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Book ; Online: The Cultural Identity and Education of University Students in Selected East-Central Countries : A Polish-Czech Comparative Study (Edition 1)

Ogrodzka-Mazur, Ewa / Szafrańska, Anna / Malach, Josef / Chmura, Milan

2021

Keywords	Higher & further education, tertiary education ; Education ; Higher
Size	1 Online-Ressource
Publisher	V&R unipress
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021048071
ISBN	9783737012546 ; 3737012547
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: High levels of benzodiazepines after treatment of moderate alcohol withdrawal syndrome: the problem of incomplete detoxification.

Basińska-Szafrańska, Anna R

Postepy psychiatrii neurologii

2022 Volume 31, Issue 1, Page(s) 1–5

Abstract: Purpose: Some alcohol-dependence relapses occur soon after a concluded detoxification treatment. A popular agent used in that treatment is diazepam, which effectively relieves withdrawal symptoms due to its long half-life and affinity to the same ... ...

Abstract	Purpose: Some alcohol-dependence relapses occur soon after a concluded detoxification treatment. A popular agent used in that treatment is diazepam, which effectively relieves withdrawal symptoms due to its long half-life and affinity to the same receptors. It is hypothesized here that these attributes, after nominally completed detoxification, result in, respectively, persisting benzodiazepine (BZD) influence and a distorted (optimistic) clinical presentation. This could contribute to later reemergence of withdrawal symptoms caused by delayed final elimination of BZDs, as the evidence puts into doubt the concept of a gentle self-taper of a long-acting drug. Methods: Serum-BZD concentration levels were measured with a radioimmunoassay at the end of routine treatment of moderately- intense alcohol withdrawal syndrome. These data were cross-referenced with individual diazepam administration schedules, including the maximal daily dose and the day of its administration, and the day of overall diazepam cessation. Results: Most patients revealed clinically relevant serum-BZD levels. These correlated with the doses but also with the day of maximal- dose administration and the day of diazepam withdrawal. Conclusions: The confrontation with actual abstinence comes after detoxification. Delayed elimination of diazepam may be a contributing factor in the re-emergence of symptoms and early post-detox relapses. The optimization of the procedure has been discussed in terms of concentration evolution and known treatment schedules. Maximal initial dosage compression and further decisive counteracting the tendencies of diazepam towards accumulation increase the patient's chance of going through the low-concentration crisis under medical assistance.
Language	English
Publishing date	2022-03-22
Publishing country	Poland
Document type	Journal Article
ISSN	2720-5371
ISSN (online)	2720-5371
DOI	10.5114/ppn.2022.114662
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of a long-acting substitute in detoxification from benzodiazepines: safety (accumulation) problems and proposed mitigation procedure.

Basińska-Szafrańska, Anna

European journal of clinical pharmacology

2022 Volume 78, Issue 11, Page(s) 1833–1841

Abstract: Objective: In the majority of approaches, detoxification of patients with benzodiazepine (BZD) addiction is preceded by conversion to long-acting BZDs. Resulting BZD accumulation, however, is neither monitored nor prevented. An unrecognized shift of the ...

