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  1. Article ; Online: Playing the infinite in sarcoma care and research.

    Sys, Gwen M L

    Journal of cancer policy

    2023  Volume 38, Page(s) 100439

    MeSH term(s) Humans ; Sarcoma/diagnosis
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Letter
    ISSN 2213-5383
    ISSN (online) 2213-5383
    DOI 10.1016/j.jcpo.2023.100439
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  2. Article ; Online: Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts.

    Fischer, Suzanne / Creytens, David / Gijsels, Stefanie / Descamps, Benedicte / Lapeire, Lore / Hendrix, An / Sys, Gwen / De Wever, Olivier

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102863

    Abstract: Despite optimal multimodal treatment including surgical resection, 50%-80% of high-grade soft tissue sarcoma (STS) patients metastasize. Here, we present a protocol for the generation and use of post-surgical minimal residual disease models to ... ...

    Abstract Despite optimal multimodal treatment including surgical resection, 50%-80% of high-grade soft tissue sarcoma (STS) patients metastasize. Here, we present a protocol for the generation and use of post-surgical minimal residual disease models to investigate metastatic relapse in STS patient-derived xenografts. We describe steps for orthotopic engraftment of high-grade STS patient-derived tumor tissue. We then detail procedures for primary tumor resection with broad, negative resection margins and follow-up until metastases using MRI. For complete details on the use and execution of this protocol, please refer to Fischer et al. (2023).
    MeSH term(s) Humans ; Neoplasm, Residual ; Heterografts ; Sarcoma/diagnostic imaging ; Sarcoma/surgery ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/surgery ; Soft Tissue Neoplasms/pathology ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102863
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  3. Article ; Online: Enhancing rotational placement of reconstruction prostheses of the distal femur after sarcoma resection.

    De Smet, Arne / Verrewaere, Dries / Sys, Gwen

    Medical engineering & physics

    2020  Volume 81, Page(s) 47–57

    Abstract: Introduction: Currently there are no accepted international guidelines for the correct placement of reconstruction prostheses in the axial plane of the femur after en bloc resection. The most accepted method is based on the linea aspera as an ... ...

    Abstract Introduction: Currently there are no accepted international guidelines for the correct placement of reconstruction prostheses in the axial plane of the femur after en bloc resection. The most accepted method is based on the linea aspera as an intraoperative landmark, indicating posterior. This study was conducted to address the reliability of the linea aspera as a landmark for rotational alignment.
    Material and methods: 50 CT angiographies of the right limb were used for this purpose. These 2D images were reconstructed into 3D models using proprietary software (materialize NV, Leuven, Belgium). The posterior condylar line was used as a reference axis. The orientation of the linea aspera was described as the angle between the perpendicular line to the PCL, through the center of the diaphysis, and the lateral (α) and medial labium (β).
    Results: The linear mixed model shows that the α- and β-angles are significantly associated with the distance from the joint line (p<0.001) and vary significantly between subjects (p<0.001). The α-angle has the lowest variance and approximates more closely true posterior, while the median β-angle never overlaps true posterior.
    Discussion: When a surgeon would blindly rely on the linea aspera as a posterior landmark roughly 78% of the femoral implants would exceed the accepted ±3° deviation around the surgical transepicondylar axis (sTEA) as defined in total knee replacement. The linea aspera is not a reliable landmark for axial rotation of femoral implants. The position is highly dependent on the osteotomy height and in addition differs between individual patients. Preoperative assessment of the linea aspera is advocated in order to reduce the risk of malrotation. As the height of the osteotomy cannot always be determined correctly preoperatively, a table was designed as a guideline for how much a deviation from the planned resection height will affect the rotation of the implant.
    MeSH term(s) Arthroplasty, Replacement, Knee ; Female ; Femur/surgery ; Humans ; Knee Joint/surgery ; Male ; Reproducibility of Results ; Rotation ; Sarcoma/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1181080-4
    ISSN 1873-4030 ; 1350-4533
    ISSN (online) 1873-4030
    ISSN 1350-4533
    DOI 10.1016/j.medengphy.2020.05.001
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  4. Article ; Online: Diagnosis and monitoring denosumab therapy of giant cell tumors of bone: radiologic-pathologic correlation.

    Lejoly, Maryse / Van Den Berghe, Thomas / Creytens, David / Huysse, Wouter / Lapeire, Lore / Sys, Gwen / Verstraete, Koenraad

    Skeletal radiology

    2023  Volume 53, Issue 2, Page(s) 353–364

    Abstract: Objective: To determine the value of CT and dynamic contrast-enhanced (DCE-)MRI for monitoring denosumab therapy of giant cell tumors of bone (GCTB) by correlating it to histopathology.: Materials and methods: Patients with GCTB under denosumab ... ...

