Article ; Online: Oral mucous membrane pemphigoid: updates in diagnosis and management.
2024 Volume 236, Issue 4, Page(s) 293–296
Abstract: Mucous membrane pemphigoid (MMP) is a rare, immune-mediated, vesiculobullous disease that predominantly affects the oral cavity and conjunctiva. In MMP, autoantibodies are directed against hemidesmosomal proteins in the basement membrane zone, most ... ...
| Abstract | Mucous membrane pemphigoid (MMP) is a rare, immune-mediated, vesiculobullous disease that predominantly affects the oral cavity and conjunctiva. In MMP, autoantibodies are directed against hemidesmosomal proteins in the basement membrane zone, most commonly BP180. Clinical signs and symptoms include gingival desquamation, erosions, and ulcerations. Differential diagnoses include other immune-mediated blistering diseases, such as bullous pemphigoid. Definitive diagnosis is reached through history taking, physical examination, tissue biopsy and/or serology testing. MMP, although not curable, is typically managed with topical or systemic corticosteroids, in addition to immunosuppressive therapies and biologic agents in recalcitrant cases. Untreated MMP can lead to life-threatening complications, such as blindness. As a condition that affects the oral cavity, it is important that dentists understand how to recognise, diagnose and manage the disease. |
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| MeSH term(s) | Humans ; Pemphigoid, Bullous/diagnosis ; Pemphigoid, Bullous/drug therapy ; Pemphigoid, Benign Mucous Membrane/diagnosis ; Pemphigoid, Benign Mucous Membrane/drug therapy ; Oral Ulcer ; Autoantibodies/therapeutic use ; Mucous Membrane/pathology | ||||||||||
| Chemical Substances | Autoantibodies | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2024-02-23 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 218090-x | ||||||||||
| ISSN | 1476-5373 ; 0007-0610 | ||||||||||
| ISSN (online) | 1476-5373 | ||||||||||
| ISSN | 0007-0610 | ||||||||||
| DOI | 10.1038/s41415-024-7064-x | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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