Abstract	Objective: In the majority of approaches, detoxification of patients with benzodiazepine (BZD) addiction is preceded by conversion to long-acting BZDs. Resulting BZD accumulation, however, is neither monitored nor prevented. An unrecognized shift of the key low-concentration phase beyond the nominal treatment period may underlie delayed unassisted crises and treatment failures. This open, single-arm, semi-naturalistic study examines the anti-accumulation paradigm to minimize the high-concentration treatment phase and to regain time for medical assistance during the low-concentration phase. Methods: In 133 of 165 patients with BZD dependency, after conversion to diazepam by titration up to the satiation state, the loading dose and satiating concentration were recorded. The subsequent anti-accumulation procedure consisted of aggressive daily dose reductions under laboratory feedback (serum BZD concentration, radioimmunoassay) until accumulation stopped. The final overaccumulation ratio (OA) and maintenance-dose/loading-dose ratio (MTN) were estimated. The post-conversion peak-concentration/loading-dose ratio was illustratively compared with the concentration/dose ratio in 32 long-term diazepam users demonstrating the natural plateau. Results: Despite gender- and age-related differences in loading and maintenance doses and in satiating and peak concentrations (higher in younger and male patients), their quotients remained similar. The MTN ratio had an average value of 0.29 and a median value of 0.25, with OA ratios of 1.54 and 1.39, respectively. The concentration/dose ratio was approximately 3 times lower than that in regular diazepam users. With effective elimination starting (on average) from the 6th day, the treatment, including post-elimination recovery, lasted on average 52 days. Conclusions: The MTN values show how harmfully popular tapering schedules intensify and extend the high-concentration stage during alleged detoxification, leading to unrecognized delays in elimination, and delayed withdrawal crises. The common errors are discussed. An individual MTN, estimated from laboratory feedback (the anti-accumulation paradigm), expeditiously moves patients to the onset of actual detoxification. This action regains time to maintain medical assistance until treatment is properly completed.
MeSH term(s)	Anti-Anxiety Agents ; Benzodiazepines/adverse effects ; Diazepam/therapeutic use ; Humans ; Hypnotics and Sedatives/therapeutic use ; Male ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/prevention & control
Chemical Substances	Anti-Anxiety Agents ; Hypnotics and Sedatives ; Benzodiazepines (12794-10-4) ; Diazepam (Q3JTX2Q7TU)
Language	English
Publishing date	2022-09-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-022-03388-x
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Article ; Online: Delayed crises following benzodiazepine withdrawal: deficient adaptive mechanisms or simple pharmacokinetics? Detoxification assisted by serum-benzodiazepine elimination tracking.

Basińska-Szafrańska, Anna

European journal of clinical pharmacology

2021 Volume 78, Issue 1, Page(s) 101–110

Abstract: Objective: Rapid relapses after successful withdrawal occur even in apparently motivated benzodiazepine (BZD)-dependent patients. Regardless of known personality or biological (re-adaptation) issues, the aim of this open-label, single-arm, ... ...

Abstract	Objective: Rapid relapses after successful withdrawal occur even in apparently motivated benzodiazepine (BZD)-dependent patients. Regardless of known personality or biological (re-adaptation) issues, the aim of this open-label, single-arm, seminaturalistic study was to search for any detoxification errors contributing to failures. Methods: The data came from 350 inpatients. Based on serum-BZD evolution criteria, the procedure was divided into four stages: substitution, accumulation, elimination and post-elimination observation. After switching the patients to a long-acting substitute (diazepam), to prevent data falsification due to unwanted overaccumulation, the doses were expeditiously reduced under laboratory feedback until accumulation stopped. With the start of effective elimination, the tapering rate slowed and was individually adjusted to the patient's current clinical state. The tracking of both serum-BZD concentration and the corresponding intensity of withdrawal symptoms was continued throughout the entire elimination phase, also following successful drug withdrawal. Detoxification was concluded only after the patient's post-elimination stabilization. Results: Regardless of various initial serum-BZD concentration levels and the customized dose-reduction rate, and despite the novel lab-driven actions preventing initial overaccumulation, elimination was systematically proven to be protracted and varied within the 2- to 95-day range after the final dose. Within this period, withdrawal syndrome culminated several times, with varying combinations of symptoms. The last crisis occurrence (typically 2-3 weeks after withdrawal) correlated with the final serum-BZD elimination. The factors that prolonged elimination and delayed the final crisis were patient age, duration of addiction, adjunct valproate medication and elimination stage start parameters growing with former overaccumulation. Conclusions: The low-concentration detoxification stage is critical for patients' confrontations with recurring withdrawal symptoms. Underestimated elimination time following drug withdrawal and premature conclusions of detoxification expose patients to unassisted withdrawal crises. Concentration tracking defines proper limits for medical assistance, preventing early relapses.
MeSH term(s)	Age Factors ; Benzodiazepines/administration & dosage ; Diazepam/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Sex Factors ; Substance Withdrawal Syndrome/prevention & control ; Substance-Related Disorders/drug therapy
Chemical Substances	Benzodiazepines (12794-10-4) ; Diazepam (Q3JTX2Q7TU)
Language	English
Publishing date	2021-09-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-021-03205-x
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Article ; Online: Metabolic diversity as a reason for unsuccessful detoxification from benzodiazepines: the rationale for serum BZD concentration monitoring.

