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  1. Article ; Online: Fever, Dysuria, and AKI in a Kidney Transplant Patient.

    Akcasu, Ege / Safak, Seda / Turkmen, Aydin

    Kidney360

    2022  Volume 3, Issue 2, Page(s) 403–404

    MeSH term(s) Acute Kidney Injury/diagnosis ; Dysuria/etiology ; Humans ; Hydronephrosis ; Kidney Transplantation/adverse effects ; Pyelonephritis
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0003422021
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  2. Article ; Online: Outcome of Renal Transplantation in Patients With Diabetes Mellitus: A Single-Center Experience.

    Akagun, Tulin / Yelken, Berna / Usta, Murat / Turkmen, Aydin

    Transplantation proceedings

    2022  Volume 54, Issue 8, Page(s) 2174–2178

    Abstract: Background: An increasing proportion of kidney recipients have diabetes mellitus (DM). Some concerns have been raised about the kidney transplantation results in diabetic patients. Therefore, we assessed the effect of DM on morbidity and mortality of ... ...

    Abstract Background: An increasing proportion of kidney recipients have diabetes mellitus (DM). Some concerns have been raised about the kidney transplantation results in diabetic patients. Therefore, we assessed the effect of DM on morbidity and mortality of diabetic patients with renal transplantation.
    Methods: We retrospectively studied adult patients with and without DM who underwent living donor transplantation between 2007 and 2016. Information concerning demographic and clinical data were retrospectively analyzed by reviewing the patient files.
    Results: Of the 1536 transplant recipients, 126 (8%) had diabetes mellitus (mean age 49.4 ± 11.8) and 525 patients were evaluated in the non-diabetic control group (mean age 36.2 ± 15.9). The diabetic and non-diabetic patient groups had a mean follow-up after kidney transplantation 42.5 months (0.27-101.7 months) and 58.8 ± 10.6 months, respectively. In the diabetic patient group, only 3 patients had lost graft and 13 patients were exitus. Three patients had lost graft and 5 patients were exitus in non-diabetic patient group. Cardiac death (54.5%) was the most common cause of mortality in diabetic group. The 6-year patient and graft survival rates are 84.9% and 95.3%; 97.5% and 97.2% in the diabetic and non-diabetic patient groups, respectively.
    Conclusions: Both infection and cardiovascular diseases increase morbidity and mortality in renal transplant patients with diabetes mellitus. The mortality risk of diabetic patients after renal transplantation is higher than the non-diabetic kidney recipients. Therefore, diabetic patients need meticulous cardiac evaluation before renal transplantation and a close follow-up, in terms of infection, after transplantation.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Young Adult ; Kidney Transplantation/methods ; Graft Survival ; Retrospective Studies ; Diabetes Mellitus/etiology ; Living Donors ; Kidney Failure, Chronic/etiology ; Diabetic Nephropathies/complications
    Language English
    Publishing date 2022-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.08.024
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    Zs.A 835: Show issues Location:
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  3. Article ; Online: Rare Adverse Event after CoronaVac

    Artan, Ayşe Serra / Demir, Erol / Güller, Nurana / Türkmen, Aydın

    Balkan medical journal

    2022  Volume 39, Issue 4, Page(s) 305–306

    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Neutropenia/etiology ; Transplant Recipients
    Language English
    Publishing date 2022-07-07
    Publishing country Turkey
    Document type Letter
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3131
    ISSN (online) 2146-3131
    ISSN 2146-3131
    DOI 10.4274/balkanmedj.galenos.2022.2022-4-30
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  4. Article: Experience of kidney transplantation to a patient with Bernard Soulier syndrome: A case report.

    Karataş, Cihan / Akyollu, Başak / Arpalı, Emre / Yelken, Berna / Türkmen, Aydın / Koçak, Burak

    Turkish journal of surgery

    2023  Volume 39, Issue 1, Page(s) 86–88

    Abstract: Renal transplantation could be a challenging operation in patients with haemorrhagic diathesis, with predictable difficulties or even with unpredictable hurdles. Bernard Soulier Syndrome (BSS) is one of the ethiologies of the thrombocytopenia and it is a ...

