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Article ; Online: Impact of remote monitoring in heart failure patients with cardiac implantable electronic devices during COVID-19 pandemic: a single center experience.

Ezer, Péter / Gergics, Marin / Szokodi, István / Kónyi, Attila

2022 Volume 17, Issue 1, Page(s) 213

Abstract: Background: Coronavirus disease 2019 (COVID-19) had spread into a pandemic affecting healthcare providers worldwide. Heart failure patients with implanted cardiac devices require close follow-up in-spite of pandemic related healthcare restrictions.: ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) had spread into a pandemic affecting healthcare providers worldwide. Heart failure patients with implanted cardiac devices require close follow-up in-spite of pandemic related healthcare restrictions. Methods: Patients were retrospectively registered and clinical outcomes were compared of 61 remote monitored (RMG) versus 71 conventionally (in-office only) followed (CFG) cardiac device implanted, heart failure patients. Follow-up length was 12 months, during the COVID-19 pandemic related intermittent insitutional restrictions. We used a specified heart failure detection algorithm in RMG. This investigation compared worsening heart failure-, arrhythmia- and device related adverse events as primary outcome and heart failure hospitalization rates as secondary outcome in the two patient groups. Results: No significant difference was observed in the primary composite end-point during the first 12 months of COVID-19 pandemic (p = 0.672). In RMG, patients who had worsening heart failure event had relative modest deterioration in heart failure functional class (p = 0.026), relative lower elevation of N terminal-pro BNP levels (p < 0.01) at in-office evaluation and were less hospitalized for worsening heart failure in the first 6 months of pandemic (p = 0.012) compared to CFG patients. Conclusions: Specified remote monitoring alert-based detection algorithm and workflow in device implanted heart failure patients may potentially indicate early worsening in heart failure status. Preemptive adequate intervention may prevent further progression of deteriorating heart failure and thus prevent heart failure hospitalizations.
MeSH term(s)	COVID-19 ; Cardiac Resynchronization Therapy ; Defibrillators, Implantable ; Electronics ; Heart Failure ; Humans ; Pandemics
Language	English
Publishing date	2022-08-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-022-01963-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Automatic daily remote monitoring in heart failure patients implanted with a cardiac resynchronisation therapy-defibrillator: a single-centre observational pilot study.

Ezer, Peter / Farkas, Nelli / Szokodi, István / Kónyi, Attila

Archives of medical science : AMS

2021 Volume 19, Issue 1, Page(s) 73–85

Abstract: Introduction: The impact of remote monitoring (RM) on clinical outcomes in heart failure (HF) patients with cardiac resynchronisation therapy-defibrillator (CRT-D) implantation is controversial. This study sought to evaluate the performance of an RM ... ...

Abstract	Introduction: The impact of remote monitoring (RM) on clinical outcomes in heart failure (HF) patients with cardiac resynchronisation therapy-defibrillator (CRT-D) implantation is controversial. This study sought to evaluate the performance of an RM follow-up protocol using modified criteria of the PARTNERS HF trial in comparison with a conventional follow-up scheme. Material and methods: We compared cardiovascular (CV) mortality (primary endpoint) and hospitalisation events for decompensated HF, and the number of ambulatory in-office visits (secondary endpoint) in CRT-D implanted patients with automatic RM utilising daily transmissions (RM group, Results: After a median follow-up of 25 months, a significant advantage was seen in the RM group in terms of CV mortality (1 vs. 6 death event, Conclusions: Follow-up of CRT-D patients using automatic RM with daily transmissions based on modified PARTNERS HF criteria enabled more effective ambulatory interventions leading indirectly to improved CV survival. Moreover, RM directly decreased the number of HF hospitalizations and ambulatory follow-up burden compared to CRT-D patients with conventional follow-up.
Language	English
Publishing date	2021-03-25
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms/131958
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Article ; Online: Apelin as a Potential Regulator of Peak Athletic Performance.

