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Book ; Online: Utilizing ChatGPT to Enhance Clinical Trial Enrollment

Peikos, Georgios / Symeonidis, Symeon / Kasela, Pranav / Pasi, Gabriella

2023

Abstract: Clinical trials are a critical component of evaluating the effectiveness of new medical interventions and driving advancements in medical research. Therefore, timely enrollment of patients is crucial to prevent delays or premature termination of trials. ... ...

Abstract	Clinical trials are a critical component of evaluating the effectiveness of new medical interventions and driving advancements in medical research. Therefore, timely enrollment of patients is crucial to prevent delays or premature termination of trials. In this context, Electronic Health Records (EHRs) have emerged as a valuable tool for identifying and enrolling eligible participants. In this study, we propose an automated approach that leverages ChatGPT, a large language model, to extract patient-related information from unstructured clinical notes and generate search queries for retrieving potentially eligible clinical trials. Our empirical evaluation, conducted on two benchmark retrieval collections, shows improved retrieval performance compared to existing approaches when several general-purposed and task-specific prompts are used. Notably, ChatGPT-generated queries also outperform human-generated queries in terms of retrieval performance. These findings highlight the potential use of ChatGPT to enhance clinical trial enrollment while ensuring the quality of medical service and minimizing direct risks to patients. Comment: Under Review
Keywords	Computer Science - Information Retrieval ; Computer Science - Computation and Language
Subject code	004
Publishing date	2023-06-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Microwave ablation of a solitary colorectal liver metastasis complicated by stomach perforation and gastrocutaneous fistula - a case report.

Symeonidis, S / Giankoulof, C / Christidis, P / Anestiadou, E / Loutzidou, L / Bitsianis, S / Ioannidis, O / Tsalis, K / Angelopoulos, S / Petsatodis, E

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

2022 Volume 35, Issue 4, Page(s) 323–327

Abstract: Background: Organ perforation secondary to thermal ablation is a rare but severe complication that can occur in certain patients, in whom tissue dissection and preservation cannot be adequately achieved.: Case description: A 69-year-old man presented ...

Title translation	Mikrovlnná ablace solitární jaterní metastázy kolorektálního karcinomu komplikované perforací žaludku a gastrokutánní píštělí - kazuistika.
Abstract	Background: Organ perforation secondary to thermal ablation is a rare but severe complication that can occur in certain patients, in whom tissue dissection and preservation cannot be adequately achieved. Case description: A 69-year-old man presented with a gastrocutaneous fistula 20 days after a microwave ablation of liver metastases from colorectal cancer. Besides skin rash, local tenderness, and gastric content discharge from a wound where the probe had been placed, no other signs or symptoms were present. The patient was treated surgically, and a wedge-shaped gastric resection was performed. His postoperative course was uneventful. After 8 months, the patient underwent the same procedure for local progression of the same lesion, using a pulsed MW antenna and a dedicated hydrodissection needle, without complications. Conclusions: A gastrocutaneous fistula is a rare complication of microwave ablation. However, adequate hydrodissection can minimize the risk for the development of these complications. Proper treatment of these complications does not preclude repeated usage of microwave ablation in the future.
MeSH term(s)	Aged ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Gastric Fistula/etiology ; Gastric Fistula/surgery ; Humans ; Liver Neoplasms/therapy ; Male ; Microwaves/adverse effects ; Stomach/pathology ; Treatment Outcome
Language	English
Publishing date	2022-06-23
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	1217739-8
ISSN	1802-5307 ; 0862-495X
ISSN (online)	1802-5307
ISSN	0862-495X
DOI	10.48095/ccko2022323
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HTR for Greek Historical Handwritten Documents.

Tsochatzidis, Lazaros / Symeonidis, Symeon / Papazoglou, Alexandros / Pratikakis, Ioannis

Journal of imaging

2021 Volume 7, Issue 12

Abstract: Offline handwritten text recognition (HTR) for historical documents aims for effective transcription by addressing challenges that originate from the low quality of manuscripts under study as well as from several particularities which are related to the ... ...

