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Article ; Online: Effect of exopolysaccharides from cariogenic bacteria on human gingival fibroblasts.

Szkaradkiewicz-Karpińska, Anna K / Szkaradkiewicz, Andrzej

International journal of medical sciences

2021 Volume 18, Issue 12, Page(s) 2666–2672

Abstract: Bacterial biofilm (dental plaque) plays a key role in caries etiopathogenesis and chronic periodontitis in humans. Dental plaque formation is determined by exopolysaccharides (EPSs) produced by cariogenic and periopathogenic bacteria. The most frequent ... ...

Abstract	Bacterial biofilm (dental plaque) plays a key role in caries etiopathogenesis and chronic periodontitis in humans. Dental plaque formation is determined by exopolysaccharides (EPSs) produced by cariogenic and periopathogenic bacteria. The most frequent cariogenic bacteria include oral streptococci (in particular
MeSH term(s)	Adenosine Triphosphate/analysis ; Adenosine Triphosphate/metabolism ; Biofilms ; Cell Line ; Dental Caries/immunology ; Dental Caries/microbiology ; Fibroblasts/immunology ; Fibroblasts/metabolism ; Gingiva/cytology ; Gingiva/immunology ; Gingiva/microbiology ; Gingivitis/immunology ; Gingivitis/microbiology ; Humans ; Lactobacillus acidophilus/immunology ; Lactobacillus acidophilus/metabolism ; Polysaccharides, Bacterial/immunology ; Polysaccharides, Bacterial/metabolism ; Streptococcus mutans/immunology ; Streptococcus mutans/metabolism
Chemical Substances	Polysaccharides, Bacterial ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2021-05-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.57221
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Article: Towards a more effective strategy for COVID-19 prevention (Review).

Szkaradkiewicz-Karpińska, Anna K / Szkaradkiewicz, Andrzej

Experimental and therapeutic medicine

2020 Volume 21, Issue 1, Page(s) 33

Abstract: At the end of 2019, a new disease, similar to severe acute respiratory syndrome (SARS) associated with SARS-CoV was reported in Wuhan, China. It was quickly discovered that the etiological factor of the new disease (COVID-19) was a previously unknown ... ...

Abstract	At the end of 2019, a new disease, similar to severe acute respiratory syndrome (SARS) associated with SARS-CoV was reported in Wuhan, China. It was quickly discovered that the etiological factor of the new disease (COVID-19) was a previously unknown SARS coronavirus 2 (SARS-CoV-2). The global spread of of COVID-19 has lead to the declaration of a pandemic status in 2019-2020 as declared by the World Health Organization and Public Health Emergency of International Concern. SARS-CoV-2 characterizes with high epidemic potential and is effectively disseminated between humans. SARS-CoV and SARS-CoV-2 are closely related pathogens. Their prime route of distribution is air-droplet transmission. Combating infectious diseases disseminated by inhalation is very difficult, and mainly relies on the use of vaccines. However, despite the lack of an effective anti-SARS-CoV vaccine and specific antiviral drugs, the strict sanitary procedures proved to be sufficient to stop the SARS epidemic in June 2003. However, epidemic research has indicated that SARS-CoV-2 is transmitted in humans significantly more effectively than SARS-CoV; therefore, the COVID-19 pandemic continues to expand. This indicates that the so far anti-epidemic activities to control COVID-19 are insufficient. In the current review, the possibility of using interferon α (IFN-α) as a preventive agent of COVID-19 is discussed. The current data concerning anti-COVID-19 vaccines and specific drugs against SARS-CoV-2 are also discussed. The aim of the current review is to contribute to the introduction of a more efficient strategy in the protection of the human population against COVID-19.
Language	English
Publishing date	2020-11-11
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2020.9465
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Article ; Online: MUC7 Level As A New Saliva Risk Factor For Dental Caries In Adult Patients.

Szkaradkiewicz-Karpińska, Anna K / Ronij, Anna / Goślińska-Kuźniarek, Olga / Przybyłek, Izabela / Szkaradkiewicz, Andrzej

International journal of medical sciences

2019 Volume 16, Issue 2, Page(s) 241–246

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Adult ; Dental Caries/etiology ; Dental Caries/metabolism ; Humans ; Mucin-5B/metabolism ; Mucins/metabolism ; Risk Factors ; Saliva/metabolism ; Salivary Proteins and Peptides/metabolism
Chemical Substances	MUC5B protein, human ; MUC7 protein, human ; Mucin-5B ; Mucins ; Salivary Proteins and Peptides
Language	English
Publishing date	2019-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.29027
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Article ; Online: Effect of novobiocin on the viability of human gingival fibroblasts (HGF-1).

