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  1. Article ; Online: Introducing peanut early in life - Ready for the general population?

    Szépfalusi, Zsolt / Eiwegger, Thomas

    Allergy

    2023  Volume 78, Issue 5, Page(s) 1142–1144

    MeSH term(s) Humans ; Arachis/adverse effects ; Peanut Hypersensitivity/diagnosis ; Peanut Hypersensitivity/epidemiology ; Desensitization, Immunologic
    Language English
    Publishing date 2023-03-30
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15676
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  2. Article ; Online: Preventive allergen immunotherapy with inhalant allergens in children.

    Dwivedi, Varsha / Kopanja, Sonja / Schmidthaler, Klara / Sieber, Justyna / Bannert, Christina / Szépfalusi, Zsolt

    Allergy

    2024  

    Abstract: The efficacy and safety of preventive allergen immunotherapy (pAIT) in children are currently under investigation. Here, we provide an overview of pAIT with respiratory allergens concerning the prevention of new sensitizations, allergic disease onset and ...

    Abstract The efficacy and safety of preventive allergen immunotherapy (pAIT) in children are currently under investigation. Here, we provide an overview of pAIT with respiratory allergens concerning the prevention of new sensitizations, allergic disease onset and progression as well as further immunomodulatory effects. Three databases were searched for clinical pAIT studies in children. Selected publications were reviewed for preventive outcomes according to prevention level (primary, secondary, and tertiary), allergen type, administration route, dose, and treatment duration. The primary prevention approach appears safe but showed no allergen-specific effect on new sensitizations. Secondary prevention seems feasible and may induce regulatory T cell-mediated immunotolerance. The number of studies at these prevention levels is limited. Tertiary prevention with grass and/or tree pollen-based pAIT has shown efficacy in preventing disease progression from allergic rhinitis/conjunctivitis to asthma. Data on tertiary pAIT with house dust mites and other allergen types are inconclusive. Subcutaneous and sublingual routes appear similarly effective, but head-to-head comparative paediatric studies are scarce. Additionally, there are fewer placebo-controlled studies. Nevertheless, immunomodulatory outcomes of pAIT are encouraging. Currently, limited but favourably suggestive evidence is available for preventing respiratory allergic diseases in children by pAIT. Primary and secondary prevention have potential and warrant further investigation through well-designed studies.
    Language English
    Publishing date 2024-04-08
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16115
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  3. Article ; Online: Subsequent MRI of pediatric patients after an adverse reaction to Gadolinium-based contrast agents.

    Hojreh, Azadeh / Peyrl, Andreas / Bundalo, Aleksandra / Szepfalusi, Zsolt

    PloS one

    2020  Volume 15, Issue 4, Page(s) e0230781

    Abstract: Background: Gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance imaging (MRI) scans often must be used repeatedly in pediatric oncologic patients. Although GBCAs are usually well tolerated, severe and life-threatening allergic reactions ... ...

    Abstract Background: Gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance imaging (MRI) scans often must be used repeatedly in pediatric oncologic patients. Although GBCAs are usually well tolerated, severe and life-threatening allergic reactions might occur, which can result in overly cautions adherence to special precautions in patients.
    Purpose: To evaluate the management of the reported GBCA-associated adverse reactions in subsequent contrast-enhanced MRIs in pediatric patients, distinguishing non-allergic and allergic reactions.
    Materials and methods: In this retrospective, cross-sectional study, consecutive pediatric neurooncological patients who underwent GBCA-enhanced MRI at our university hospital, between 2007 and 2016, were eligible. The patients' history was evaluated with regard to any adverse events after GBCA administration. In a subset of patients with reported adverse reactions, the institutional premedication regime or an allergy work-up in clinical practice were performed, using either skin-prick tests or intravenous provocation tests in a double-blind procedure.
    Results: Included were 8156 contrast-enhanced MRI scans in 2109 patients. Nineteen acute adverse events (19/8156; 0.23%) in 17 patients (17/2109; 0.81%) were reported. Despite a premedication regime in 14 patients, three patients (3/14; 21.4%) reported a breakthrough reaction. None of the 12 patients who underwent skin-prick tests or intravenous provocation tests showed allergic reactions. At least one well-tolerated GBCA was identified in almost every tested patient.
    Conclusion: A fast-track allergy work-up can help to distinguish non-allergic and allergic reactions and to identify a well-tolerated GBCA, thus avoiding unnecessary premedication for subsequent GBCA administrations.
    MeSH term(s) Administration, Intravenous/methods ; Adolescent ; Child ; Child, Preschool ; Contrast Media/adverse effects ; Cross-Sectional Studies ; Double-Blind Method ; Drug Hypersensitivity/etiology ; Female ; Gadolinium/adverse effects ; Humans ; Hypersensitivity, Immediate/etiology ; Magnetic Resonance Imaging/adverse effects ; Male ; Premedication/methods ; Retrospective Studies ; Skin Tests/methods
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0230781
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  4. Article: Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years.

    Sieber, Justyna / Renner, Sabine / Lakatos-Krepcik, Andrea / Szépfalusi, Zsolt

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 663228

    Abstract: Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated ... ...