    Abstract Objective: To determine the value of CT and dynamic contrast-enhanced (DCE-)MRI for monitoring denosumab therapy of giant cell tumors of bone (GCTB) by correlating it to histopathology.
    Materials and methods: Patients with GCTB under denosumab treatment and monitored with CT and (DCE-)MRI (2012-2021) were retrospectively included. Imaging and (semi-)quantitative measurements were used to assess response/relapse. Tissue samples were analyzed using computerized segmentation for vascularization and number of neoplastic and giant cells. Pearson's correlation/Spearman's rank coefficient and Kruskal-Wallis tests were used to assess correlations between histopathology and radiology.
    Results: Six patients (28 ± 8years; five men) were evaluated. On CT, good responders showed progressive re-ossification (+7.8HU/month) and cortical remodeling (woven bone). MRI showed an SI decrease relative to muscle on T1-weighted (-0.01 A.U./month) and on fat-saturated T2-weighted sequences (-0.03 A.U./month). Time-intensity-curves evolved from a type IV with high first pass, high amplitude, and steep wash-out to a slow type II. An increase in time-to-peak (+100%) and a decrease in Ktrans (-71%) were observed. This is consistent with microscopic examination, showing a decrease of giant cells (-76%), neoplastic cells (-63%), and blood vessels (-28%). There was a strong statistical significant inverse correlation between time-to-peak and microvessel density (ρ = -0.9, p = 0.01). Significantly less neoplastic (p = 0.03) and giant cells (p = 0.04) were found with a time-intensity curve type II, compared to a type IV. Two patients showed relapse after initial good response when stopping denosumab. Inverse imaging and pathological findings were observed.
    Conclusion: CT and (DCE-)MRI show a good correlation with pathology and allow adequate evaluation of response to denosumab and detection of therapy failure.
    MeSH term(s) Male ; Humans ; Denosumab/therapeutic use ; Retrospective Studies ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/drug therapy ; Neoplasm Recurrence, Local ; Giant Cell Tumor of Bone/diagnostic imaging ; Giant Cell Tumor of Bone/drug therapy ; Giant Cell Tumor of Bone/pathology ; Recurrence ; Radiology ; Bone Density Conservation Agents
    Chemical Substances Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents
    Language English
    Publishing date 2023-07-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-023-04403-7
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  5. Article ; Online: NGS-analysis to the rescue: dual checkpoint inhibition in metastatic osteosarcoma - a case report and review of the literature.

    Nuytemans, Laure / Sys, Gwen / Creytens, David / Lapeire, Lore

    Acta clinica Belgica

    2019  Volume 76, Issue 2, Page(s) 162–167

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Adult ; Animals ; B7-H1 Antigen ; Carcinoma, Non-Small-Cell Lung ; High-Throughput Nucleotide Sequencing ; Humans ; Kidney Neoplasms ; Lung Neoplasms ; Male ; Mice ; Osteosarcoma/drug therapy
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2019-10-21
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2019.1683129
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  6. Article: Late Lung Metastasis in a Patient with a Clear Cell Chondrosarcoma: An Indication for a Life-Long Follow-Up?

    West, Paulien / Jacobs, Celine / Saerens, Michael / Creytens, David / Sys, Gwen / Lapeire, Lore

    Case reports in oncological medicine

    2021  Volume 2021, Page(s) 7205649

    Abstract: Background: Clear cell chondrosarcoma (CCCS) is a rare subtype of chondrosarcoma and comprises between 1.6% and 2.5% of all chondrosarcoma. They are known to be chemo- and radiotherapy resistant; surgical resection is therefore the therapy of choice.: ...

    Abstract Background: Clear cell chondrosarcoma (CCCS) is a rare subtype of chondrosarcoma and comprises between 1.6% and 2.5% of all chondrosarcoma. They are known to be chemo- and radiotherapy resistant; surgical resection is therefore the therapy of choice.
    Methods: We present a 63-year-old woman with a progressive lung nodule 20 years after initial diagnosis and treatment of a clear cell chondrosarcoma of the right os naviculare.
    Results: On serial CT scans of the chest, an asymptomatic, slowly growing nodule in the left upper lung lobe was detected. CT-guided transthoracic biopsy of this nodule confirmed the diagnosis of a chondrosarcoma lung metastasis. Video-assisted thoracoscopic wedge resection was performed with complete removal of the nodule. The patient recovered well from surgery and remains in good health during further follow-up.
    Conclusion: Given the tendency of clear cell chondrosarcoma to recur and metastasize after extended periods of time, a long-term, possibly life-long follow-up and clinical surveillance is advisable in these patients.
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2629911-2
    ISSN 2090-6714 ; 2090-6706
    ISSN (online) 2090-6714
    ISSN 2090-6706
    DOI 10.1155/2021/7205649
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  7. Article ; Online: Identification and validation of extracellular vesicle reference genes for the normalization of RT-qPCR data.