    Abstract Renal transplantation could be a challenging operation in patients with haemorrhagic diathesis, with predictable difficulties or even with unpredictable hurdles. Bernard Soulier Syndrome (BSS) is one of the ethiologies of the thrombocytopenia and it is a rare hereditary disease associated with defects of the platelet glycoprotein complex glycoprotein Ib/V/IX and characterized by large platelets, thrombocytopenia, and severe bleeding symptoms. Here, we present a challenging renal transplantation in BSS.
    Language English
    Publishing date 2023-03-03
    Publishing country Turkey
    Document type Case Reports
    ISSN 2564-6850
    ISSN 2564-6850
    DOI 10.47717/turkjsurg.2022.4567
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  5. Article ; Online: Risk factors, pathogenesis, presentation and management of BK virus infection in kidney transplantation.

    Demir, Erol / Turkmen, Aydin / Sever, Mehmet Sukru

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2021  Volume 36, Issue 6, Page(s) 985–987

    Language English
    Publishing date 2021-05-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfz214
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  6. Article: Differences in clinical outcomes of COVID-19 among vaccinated and unvaccinated kidney transplant recipients

    Demir, Erol / Dheir, Hamad / Safak, Seda / Serra Artan, Ayse / Sipahi, Savas / Turkmen, Aydin

    Vaccine. 2022 May 26, v. 40, no. 24

    2022  

    Abstract: The remarkable efficacy and effectiveness of COVID-19 vaccines have been described in healthy individuals, but kidney transplant recipients have been excluded from these studies. Therefore, real-world evidence of these vaccines can guide clinicians in ... ...

    Abstract The remarkable efficacy and effectiveness of COVID-19 vaccines have been described in healthy individuals, but kidney transplant recipients have been excluded from these studies. Therefore, real-world evidence of these vaccines can guide clinicians in predicting complications in kidney transplant recipients and how many doses of vaccines are protective. In this study, we aimed to investigate the impact of the COVID-19 vaccines on kidney transplant recipients with SARS-CoV-2 infection. This matched case-control study included vaccinated kidney transplant recipients with COVID-19 from two centers between 1 May and 1 October 2021. All patients in the vaccinated group received a minimum of two doses of the vaccine and were diagnosed with COVID-19 at least one month after the last dose. Each vaccinated patient was matched with an unvaccinated kidney transplant recipient diagnosed with COVID. The endpoints were all-cause mortality, hospitalization, intensive care unit admission, acute kidney injury, cytokine storm, and acute respiratory distress syndrome. The median age of vaccinated seventy-two participants was 45 years, and 41 of the participants were men in the vaccinated group. Four patients in the vaccinated group and nine patients in the control group died during follow-up (p = 0.247). Seventeen patients in the vaccinated group, thirty-four participants in the control group were hospitalized (p = 0.004); five vaccinated patients and ten unvaccinated patients were followed-up in the ICU during follow-up (p = 0.168). Thirteen of the vaccinated and twelve unvaccinated patients developed acute kidney injury (p = 0.16). The occurrence of cytokine storm (n = 4 vs. n = 11; p = 0.061) and acute respiratory distress syndrome (n = 5 vs. n = 10; p = 0.168) was higher in the patient group compared to the control group. COVID-19 remains a fatal disease despite advancing treatment modalities and preventive strategies. COVID-19 vaccines can't prevent death in all kidney transplant recipients, but they decrease hospitalization rate and duration in most patients.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; acute kidney injury ; acute respiratory distress syndrome ; case-control studies ; cytokines ; death ; kidney transplant ; mortality ; patients ; vaccines
    Language English
    Dates of publication 2022-0526
    Size p. 3313-3319.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.04.066
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 1930: Show issues Location:
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    Zs.MO 458: Show issues

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  7. Article ; Online: Differences in clinical outcomes of COVID-19 among vaccinated and unvaccinated kidney transplant recipients.

    Demir, Erol / Dheir, Hamad / Safak, Seda / Serra Artan, Ayse / Sipahi, Savas / Turkmen, Aydin

    Vaccine

    2022  Volume 40, Issue 24, Page(s) 3313–3319

    Abstract: Introduction: The remarkable efficacy and effectiveness of COVID-19 vaccines have been described in healthy individuals, but kidney transplant recipients have been excluded from these studies. Therefore, real-world evidence of these vaccines can guide ... ...