Basińska-Szafrańska, Anna

European journal of clinical pharmacology

2021 Volume 77, Issue 6, Page(s) 795–808

Abstract: Purpose: Many harms secondary to benzodiazepine (BZD) dependence force users towards detoxification treatment. However, even strongly motivated patients tolerate the process badly or experience early relapse. The detoxification procedure has not yet ... ...

Abstract	Purpose: Many harms secondary to benzodiazepine (BZD) dependence force users towards detoxification treatment. However, even strongly motivated patients tolerate the process badly or experience early relapse. The detoxification procedure has not yet been standardized. The objective of this paper is to examine the hypothesis that faulty detoxification routines may have caused some failures. Methods: The detoxification approaches found in the literature were compared stage by stage. The review was used to identify possible common, across-the-board systematic errors. Results: The presented literature review confirms that the widespread divergence in the BZD metabolism rate is effectively neglected during detoxification routines. Without laboratory measurements, these differences, additionally interfered with by auxiliary drugs, undermine not only the scheduled but even the symptom-driven procedures. An initial substitution with a long-acting BZD, although recommended, may lead to over-accumulation. This excess, varying between patients and incompatible with the current tapering stage, may lead to repeated overestimation of the patient's adjustments to reduced doses. Consequently, the patient's good clinical presentation at withdrawal, resulting in a conclusion of detoxification, may actually reflect a persistently high serum BZD concentration. The low-concentration stage, if shifted past the end of treatment, exposes patients to unexpected, unassisted withdrawal crises. With laboratory feedback, these crises, unlike the symptoms related to deficient re-adaptation mechanisms, could be prevented. Moreover, by minimizing the high-concentration phase, time can be saved for properly assisted low-concentration challenges. Conclusion: A customized detoxification procedure driven not only by the intensity of withdrawal symptoms but also by serum BZD monitoring may prevent some failures. As the standard regimen, it would make detoxification from BZDs more reliable and effective.
MeSH term(s)	Benzodiazepines/administration & dosage ; Benzodiazepines/adverse effects ; Benzodiazepines/blood ; Benzodiazepines/pharmacokinetics ; Drug Monitoring ; Half-Life ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/adverse effects ; Hypnotics and Sedatives/blood ; Hypnotics and Sedatives/pharmacokinetics ; Severity of Illness Index ; Substance Withdrawal Syndrome/drug therapy ; Substance Withdrawal Syndrome/physiopathology
Chemical Substances	Hypnotics and Sedatives ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2021-01-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-020-03048-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The divided town of Český Těšín/Cieszyn as the most integrated part of the Czech-Polish borderland

Böhm Hynek / Boháč Artur / Nowak-Żółty Edyta / Szafrańska Anna

Moravian Geographical Reports, Vol 31, Iss 4, Pp 194-

A life in the cross-border educational togetherness or side by side?

2023 Volume 202

Abstract: The (non)contribution of schools towards cross-border integration in the divided town of Těšín/Cieszyn, located on the Czech-Polish border, is analysed in this article. The pandemic-related border closures revealed a substantial level of togetherness in ... ...