Szkaradkiewicz, Anna K / Karpiński, Tomasz M / Szkaradkiewicz, Andrzej

BMC pharmacology & toxicology

2014 Volume 15, Page(s) 25

Abstract: Background: Novobiocin is a coumarin antibiotic, which affects also eukaryotic cells inhibiting activity of Heat shock protein 90 (Hsp90). The Hsp90 represents a molecular chaperone critical for stabilization and activation of many proteins, ... ...

Abstract	Background: Novobiocin is a coumarin antibiotic, which affects also eukaryotic cells inhibiting activity of Heat shock protein 90 (Hsp90). The Hsp90 represents a molecular chaperone critical for stabilization and activation of many proteins, particularly oncoproteins that drive cancer progression. Currently, Hsp90 inhibitors focus a significant attention since they form a potentially new class of drugs in therapy of cancer. However, in the process of tumorigenesis a significant role is played also by the microenvironment of the tumour, and, in particular, by cancer-associated fibroblasts (CAFs). This study aimed at examination of the effect played by novobiocin on viability of human gingival fibroblasts (HGF-1). Methods: The studies were conducted using 24 h cultures of human gingival fibroblasts - HGF-1 (CRL-2014) in Chamber Slides, in presence of 0.1, 0.5, 1.0, 2.5 or 5.0 mM novobiocin. Cell viability was evaluated using fluorescence test, ATP assay and LDH release. Results: Viability of HGF-1 was drastically reduced after 5 hour treatment with novobiocin in concentrations of 1 mM or higher. In turn, the percentage of LDH-releasing cells after 5 h did not differ from control value although it significantly increased after 10 h incubation with 1 mM and continued to increase till the 20th hour. Conclusions: The obtained data indicate that novobiocin may induce death of human gingival fibroblasts. Therefore, application of the Hsp90 inhibitor in neoplastic therapy seems controversial: on one hand novobiocin reduces tumour-associated CAFs but, on the other, it may induce a significant destruction of periodontium.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Cell Line ; Cell Survival/drug effects ; Fibroblasts/drug effects ; Gingiva/cytology ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Humans ; L-Lactate Dehydrogenase/metabolism ; Novobiocin/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Antineoplastic Agents ; HSP90 Heat-Shock Proteins ; Novobiocin (17EC19951N) ; Adenosine Triphosphate (8L70Q75FXE) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	English
Publishing date	2014-05-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/2050-6511-15-25
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Article: Cowpox virus infection in a child after contact with a domestic cat: a case report.

Żaba, Ryszard / Jałowska, Magdalena / Kowalczyk, Michał J / Bowszyc-Dmochowska, Monika / Adamski, Zygmunt / Szkaradkiewicz, Andrzej

The new microbiologica

2017 Volume 40, Issue 2, Page(s) 148–150

Abstract: Human cowpox represents a seldom diagnosed zoonosis but this diagnosis should be considered more frequently as the number of cases has increased in recent years. We describe a case of cowpox in an 11-yearold boy following regular direct daily contact ... ...

Abstract	Human cowpox represents a seldom diagnosed zoonosis but this diagnosis should be considered more frequently as the number of cases has increased in recent years. We describe a case of cowpox in an 11-yearold boy following regular direct daily contact with a domestic cat. The 11-year-old patient, an otherwise healthy boy, demonstrated skin ulceration located at his chin, with enlargement of regional lymph nodes and fever reaching 39°C. The diagnosis of cowpox was made on the basis of PCR involving DNA isolated from a scab covering the skin lesion. Application of PCR involving DNA isolated from the scab covering the lesion with parallel use of OPXV-specific (ORF F4L) and CPXV-specific (ORF B9R) oligonucleotide primer sequences is recommended for rapid laboratory confirmation of the diagnosis.
MeSH term(s)	Animals ; Cat Diseases/parasitology ; Cat Diseases/transmission ; Cats ; Child ; Cowpox/parasitology ; Cowpox/pathology ; Cowpox/transmission ; Humans ; Male ; Zoonoses
Language	English
Publishing date	2017-04
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	756168-4
ISSN	1121-7138 ; 0391-5352
ISSN	1121-7138 ; 0391-5352
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Article: Opposite effect of supernatants from selected periopathogens and oral lactobacilli cultures on ATP levels in human gingival fibroblasts.

