometric method has been described for the determination of paracetamol. The method is based on the catalytic effect of manganese(II) on the oxidation of paracetamol by chromium(VI) in the presence of HClO4 (= 0.23 mol dm−3). Optimum reaction time is 4 to 6 minutes at a temperature of 30∘C. The addition of manganese(II) ions largely decreased the absorbance of chromium(VI) at 350 nm. This reaction can be utilized for the determination of paracetamol in drugs.
    Keywords Science ; Q ; Chemistry ; QD1-999 ; Physical and theoretical chemistry ; QD450-801
    Subject code 660
    Language English
    Publishing date 2007-11-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effectiveness Study of Paromomycin IM Injection (PMIM) for the Treatment of Visceral Leishmaniasis (VL) in Bangladesh.

    Kazi M Jamil / Rashidul Haque / Ridwanur Rahman / M Abul Faiz / Abu Toha Md Rezwanul Haque Bhuiyan / Amresh Kumar / Syed Misbah Hassan / Heather Kelly / Pritu Dhalaria / Sonali Kochhar / Philippe Desjeux / Mohammad A A Bhuiyan / Mohammed M Khan / Raj Shankar Ghosh

    PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e

    2015  Volume 0004118

    Abstract: BACKGROUND:This study was conducted in Bangladeshi patients in an outpatient setting to support registration of Paromomycin Intramuscular Injection (PMIM) as a low-cost treatment option in Bangladesh. METHODOLOGY:This Phase IIIb, open-label, multi-center, ...

    Abstract BACKGROUND:This study was conducted in Bangladeshi patients in an outpatient setting to support registration of Paromomycin Intramuscular Injection (PMIM) as a low-cost treatment option in Bangladesh. METHODOLOGY:This Phase IIIb, open-label, multi-center, single-arm trial assessed the efficacy and safety of PMIM administered at 11 mg/kg (paromomycin base) intramuscularly once daily for 21 consecutive days to children and adults with VL in a rural outpatient setting in Bangladesh. Patients ≥5 and ≤55 years were eligible if they had signs and symptoms of VL (intermittent fever, weight loss/decreased appetite, and enlarged spleen), positive rK39 test, and were living in VL-endemic areas. Compliance was the percentage of enrolled patients who received 21 daily injections over no more than 22 days. Efficacy was evaluated by initial clinical response, defined as resolution of fever and reduction of splenomegaly at end of treatment, and final clinical response, defined as the absence of new clinical signs and symptoms of VL 6 months after end of treatment. Safety was assessed by evaluation of adverse events. PRINCIPAL FINDINGS:A total of 120 subjects (49% pediatric) were enrolled. Treatment compliance was 98.3%. Initial clinical response in the Intent-to-Treat population was 98.3%, and final clinical response 6 months after end of treatment was 94.2%. Of the 119 subjects who received ≥1 dose of PMIM, 28.6% reported at least one adverse event. Injection site pain was the most commonly reported adverse event. Reversible renal impairment and/or hearing loss were reported in 2 subjects. CONCLUSIONS/SIGNIFICANCE:PMIM was an effective and safe treatment for VL in Bangladesh. The short treatment duration and lower cost of PMIM compared with other treatment options may make this drug a preferred treatment to be investigated as part of a combination therapy regimen. This study supports the registration of PMIM for use in government health facilities in Bangladesh. TRIAL REGISTRATION:ClinicalTrials.gov identifier: NCT01328457.
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  5. Article ; Online: Effectiveness Study of Paromomycin IM Injection (PMIM) for the Treatment of Visceral Leishmaniasis (VL) in Bangladesh.

    Jamil, Kazi M / Haque, Rashidul / Rahman, Ridwanur / Faiz, M Abul / Bhuiyan, Abu Toha Md Rezwanul Haque / Kumar, Amresh / Hassan, Syed Misbah / Kelly, Heather / Dhalaria, Pritu / Kochhar, Sonali / Desjeux, Philippe / Bhuiyan, Mohammad A A / Khan, Mohammed M / Ghosh, Raj Shankar

    PLoS neglected tropical diseases

    2015  Volume 9, Issue 10, Page(s) e0004118

    Abstract: Background: This study was conducted in Bangladeshi patients in an outpatient setting to support registration of Paromomycin Intramuscular Injection (PMIM) as a low-cost treatment option in Bangladesh.: Methodology: This Phase IIIb, open-label, multi- ...

    Abstract Background: This study was conducted in Bangladeshi patients in an outpatient setting to support registration of Paromomycin Intramuscular Injection (PMIM) as a low-cost treatment option in Bangladesh.
    Methodology: This Phase IIIb, open-label, multi-center, single-arm trial assessed the efficacy and safety of PMIM administered at 11 mg/kg (paromomycin base) intramuscularly once daily for 21 consecutive days to children and adults with VL in a rural outpatient setting in Bangladesh. Patients ≥5 and ≤55 years were eligible if they had signs and symptoms of VL (intermittent fever, weight loss/decreased appetite, and enlarged spleen), positive rK39 test, and were living in VL-endemic areas. Compliance was the percentage of enrolled patients who received 21 daily injections over no more than 22 days. Efficacy was evaluated by initial clinical response, defined as resolution of fever and reduction of splenomegaly at end of treatment, and final clinical response, defined as the absence of new clinical signs and symptoms of VL 6 months after end of treatment. Safety was assessed by evaluation of adverse events.
    Principal findings: A total of 120 subjects (49% pediatric) were enrolled. Treatment compliance was 98.3%. Initial clinical response in the Intent-to-Treat population was 98.3%, and final clinical response 6 months after end of treatment was 94.2%. Of the 119 subjects who received ≥1 dose of PMIM, 28.6% reported at least one adverse event. Injection site pain was the most commonly reported adverse event. Reversible renal impairment and/or hearing loss were reported in 2 subjects.
    Conclusions/significance: PMIM was an effective and safe treatment for VL in Bangladesh. The short treatment duration and lower cost of PMIM compared with other treatment options may make this drug a preferred treatment to be investigated as part of a combination therapy regimen. This study supports the registration of PMIM for use in government health facilities in Bangladesh.
    Trial registration: ClinicalTrials.gov identifier: NCT01328457.
    MeSH term(s) Adolescent ; Adult ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/adverse effects ; Anti-Infective Agents/economics ; Bangladesh ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/pathology ; Female ; Health Care Costs ; Humans ; Injections, Intramuscular ; Leishmaniasis, Visceral/drug therapy ; Male ; Middle Aged ; Paromomycin/administration & dosage ; Paromomycin/adverse effects ; Paromomycin/economics ; Treatment Outcome ; Young Adult
    Chemical Substances Anti-Infective Agents ; Paromomycin (61JJC8N5ZK)
    Language English
    Publishing date 2015-10-23
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0004118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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