Ligetvári, Roland / Szokodi, István / Far, Gabriella / Csöndör, Éva / Móra, Ákos / Komka, Zsolt / Tóth, Miklós / Oláh, András / Ács, Pongrác

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: Apelin, as a cardiokine/myokine, is emerging as an important regulator of cardiac and skeletal muscle homeostasis. Loss of apelin signaling results in premature cardiac aging and sarcopenia. However, the contribution of apelin to peak athletic ... ...

Abstract	Apelin, as a cardiokine/myokine, is emerging as an important regulator of cardiac and skeletal muscle homeostasis. Loss of apelin signaling results in premature cardiac aging and sarcopenia. However, the contribution of apelin to peak athletic performance remains largely elusive. In this paper, we assessed the impact of maximal cardiorespiratory exercise testing on the plasma apelin levels of 58 male professional soccer players. Circulating apelin-13 and apelin-36, on average, increased transiently after a single bout of treadmill exercise; however, apelin responses (Δapelin = peak - baseline values) showed a striking interindividual variability. Baseline apelin-13 levels were inversely correlated with those of Δapelin-13 and Δapelin-36. Δapelin-13 showed a positive correlation with the maximal metabolic equivalent, relative maximal O
MeSH term(s)	Male ; Humans ; Apelin/metabolism ; Exercise/physiology ; Muscle, Skeletal/metabolism ; Sarcopenia/metabolism ; Athletic Performance ; Oxygen Consumption/physiology
Chemical Substances	Apelin
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098195
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Article: Single-Center Experience with the Balloon-Expandable Myval Transcatheter Aortic Valve System in Patients with Bicuspid Anatomy: Procedural and 30-Day Follow-Up.

Magyari, Balázs / Kittka, Bálint / Goják, Ilona / Schönfeld, Kristóf / Szapáry, László Botond / Simon, Mihály / Kiss, Rudolf / Bertalan, Andrea / Várady, Edit / Gyimesi, András / Szokodi, István / Horváth, Iván Gábor

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Aims: ...

Abstract	Aims:
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020513
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Article: Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up.

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: Aims: ...

Abstract	Aims:
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13041088
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Article ; Online: Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model.

Kilpiö, Teemu / Skarp, Sini / Perjés, Ábel / Swan, Julia / Kaikkonen, Leena / Saarimäki, Samu / Szokodi, István / Penninger, Josef M / Szabó, Zoltán / Magga, Johanna / Kerkelä, Risto

American journal of physiology. Cell physiology

2024 Volume 326, Issue 5, Page(s) C1437–C1450

Abstract: Plasma apelin levels are reduced in aging and muscle wasting conditions. We aimed to investigate the significance of apelin signaling in cardiac and skeletal muscle responses to physiological stress. Apelin knockout (KO) and wild-type (WT) mice were ... ...

Abstract	Plasma apelin levels are reduced in aging and muscle wasting conditions. We aimed to investigate the significance of apelin signaling in cardiac and skeletal muscle responses to physiological stress. Apelin knockout (KO) and wild-type (WT) mice were subjected to high-intensity interval training (HIIT) by treadmill running. The effects of apelin on energy metabolism were studied in primary mouse skeletal muscle myotubes and cardiomyocytes. Apelin increased mitochondrial ATP production and mitochondrial coupling efficiency in myotubes and promoted the expression of mitochondrial genes both in primary myotubes and cardiomyocytes. HIIT induced mild concentric cardiac hypertrophy in WT mice, whereas eccentric growth was observed in the left ventricles of apelin KO mice. HIIT did not affect myofiber size in skeletal muscles of WT mice but decreased the myofiber size in apelin KO mice. The decrease in myofiber size resulted from a fiber type switch toward smaller slow-twitch type I fibers. The increased proportion of slow-twitch type I fibers in apelin KO mice was associated with upregulation of myosin heavy chain slow isoform expression, accompanied with upregulated expression of genes related to fatty acid transport and downregulated expression of genes related to glucose metabolism. Mechanistically, skeletal muscles of apelin KO mice showed defective induction of insulin-like growth factor-1 signaling in response to HIIT. In conclusion, apelin is required for proper skeletal and cardiac muscle adaptation to high-intensity exercise. Promoting apelinergic signaling may have benefits in aging- or disease-related muscle wasting conditions.
MeSH term(s)	Animals ; Apelin/metabolism ; Apelin/genetics ; Mice, Knockout ; Adaptation, Physiological ; Mice ; Physical Conditioning, Animal/physiology ; Muscle, Skeletal/metabolism ; High-Intensity Interval Training/methods ; Male ; Myocytes, Cardiac/metabolism ; Energy Metabolism ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal/metabolism ; Muscle Fibers, Slow-Twitch/metabolism ; Cardiomegaly/metabolism ; Cardiomegaly/genetics ; Cardiomegaly/physiopathology ; Cardiomegaly/pathology
Chemical Substances	Apelin ; Apln protein, mouse
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00427.2023
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Article: L-Arginine-Nitric Oxide-Asymmetric Dimethylarginine Pathway and the Coronary Circulation: Translation of Basic Science Results to Clinical Practice.