Abstract	Offline handwritten text recognition (HTR) for historical documents aims for effective transcription by addressing challenges that originate from the low quality of manuscripts under study as well as from several particularities which are related to the historical period of writing. In this paper, the challenge in HTR is related to a focused goal of the transcription of Greek historical manuscripts that contain several particularities. To this end, in this paper, a convolutional recurrent neural network architecture is proposed that comprises octave convolution and recurrent units which use effective gated mechanisms. The proposed architecture has been evaluated on three newly created collections from Greek historical handwritten documents that will be made publicly available for research purposes as well as on standard datasets like IAM and RIMES. For evaluation we perform a concise study which shows that compared to state of the art architectures, the proposed one deals effectively with the challenging Greek historical manuscripts.
Language	English
Publishing date	2021-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2824270-1
ISSN	2313-433X ; 2313-433X
ISSN (online)	2313-433X
ISSN	2313-433X
DOI	10.3390/jimaging7120260
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Article ; Online: Laparoscopic para-aortic lymphadenectomy for metastatic colon cancer in a patient with left-sided inferior vena cava: a case report.

Kotidis, Efstathios / Anestiadou, Elissavet / Karamitsou, Aikaterini / Gemousakakis, Georgios / Ioannidis, Orestis / Bitsianis, Stefanos / Symeonidis, Savvas / Ouzounidis, Nikolaos / Lomvardeas, Odysseas / Aggelopoulos, Stamatios

Folia medica

2024 Volume 65, Issue 6, Page(s) 1015–1019

Abstract: Transposition of inferior vena cava, or, left-sided inferior vena cava (LS-IVC) is a rare clinical entity, in which the inferior vena cava ascends along the left side of the abdominal aorta. Literature contains mainly clinical case reports. Although it ... ...

Abstract	Transposition of inferior vena cava, or, left-sided inferior vena cava (LS-IVC) is a rare clinical entity, in which the inferior vena cava ascends along the left side of the abdominal aorta. Literature contains mainly clinical case reports. Although it is usually not associated with clinical symptomatology, this anomaly should be detected during preoperative planning to avoid iatrogenic injuries intraoperatively. We present a case of left-sided inferior vena cava encountered during laparoscopic lymphadenectomy in a 45-year-old man with previous laparoscopic hemicolectomy due to colon adenocarcinoma. Preoperative CT abdomen revealed the left-sided location of infrarenal IVC and laparoscopic trans-peritoneal aortic lymphadenectomy was decided. Intraoperatively, transposition of inferior vena cava was confirmed in accordance with the CT findings. Resection of lymph node block was conducted with no complications and with minimal blood loss. The postoperative course was uneventful, and the patient was discharged from the hospital the day following surgery. In conclusion, transposition of the inferior vena cava, although rare, constitutes an anatomical variant that should be identified preoperatively to decrease intraoperative risks. Several anatomical variants have been associated with left-sided inferior vena cava.
MeSH term(s)	Male ; Humans ; Middle Aged ; Vena Cava, Inferior/surgery ; Vena Cava, Inferior/abnormalities ; Adenocarcinoma/surgery ; Colonic Neoplasms/surgery ; Laparoscopy ; Lymph Node Excision ; Rectal Neoplasms/surgery
Language	English
Publishing date	2024-02-14
Publishing country	Bulgaria
Document type	Case Reports ; Journal Article
ZDB-ID	300275-5
ISSN	1314-2143 ; 0430-8638 ; 0204-8043
ISSN (online)	1314-2143
ISSN	0430-8638 ; 0204-8043
DOI	10.3897/folmed.65.e96691
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Article: Use of Deferasirox Film-Coated Tablets in Pediatric Patients with Transfusion Dependent Thalassemia: A Single Center Experience.

Adramerina, Alkistis / Printza, Nikoleta / Hatzipantelis, Emmanouel / Symeonidis, Symeon / Tarazi, Labib / Teli, Aikaterini / Economou, Marina

Biology

2022 Volume 11, Issue 2

Abstract: Thalassemic syndromes are characterized by clinical heterogenicity. For severe disease forms, lifelong blood transfusions remain the mainstay of therapy, while iron overload monitoring and adequate chelation treatment are required in order to ensure ... ...