    Pinheiro, Cláudio / Guilbert, Niké / Lippens, Lien / Roux, Quentin / Boiy, Robin / Fischer, Suzanne / Van Dorpe, Sofie / De Craene, Bram / Berx, Geert / Boterberg, Tom / Sys, Gwen / Denys, Hannelore / Miinalainen, Ilkka / Mestdagh, Pieter / Vandesompele, Jo / De Wever, Olivier / Hendrix, An

    Journal of extracellular vesicles

    2024  Volume 13, Issue 4, Page(s) e12421

    Abstract: Extracellular vesicles (EVs) contain a plethora of biomolecules, including nucleic acids, with diverse diagnostic and therapeutic application potential. Although reverse transcription-quantitative PCR (RT-qPCR) is the most widely applied laboratory ... ...

    Abstract Extracellular vesicles (EVs) contain a plethora of biomolecules, including nucleic acids, with diverse diagnostic and therapeutic application potential. Although reverse transcription-quantitative PCR (RT-qPCR) is the most widely applied laboratory technique to evaluate gene expression, its applicability in EV research is challenged by the lack of universal and stably present reference genes (RGs). In this study, we identify, validate and establish SNRPG, OST4, TOMM7 and NOP10 as RGs for the normalization of EV-associated genes by RT-qPCR. We show the stable presence of SNRPG, OST4, TOMM7 and NOP10 in multiple cell lines and their secreted EVs (n = 12) under different (patho)physiological conditions as well as in human-derived biofluids (n = 3). Enzymatic treatments confirm the presence of SNRPG, OST4, TOMM7 and NOP10 inside EVs. In addition, the four EV-associated RGs are stably detected in a size-range of EV subpopulations. RefFinder analysis reveals that SNRPG, OST4, TOMM7 and NOP10 are more stable compared to RGs established specifically for cultured cells or tissues such as HMBS, YWHAZ, SDHA and GAPDH. In summary, we present four universal and stably present EV-associated RGs to enable normalization and thus steer the implementation of RT-qPCR for the analysis of EV-associated RNA cargo for research or clinical applications.
    MeSH term(s) Humans ; Reverse Transcription ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; RNA/metabolism ; Cell Line ; Cells, Cultured ; snRNP Core Proteins/metabolism
    Chemical Substances RNA (63231-63-0) ; SNRPG protein, human ; snRNP Core Proteins
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2683797-3
    ISSN 2001-3078 ; 2001-3078
    ISSN (online) 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12421
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  8. Article ; Online: Post-operative minimal residual disease models to study metastatic relapse in soft-tissue sarcoma patient-derived xenografts.

    Fischer, Suzanne / Creytens, David / De Geyter, Sofie / De Vlieghere, Elly / Pattyn, Piet / Bekaert, Sarah-Lee / Durinck, Kaat / Van Roy, Nadine / Hendrix, An / Lapeire, Lore / Sys, Gwen / De Wever, Olivier

    Clinical and translational medicine

    2023  Volume 13, Issue 6, Page(s) e1290

    MeSH term(s) Animals ; Humans ; Neoplasm, Residual ; Heterografts ; Neoplasm Recurrence, Local ; Sarcoma/pathology ; Sarcoma/surgery ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/surgery ; Disease Models, Animal
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Letter
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1290
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  9. Article ; Online: RAF1-

    Cordier, Fleur / Loontiens, Siebe / Van der Meulen, Joni / Lapeire, Lore / van Ramshorst, Gabrielle H / Sys, Gwen / Van Dorpe, Jo / Creytens, David

    International journal of surgical pathology

    2023  Volume 32, Issue 1, Page(s) 133–139

    Abstract: We report an exceptional case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity, which harbored ... ...

    Abstract We report an exceptional case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity, which harbored a
    MeSH term(s) Humans ; Sarcoma/pathology ; Ossification, Heterotopic/genetics ; Soft Tissue Neoplasms/complications ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/pathology ; Choristoma ; Biomarkers, Tumor
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231167493
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  10. Article ; Online: A challenging case of a poorly differentiated small cell variant of synovial sarcoma with unusual immunophenotype.

    Cordier, Fleur / Lapeire, Lore / Sys, Gwen / Van Dorpe, Jo / Creytens, David

    Pathology

    2020  Volume 53, Issue 5, Page(s) 658–660

    MeSH term(s) Cell Differentiation ; Humans ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Sarcoma, Synovial/diagnosis ; Sarcoma, Synovial/genetics
    Language English
    Publishing date 2020-11-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2020.08.028
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