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Article ; Online: FIT for colonoscopy: Benefits of the faecal immunochemical test for triaging symptomatic patients.

Symonds, Erin L / Winter, Jean M

The Lancet regional health. Europe

2022 Volume 23, Page(s) 100528

Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Journal Article
ISSN	2666-7762
ISSN (online)	2666-7762
DOI	10.1016/j.lanepe.2022.100528
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Article ; Online: BCAT1

Laven-Law, Geraldine / Kichenadasse, Ganessan / Young, Graeme P / Symonds, Erin L / Winter, Jean M

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

2024 Volume 29, Issue 4, Page(s) 194–204

Abstract: Introduction: Methylated circulating tumour DNA (ctDNA) blood tests for : Methods: Tissue DNA methylation data from colorectal (COAD, READ), gastroesophageal (ESCA, STAD), pancreatic (PAAD) and cholangiocarcinoma (CHOL) adenocarcinoma cohorts within ... ...

Abstract	Introduction: Methylated circulating tumour DNA (ctDNA) blood tests for Methods: Tissue DNA methylation data from colorectal (COAD, READ), gastroesophageal (ESCA, STAD), pancreatic (PAAD) and cholangiocarcinoma (CHOL) adenocarcinoma cohorts within The Cancer Genome Atlas were used for differential methylation analyses. Clinicodemographic predictors of Results: Hypermethylated Discussion: Existing CRC methylated ctDNA blood tests for
MeSH term(s)	Humans ; Septins/genetics ; Septins/blood ; DNA Methylation ; Ikaros Transcription Factor/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/blood ; Adenocarcinoma/genetics ; Adenocarcinoma/diagnosis ; Adenocarcinoma/blood ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/blood ; Male ; Circulating Tumor DNA/genetics ; Circulating Tumor DNA/blood ; Female ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/blood ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/diagnosis ; Cholangiocarcinoma/blood ; Middle Aged ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/blood
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1324372-x
ISSN	1366-5804 ; 1354-750X
ISSN (online)	1366-5804
ISSN	1354-750X
DOI	10.1080/1354750X.2024.2340663
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Zs.A 4864: Show issues

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Article ; Online: Validation of the Consumer Health Activation Index (CHAI) in general population samples of older Australians.

Flight, Ingrid / Harrison, Nathan J / Symonds, Erin L / Young, Graeme / Wilson, Carlene

PEC innovation

2023 Volume 3, Page(s) 100224

Abstract: Objective: To validate the 10-item Consumer Health Activation Index (CHAI), developed in the United States, as an activation measure for interventions targeted at the Australian older general population.: Methods: The study was a cross sectional ... ...

Abstract	Objective: To validate the 10-item Consumer Health Activation Index (CHAI), developed in the United States, as an activation measure for interventions targeted at the Australian older general population. Methods: The study was a cross sectional design. Exploratory factor analysis (EFA) was conducted on survey data from a community sample of participants ( Results: EFA revealed a 7-item, two-factor structure ('Health self-management' and 'Patient-provider engagement'). CFA indicated optimum model fit was obtained with this structure. Subscale reliability and validity were confirmed, with significant correlation to age, functional health literacy and health screening. Conclusion: In contrast to the original structure, optimum model fit was obtained with a two-factor solution and retention of seven items. The subscales have utility as a measure of health activation for tailoring of information in this group. Innovation: A freely-available, unidimensional health activation measure has demonstrated an underlying two-scale structure that will enable tailored approaches toward the enhancement and maintenance of self- and externally-managed health behaviours in an Australian population.
Language	English
Publishing date	2023-10-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-6282
ISSN (online)	2772-6282
DOI	10.1016/j.pecinn.2023.100224
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Article: Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer.

Al Naji, Hiba / Winter, Jean M / Pedersen, Susanne K / Roy, Amitesh / Byrne, Susan E / Young, Graeme P / Symonds, Erin L

Biomarker insights

2024 Volume 19, Page(s) 11772719241232870

Abstract: Background: Colorectal cancer (CRC) has a high rate of recurrence, in particular for advanced disease, but prognosis based on staging and pathology at surgery can have limited efficacy. The presence of circulating tumor DNA (ctDNA) at diagnosis could be ...

Abstract	Background: Colorectal cancer (CRC) has a high rate of recurrence, in particular for advanced disease, but prognosis based on staging and pathology at surgery can have limited efficacy. The presence of circulating tumor DNA (ctDNA) at diagnosis could be used to improve the prediction for disease recurrence. Objectives: To assess the impact of detecting methylated Design: A retrospective cohort study. Methods: The cohort included 180 patients (36 with recurrent CRC), who had undergone complete treatment and surveillance for a minimum of 3 years. Participant clinical details and ctDNA methylated Results: Clinical factors independently associated with reduced disease-free survival included nodal involvement (HR = 3.83, 95% CI 1.56-9.43, Conclusions: Nodal invasion, metastatic disease, distal tumor site, low resection margins and perineural invasion were associated with disease recurrence. Pre-treatment methylated ctDNA measurement can improve the predictive value for recurrence in a subset of patients, particularly those with perineural involvement. Registration: Australian and New Zealand Clinical Trials Registry #12611000318987.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2256754-9
ISSN	1177-2719
ISSN	1177-2719
DOI	10.1177/11772719241232870
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Article ; Online: Surveillance colonoscopy findings in asymptomatic participants over 75 years of age.