Abstract	Thalassemic syndromes are characterized by clinical heterogenicity. For severe disease forms, lifelong blood transfusions remain the mainstay of therapy, while iron overload monitoring and adequate chelation treatment are required in order to ensure effective disease management. Compared to previous chelators, the new deferasirox film-coated tablet (DFX FCT) is considered to offer a more convenient and well-tolerated treatment scheme, aiming at better treatment-related and patient-related outcomes. The present study's objective was to prospectively evaluate the safety and efficacy of DFX FCT in children and adolescents with transfusion-dependent thalassemia. Data collected included patient demographics, hematology and biochemistry laboratory work up, magnetic resonance imaging of heart and liver for iron load, as well as ophthalmological and audiological examination prior to and a year following drug administration. Study results confirmed DFX FCT safety in older children in a manner similar to adults, but demonstrated increased frequency of adverse events in younger patients, mainly, involving liver function. With regards to efficacy, study results confirmed the preventive role of DFX FCT in iron loading of liver and heart, however, higher doses than generally recommended were required in order to ensure adequate chelation.
Language	English
Publishing date	2022-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11020247
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Near-infrared cholangiography with intragallbladder indocyanine green injection in minimally invasive cholecystectomy.

Symeonidis, Savvas / Mantzoros, Ioannis / Anestiadou, Elissavet / Ioannidis, Orestis / Christidis, Panagiotis / Bitsianis, Stefanos / Bisbinas, Vasiliki / Zapsalis, Konstantinos / Karastergiou, Trigona / Athanasiou, Dimitra / Apostolidis, Stylianos / Angelopoulos, Stamatios

World journal of gastrointestinal surgery

2024 Volume 16, Issue 4, Page(s) 1017–1029

Abstract: Laparoscopic cholecystectomy (LC) remains one of the most commonly performed procedures in adult and paediatric populations. Despite the advances made in intraoperative biliary anatomy recognition, iatrogenic bile duct injuries during LC represent a ... ...

Abstract	Laparoscopic cholecystectomy (LC) remains one of the most commonly performed procedures in adult and paediatric populations. Despite the advances made in intraoperative biliary anatomy recognition, iatrogenic bile duct injuries during LC represent a fatal complication and consist an economic burden for healthcare systems. A series of methods have been proposed to prevent bile duct injury, among them the use of indocyanine green (ICG) fluorescence. The most commonly reported method of ICG injection is the intravenous administration, while literature is lacking studies investigating the direct intragallbladder ICG injection. This narrative mini-review aims to assess the potential applications, usefulness, and limitations of intragallbladder ICG fluorescence in LC. Authors screened the available international literature to identify the reports of intragallbladder ICG fluorescence imaging in minimally invasive cholecystectomy, as well as special issues regarding its use. Literature search retrieved four prospective cohort studies, three case-control studies, and one case report. In the three case-control studies selected, intragallbladder near-infrared cholangiography (NIRC) was compared with standard LC under white light, with intravenous administration of ICG for NIRC and with standard intraoperative cholangiography (IOC). In total, 133 patients reported in the literature have been administered intragallbladder ICG administration for biliary mapping during LC. Literature includes several reports of intragallbladder ICG administration, but a standardized technique has not been established yet. Published data suggest that NIRC with intragallbladder ICG injection is a promising method to achieve biliary mapping, overwhelming limitations of IOC including intervention and radiation exposure, as well as the high hepatic parenchyma signal and time interval needed in intravenous ICG fluorescence. Evidence-based guidelines on the role of intragallbladder ICG fluorescence in LC require the assessment of further studies and multicenter data collection into large registries.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573700-4
ISSN	1948-9366
ISSN	1948-9366
DOI	10.4240/wjgs.v16.i4.1017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Biliary Anatomy Visualization and Surgeon Satisfaction Using Standard Cholangiography versus Indocyanine Green Fluorescent Cholangiography during Elective Laparoscopic Cholecystectomy: A Randomized Controlled Trial.