Cziráki, Attila / Lenkey, Zsófia / Sulyok, Endre / Szokodi, István / Koller, Akos

Frontiers in pharmacology

2020 Volume 11, Page(s) 569914

Abstract: By 1980, it was thought that we already knew most of the major mechanisms regulating vascular tone. However, after the somewhat serendipity discovery that endothelium is involved in mediation of relaxation to acetylcholine, a whole new world opened up ... ...

Abstract	By 1980, it was thought that we already knew most of the major mechanisms regulating vascular tone. However, after the somewhat serendipity discovery that endothelium is involved in mediation of relaxation to acetylcholine, a whole new world opened up and we had to rewrite our concept regarding vascular function and its regulation (not to mention many other fields). The new player was an endothelium derived relaxing factor, which molecular constitution has been identified to be nitric oxide (NO). This review summarizes the major molecular steps concerning how NO is synthetized from L-arginine. Also, the fate of L-arginine is described
Language	English
Publishing date	2020-09-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.569914
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Article ; Online: Single center experience with the balloon-expandable Myval transcatheter aortic valve system with the first 100 patients: 30-day and 1-year follow-up.

Magyari, Balázs / Kittka, Bálint / Goják, Ilona / Kasza, Gábor / Schönfeld, Kristóf / Szapáry, László Botond / Simon, Mihály / Kiss, Rudolf / Bertalan, Andrea / Várady, Edit / Gyimesi, András / Szokodi, István / Horváth, Iván

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2023 Volume 102, Issue 7, Page(s) 1317–1330

Abstract: Aims: To report our single-center data, regarding the first 100 patients who underwent TAVR procedure with the new balloon-expandable MYVAL system. We report 30-day and 1-year outcomes in low to high-risk TAVR patient population.: Methods: From ... ...

Abstract	Aims: To report our single-center data, regarding the first 100 patients who underwent TAVR procedure with the new balloon-expandable MYVAL system. We report 30-day and 1-year outcomes in low to high-risk TAVR patient population. Methods: From November 2019 to July 2021, 100 consecutive patients underwent TAVR procedure. Patient outcome was classified according to the VARC-2 definitions. The device performance was assessed using transthoracic echocardiography. Data collection was allowed by the Local Ethical Committee. Results: The mean age was 74.7 years, 63 (63%) were male. The mean Euroscore II and STS score were 4.8 ± 4.9 and 5.6 ± 3.9, respectively. Transfemoral access was the most frequent (surgical vs. percutaneous 2% vs. 97%) and in one patient surgical subclavian access was used. VARC-2 outcomes were as follows: device success 99%, STROKE 1%, major and minor vascular complication was 1% and 11%, respectively, the rate of new permanent pacemaker implantation was 30.7%. At discharge, the incidence of grade I, grade II aortic regurgitation was 39% and 1%, respectively, without relevant PVL. In-hospital mortality was only 1%. These results included a high proportion (17%) of patients with bicuspid aortic valves. At 1 year, the all-cause mortality rate was 7% (only two due to cardiac event) and only a single patient had valve-related dysfunction requiring surgical aortic replacement. Conclusions: TAVR procedure with MYVAL transcatheter heart valve system shows excellent 30-day and 1-year outcomes regarding patient survival, technical success, and valve-related adverse events. The limitations of our study comprise a single-center study with retrospective data collection.
MeSH term(s)	Humans ; Male ; Aged ; Female ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Transcatheter Aortic Valve Replacement ; Follow-Up Studies ; Retrospective Studies ; Treatment Outcome ; Heart Valve Prosthesis ; Prosthesis Design
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30868
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Article ; Online: The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction.

