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Article ; Online: MicroRNAs as Biomarkers and Therapeutic Targets in Heart Failure

Szabó István Adorján / Frigy Atilla

Acta Medica Marisiensis, Vol 65, Iss 3, Pp 77-

2019 Volume 79

Abstract: Heart failure still represents a real challenge both in everyday practice and research, due to the complex issues related to its pathogenesis and management. Humoral biomarkers have emerged in the last decades as useful tools in the diagnosis, risk ... ...

Abstract	Heart failure still represents a real challenge both in everyday practice and research, due to the complex issues related to its pathogenesis and management. Humoral biomarkers have emerged in the last decades as useful tools in the diagnosis, risk stratification and guiding the treatment of heart failure. These molecules are related to different pathological and adaptive processes, like myocardial injury, neurohormonal activation and cardiac remodeling, their most widespread representatives being the natriuretic peptides (e.g. NT-proBNP). The role of altered gene expression and transcription as the basis of myocardial structural and functional changes in heart failure is largely recognized. MicroRNAs (miRNAs) are non-coding RNAs which have a major role in post-transcriptional gene expression by interfering with messenger RNA molecules. Our short review summarizes the molecular biology of miRNAs and their possible role as biomarkers in the diagnosis and prognosis of heart failure. Furthermore, the therapeutical perspectives conferred by these molecules are also presented.
Keywords	mirna ; biomarkers ; heart failure ; Medicine ; R
Subject code	610
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Electrocardiographic Changes Associated with Early Repolarization Pattern in Healthy Young Males.

Frigy, Attila / Gábor-Kelemen, Hunor / László, Szabolcs Attila / Szabó, István Adorján / Kocsis, Lóránd

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 8

Abstract: Background and Objectives: Early repolarization pattern (ERP) has recently been shown to be related with an increased risk of ventricular arrhythmias in susceptible individuals. Materials and Methods: We studied the ERP-associated ECG changes, with ... ...

Abstract	Background and Objectives: Early repolarization pattern (ERP) has recently been shown to be related with an increased risk of ventricular arrhythmias in susceptible individuals. Materials and Methods: We studied the ERP-associated ECG changes, with potential clinical relevance, in 220 young (age 22.1 ± 1.6 years), healthy, male subjects using 12-lead ECG recordings. A total of 38 subjects (17.3%) fulfilled the diagnostic criteria for ERP, and a total of 90 ECG characteristics were compared between the groups of subjects with and without ERP. Results: None of the ECGs were pathological, and 22 ECG parameters differed significantly (p < 0.05) between the subjects with and without ERP. Among them, the P wave-related parameters (e.g., average P wave duration: 101.5 ± 9.2 ms vs. 106.8 ± 9.9 ms, p = 0.004) and the presence of fragmented QRS complexes (67.6% vs. 92.1%, p = 0.002) revealed a potential propensity for atrial and ventricular arrhythmogenesis. The time-domain parameters of repolarization, those not corrected for QRS duration, showed shorter values (e.g., Tpeak-Tend interval: 70.9 ± 8.1 ms vs. 67.8 ± 8.0 ms, p = 0.036), reflecting the accelerated repolarization. Conclusions: Certain ECG characteristics seem to be more associated with ERP. The clinical significance of this finding at the individual level needs further prospective investigations.
MeSH term(s)	Adult ; Arrhythmias, Cardiac/diagnosis ; Electrocardiography ; Humans ; Male ; Young Adult
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58081048
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Article ; Online: Comparative study of echocardiographic parameters in young males with early repolarization pattern

Szabó, István Adorján / Kocsis, Loránd / László, Szabolcs / Fehérvári, Lajos / Fárr, Ana-Maria / Frigy, Attila

Orvosi hetilap

2021 Volume 162, Issue 19, Page(s) 741–745

Title translation	Korai repolarizációs mintázatot mutató fiatal férfiak echokardiográfiás jellemzőinek összehasonlító vizsgálata.
MeSH term(s)	Adult ; Echocardiography ; Humans ; Male ; Prognosis ; Prospective Studies ; Young Adult
Language	Hungarian
Publishing date	2021-05-09
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2021.32061
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Article: Prognostic Value of Lung Ultrasound in Aortic Stenosis.

Szabó, István Adorján / Gargani, Luna / Morvai-Illés, Blanka / Polestyuk-Németh, Nóra / Frigy, Attila / Varga, Albert / Ágoston, Gergely

Frontiers in physiology

2022 Volume 13, Page(s) 838479

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.838479
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Article ; Online: Applicability of lung ultrasound in the assessment of COVID-19 pneumonia: Diagnostic accuracy and clinical correlations.