Szkaradkiewicz, Anna K / Karpin Ski, Tomasz M / Zeidler, Agnieszka / Szkaradkiewicz, Andrzej

The new microbiologica

2014 Volume 37, Issue 4, Page(s) 509–516

Abstract: Studies were performed on the effects of supernatants obtained from bacterial cultures, including cultures of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Lactobacillus acidophilus strains on ATP levels in ... ...

Abstract	Studies were performed on the effects of supernatants obtained from bacterial cultures, including cultures of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Lactobacillus acidophilus strains on ATP levels in human gingival fibroblasts (HGF-1) and on their viability. ATP levels were evaluated using luminescence test and cell viability was estimated using a fluorescence test. In control cultures mean levels of ATP in HGF-1 amounted to 4.90±0.32 mln RLU. Supernatants of P. gingivalis and A. actinomycetemcomitans cultures were found to significantly reduce ATP production in HGF-1 (mean levels of ATP amounted to 3.41±0.33 and 3.55±0.3 mln RLU respectively), which was not accompanied by an increased proportion of dead fibroblasts. Supernatants of P. intermedia induced no significant alterations in ATP level in HGF-1. In turn, supernatants of L. acidophilus H2O2 (+) and H2O2 (-) cultures significantly increased ATP levels in HGF-1 (the mean levels amounted to 5.94±0.31 mln RLU and 5.88±0.28 mln RLU respectively). The results indicate that extracellular products of P. gingivalis and A. actinomycetemcomitans most probably represent mitochondria-targeted peptides, which reduce synthesis of ATP in HGF-1. In turn, extracellular products of L. acidophilus seem to represent exopolysaccharides (EPS) with pro-oxidant activity, which stimulate synthesis of ATP in HGF-1.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Adult ; Aggregatibacter actinomycetemcomitans/chemistry ; Aggregatibacter actinomycetemcomitans/metabolism ; Cell Survival ; Culture Media/metabolism ; Culture Media/pharmacology ; Female ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gingiva/cytology ; Gingiva/metabolism ; Gingiva/microbiology ; Humans ; Lactobacillus/chemistry ; Lactobacillus/metabolism ; Male ; Middle Aged ; Mouth/metabolism ; Mouth/microbiology ; Periodontitis/metabolism ; Periodontitis/microbiology ; Periodontitis/physiopathology ; Porphyromonas gingivalis/chemistry ; Porphyromonas gingivalis/metabolism ; Prevotella intermedia/chemistry ; Prevotella intermedia/metabolism
Chemical Substances	Culture Media ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2014-10
Publishing country	Italy
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	756168-4
ISSN	1121-7138 ; 0391-5352
ISSN	1121-7138 ; 0391-5352
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Article ; Online: Expression of cagA, virB/D Complex and/or vacA Genes in Helicobacter pylori Strains Originating from Patients with Gastric Diseases.

Szkaradkiewicz, Andrzej / Karpiński, Tomasz M / Linke, Krzysztof / Majewski, Przemysław / Rożkiewicz, Dorota / Goślińska-Kuźniarek, Olga

PloS one

2016 Volume 11, Issue 2, Page(s) e0148936

Abstract: In order to better understand pathogenicity of Helicobacter pylori, particularly in the context of its carcinogenic activity, we analysed expression of virulence genes: cagA, virB/D complex (virB4, virB7, virB8, virB9, virB10, virB11, virD4) and vacA in ... ...

