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Article ; Online: A korai, szájon keresztüli táplálás nem jelent veszélyt a felső tápcsatornai műtétek után.

Sindler, Dóra Lili / Papp, Csenge / Csontos, Armand / Szakó, Lajos / Vereczkei, András / Halvax, Péter / Palkovics, András / Papp, András

Orvosi hetilap

2024 Volume 165, Issue 1, Page(s) 24–29

Title translation	Early oral feeding does not pose a risk after upper gastrointestinal surgeries.
Language	Hungarian
Publishing date	2024-01-07
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2024.32936
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Article ; Online: Effects of neoadjuvant chemotherapy

Csontos, Armand / Fazekas, Alíz / Szakó, Lajos / Farkas, Nelli / Papp, Csenge / Ferenczi, Szilárd / Bellyei, Szabolcs / Hegyi, Péter / Papp, András

World journal of gastroenterology

2024 Volume 30, Issue 11, Page(s) 1621–1635

Abstract: Background: Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer; however, the superiority of neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT) is unclear. Therefore, a discussion of ... ...

Abstract	Background: Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer; however, the superiority of neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT) is unclear. Therefore, a discussion of these two modalities is necessary. Aim: To investigate the benefits and complications of neoadjuvant modalities. Methods: To address this concern, predefined criteria were established using the PICO protocol. Two independent authors performed comprehensive searches using predetermined keywords. Statistical analyses were performed to identify significant differences between groups. Potential publication bias was visualized using funnel plots. The quality of the data was evaluated using the Risk of Bias Tool 2 (RoB2) and the GRADE approach. Results: Ten articles, including 1928 patients, were included for the analysis. Significant difference was detected in pathological complete response (pCR) [ Conclusion: Although nCRT may have a higher pCR rate, it does not translate to greater long-term survival. Moreover, nCRT is associated with higher 30-d mortality, although the specific cause for postoperative complications could not be identified. In the case of nCT, toxic side effects are suspected, which can reduce the quality of life. Given the quality of available studies, further randomized trials are required.
MeSH term(s)	Humans ; Neoadjuvant Therapy/adverse effects ; Quality of Life ; Adenocarcinoma/therapy ; Chemoradiotherapy/adverse effects ; Esophageal Neoplasms/therapy
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v30.i11.1621
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Article: Faster recovery and bowel movement after early oral feeding compared to late oral feeding after upper GI tumor resections: a meta-analysis.

Sindler, Dóra Lili / Mátrai, Péter / Szakó, Lajos / Berki, Dávid / Berke, Gergő / Csontos, Armand / Papp, Csenge / Hegyi, Péter / Papp, András

Frontiers in surgery

2023 Volume 10, Page(s) 1092303

Abstract: Background: There were more than 1 million new cases of stomach cancer concerning oesophageal cancer, there were more than 600,000 new cases of oesophageal cancer in 2020. After a successful resection in these cases, the role of early oral feeding (EOF) ...

Abstract	Background: There were more than 1 million new cases of stomach cancer concerning oesophageal cancer, there were more than 600,000 new cases of oesophageal cancer in 2020. After a successful resection in these cases, the role of early oral feeding (EOF) was questionable, due to the possibility of fatal anastomosis leakage. It is still debated whether EOF is more advantageous compared to late oral feeding. Our study aimed to compare the effect of early postoperative oral feeding and late oral feeding after upper gastrointestinal resections due to malignancy. Methods: Two authors performed an extensive search and selection of articles independently to identify randomized control trials (RCT) of the question of interest. Statistical analyses were performed including mean difference, odds ratio with 95% confidence intervals, statistical heterogeneity, and statistical publication bias, to identify potential significant differences. The Risk of Bias and the quality of evidence were estimated. Results: We identified 6 relevant RCTs, which included 703 patients. The appearance of the first gas (MD = -1.16; Conclusion: Early postoperative oral feeding, compared to late oral feeding has no risk of several possible postoperative morbidities after upper GI surgeries, but has several advantageous effects on a patient's recovery. Systematic review registration: identifier, CRD 42022302594.
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1092303
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Article: Dyspepsia-Like Symptoms in

Zádori, Noémi / Németh, Dávid / Frim, Levente / Vörhendi, Nóra / Szakó, Lajos / Váncsa, Szilárd / Hegyi, Péter / Czimmer, József

International journal of general medicine

2022 Volume 15, Page(s) 7789–7796

Abstract: Introduction: Dyspeptic symptoms are frequent in the general population, with a high socioeconomic burden. : Methods: This retrospective study included data from patients with : Results: From a total of 285 patients, 175 were included in this ... ...