    Abstract Introduction: The remarkable efficacy and effectiveness of COVID-19 vaccines have been described in healthy individuals, but kidney transplant recipients have been excluded from these studies. Therefore, real-world evidence of these vaccines can guide clinicians in predicting complications in kidney transplant recipients and how many doses of vaccines are protective. In this study, we aimed to investigate the impact of the COVID-19 vaccines on kidney transplant recipients with SARS-CoV-2 infection.
    Material and method: This matched case-control study included vaccinated kidney transplant recipients with COVID-19 from two centers between 1 May and 1 October 2021. All patients in the vaccinated group received a minimum of two doses of the vaccine and were diagnosed with COVID-19 at least one month after the last dose. Each vaccinated patient was matched with an unvaccinated kidney transplant recipient diagnosed with COVID. The endpoints were all-cause mortality, hospitalization, intensive care unit admission, acute kidney injury, cytokine storm, and acute respiratory distress syndrome.
    Results: The median age of vaccinated seventy-two participants was 45 years, and 41 of the participants were men in the vaccinated group. Four patients in the vaccinated group and nine patients in the control group died during follow-up (p = 0.247). Seventeen patients in the vaccinated group, thirty-four participants in the control group were hospitalized (p = 0.004); five vaccinated patients and ten unvaccinated patients were followed-up in the ICU during follow-up (p = 0.168). Thirteen of the vaccinated and twelve unvaccinated patients developed acute kidney injury (p = 0.16). The occurrence of cytokine storm (n = 4 vs. n = 11; p = 0.061) and acute respiratory distress syndrome (n = 5 vs. n = 10; p = 0.168) was higher in the patient group compared to the control group.
    Conclusion: COVID-19 remains a fatal disease despite advancing treatment modalities and preventive strategies. COVID-19 vaccines can't prevent death in all kidney transplant recipients, but they decrease hospitalization rate and duration in most patients.
    MeSH term(s) Acute Kidney Injury ; COVID-19/prevention & control ; COVID-19 Vaccines ; Case-Control Studies ; Cytokine Release Syndrome ; Female ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Respiratory Distress Syndrome ; SARS-CoV-2 ; Transplant Recipients ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.04.066
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    Zs.MO 458: Show issues

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  8. Article: Pregnancy in Living Kidney Donors: An Evidence-Based Review.

    Artan, Ayse Serra / Fleetwood, Vidyaratna / Guller, Nurane / Oto, Ozgur Akin / Mirioglu, Safak / Yazici, Halil / Turkmen, Aydin / Caliskan, Yasar / Lentine, Krista L

    Current transplantation reports

    2023  Volume 10, Issue 3, Page(s) 110–116

    Abstract: Purpose of review: To review the current studies and guidelines on the risk of adverse pregnancy outcomes in female kidney donors.: Recent findings: Living kidney donors include a significant amount of young women of child-bearing age. Safety and ... ...

    Abstract Purpose of review: To review the current studies and guidelines on the risk of adverse pregnancy outcomes in female kidney donors.
    Recent findings: Living kidney donors include a significant amount of young women of child-bearing age. Safety and possible risks of pregnancy after donation are a concern for female kidney donor candidates. Many current studies indicate a higher risk of preeclampsia in women after kidney donation. Considering the increasing number of living kidney donors, the maternal outcomes of living kidney donation is an active area of research.
    Summary: Guidelines and consensus statements on the risk of pregnancy in living kidney donors recommend close monitoring of blood pressure, weight gain, and proteinuria during pregnancy. Current studies indicate an increased risk of hypertensive disorders of pregnancy in living kidney donors. Counseling and informing donor candidates about the possible risks is important.
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2196-3029
    ISSN 2196-3029
    DOI 10.1007/s40472-023-00402-8
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  9. Article ; Online: Diagnostic yield and safety of percutaneous native kidney biopsy in pregnancy: 20-years of single-center experience.

    Yazici, Halil / Dirim, Ahmet Burak / Garayeva, Nurana / Safak, Seda / Ozluk, Yasemin / Hurdogan, Ozge / Oto, Ozgur Akin / Artan, Ayse Serra / Turkmen, Aydin

    Journal of nephrology

    2023  Volume 36, Issue 9, Page(s) 2507–2517

    Abstract: Background: Percutaneous kidney biopsy is a fundamental procedure in nephrology. Although pregnancy is not a contraindication, a careful risk-benefit assessment is mandatory in pregnancy. We aimed to evaluate safety and diagnostic accuracy of ... ...