Szentes, Veronika / Gazdag, Mária / Szokodi, István / Dézsi, Csaba A

Frontiers in immunology

2018 Volume 9, Page(s) 1932

Abstract: The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development. Recent studies have indicated the role of these chemokines also in ... ...

Abstract	The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development. Recent studies have indicated the role of these chemokines also in cardiovascular diseases. We aimed to present current knowledge regarding the role of CXCR3-binding chemokines in the pathogenesis of atherosclerosis and during acute myocardial infarction.
MeSH term(s)	Atherosclerosis/metabolism ; Chemokines/metabolism ; Humans ; Myocardial Infarction/metabolism ; Receptors, CXCR3/metabolism ; Signal Transduction
Chemical Substances	CXCR3 protein, human ; Chemokines ; Receptors, CXCR3
Language	English
Publishing date	2018-08-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.01932
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Article ; Online: Influencing Factors of Cardiac Adaptation in Adolescent Athletes.

Szabo, Dora / Nagy, Dora / Melczer, Csaba / Acs, Pongrac / Ratgeber, Laszlo / Szokodi, Istvan / Toth, Miklos / Cziraki, Attila / Eklics, Kata / Sarszegi, Zsolt

International journal of sports medicine

2021 Volume 42, Issue 13, Page(s) 1209–1221

Abstract: Endurance training-induced changes in left ventricular diastolic function and right ventricular parameters have been investigated extensively in adolescent athletes. Our aim was to examine the parameters for adolescent athletes (n=121, 15.1±1.6 years) ... ...

Abstract	Endurance training-induced changes in left ventricular diastolic function and right ventricular parameters have been investigated extensively in adolescent athletes. Our aim was to examine the parameters for adolescent athletes (n=121, 15.1±1.6 years) compared to adult athletes and age-matched non-athletes. We explored the effects of influencing factors on the echocardiographic parameters. Significantly higher E/A (p<0.05) and e' values (p<0.001) were detected in adolescent athletes compared to age-matched non-athletes' and also adult athletes' parameters. Significantly lower structural and functional right ventricular parameters (p<0.05) were detected in adult athletes. In adolescent athletes significantly higher right ventricular diameters, tricuspid S wave, right ventricular end-diastolic and end-systolic area values (p<0.05) were found compared to the matching parameters of non-athletes. We found significantly higher corrected tricuspid annular plane systolic excursion values (p<0.001) in athletes compared to the non-athletes. Based on multivariate analysis lean body mass, body surface area, age and cumulative training time were proved as strong predictive factors of both left ventricular diastolic and right ventricular parameters. Supernormal left ventricular diastolic function and significantly higher right ventricular parameters are indicative of cardiac adaptation. Well-defined cut-off values should be applied to discriminate pathological conditions in the relation of the influencing factors.
MeSH term(s)	Adaptation, Physiological ; Adolescent ; Adult ; Athletes ; Echocardiography ; Endurance Training ; Humans ; Ventricular Function, Left ; Ventricular Function, Right
Language	English
Publishing date	2021-05-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	603122-5
ISSN	1439-3964 ; 0172-4622 ; 0943-917X
ISSN (online)	1439-3964
ISSN	0172-4622 ; 0943-917X
DOI	10.1055/a-1386-4805
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