Abstract	Introduction: Dyspeptic symptoms are frequent in the general population, with a high socioeconomic burden. Methods: This retrospective study included data from patients with Results: From a total of 285 patients, 175 were included in this study. Among these patients, 95 experienced dyspeptic symptoms (54.29%) and were associated more with AISP (p = 0.012), especially with celiac seropositivity (p = 0.045), anti-neutrophil cytoplasmic antibody (ANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA) positivity (p = 0.043). A significant association was not found with other tested autoimmune (AI)-related antibody positivity. Conclusion: Positivity of seromarkers of autoimmune diseases in chronic gastritis may predispose to have dyspeptic symptoms and may be the causative factor behind some cases of uninvestigated dyspepsia. These data suggest that further prospective studies are needed to clarify whether screening for autoantibodies in patients with dyspepsia is cost-effective and helps the earlier diagnosis of autoimmune diseases.
Language	English
Publishing date	2022-10-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S380419
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Article ; Online: Prevalence of Autoimmune-phenomena behind Chronic Gastritis of Unknown Origin, and their Role in the Poor Histological Outcome of the Stomach: A Single-centre, Retrospective Cross-sectional Study.

Zádori, Noémi / Németh, Dávid / Szakó, Lajos / Váncsa, Szilárd / Vörhendi, Nóra / Szakács, Zsolt / Frim, Levente / Hegyi, Péter / Czimmer, Jozsef

Journal of gastrointestinal and liver diseases : JGLD

2022 Volume 31, Issue 2, Page(s) 168–175

Abstract: Background and aims: The underlying aetiology of chronic gastritis (CG) often remains unknown due to its underrated significance in clinical practice. However, the role of chronic inflammation of the stomach in the development of atrophy, intestinal ... ...

Abstract	Background and aims: The underlying aetiology of chronic gastritis (CG) often remains unknown due to its underrated significance in clinical practice. However, the role of chronic inflammation of the stomach in the development of atrophy, intestinal metaplasia (IM) and eventually of gastric cancer is well documented. We aimed to explore the possible aetiological factors of CG, determine the prevalence of systemic autoimmune disorders in patients with CG of unknown aetiology, and clarify the role of autoantibodies in the development of precancerous lesions in the stomach. Methods: This is a retrospective, cross-sectional study, conducted from January 2016 to January 2020, including data from 175 patients with CG. Exclusion criteria were: (1) acute gastritis; (2) reactive gastropathy; (3) gastric cancer; (4) subjects without any serology testing results; and (5) Helicobacter pylori positivity. The primary endpoint was a composite endpoint involving gastric atrophy and IM. Results: Fifty-five per cent of patients with CG had autoantibodies. Systemic lupus erythematosus (SLE)-related antibodies were positive in most of the cases, including antinuclear antibody (ANA) positivity, which was found in 19.13% of the patients. Autoimmune positivity was shown to be associated with precancerous lesions in the stomach (p<0.001): IM, atrophy and IM with atrophy. Anti-parietal cell antibody positivity seems to be a significant risk factor for IM and IM with atrophy. Autoimmune thyroiditis-related antibodies and ANA positivity by itself were only associated with atrophy; SLE-related antibodies and inflammatory bowel diseases related antibodies (ASCA and ANCA) correlated either with IM or with atrophy. No significant relation was found between any other investigated autoimmune disease-related antibodies and precancerous lesions. Conclusions: Autoimmune positivity often underlies gastritis of unknown aetiology and predisposes to precancerous lesions in the stomach. These antibodies can serve as non-invasive markers for the of optimal timing of an endoscopic follow-up strategy. Furthermore, CG can be an early symptom of a systemic autoimmune disorder.
MeSH term(s)	Atrophy ; Autoantibodies ; Cross-Sectional Studies ; Gastritis/epidemiology ; Gastritis/pathology ; Gastritis, Atrophic/diagnosis ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Lupus Erythematosus, Systemic/complications ; Metaplasia ; Precancerous Conditions/pathology ; Prevalence ; Retrospective Studies ; Stomach Neoplasms/pathology
Chemical Substances	Autoantibodies
Language	English
Publishing date	2022-06-12
Publishing country	Romania
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2427021-0
ISSN	1842-1121 ; 1841-8724
ISSN (online)	1842-1121
ISSN	1841-8724
DOI	10.15403/jgld-4218
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Article ; Online: Tenodesis yields better functional results than tenotomy in long head of the biceps tendon operations-a systematic review and meta-analysis.