    Abstract Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application.
    Language English
    Publishing date 2021-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.663228
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  5. Article ; Online: Multiple Drug Hypersensitivity in a Small Child with DRESS Syndrome - A Case Report.

    Gruber, Saskia / Gona-Hoepler, Livia / Bangert, Christine / Diesner, Susanne C / Schmidthaler, Klara / Szepfalusi, Zsolt

    Klinische Padiatrie

    2022  

    Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) belongs to the group of severe cutaneous adverse reactions. Here we report a case of drug hypersensitivity against multiple antibiotics with DRESS in a young child with necrotizing pneumonia. ...

    Title translation Multiple Arzneimittelreaktionen bei einem Kleinkind mit DRESS Syndrom – Ein Fallbericht.
    Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) belongs to the group of severe cutaneous adverse reactions. Here we report a case of drug hypersensitivity against multiple antibiotics with DRESS in a young child with necrotizing pneumonia.
    Language English
    Publishing date 2022-07-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/a-1857-5062
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  6. Article ; Online: PM/Scl-Overlap-Syndrom bei einem 14-jährigen Mädchen nach SARS-CoV-2-Infektion.

    Dadak, Lisbeth / Heil, Peter Maximilian / Geleff, Silvana / Prosch, Helmut / Idzko, Marco / Hojreh, Azadeh / Szepfalusi, Zsolt / Valent, Isabella / Emminger, Wolfgang

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 6, Page(s) 661–663

    Language German
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15044_g
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  7. Article ; Online: PM/Scl overlap syndrome in a 14-year-old girl manifesting after a SARS-CoV-2 infection.

    Dadak, Lisbeth / Heil, Peter Maximilian / Geleff, Silvana / Prosch, Helmut / Idzko, Marco / Hojreh, Azadeh / Szepfalusi, Zsolt / Valent, Isabella / Emminger, Wolfgang

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 6, Page(s) 661–663

    MeSH term(s) Female ; Humans ; Adolescent ; COVID-19/complications ; COVID-19/diagnosis ; SARS-CoV-2 ; Autoimmune Diseases ; Autoantibodies ; Connective Tissue Diseases ; Scleroderma, Systemic
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-06-01
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15044
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  8. Article: Nahrungsmittelallergien im Kindesalter

    Szépfalusi, Zsolt

    Wiener medizinische Wochenschrift

    2012  Volume 162, Issue 23/24, Page(s) 525

    Language German
    Document type Article
    ZDB-ID 123613-1
    ISSN 0254-7945 ; 0043-5341
    Database Current Contents Medicine

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  9. Article ; Online: The maturation of the fetal and neonatal immune system.

    Szépfalusi, Zsolt

    publication RETRACTED

    The Journal of nutrition

    2008  Volume 138, Issue 9, Page(s) 1773S–1781S

    Abstract: The prevalence of allergic diseases has risen markedly since the 1960s, particularly in the developed countries of the Western world. These diseases manifest initially during infancy and childhood and are apparently becoming more persistent in successive ...

    Abstract The prevalence of allergic diseases has risen markedly since the 1960s, particularly in the developed countries of the Western world. These diseases manifest initially during infancy and childhood and are apparently becoming more persistent in successive birth cohorts. The importance of genetic susceptibility in the disease process is widely recognized, and it is further recognized that the ultimate expression of the disease is the result of complex interactions between genetic and environmental factors, with nutrition representing 1 main variable, neither of which have yet been comprehensively characterized. There is increasing evidence that the level of complexity inherent in the pathogenesis of allergic diseases may be even greater than is currently contemplated, as an additional set of crucial factors appear to be involved. Notably, it appears likely that the ultimate effects of the "gene-environment" interaction within individuals may also be related to the developmental status of the relevant target tissues at the time the interactions occur. Examples of the latter, discussed below, are elements of innate and adaptive immune function and aspects of food allergy and of airway function relevant to atopic asthma.
    MeSH term(s) Animals ; Disease Susceptibility ; Fetal Development/immunology ; Fetus/immunology ; Humans ; Immune System/embryology ; Immune System/growth & development ; Immunophenotyping ; Infant, Newborn ; Lymphoid Tissue/growth & development ; Nutritional Physiological Phenomena ; T-Lymphocytes/immunology ; T-Lymphocytes/physiology ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2008-08-18
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/138.9.1773S
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  10. Article ; Online: The impact of maternal-fetal omalizumab transfer on peanut-specific responses in an ex vivo placental perfusion model.

    Kothari, Akash / Hirschmugl, Birgit / Lee, Jean-Soo / Pfaller, Birgit / Schmidthaler, Klara / Szépfalusi, Zsolt / Wadsack, Christian / Eiwegger, Thomas

    Allergy

    2022  Volume 77, Issue 12, Page(s) 3684–3686

    MeSH term(s) Female ; Humans ; Pregnancy ; Omalizumab/therapeutic use ; Arachis ; Placenta ; Peanut Hypersensitivity ; Perfusion ; Maternal-Fetal Exchange
    Chemical Substances Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2022-08-14
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15468
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