Abstract	In order to better understand pathogenicity of Helicobacter pylori, particularly in the context of its carcinogenic activity, we analysed expression of virulence genes: cagA, virB/D complex (virB4, virB7, virB8, virB9, virB10, virB11, virD4) and vacA in strains of the pathogen originating from persons with gastric diseases. The studies were conducted on 42 strains of H. pylori isolated from patients with histological diagnosis of non-atrophic gastritis-NAG (group 1, including subgroup 1 containing cagA+ isolates and subgroup 2 containing cagA- strains), multifocal atrophic gastritis-MAG (group 2) and gastric adenocarcinoma-GC (group 3). Expression of H. pylori genes was studied using microarray technology. In group 1, in all strains of H. pylori cagA+ (subgroup 1) high expression of the gene as well as of virB/D was disclosed, accompanied by moderate expression of vacA. In strains of subgroup 2 a moderate expression of vacA was detected. All strains in groups 2 and 3 carried cagA gene but they differed in its expression: a high expression was detected in isolates of group 2 and its hyperexpression in strains of group 3 (hypervirulent strains). In both groups high expression of virB/D and vacA was disclosed. Our results indicate that chronic active gastritis may be induced by both cagA+ strains of H. pylori, manifesting high expression of virB/D complex but moderate activity of vacA, and cagA- strains with moderate expression of vacA gene. On the other hand, in progression of gastric pathology and carcinogenesis linked to H. pylori a significant role was played by hypervirulent strains, manifesting a very high expression of cagA and high activity of virB/D and vacA genes.
MeSH term(s)	Adult ; Aged ; Antigens, Bacterial/biosynthesis ; Antigens, Bacterial/genetics ; Antigens, Bacterial/metabolism ; Bacterial Outer Membrane Proteins/biosynthesis ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/metabolism ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Exons ; Female ; Gastritis, Atrophic/microbiology ; Gastroscopy ; Gene Expression Regulation, Bacterial ; Helicobacter Infections/genetics ; Helicobacter Infections/metabolism ; Helicobacter Infections/microbiology ; Helicobacter pylori/genetics ; Humans ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Real-Time Polymerase Chain Reaction ; Stomach Diseases/microbiology ; Stomach Neoplasms/microbiology
Chemical Substances	Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Bacterial Proteins ; VacA protein, Helicobacter pylori ; cagA protein, Helicobacter pylori
Language	English
Publishing date	2016-02-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0148936
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Article: Antagonistyczne oddziaływanie Lactobacillus acidophilus wobec klinicznych szczepów Helicobacter pylori.

Andrzejewska, Ewa / Szkaradkiewicz, Andrzej

Medycyna doswiadczalna i mikrobiologia

2007 Volume 59, Issue 1, Page(s) 59–64

Abstract: The purpose of the study was to determine the antagonistic effect of Lactobacillus strains, isolated from saliva of healthy people on clinical strains of H. pylori. Two kinds of Lactobacillus strains were used in the tests i.e. strains producing hydrogen ...

Title translation	Evaluation of the antagonistic effect of Lactobacillus acidophilus on clinical strains of Helicobacter pylori.
Abstract	The purpose of the study was to determine the antagonistic effect of Lactobacillus strains, isolated from saliva of healthy people on clinical strains of H. pylori. Two kinds of Lactobacillus strains were used in the tests i.e. strains producing hydrogen peroxide as well as strains not producing the metabolite. Clinical isolates of H. pylori were taken from the patients with confirmed duodenal and gastric ulcers. The evaluation of antagonistic effect between microorganisms was performed by using agar slab method. It was observed that Lactobacillus acidophilus had an antagonistic effect on growth of all strains of H. pylori tested. However, the particular Lactobacillus strains differed with respect to their inhibitory properties. Hydrogen peroxide did not have any significant impact on the inhibition of the growth of Helicobacter pylori.
MeSH term(s)	Antibiosis/physiology ; Culture Media, Conditioned ; Culture Techniques ; Duodenal Ulcer/microbiology ; Duodenal Ulcer/pathology ; Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Helicobacter pylori/growth & development ; Humans ; Hydrogen Peroxide/metabolism ; Lactobacillus acidophilus/classification ; Lactobacillus acidophilus/isolation & purification ; Lactobacillus acidophilus/metabolism ; Peptic Ulcer/microbiology ; Peptic Ulcer/pathology ; Sensitivity and Specificity
Chemical Substances	Culture Media, Conditioned ; Hydrogen Peroxide (BBX060AN9V)
Language	Polish
Publishing date	2007
Publishing country	Poland
Document type	English Abstract ; Evaluation Studies ; Journal Article
ZDB-ID	411641-0
ISSN	0025-8601 ; 0465-5893 ; 0368-9158
ISSN	0025-8601 ; 0465-5893 ; 0368-9158
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Article: The Participation of p53 and bcl-2 Proteins in Gastric Carcinomas Associated with Helicobacterpylori and/or Epstein-Barr Virus (EBV).

Szkaradkiewicz, Andrzej / Karpiński, Tomasz M / Majewski, Jan / Malinowska, Kamila / Goślińska-Kuźniarek, Olga / Linke, Krzysztof

Polish journal of microbiology

2015 Volume 64, Issue 3, Page(s) 211–216

Abstract: In the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carcinomas in patients with Helicobacter pylori or EBV or without H. pylori/EBV infection. The studies were conducted on 64 adult patients with gastric ... ...