Ciurba, Bianca Emilia / Sárközi, Hédi Katalin / Szabó, István Adorjan / Ianoși, Edith Simona / Grigorescu, Bianca Liana / Csipor-Fodor, Alpar / Tudor, Toma P / Jimborean, Gabriela

Respiratory investigation

2022 Volume 60, Issue 6, Page(s) 762–771

Abstract: Background: The purpose of this study was to assess the diagnostic accuracy of lung ultrasound (LUS) in determining the severity of coronavirus disease 2019 (COVID-19) pneumonia compared with thoracic computed tomography (CT) and establish the ... ...

Abstract	Background: The purpose of this study was to assess the diagnostic accuracy of lung ultrasound (LUS) in determining the severity of coronavirus disease 2019 (COVID-19) pneumonia compared with thoracic computed tomography (CT) and establish the correlations between LUS score, inflammatory markers, and percutaneous oxygen saturation (SpO Methods: This prospective observational study, conducted at Târgu-Mureș Pulmonology Clinic included 78 patients with confirmed severe acute respiratory syndrome coronavirus-2 infection via nasopharyngeal real-time-polymerase chain reaction (RT-PCR) (30 were excluded). Enrolled patients underwent CT, LUS, and blood tests on admission. Lung involvement was evaluated in 16 thoracic areas, using AB Results: LUS revealed bilateral B-lines (97.8%), pleural irregularities with thickening/discontinuity (75%), and subpleural consolidations (70.8%). Uncommon sonographic patterns were alveolar consolidations with bronchogram (33%) and pleural effusion (2%). LUS score cutoff values of ≤14 and > 22 predicted mild COVID-19 (sensitivity [Se] = 84.6%; area under the curve [AUC] = 0.72; P = 0.002) and severe COVID-19 (Se = 50%, specificity (Sp) = 91.2%, AUC = 0.69; P = 0.02), respectively, and values > 29 predicted the patients' transfer to the intensive care unit (Se = 80%, Sp = 97.7%). LUS score positively correlated with CT score (r = 0.41; P = 0.003) and increased with the decrease of SpO Conclusions: LUS is a useful, non-invasive and effective tool for diagnosis, monitoring evolution, and prognostic stratification of COVID-19 patients.
MeSH term(s)	Humans ; COVID-19/diagnostic imaging ; SARS-CoV-2 ; Lung/diagnostic imaging ; Ultrasonography/methods ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2022-08-08
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2022.06.015
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Article: Elevated CA-125 as Humoral Biomarker of Congestive Heart Failure: Illustrative Cases and a Short Review of Literature.

Frigy, Attila / Belényi, Boglárka / Kirchmaier, Ádám / Fekete, Nándor / Szabó, István Adorján

Case reports in cardiology

2020 Volume 2020, Page(s) 1642914

Abstract: Despite the recent, remarkable achievements in cardiology, heart failure (HF) remains a major public health problem due to its increasing prevalence, frequent hospitalizations, and significant mortality. Humoral biomarkers in HF are capable to reflect ... ...

Abstract	Despite the recent, remarkable achievements in cardiology, heart failure (HF) remains a major public health problem due to its increasing prevalence, frequent hospitalizations, and significant mortality. Humoral biomarkers in HF are capable to reflect different aspects of the cardiac morpho-functional changes and the related pathophysiological processes and could have important diagnostic, prognostic, and therapeutical roles. CA-125 is a well-known tumor marker (mainly for ovarian cancer), and also a useful, but less applied cardiac biomarker. Practical aspects, possible pitfalls related with increased CA-125 levels are illustrated by two cases, both with HF, with the biomarker determined for other reasons and having high levels in the context of the cardiac decompensation. The paper presents a short review of the main biochemical, pathophysiological, and clinical data linked to CA-125, with special accent on its utility in patients with HF.
Language	English
Publishing date	2020-05-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627627-6
ISSN	2090-6412 ; 2090-6404
ISSN (online)	2090-6412
ISSN	2090-6404
DOI	10.1155/2020/1642914
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Article ; Online: S100A8∕A9 is a valuable biomarker and treatment target to detect and modulate neutrophil involvement in myocardial infarction.

Mareş, Răzvan Gheorghiţă / Sabău, Adrian Horaţiu / Cocuz, Iuliu Gabriel / Tomuţ, Mihaela Elena / Szabo, Istvan Adorjan / Szőke, Andreea Raluca / Tinca, Andreea Cătălina / Jakobsson, Gabriel / Cotoi, Ovidiu Simion / Şchiopu, Alexandru

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

2023 Volume 64, Issue 2, Page(s) 151–158

Abstract: Myocardial infarction (MI) leads to irreversible ischemic damage of the heart muscle and is the leading cause of heart failure. The ischemic cardiac injury triggers a potent local and systemic immune response. In the acute phase post-MI, neutrophils ... ...