Symeonidis, Savvas / Mantzoros, Ioannis / Anestiadou, Elissavet / Ioannidis, Orestis / Christidis, Panagiotis / Bitsianis, Stefanos / Zapsalis, Konstantinos / Karastergiou, Trigona / Athanasiou, Dimitra / Apostolidis, Stylianos / Angelopoulos, Stamatios

Journal of clinical medicine

2024 Volume 13, Issue 3

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030864
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Treatment Individualization Using Pharmacokinetic Studies and Joint Ultrasound Imaging in Pediatric Patients With Hemophilia.

Adramerina, Alkistis / Teli, Aikaterini / Symeonidis, Symeon / Gelsis, Ioannis / Gourtsa, Vaia / Economou, Marina

Journal of pediatric hematology/oncology

2021 Volume 44, Issue 5, Page(s) 237–242

Abstract: Hemophilia is characterized by bleeding diathesis, primarily affecting the joints. Prophylactic use of missing factor aims at limiting the number of bleeds and, in the long term, the risk of permanent joint damage. However, standard prophylactic regimens ...

Abstract	Hemophilia is characterized by bleeding diathesis, primarily affecting the joints. Prophylactic use of missing factor aims at limiting the number of bleeds and, in the long term, the risk of permanent joint damage. However, standard prophylactic regimens are usually applied empirically, not adjusting for variations in bleeding phenotype or drug metabolism. Aim of the present study was to evaluate the need for individualizing prophylaxis, with guidance of pharmacokinetic (PK) studies and joint ultrasound in a setting of everyday clinical practice. To evaluate adequacy of applied regimens, joint status was assessed using the Hemophilia Joint Health Score as well as ultrasound imaging, while PK studies were performed using the Web-Accessible Population Pharmacokinetic Service-Hemophilia. Imaging results were consistent with early joint damage in a large proportion of pediatric patients, whereas PK measures were indicative of inadequate prophylaxis in many cases-despite the limited number of bleeds reported by patients. The study revealed the need for prophylaxis adjustment in the majority of patients. Real world data confirm that traditional prophylaxis is often unable to achieve therapeutic goals, while an individualized approach, guided by the use of novel modalities, may be of great benefit to young hemophilia patients.
MeSH term(s)	Child ; Factor VIII/therapeutic use ; Hemarthrosis/diagnostic imaging ; Hemarthrosis/etiology ; Hemarthrosis/prevention & control ; Hemophilia A/complications ; Hemophilia A/diagnostic imaging ; Hemophilia A/drug therapy ; Hemorrhage/drug therapy ; Hemorrhage/etiology ; Hemorrhage/prevention & control ; Humans ; Phenotype ; Ultrasonography
Chemical Substances	Factor VIII (9001-27-8)
Language	English
Publishing date	2021-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000002323
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Amyand's Hernia as a Random Finding in Acute Abdominal Pain and the Role of Thorough Investigation: a Case Report.

Tsalis, Konstantinos / Symeonidis, Savvas / Anestiadou, Elissavet / Bitsianis, Stefanos / Christidis, Panagiotis / Loutzidou, Lydia / Ouzounidis, Nikolaos / Kotidis, Efstathios / Gemousakakis, Georgios / Angelopoulos, Stamatios

Maedica

2022 Volume 17, Issue 3, Page(s) 720–725

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-12-20
Publishing country	Romania
Document type	Editorial
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
DOI	10.26574/maedica.2022.17.3.720
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Article: Abdominal Wall Defect Reconstruction with Use of Biological Mesh and Negative Pressure Wound Therapy: a Case Report.

Symeonidis, Savvas / Anestiadou, Elissavet / Bitsianis, Stefanos / Gemousakakis, Georgios / Ntampakis, Georgios / Loutzidou, Lydia / Ouzounidis, Nikolaos / Kotidis, Efstathios / Mantzoros, Ioannis / Angelopoulos, Stamatios

Maedica

2022 Volume 17, Issue 2, Page(s) 518–523

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2022-07-11
Publishing country	Romania
Document type	Editorial
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
DOI	10.26574/maedica.2022.17.2.518
Database	MEDical Literature Analysis and Retrieval System OnLINE

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