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  1. Article ; Online: RING1 Inhibition Has a Cell-Specific Antitumoral Role by Promoting Autophagy in Endometrial Cancer Cells.

    Szustka, Aleksandra / Kozal, Karolina / Krześlak, Anna

    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    2024  Volume 58, Issue 1, Page(s) 1–13

    Abstract: Background/aims: Factors influencing gene expression through chemical modifications of histones may play an important role in the regulation of the autophagy process in cancers. RING1A or RING1B are responsible for the catalytical activity of Polycomb ... ...

    Abstract Background/aims: Factors influencing gene expression through chemical modifications of histones may play an important role in the regulation of the autophagy process in cancers. RING1A or RING1B are responsible for the catalytical activity of Polycomb repressive complex 1 (PRC1) which monoubiquitylate histone H2A. The aim of the study was to determine the effect of the RING1A/B protein inhibition on the autophagy process in endometrial cancer cells and the anticancer effectiveness of RING1 inhibitor PRT4165 in combination with autophagy inhibitors.
    Methods: The expression of autophagy genes and proteins were analyzed in endometrial cancer cells HEC-1A and Ishikawa grown in different glucose concentrations and treated with PRT4165. To assess the effectiveness of PRT4165 used alone or in combination with HCQ or Lys05, IC
    Results: The results confirm the impact of RINGs on autophagy and apoptosis in endometrial cancer cells. PRT4165 inhibitor causes changes in the expression of ATG genes and autophagy markers and the effect depends on glucose concentration and cell types. However, the anticancer effectiveness of PRT4165 was lower when it was used in combination with autophagy inhibitors, suggesting that such a combination is not a promising anticancer strategy.
    Conclusion: The results indicate the importance of the RINGs in the process of autophagy and apoptosis. Further potentially more effective combinations of PRT4165 with autophagy modulators should be sought.
    MeSH term(s) Female ; Humans ; Autophagy ; Cell Line, Tumor ; Endometrial Neoplasms/drug therapy ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Glucose/pharmacology ; Histones/pharmacology ; Indans ; Pyridines/pharmacology
    Chemical Substances 2-pyridine-3-yl-methylene-indan-1,3-dione ; Glucose (IY9XDZ35W2) ; Histones ; Indans ; Pyridines ; RING1 protein, human (EC 2.3.2.27)
    Language English
    Publishing date 2024-01-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.33594/000000679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Glucose and Cell Context-Dependent Impact of BMI-1 Inhibitor PTC-209 on AKT Pathway in Endometrial Cancer Cells.

    Zaczek, Agnieszka / Szustka, Aleksandra / Krześlak, Anna

    Cancers

    2022  Volume 14, Issue 23

    Abstract: Purpose: In our study, the glucose and cell context-dependent impact of the BMI-1 inhibitor PTC-209 on the AKT pathway in endometrial cancer cells was determined.: Methods: The expression of BMI-1 was inhibited by PTC-209 in endometrial cancer cells ... ...

    Abstract Purpose: In our study, the glucose and cell context-dependent impact of the BMI-1 inhibitor PTC-209 on the AKT pathway in endometrial cancer cells was determined.
    Methods: The expression of BMI-1 was inhibited by PTC-209 in endometrial cancer cells HEC-1A and Ishikawa stimulated with insulin and grown in different glucose concentrations. The migration, invasion, viability, and proliferative potential after PTC-209 treatment was assessed using wound-healing, Transwell assay, Matrigel-coated inserts, and MTT tests. Chromatin immunoprecipitation was used to determine the localization of BMI-1 protein at promoter sites of the genes tested.
    Results: BMI-1 inhibition caused an increase in
    Conclusions: Our results indicate that the relationship between BMI-1 and phosphatases involved in AKT regulation depends on the glucose concentration and insulin stimulation.
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14235947
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  3. Article ; Online: Molecular Targets of Natural Compounds with Anti-Cancer Properties.

    Kubczak, Małgorzata / Szustka, Aleksandra / Rogalińska, Małgorzata

    International journal of molecular sciences

    2021  Volume 22, Issue 24

    Abstract: Cancer is the second leading cause of death in humans. Despite rapid developments in diagnostic methods and therapies, metastasis and resistance to administrated drugs are the main obstacles to successful treatment. Therefore, the main challenge should ... ...

    Abstract Cancer is the second leading cause of death in humans. Despite rapid developments in diagnostic methods and therapies, metastasis and resistance to administrated drugs are the main obstacles to successful treatment. Therefore, the main challenge should be the diagnosis and design of optimal therapeutic strategies for patients to increase their chances of responding positively to treatment and increase their life expectancy. In many types of cancer, a deregulation of multiple pathways has been found. This includes disturbances in cellular metabolism, cell cycle, apoptosis, angiogenesis, or epigenetic modifications. Additionally, signals received from the microenvironment may significantly contribute to cancer development. Chemical agents obtained from natural sources seem to be very attractive alternatives to synthetic compounds. They can exhibit similar anti-cancer potential, usually with reduced side effects. It was reported that natural compounds obtained from fruits and vegetables, e.g., polyphenols, flavonoids, stilbenes, carotenoids and acetogenins, might be effective against cancer cells in vitro and in vivo. Several published results indicate the activity of natural compounds on protein expression by its influence on transcription factors. They could also be involved in alterations in cellular response, cell signaling and epigenetic modifications. Such natural components could be used in our diet for anti-cancer protection. In this review, the activities of natural compounds, including anti-cancer properties, are described. The influence of natural agents on cancer cell metabolism, proliferation, signal transduction and epigenetic modifications is highlighted.
    MeSH term(s) Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Biological Products/chemistry ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Cell Proliferation/drug effects ; Epigenesis, Genetic/drug effects ; Fruit/chemistry ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Plants/chemistry ; Signal Transduction ; Tumor Microenvironment/drug effects ; Vegetables/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Biological Products
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Potencjalne zastosowania komórek macierzystych w medycynie regeneracyjnej i transplantologii.