Abstract	Myocardial infarction (MI) leads to irreversible ischemic damage of the heart muscle and is the leading cause of heart failure. The ischemic cardiac injury triggers a potent local and systemic immune response. In the acute phase post-MI, neutrophils infiltrate the myocardium in large numbers and induce further cardiomyocyte death, expanding the infarcted area. The alarmin S100A8∕A9 is a proinflammatory mediator primarily produced by myeloid cells, with an emerging role in MI. We previously demonstrated that short-term inhibition of S100A8∕A9 during the inflammatory phase of the immune response to MI improves long-term cardiac function. In the present study, we investigated the effects of S100A8∕A9 blockade on myocardial inflammation and post-ischemic myocardial injury in a mouse model of coronary artery ligation. Immunohistochemical (IHC) staining revealed that the presence of S100A9 is strongly correlated with neutrophil infiltration in the myocardium on days 1 and 3 post-MI. A 3-day treatment with the S100A8∕A9 blocker ABR-238901 starting immediately after MI decreased the number of neutrophils and S100A9 presence in the myocardium and had a positive impact on cardiac damage, reducing infarction size. These findings promote S100A9 as an IHC biomarker of neutrophil infiltration and a promising immunomodulatory target to regulate neutrophil recruitment, reduce ischemic injury and promote long-term beneficial cardiac recovery after MI.
MeSH term(s)	Mice ; Animals ; Neutrophils ; Myocardial Infarction ; Myocardium ; Disease Models, Animal ; Biomarkers ; Mice, Inbred C57BL
Chemical Substances	ABR-238901 ; Biomarkers
Language	English
Publishing date	2023-07-31
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1062519-7
ISSN	2066-8279 ; 1220-0522 ; 0035-4007
ISSN (online)	2066-8279
ISSN	1220-0522 ; 0035-4007
DOI	10.47162/RJME.64.2.04
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Article: The Prognostic Value of Lung Ultrasound in Patients With Newly Diagnosed Heart Failure With Preserved Ejection Fraction in the Ambulatory Setting.

Morvai-Illés, Blanka / Polestyuk-Németh, Nóra / Szabó, István Adorján / Monoki, Magdolna / Gargani, Luna / Picano, Eugenio / Varga, Albert / Ágoston, Gergely

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 758147

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.758147
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Article: Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction.

Fehérvári, Lajos / Frigy, Attila / Kocsis, Lóránd / Szabó, István Adorján / Szabo, Timea Magdolna / Urkon, Melinda / Jakó, Zita / Nagy, Előd Ernő

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 5

Abstract: Arterial stiffness (AS) is a complex vascular phenomenon with consequences for central hemodynamics and left-ventricular performance. Circulating biomarkers have been associated with AS; however, their value in heart failure is poorly characterized. Our ... ...

Abstract	Arterial stiffness (AS) is a complex vascular phenomenon with consequences for central hemodynamics and left-ventricular performance. Circulating biomarkers have been associated with AS; however, their value in heart failure is poorly characterized. Our aim was to evaluate the clinical and biomarker correlates of AS in the setting of heart failure with reduced ejection fraction (HFrEF). In 78 hospitalized, hemodynamically stable patients (20 women, 58 men, mean age 65.8 ± 1.41 years) with HFrEF, AS was measured using aortic pulse wave velocity (PWV). Serum OPG, RANKL, sclerostin, and DKK-1 were determined, and the relationships between the clinical variables, vascular-calcification-related biomarkers, and PWV were evaluated by correlation analysis and linear and logistic regression models. OPG and the OPG/RANKL ratio were significantly higher in the group of patients (
Language	English
Publishing date	2021-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11050764
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Article ; Online: Transthoracic 3D Echocardiographic Imaging of Type A Aortic Dissection – Case Presentation

Szabó István Adorján / Kocsis Ildikó / Fogarasi Zoltán / Belényi Boglárka / Frigy Attila

Acta Medica Marisiensis, Vol 63, Iss 3, Pp 152-

2017 Volume 154

Abstract: In type A aortic dissection (AoD) an early and accurate diagnosis is essential to improve survival, by applying urgent surgical repair. 3D transthoracic echocardiography (3D-TTE), an advanced noninvasive imaging technique, could offer a comprehensive ... ...

Abstract	In type A aortic dissection (AoD) an early and accurate diagnosis is essential to improve survival, by applying urgent surgical repair. 3D transthoracic echocardiography (3D-TTE), an advanced noninvasive imaging technique, could offer a comprehensive evaluation of the ascending aorta and aortic arch in this regard. Both modalities of real-time 3D imaging – live 3D and full-volume aquisition – proved to be useful in evaluating the localization and extent of AoD. Our case illustrates the utility of 3D-TTE in the complex assessment AoD. By providing the proper anatomical dataset, 3D-TTE could facilitate considerably the diagnosis of type A AoD.
Keywords	type a aortic dissection ; 3d transthoracic echocardiography ; Medicine ; R
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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