Vajda, Mátyás / Szakó, Lajos / Hegyi, Péter / Erőss, Bálint / Görbe, Anikó / Molnár, Zsolt / Kozma, Kincső / Józsa, Gergő / Bucsi, László / Schandl, Károly

International orthopaedics

2022 Volume 46, Issue 5, Page(s) 1037–1051

Abstract: Background: Pathology of the long head of the biceps tendon (LHBT) is a common disorder affecting muscle function and causing considerable pain for the patient. The literature on the two surgical treatment methods (tenotomy and tenodesis) is ... ...

Abstract	Background: Pathology of the long head of the biceps tendon (LHBT) is a common disorder affecting muscle function and causing considerable pain for the patient. The literature on the two surgical treatment methods (tenotomy and tenodesis) is controversial; therefore, our aim was to compare the results of these interventions. Methods: We performed a meta-analysis using the following strategy: (P) patients with LHBT pathology, (I) tenodesis, (C) tenotomy, (O) elbow flexion and forearm supination strength, pain assessed on the ten-point Visual Analog Scale (VAS), bicipital cramping pain, Constant, ASES, and SST score, Popeye deformity, and operative time. We included only randomized clinical trials. We searched five databases. During statistical analysis, odds ratios (OR) and weighted mean differences (WMD) were calculated for dichotomous and continuous outcomes, respectively, using the Bayesian method with random effect model. Results: We included 11 studies in the systematic review, nine of these were eligible for the meta-analysis, containing data about 572 patients (279 in the tenodesis, 293 in the tenotomy group). Our analysis concluded that tenodesis is more beneficial considering 12-month elbow flexion strength (WMD: 3.67 kg; p = 0.006), 12-month forearm supination strength (WMD: 0.36 kg; p = 0.012), and 24-month Popeye deformity (OR: 0.19; p < 0.001), whereas tenotomy was associated with decreased 3-month pain scores on VAS (WMD: 0.99; p < 0.001). We did not find significant difference among the other outcomes. Conclusion: Tenodesis yields better results in terms of biceps function and is non-inferior regarding long-term pain, while tenotomy is associated with earlier pain relief.
MeSH term(s)	Arthroscopy ; Bayes Theorem ; Humans ; Muscle, Skeletal/surgery ; Pain/surgery ; Rotator Cuff Injuries/surgery ; Tendons/surgery ; Tenodesis/methods ; Tenotomy/adverse effects ; Tenotomy/methods
Language	English
Publishing date	2022-03-07
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-022-05338-9
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Article ; Online: Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients.

Zádori, Noémi / Szakó, Lajos / Váncsa, Szilárd / Vörhendi, Nóra / Oštarijaš, Eduard / Kiss, Szabolcs / Frim, Levente / Hegyi, Péter / Czimmer, József

Frontiers in immunology

2021 Volume 12, Page(s) 750533

Abstract: Background: Gastric cancer is one of the most common cancers worldwide, with a high mortality rate. The potential etiological role of autoimmune (AI) disorders has been described in gastric cancer; however, the literature is controversial. This study ... ...