    Abstract Background: Percutaneous kidney biopsy is a fundamental procedure in nephrology. Although pregnancy is not a contraindication, a careful risk-benefit assessment is mandatory in pregnancy. We aimed to evaluate safety and diagnostic accuracy of percutaneous kidney biopsy in pregnancy in a single-center retrospective study.
    Methods: Percutaneous kidney biopsy was performed in 19 pregnant patients. Demographics, estimated glomerular filtration rates, serum albumin levels, and proteinuria levels at the time of biopsy were evaluated. Biopsy-related complications, diagnoses, and treatments during the follow-up were analyzed. In addition, delivery success, preeclampsia, early delivery, low birth weight rates, and long-term outcomes of the patients were retrieved and analyzed.
    Results: Mean patient age was 27 (range 16-41) years. Median gestational week at kidney biopsy was 20th. All but one biopsies were diagnostic. Median gestational week of delivery was 35 (range 23-39) gestational weeks. Preterm delivery (< 37 gestational weeks) and low birth weight (< 2500 mg) occurred in 73.7% and 52.6% of cases, respectively. Median weight at birth was 2500 mg. The incidence of preeclampsia was 57.9%. Overall 89.5% of the children survived. Median post-biopsy follow-up was 64 months. Maternal mortality was not observed during the follow-up period. End stage kidney disease developed in one patient. The results of percutaneous kidney biopsy led to therapeutic decisions in 73.7% of cases.
    Conclusions: Although percutaneous kidney biopsy is not frequently performed during pregnancy, it is relatively safe and usually diagnostic, and may guide further follow-up.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Child ; Female ; Humans ; Adolescent ; Young Adult ; Adult ; Pre-Eclampsia/diagnosis ; Retrospective Studies ; Biopsy/adverse effects ; Premature Birth ; Kidney/pathology
    Language English
    Publishing date 2023-09-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01753-2
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    Zs.A 3369: Show issues Location:
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  10. Article ; Online: Thromboembolic complications after COVID-19 in kidney transplant recipients.

    Artan, Ayse Serra / Dirim, Ahmet Burak / Yavuzkilic, Halil / Demir, Erol / Oto, Ozgur Akin / Guller, Nurana / Safak, Seda / Yazici, Halil / Turkmen, Aydin

    Nephrology (Carlton, Vic.)

    2023  Volume 29, Issue 1, Page(s) 39–47

    Abstract: Aim: Increased venous thrombosis and arterial embolism rates are observed in the general population during or after COVID-19. Data regarding the kidney transplant population are scarce. In this study, we aim to investigate the thrombotic complications ... ...

    Abstract Aim: Increased venous thrombosis and arterial embolism rates are observed in the general population during or after COVID-19. Data regarding the kidney transplant population are scarce. In this study, we aim to investigate the thrombotic complications and risk factors associated with thrombotic complications in kidney transplant patients.
    Methods: This retrospective observational study included adult kidney transplant recipients diagnosed with COVID-19 between March 2020 and June 2022. The endpoint was the occurrence of thromboembolic events.
    Results: Four hundred and sixty-nine patients were followed for a median of 10.8 months after COVID-19. Forty patients (8.5%) died. Thromboembolic complications developed in 51 (11.9%) of the surviving patients. Twenty-four patients with thromboembolic events were receiving prophylactic anticoagulation before the event. The patients with mild, moderate, and severe COVID-19 were 292, 129, and 48, respectively. Patients with moderate COVID-19 had a significantly higher percentage of thromboembolic complications than patients with mild COVID-19. Older age, prior heart disease, and moderate COVID-19 were significantly associated with thromboembolic events. The incidence of thromboembolic events after COVID-19 is 10.9 per 100 patient-year.
    Conclusion: Thromboembolic complications were observed at increased rates in kidney transplant recipients after COVID-19. Therefore, prospective and cohort studies for post-COVID-19 complications regarding the treatment modalities are urgently needed.
    MeSH term(s) Adult ; Humans ; Kidney Transplantation/adverse effects ; COVID-19/complications ; COVID-19/epidemiology ; Prospective Studies ; Thromboembolism/diagnosis ; Thromboembolism/epidemiology ; Thromboembolism/etiology ; Venous Thrombosis/etiology ; Retrospective Studies ; Transplant Recipients
    Language English
    Publishing date 2023-09-20
    Publishing country Australia
    Document type Observational Study ; Journal Article
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14242
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