    Szustka, Aleksandra / Rogalińska, Małgorzata

    Postepy biochemii

    2017  Volume 63, Issue 2, Page(s) 143–150

    Abstract: There are some cells in human body which have an ability to self-renewal and differentiation into particular type of cell. They are classified according to the source of gain and ability to differentiate. Several studies carry on directed stem cells ... ...

    Title translation Potential application for stem cells in regenerative medicine and transplantology.
    Abstract There are some cells in human body which have an ability to self-renewal and differentiation into particular type of cell. They are classified according to the source of gain and ability to differentiate. Several studies carry on directed stem cells programming toward formation of particular type of cells and also reprogramming somatic stem cells for induced pluripotent stem cells. In the future it could bring hope in elaboration of new ways of disease curing that will give a chance for getting healthy (especially cancers). Stem cells display application in regenerative medicine. They facilitate in repair of damaged or dysfunctional tissues using cells derived from patients. In many cancer types the presence of cancer stem cells was observed. Their ability to self-renewal and unlimited proliferation might be the reason of metastasis and relapse of cancer. The knowledge on complexed signaling pathways and mechanisms of their regulation may be crucial and should lead to elaboration of effective anticancer therapies.
    MeSH term(s) Cell Differentiation ; Humans ; Induced Pluripotent Stem Cells ; Regenerative Medicine ; Signal Transduction
    Language Polish
    Publishing date 2017
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 414019-9
    ISSN 0032-5422
    ISSN 0032-5422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 633: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Anti-Platelet Properties of Phenolic and Nonpolar Fractions Isolated from Various Organs of

    Skalski, Bartosz / Rywaniak, Joanna / Szustka, Aleksandra / Żuchowski, Jerzy / Stochmal, Anna / Olas, Beata

    International journal of molecular sciences

    2021  Volume 22, Issue 6

    Abstract: Sea buckthorn ( ...

    Abstract Sea buckthorn (
    MeSH term(s) Blood Platelets/drug effects ; Elaeagnaceae/chemistry ; Flow Cytometry ; Hemostasis/drug effects ; Humans ; Phenols/isolation & purification ; Phenols/pharmacology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Platelet Activation/drug effects
    Chemical Substances Phenols ; Plant Extracts
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22063282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dose and drug changes in chronic lymphocytic leukemia cell response in vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors.

    Kubczak, Małgorzata / Szustka, Aleksandra / Błoński, Jerzy Z / Gucký, Tomaš / Misiewicz, Małgorzata / Krystof, Vladmir / Robak, Paweł / Rogalińska, Małgorzata

    Molecular medicine reports

    2019  Volume 19, Issue 5, Page(s) 3593–3603

    Abstract: Chronic lymphocytic leukemia (CLL) treatment is improving; however, some patients do not respond to therapy. Due to the high heterogeneity in disease development, there is an urgent need for personalization of therapy. In the present study, the response ... ...

    Abstract Chronic lymphocytic leukemia (CLL) treatment is improving; however, some patients do not respond to therapy. Due to the high heterogeneity in disease development, there is an urgent need for personalization of therapy. In the present study, the response of leukemic mononuclear cells to anticancer drugs used for CLL treatment (cladribine + mafosfamide; CM or CM combined with rituximab; RCM) was compared with the response to new cyclin‑dependent kinase (CDK) inhibitors: BP14 and BP30. Viable apoptotic and necrotic cells were quantified by flow cytometry using propidium iodide and Yo‑Pro stains. CDK inhibitors were studied in several doses to determine the reduction of necrosis and simultaneous increase of apoptosis in leukemic cell incubations with anticancer agents. The distinct cell response to applied doses/anticancer agents was observed. Results obtained in the current manuscript confirmed that modulation of doses is important. This was particularly indicated in results obtained at 24 h of cells incubation with anticancer agent. While an important time for analysis of anticancer response efficacy (monitoring of apoptosis induction potential) seems to be 48 h of cells exposition to anticancer agents. High variability in response to the drugs revealed that both the nature and the dose of the anticancer agents could be important in the final effect of the therapy. The present findings support the thesis that personalized medicine, before drug administration in the clinic, could be important to avoid the application of ineffective therapy.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Dose-Response Relationship, Drug ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Male ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacology ; Tumor Cells, Cultured
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Cyclin-Dependent Kinases (EC 2.7.11.22)
    Language English
    Publishing date 2019-03-05
    Publishing country Greece
    Document type Journal Article
    ISSN 1791-3004
    ISSN (online) 1791-3004
    DOI 10.3892/mmr.2019.10007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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