Abstract	The (non)contribution of schools towards cross-border integration in the divided town of Těšín/Cieszyn, located on the Czech-Polish border, is analysed in this article. The pandemic-related border closures revealed a substantial level of togetherness in this town, manifested by various social activities. Moreover, a part of these (during the pandemic restricted) cross-border social practices were those in education. We applied a mix of quantitative and qualitative methods to diagnose the directions of cross-border educational flows, the approach of schools towards the identified joint cross-border social practices, and the possible level of togetherness. As a result, one-sidedness (Polish pupils attending schools in the Czech Republic) of cross-border flows was identified – which also follows the direction of a cross-border workforce. Except for the schools with Polish as the instruction language, located in the Czech part of the town, primarily serving Polish speakers living in the Czech Republic, we can mention hardly any mutually shared feeling of togetherness and an actual place-based approach towards educational governance in this divided town. We observe some ties in education between the autochthonous Polish minority in the Czech Republic and the Poles in Poland, without the involvement of pupils or teachers of Czech ethnicity, who do not reflect opportunities behind the border.
Keywords	cross-border integration ; schools ; těšín/cieszyn ; barriers ; functional integration ; poland ; czech republic ; Geography (General) ; G1-922
Subject code	940
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bread making potential of Triticum aestivum and Triticum spelta species

Podolska Grażyna / Aleksandrowicz Edyta / Szafrańska Anna

Open Life Sciences, Vol 15, Iss 1, Pp 30-

2020 Volume 40

Abstract: The aim of this study was to assess the effect of two winter wheat species: Triticum aestivum ssp. vulgare, and Triticum spelta, cultivated in different percentage of cereals in crop rotation, on their bread making potential. The analyzed grain samples ... ...

Abstract	The aim of this study was to assess the effect of two winter wheat species: Triticum aestivum ssp. vulgare, and Triticum spelta, cultivated in different percentage of cereals in crop rotation, on their bread making potential. The analyzed grain samples were obtained from a field experiment conducted during three years 2014-2016 at the Experimental Station in Osiny (51°35’, 21°55’), Institute of Soil Science and Plant Cultivation, State Research Institute, Puławy, Poland. The experiment was established following different percentages of shared cereals in crop rotation (SCCR): 50, 75 and 100%. Wheat cultivation was performed in accordance with good agricultural practice standards. Protein content, gluten content, Zeleny sedimentation index and alveograph properties were determined. Wheat species strongly influenced bread potential. The Triticum aestivum compared to Triticum spelta was characterized by significantly higher gluten quality and Zeleny sedimentation index as well as better alveograph properties. Common wheat showed the highest baking value (W). Spelt wheat was characterized by the lowest tenacity (P) and the highest extensibility (L). Moreover, the percentage of cereals in crop rotation had an effect on grain and dough quality parameters. Cultivation of wheat in 100% share of cereals resulted in the lowest grain and dough quality.
Keywords	alveograph ; grain and dough quality ; percentage of cereals in crop rotation ; common wheat ; spelt wheat ; Biology (General) ; QH301-705.5
Subject code	571
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Characteristics of Oat and Buckwheat Malt Grains for Use in the Production of Fermented Foods.

Salamon, Agnieszka / Kowalska, Hanna / Ignaczak, Anna / Marzec, Agata / Kowalska, Jolanta / Szafrańska, Anna

Foods (Basel, Switzerland)

2023 Volume 12, Issue 20

Abstract: Malted gluten-free cereal grains and pseudo-cereals are interesting raw materials for producing fermented foods. The aim of the work was to assess selected technological quality characteristics and antioxidant properties of special malts in terms of use ... ...

Abstract	Malted gluten-free cereal grains and pseudo-cereals are interesting raw materials for producing fermented foods. The aim of the work was to assess selected technological quality characteristics and antioxidant properties of special malts in terms of use in the production of fermented foods. The research material consisted of malts made from oat, buckwheat, and brewing barley. Malting was performed on a microtechnical scale according to the standard scheme for brewing barley grain. The basic quality parameters of cereal grains obtained malts, and laboratory wort were assessed according to methods applicable in brewing. Atypical brewing malts were characterized by parameters such as malt extractability, protein solubilization, diastatic force, mash filtration time, and wort viscosity. The best results, comparable to barley malt, were obtained for naked oat malt. Malted buckwheat grains turned out to be the least biochemically modified, although their use in the production of beer and/or other fermented beverages is supported by the high content of bioactive substances and antioxidant potential. As the malting process of cereal plants improves their antioxidant properties and increases their nutritional value, oat and buckwheat malts can be successfully used to produce gluten-free fermented beverages or as an addition to fermented products, e.g., in baking and confectionery.
Language	English
Publishing date	2023-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12203747
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Interaction of dough preparation method, green tea extract and baking temperature on the quality of rye bread and acrylamide content