Abstract	Background: Gastric cancer is one of the most common cancers worldwide, with a high mortality rate. The potential etiological role of autoimmune (AI) disorders has been described in gastric cancer; however, the literature is controversial. This study aims to provide a comprehensive summary of the association between autoimmune disorders and the incidence of gastric cancer. Methods: This study was registered on PROSPERO under registration number CRD42021262875. The systematic literature search was conducted in four scientific databases up to May 17, 2021. Studies that reported standardized incidence rate (SIR) of gastric cancer in autoimmune disorders were eligible. We calculated pooled SIRs with 95% confidence intervals (CIs) in this meta-analysis. Results: We included 43 articles describing 36 AI disorders with data of 499,427 patients from four continents in our systematic review and meta-analysis. Significantly increased incidence of gastric cancer was observed in dermatomyositis (SIR = 3.71; CI: 2.04, 6.75), pernicious anemia (SIR = 3.28; CI: 2.71, 3.96), inflammatory myopathies (SIR = 2.68; CI:1.40; 5.12), systemic lupus erythematosus (SIR = 1.48; CI: 1.09, 2.01), diabetes mellitus type I (SIR = 1.29; CI:1.14, 1,47), and Graves' disease (SIR = 1.28; CI: 1.16, 1.41). No significant associations could be found regarding other AI disorders. Conclusions: Pernicious anemia, Graves' disease, dermatomyositis, diabetes mellitus type I, inflammatory myopathies, and systemic lupus erythematosus are associated with higher incidence rates of gastric cancer. Therefore, close gastroenterological follow-up or routinely performed gastroscopy and application of other diagnostic measures may be cost-effective and clinically helpful for patients diagnosed with these autoimmune diseases.
MeSH term(s)	Anemia, Pernicious/complications ; Autoimmune Diseases/complications ; Dermatomyositis/complications ; Diabetes Mellitus, Type 1/complications ; Female ; Graves Disease/complications ; Humans ; Incidence ; Lupus Erythematosus, Systemic/complications ; Male ; Myositis/complications ; Risk Factors ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/etiology
Language	English
Publishing date	2021-11-23
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.750533
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Article ; Online: Convalescent plasma therapy for COVID-19 patients: a protocol of a prospective meta-analysis of randomized controlled trials.

Szakó, Lajos / Farkas, Nelli / Kiss, Szabolcs / Váncsa, Szilárd / Zádori, Noémi / Vörhendi, Nóra / Erőss, Bálint / Hegyi, Péter / Alizadeh, Hussain

Trials

2021 Volume 22, Issue 1, Page(s) 112

Abstract: Background: Coronavirus disease 2019 (COVID-19) is an infection with possible serious consequences. The plasma of recovered patients might serve as treatment, which we aim to assess in the form of a prospective meta-analysis focusing on mortality, multi- ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) is an infection with possible serious consequences. The plasma of recovered patients might serve as treatment, which we aim to assess in the form of a prospective meta-analysis focusing on mortality, multi-organ failure, duration of intensive care unit stay, and adverse events. Methods: A systematic search was conducted to find relevant registered randomized controlled trials in five trial registries. A comprehensive search will be done continuously on a monthly basis in MEDLINE (via PubMed), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science to find the results of previously registered randomized controlled trials. The selection will be done by two independent authors. Data extraction will be carried out by two other independent reviewers. Disagreements will be resolved by a third investigator. An update of the search of the registries and the first search of the databases will be done on the 21st of July. Data synthesis will be performed following the recommendations of the Cochrane Collaboration. In the case of dichotomous outcomes (mortality and organ failure), we will calculate pooled risk ratios with a 95% confidence interval (CI) from two-by-two tables (treatment Y/N, outcome Y/N). Data from models with multivariate adjustment (hazard ratios, odds ratio, risk ratio) will be preferred for the analysis. P less than 0.05 will be considered statistically significant. In the case of ICU stay, weighted mean difference with a 95% confidence interval will be calculated. Heterogeneity will be tested with I Discussion: Convalescent plasma therapy is a considerable alternative in COVID-19, which we aim to investigate in a prospective meta-analysis.
MeSH term(s)	COVID-19/mortality ; COVID-19/therapy ; Humans ; Immunization, Passive/methods ; Immunization, Passive/mortality ; Intensive Care Units ; Length of Stay ; Meta-Analysis as Topic ; Prospective Studies ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Treatment Outcome ; COVID-19 Serotherapy
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-021-05066-2
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Article ; Online: Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer: The superiority of minimally invasive surgery.