Agaciak, Madelyn / Wassie, Molla M / Simpson, Kalindra / Cock, Charles / Bampton, Peter / Fraser, Robert / Symonds, Erin L

JGH open : an open access journal of gastroenterology and hepatology

2024 Volume 8, Issue 5, Page(s) e13071

Abstract: Background and aim: Surveillance colonoscopy for colorectal cancer (CRC) is generally not recommended beyond 75 years of age. The study determined incidence and predictors of advanced adenoma and CRC in older individuals undergoing surveillance ... ...

Abstract	Background and aim: Surveillance colonoscopy for colorectal cancer (CRC) is generally not recommended beyond 75 years of age. The study determined incidence and predictors of advanced adenoma and CRC in older individuals undergoing surveillance colonoscopy. Methods: This was a retrospective cohort study of asymptomatic older participants (≥75 years), enrolled in a South Australian CRC surveillance program who underwent colonoscopy (2015-2020). Clinical records were extracted for demographics, personal or family history of CRC, comorbidities, polypharmacy, and colonoscopy findings. The associations between clinical variables and advanced adenoma or CRC at surveillance were assessed with multivariable Poisson regression analysis. Results: Totally 698 surveillance colonoscopies were analyzed from 574 participants aged 75-91 years (55.6% male). The incidence of CRC was 1.6% (11/698), while 37.9% (260/698) of procedures had advanced adenoma detected. Previous CRC (incidence rate ratio [IRR] 5.9, 95% CI 1.5-22.5), age ≥85 years (IRR 5.8, 95% CI 1.6-20.1) and active smoking (IRR 4.9, 95% CI 1.0-24.4) were independently associated with CRC diagnosis, while advanced adenoma at immediately preceding colonoscopy (IRR 1.6, 95% CI 1.3-2.0) and polypharmacy (IRR 1.2, 95% CI 1.0-1.5) were associated with advanced adenoma at surveillance colonoscopy in asymptomatic older participants (≥75 years). Conclusion: Advanced neoplasia was found in more than one third of the surveillance procedures completed in this cohort. Continuation of surveillance beyond age 75 yeasrs may be considered in participants who have previous CRC or are active smokers (provided they are fit to undergo colonoscopy). In other cases, such as past advanced adenoma only, the need for ongoing surveillance should be considered alongside participant preference and health status.
Language	English
Publishing date	2024-05-01
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.13071
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Article ; Online: The Diagnostic Performance of Fecal Immunochemical Tests for Detecting Advanced Neoplasia at Surveillance Colonoscopy.

Berwald, Grace / Young, Graeme P / Cock, Charles / Bampton, Peter / Fraser, Robert / Symonds, Erin L

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2023 Volume 22, Issue 4, Page(s) 878–885.e2

Abstract: Background & aims: An increasing burden on health care resources has resulted in a backlog of individuals requiring colonoscopy, with delays in surveillance possibly detrimental for individuals at increased risk of colorectal cancer (CRC). This study ... ...

Abstract	Background & aims: An increasing burden on health care resources has resulted in a backlog of individuals requiring colonoscopy, with delays in surveillance possibly detrimental for individuals at increased risk of colorectal cancer (CRC). This study investigated the use of a 2-sample fecal immunochemical test (FIT) to establish those most likely to have advanced neoplasia (AN) and in need of prioritized surveillance colonoscopy. Methods: This was a prospective study conducted in the tertiary care setting. Participants completed a 2-sample FIT (OC-Sensor, Eiken Chemical Company) within 90 days of surveillance colonoscopy. The sensitivity of FIT for detection of AN (CRC or advanced adenoma) in moderate- and high-risk individuals was determined at fecal hemoglobin thresholds between 2 and 80 μg/g feces. Results: A total of 766 patients were included (median age, 66.1 years [interquartile range, 58.1-72.9]; 49.9% male), with AN detected in 8.6% (66/766, including 5 CRC). For moderate-risk individuals (with prior history of adenoma or a significant family history of CRC), sensitivity of FIT for AN ranged from 73.5% at 2 μg/g feces, to 10.2% at 80 μg/g feces. For high-risk conditions (confirmed/suspected genetic syndromes or prior CRC), sensitivity of FIT was similar, ranging from 70.6% at the lowest positivity threshold of 2 μg/g feces, to 11.8% at 80 μg/g feces. Independent variables in the whole cohort for association with detection of AN at surveillance colonoscopy were age (odds ratio, 1.03; 95% confidence interval, 1.00-1.06) and FIT hemoglobin result ≥10 μg/g feces (odds ratio, 1.81; 95% confidence interval, 1.04-3.16). Conclusions: The use of FIT before surveillance colonoscopy provides clinicians with insights into the risk of AN. This raises the possibility of a method to triage individuals, facilitating the more efficient management of endoscopic resources.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Prospective Studies ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer/methods ; Colonoscopy ; Occult Blood ; Feces/chemistry ; Hemoglobins/analysis ; Adenoma/diagnosis
Chemical Substances	Hemoglobins
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2023.09.016
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Article ; Online: Reply.