Abstract	In the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carcinomas in patients with Helicobacter pylori or EBV or without H. pylori/EBV infection. The studies were conducted on 64 adult patients with gastric adenocarcinomas: 16 patients with H. pylori (cagA+)-positivity (group 1), 14 with EBV-positive tumours (group 2), 12 with H. pylori/EBV-positive tumours (group 3) and 22 patients with H. pylori/EBV-negative tumours (group 4). H. pylori presence in gastric tumour specimens was detected using Giemsa staining and bacterial culture technique. Moreover, cagA gene was detected using PCR. EBV infection was detected based on EBER presence in the tissue by RNA in situ hybridization. Expressions of p53 and bcl-2 proteins were analysed using immunohistochemistry. Expression of p53 was noted in 14 (84%) patients from group 1, 8 (57%) patients from group 2, 7 (58%) patients from group 3, and 19 (86%) patients from group 4, whereas expression of bcl-2 was noted in 12 (75%) patients from group 1, in 10 (71%) patients from group 2, 9 (75%) patients from group 3, and 6 (27%) patients from group 4. The obtained results allow the conclusion, that H. pylori (cagA+)-associated development of the gastric adenocarcinoma is determined by abnormalities in the p53 protein function and overexpression of anti-apoptotic bcl-2 protein, whereas EBV-associated adenocarcinomas seem to be related with apoptosis resistance associated with bcl-2 overexpression.
MeSH term(s)	Adult ; Aged ; Carcinoma/genetics ; Carcinoma/metabolism ; Carcinoma/microbiology ; Carcinoma/virology ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/metabolism ; Epstein-Barr Virus Infections/microbiology ; Epstein-Barr Virus Infections/virology ; Female ; Helicobacter Infections/genetics ; Helicobacter Infections/metabolism ; Helicobacter Infections/microbiology ; Helicobacter Infections/virology ; Helicobacter pylori/genetics ; Helicobacter pylori/physiology ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/physiology ; Humans ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/virology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Proto-Oncogene Proteins c-bcl-2 ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2015
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2234080-4
ISSN	1733-1331 ; 0137-1320
ISSN	1733-1331 ; 0137-1320
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Article: Evaluation of antimicrobial resistance of Helicobacter pylori in the last 15 years in West Poland.

Karpiński, Tomasz M / Andrzejewska, Ewa / Eder, Piotr / Linke, Krzysztof / Szkaradkiewicz, Andrzej

Acta microbiologica et immunologica Hungarica

2015 Volume 62, Issue 3, Page(s) 287–293

Abstract: Increasing resistance to drugs represents a serious problem in treatment of infections with Helicobacter pylori, providing cause of frequent therapeutic failures. Present study aimed at analysis of changes in resistance of H. pylori to antibiotics in ... ...

Abstract	Increasing resistance to drugs represents a serious problem in treatment of infections with Helicobacter pylori, providing cause of frequent therapeutic failures. Present study aimed at analysis of changes in resistance of H. pylori to antibiotics in West Poland within the recent 15 years. 108 strains of H. pylori were analysed, isolated from gastric mucosa of adult patients. Group 1 involved 66 strains isolated in years of 1998/1999. Group 2 comprised 42 isolates obtained in years of 2013/2014. Susceptibility to amoxicillin (AMX), clarithromycin (CL), tetracycline (TC) and metronidazole (MTZ) was determined by E-test (AB Biodisc). All strains on both studied groups were susceptible to AMX. In group 1 all strains proved to be susceptible to TC, while 9% and 36% of tested strains were resistant to CL and MTZ, respectively. By contrast, in group 2, 31% and 83% of strains were resistant to CL and MTZ, respectively. In parallel, 14% strains were found to be resistant to TC (according to EUCAST interpretations). In West Poland, within recent 15 years a dramatic increase was noted in H. pylori strains resistant to metronidazole. In parallel, a significant increase was noted in proportion of strains resistant to clarithromycin.
MeSH term(s)	Amoxicillin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Clarithromycin/pharmacology ; Drug Resistance, Multiple, Bacterial ; Helicobacter Infections/microbiology ; Helicobacter pylori/drug effects ; Helicobacter pylori/genetics ; Helicobacter pylori/isolation & purification ; Humans ; Metronidazole/pharmacology ; Microbial Sensitivity Tests ; Poland
Chemical Substances	Anti-Bacterial Agents ; Metronidazole (140QMO216E) ; Amoxicillin (804826J2HU) ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2015-09
Publishing country	Hungary
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	918256-1
ISSN	1588-2640 ; 1217-8950
ISSN (online)	1588-2640
ISSN	1217-8950
DOI	10.1556/030.62.2015.3.6
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