Szakó, Lajos / Németh, Dávid / Farkas, Nelli / Kiss, Szabolcs / Dömötör, Réka Zsuzsa / Engh, Marie Anne / Hegyi, Péter / Eross, Balint / Papp, András

World journal of gastroenterology

2021 Volume 28, Issue 30, Page(s) 4201–4210

Abstract: Background: Previous meta-analyses, with many limitations, have described the beneficial nature of minimal invasive procedures.: Aim: To compare all modalities of esophagectomies to each other from the results of randomized controlled trials (RCTs) ... ...

Abstract	Background: Previous meta-analyses, with many limitations, have described the beneficial nature of minimal invasive procedures. Aim: To compare all modalities of esophagectomies to each other from the results of randomized controlled trials (RCTs) in a network meta-analysis (NMA). Methods: We conducted a systematic search of the MEDLINE, EMBASE, Results: We included 11 studies in our analysis. We found a significant difference in postoperative pulmonary infection, which favored the minimally invasive intervention compared to transthoracic surgery (risk ratio 0.49; 95%CI: 0.23 to 0.99). The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery (mean difference -85 min; 95%CI: -150 to -29), hybrid intervention (mean difference -98 min; 95%CI: -190 to -9.4), minimally invasive technique (mean difference -130 min; 95%CI: -210 to -50), and robot-assisted esophagectomy (mean difference -150 min; 95%CI: -240 to -53). Other comparisons did not yield significant differences. Conclusion: Based on our results, the implication of minimally invasive esophagectomy should be favored.
MeSH term(s)	Esophageal Neoplasms/etiology ; Esophageal Neoplasms/surgery ; Esophagectomy/adverse effects ; Esophagectomy/methods ; Humans ; Laparoscopy ; Minimally Invasive Surgical Procedures/adverse effects ; Minimally Invasive Surgical Procedures/methods ; Network Meta-Analysis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Randomized Controlled Trials as Topic ; Treatment Outcome
Language	English
Publishing date	2021-11-08
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v28.i30.4201
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Article: Repeated SARS-CoV-2 Positivity: Analysis of 123 Cases

Váncsa, Szilárd / Dembrovszky, Fanni / Farkas, Nelli / Szakó, Lajos / Teutsch, Brigitta / Bunduc, Stefania / Nagy, Rita / Párniczky, Andrea / Erőss, Bálint / Péterfi, Zoltán / Hegyi, Péter

Viruses. 2021 Mar. 19, v. 13, no. 3

2021

Abstract: Repeated positivity and reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a significant concern. Our study aimed to evaluate the clinical significance of repeatedly positive testing after coronavirus disease 2019 (COVID-19) ...

Abstract	Repeated positivity and reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a significant concern. Our study aimed to evaluate the clinical significance of repeatedly positive testing after coronavirus disease 2019 (COVID-19) recovery. We performed a systematic literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. With available individual patient data reporting on repeatedly SARS-CoV-2 positive (RSP) patients, case reports, and case series were included in this analysis. We performed a descriptive analysis of baseline characteristics of repeatedly positive cases. We assessed the cases according to the length of their polymerase chain reaction (PCR) negative interval between the two episodes. Risk factors for the severity of second episodes were evaluated. Overall, we included 123 patients with repeated positivity from 56 publications, with a mean repeated positivity length of 47.8 ± 29.9 days. Younger patients were predominant in the delayed (>90 days) recurrent positive group. Furthermore, comparing patients with RSP intervals of below 60 and above 60 days, we found that a more severe disease course can be expected if the repeated positivity interval is shorter. Severe and critical disease courses might predict future repeatedly positive severe and critical COVID-19 episodes. In conclusion, our results show that the second episode of SARS-CoV-2 positivity is more severe if it happens within 60 days after the first positive PCR. On the other hand, the second episode’s severity correlates with the first.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; disease course ; disease severity ; guidelines ; meta-analysis ; patients ; polymerase chain reaction
Language	English
Dates of publication	2021-0319
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13030512
Database	NAL-Catalogue (AGRICOLA)

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