Wassie, Molla M / Young, Graeme P / Winter, Jean M / Cock, Charles / Symonds, Erin L

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2023 Volume 22, Issue 5, Page(s) 1147–1148

Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Letter
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2023.11.007
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Article ; Online: Low Incidence of Colorectal Advanced Neoplasia During Surveillance in Individuals with a Family History of Colorectal Cancer.

Barnett, Meghan I / Wassie, Molla M / Cock, Charles / Bampton, Peter A / Symonds, Erin L

Digestive diseases and sciences

2023 Volume 68, Issue 11, Page(s) 4243–4251

Abstract: Background: Family history of colorectal cancer (CRC) is used to stratify individuals into risk categories which determine timing of initial screening and ongoing CRC surveillance. Evidence for long-term CRC risk following a normal index colonoscopy in ... ...

Abstract	Background: Family history of colorectal cancer (CRC) is used to stratify individuals into risk categories which determine timing of initial screening and ongoing CRC surveillance. Evidence for long-term CRC risk following a normal index colonoscopy in family history populations is limited. Aims: To assess the incidence of advanced neoplasia and associated risk factors in a population undergoing surveillance colonoscopies due to family history of CRC. Methods: Surveillance colonoscopy findings were examined in 425 individuals with a family history of CRC, a normal index colonoscopy and a minimum of 10 years of follow-up colonoscopies. Advanced neoplasia risk was determined for three CRC family history categories (near-average, medium and high-risk), accounting for demographics and time after the first colonoscopy. Results: The median follow-up was 13.5 years (IQR 11.5-16.0), with an incidence of advanced neoplasia of 14.35% (61/425). The number of affected relatives and age of CRC diagnosis in the youngest relative did not predict the risk of advanced neoplasia (p > 0.05), with no significant differences in advanced neoplasia incidence between the family history categories (p = 0.16). Patients ≥ 60 years showed a fourfold (HR 4.14, 95% CI 1.33-12.89) higher advanced neoplasia risk during surveillance than those < 40 years at index colonoscopy. With each subsequent negative colonoscopy, the risk of advanced neoplasia at ongoing surveillance was reduced. Conclusions: The incidence of advanced neoplasia was low (14.35%), regardless of the family history risk category, with older age being the main risk for advanced neoplasia. Delaying onset of colonoscopy or lengthening surveillance intervals could be a more efficient use of resources in this population.
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-023-08053-6
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Article ; Online: Variables Associated with Detection of Methylated

Saluja, Hariti / Young, Graeme P / Kholmurodova, Feruza / Symonds, Erin L

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2021 Volume 30, Issue 4, Page(s) 774–781

Abstract: Background: DNA methylated in : Methods: A retrospective review of demographic and clinical variables was conducted on patients who were assayed for these biomarkers prior to a colonoscopy for any indication. Potential relationships between detection ...

Abstract	Background: DNA methylated in Methods: A retrospective review of demographic and clinical variables was conducted on patients who were assayed for these biomarkers prior to a colonoscopy for any indication. Potential relationships between detection of these biomarkers and patient variables in patients without colorectal cancer were identified by logistic regression. An age- and sex-matched case-control study was undertaken to identify additional associations. Results: A total of 196 of 1,593 patients undergoing colonoscopy were positive for Conclusions: False-positive results were most commonly associated with detection of methylated Impact: In the absence of colonoscopically evident colorectal cancer, a high level of circulating methylated DNA warrants investigations for cancers at other sites.
MeSH term(s)	Aged ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Case-Control Studies ; Colonoscopy ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/genetics ; DNA Methylation ; Female ; Humans ; Ikaros Transcription Factor/blood ; Ikaros Transcription Factor/genetics ; Male ; Middle Aged ; Retrospective Studies ; South Australia ; Transaminases/blood ; Transaminases/genetics
Chemical Substances	Biomarkers, Tumor ; Ikaros Transcription Factor (148971-36-2) ; BCAT1 protein, human (EC 2.6.1.) ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2021-01-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-20-1609
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Article: The Diagnostic Accuracy of a Fecal Immunochemical Test in Detecting Colorectal Cancer and Advanced Precancerous Colorectal Neoplasia in Patients with Iron Deficiency: A Protocol for Systematic Review and Meta-Analysis.

Pham, Jennifer / Laven-Law, Geraldine / Winter, Jean M / Wassie, Molla M / Cock, Charles / Symonds, Erin L

Gastroenterology research and practice

2023 Volume 2023, Page(s) 5982580

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-12-08
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2435460-0
ISSN	1687-630X ; 1687-6121
ISSN (online)	1687-630X
ISSN	1687-6121
DOI	10.1155/2023/5982580
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