Article ; Online: Predictors for spinal deformity following resection of intramedullary tumor via posterior approach: a systematic review and meta-analysis.
2023 Volume 32, Issue 12, Page(s) 4355–4361
Abstract: Purpose: The present study aimed to identify the clinical predictive factors for worsened spinal deformity (SD) following surgical resection via posterior approach for primary intramedullary tumors.: Methods: A systematic search was performed using ... ...
| Abstract | Purpose: The present study aimed to identify the clinical predictive factors for worsened spinal deformity (SD) following surgical resection via posterior approach for primary intramedullary tumors. Methods: A systematic search was performed using PubMed, Web of Science, and Scopus databases to extract potential references. Observational studies reporting predictive factors for worsened SD following surgical resection via posterior approach for primary intramedullary tumors were included. The odds ratio (OR) was calculated for dichotomous parameters. Results: Four retrospective cohort studies were included in the meta-analysis. They were comprised of two groups of patients; those who developed SD (n = 87) and those who did not (n = 227). For patients with IMSCTs, age under 25 years as well as age under 13 years were the demographic variables associated with postoperative SD (odds ratio [OR] 3.92; p = 0.0002 and OR 4.22; p = 0.003). In both the fusion and the non-fusion subgroups, preoperative spinal deformity strongly predicted postoperative SD (OR 11.94; p < 0.001), with the risk highly elevated among the non-fusion patients (OR 24.64; p < 0.0002). Thoracolumbar junction involvement was also found to be a predictor of postoperative SD for patients with IMSCT (OR 2.89; p = 0.02). Conclusion: This study highlights the importance of considering age, preoperative spinal deformity, and thoracolumbar junction involvement as predictors of postoperative spinal deformity following surgical resection for IMSCT. These findings may provide guidance for the management of these patients, including the development of preoperative planning strategies and the selection of the most appropriate surgical approach for high-risk patients. |
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| MeSH term(s) | Humans ; Adult ; Adolescent ; Laminectomy/adverse effects ; Retrospective Studies ; Spinal Cord Neoplasms/surgery ; Spinal Cord Neoplasms/pathology ; Neurosurgical Procedures/adverse effects ; Spinal Fusion ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology | |||||
| Language | English | |||||
| Publishing date | 2023-10-07 | |||||
| Publishing country | Germany | |||||
| Document type | Meta-Analysis ; Systematic Review ; Journal Article | |||||
| ZDB-ID | 1115375-1 | |||||
| ISSN | 1432-0932 ; 0940-6719 | |||||
| ISSN (online) | 1432-0932 | |||||
| ISSN | 0940-6719 | |||||
| DOI | 10.1007/s00586-023-07957-1 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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