Onacik-Gür, Sylwia / Szafrańska, Anna / Roszko, Marek / Stępniewska, Sylwia

Lebensmittel-Wissenschaft + [i.e. und] Technologie. 2022 Jan. 15, v. 154

2022

Abstract: The aim of the study was to determine the impact of three factors: dough preparation method (direct and indirect), green tea extract (GTE) addition (0.1% and 0.5% on flour basis) and baking temperature (230 and 260 °C) on rye bread quality and acrylamide ...

Abstract	The aim of the study was to determine the impact of three factors: dough preparation method (direct and indirect), green tea extract (GTE) addition (0.1% and 0.5% on flour basis) and baking temperature (230 and 260 °C) on rye bread quality and acrylamide (AA) content. All factors and their interaction had significant influence on quality parameters of dough and bread. pH of dough prepared by direct method was higher. Addition of GTE increased dough TTA, porosity and bread volume and decreased hardness of bread crumb. Breads prepared by indirect method had darker color of crust, which may be due to the higher amount of Maillard reaction products. Acrylamide formation in breads prepared from dough acidified by lactic acid (direct method) was 3.5 times lower than in breads from dough fermented by starter cultures (indirect method). Effect of GTE seemed to be unclear, because in breads made by direct method AA formation was not significantly different, however, in fermented sourdoughs content of this harmful component increased. All of the samples baked in lower temperature (230 °C) contained in average 25% less AA than baked in 260 °C.
Keywords	acrylamides ; breadmaking quality ; breads ; color ; fermentation ; flour ; green tea ; hardness ; lactic acid ; pH ; porosity ; rye ; temperature
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2021.112759
Database	NAL-Catalogue (AGRICOLA)

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Article: Bread making potential of Triticum aestivum and Triticum spelta species

Podolska, Grażyna / Aleksandrowicz, Edyta / Szafrańska, Anna

Open life sciences. 2020 Mar. 02, v. 15, no. 1

2020

Abstract	The aim of this study was to assess the effect of two winter wheat species: Triticum aestivum ssp. vulgare, and Triticum spelta, cultivated in different percentage of cereals in crop rotation, on their bread making potential. The analyzed grain samples were obtained from a field experiment conducted during three years 2014-2016 at the Experimental Station in Osiny (51°35’, 21°55’), Institute of Soil Science and Plant Cultivation, State Research Institute, Puławy, Poland. The experiment was established following different percentages of shared cereals in crop rotation (SCCR): 50, 75 and 100%. Wheat cultivation was performed in accordance with good agricultural practice standards. Protein content, gluten content, Zeleny sedimentation index and alveograph properties were determined. Wheat species strongly influenced bread potential. The Triticum aestivum compared to Triticum spelta was characterized by significantly higher gluten quality and Zeleny sedimentation index as well as better alveograph properties. Common wheat showed the highest baking value (W). Spelt wheat was characterized by the lowest tenacity (P) and the highest extensibility (L). Moreover, the percentage of cereals in crop rotation had an effect on grain and dough quality parameters. Cultivation of wheat in 100% share of cereals resulted in the lowest grain and dough quality.
Keywords	Triticum aestivum subsp. spelta ; breads ; crop rotation ; dough quality ; extensibility ; field experimentation ; gluten ; good agricultural practices ; protein content ; research institutions ; soil science ; winter wheat ; Poland
Language	English
Dates of publication	2020-0302
Size	p. 30-40.
Publishing place	De Gruyter
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2817958-4
ISSN	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2020-0004
Database	NAL-Catalogue (AGRICOLA)

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