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  1. Article ; Online: Algebraic Structure of Network Topology

    T Karunakaran

    Proceedings of Indian National Science Academy, Vol 41, Iss 3A (2015)

    2015  

    Abstract: Algebraic Structure of Network ... ...

    Abstract Algebraic Structure of Network Topology
    Keywords Science ; Q
    Language English
    Publishing date 2015-02-01T00:00:00Z
    Publisher Indian National Science Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Previous SARS-CoV-2 Infection Status Among the Current RT-PCR-Positive Individuals Affected During the Second Wave of COVID-19 Infections in Chennai, India

    Jeromie Wesley Vivian Thangaraj / Muthusamy Santhosh Kumar / C. P. Girish Kumar / Pragya Yadav / D. Sudha Rani / T. Karunakaran / Manoj Murhekar

    Frontiers in Public Health, Vol

    2022  Volume 10

    Abstract: India witnessed a very strong second wave of coronavirus disease 2019 (COVID-19) during March and June 2021. Newly emerging variants of concern can escape immunity and cause reinfection. We tested newly diagnosed COVID-19 cases during the second wave in ... ...

    Abstract India witnessed a very strong second wave of coronavirus disease 2019 (COVID-19) during March and June 2021. Newly emerging variants of concern can escape immunity and cause reinfection. We tested newly diagnosed COVID-19 cases during the second wave in Chennai, India for the presence of Immunoglobulin G (IgG) antibodies to estimate the extent of re-infection. Of the 902 unvaccinated COVID-19 positive individuals, 53 (26.5%) were reactive for IgG antibodies and non-reactive for Immunogobulin M (IgM) antibodies. Among the 53 IgG-positive individuals, the interval between symptom onset (or last contact with the known case in case of asymptomatic) was <5 days in 29 individuals, ≥5 days in 11 individuals, while 13 asymptomatic individuals did not know their last contact with a positive case. The possible re-infections ranged between 3.2% (95% CI: 2.2–4.5%) and 4.3% (95% CI: 3.4–6.2%). The findings indicate that re-infection was not a major reason of the surge in cases during second wave. The IgG seropositivity among recently diagnosed unvaccinated COVID-19 patients could provide early indications about the extent of re-infections in the area.
    Keywords SARS-CoV-2 ; reinfection ; IgG antibody ; genomic sequencing ; COVID-19 ; Public aspects of medicine ; RA1-1270
    Subject code 630
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Purification and characterization of hyaluronic acid produced by Streptococcus zooepidemicus strain 3523-7

    K. Jagadeeswara Reddy / K.T. Karunakaran

    Journal of BioScience and Biotechnology, Vol 2, Iss 3, Pp 173-

    2013  Volume 179

    Abstract: Hyaluronic acid (HA) is a hydrated gel and comprises repeating units of glucuronic acid and N-acetylglucosamine. Production and recovery of HA has gained great importance due to its vast clinical applications. In pursuit of obtaining highly pure HA, we ... ...

    Abstract Hyaluronic acid (HA) is a hydrated gel and comprises repeating units of glucuronic acid and N-acetylglucosamine. Production and recovery of HA has gained great importance due to its vast clinical applications. In pursuit of obtaining highly pure HA, we have developed a fed-batch fermentation process using Streptococcus zooepidemicus in a 25 L bioreactor that resulted in a maximum yield of 2.3 g/L HA. In addition, we have devised an efficient method for separation and recovery of hyaluronic acid from a highly viscous broth by treating with trichloroacetic acid (0.1%) and charcoal (1-2%), passing through filtration (0.45 μm) and ultrafiltration that resulted in recovery of 72.2% of clinical grade HA with molecular weight of 2.5×106 Da. We have also characterized our purified HA using FTIR and NMR spectroscopy. These studies revealed the similarity in both the FTIR spectrum as well as NMR spectrum of both reference standard and purified HA from S. zooepidemicus indicating that the reported process is more efficient in terms of better yield and high quality (99.2%).
    Keywords Hyaluronic acid ; fed-batch fermentation ; purification ; FTIR analysis ; NMR analysis ; Streptococcus zooepidemicus ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 660
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Plovdiv University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Purification and characterization of hyaluronic acid produced by Streptococcus zooepidemicus strain 3523-7

    K. Jagadeeswara Reddy / K.T. Karunakaran

    Journal of BioScience and Biotechnology. 2013, v. 2, no. 3

    2013  

    Abstract: Hyaluronic acid (HA) is a hydrated gel and comprises repeating units of glucuronic acid and N-acetylglucosamine. Production and recovery of HA has gained great importance due to its vast clinical applications. In pursuit of obtaining highly pure HA, we ... ...

    Abstract Hyaluronic acid (HA) is a hydrated gel and comprises repeating units of glucuronic acid and N-acetylglucosamine. Production and recovery of HA has gained great importance due to its vast clinical applications. In pursuit of obtaining highly pure HA, we have developed a fed-batch fermentation process using Streptococcus zooepidemicus in a 25 L bioreactor that resulted in a maximum yield of 2.3 g/L HA. In addition, we have devised an efficient method for separation and recovery of hyaluronic acid from a highly viscous broth by treating with trichloroacetic acid (0.1%) and charcoal (1-2%), passing through filtration (0.45 μm) and ultrafiltration that resulted in recovery of 72.2% of clinical grade HA with molecular weight of 2.5×106 Da. We have also characterized our purified HA using FTIR and NMR spectroscopy. These studies revealed the similarity in both the FTIR spectrum as well as NMR spectrum of both reference standard and purified HA from S. zooepidemicus indicating that the reported process is more efficient in terms of better yield and high quality (99.2%).
    Keywords N-acetylglucosamine ; Streptococcus equi subsp. zooepidemicus ; batch fermentation ; bioreactors ; charcoal ; gels ; glucuronic acid ; hyaluronic acid ; molecular weight ; nuclear magnetic resonance spectroscopy ; reference standards ; trichloroacetic acid ; ultrafiltration
    Language English
    Size p. 173-179.
    Publishing place Plovdiv University Press
    Document type Article
    ZDB-ID 2705380-5
    ISSN 1314-6246 ; 1314-6238
    ISSN (online) 1314-6246
    ISSN 1314-6238
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Simple and Rapid Method for Isolation of RNA from Gram-Negative Bacteria

    T. Karunakaran / Howard Kuramitsu

    BioTechniques, Vol 20, Iss 4, Pp 546-

    1996  Volume 547

    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 1996-04-01T00:00:00Z
    Publisher Future Science Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Burden of dengue infection in India, 2017

    Manoj V Murhekar, MD / P Kamaraj, MPhil / Muthusamy Santhosh Kumar, MPH / Siraj Ahmed Khan, PhD / Ramesh Reddy Allam, MBBS / Pradip Barde, PhD / Bhagirathi Dwibedi, MD / Suman Kanungo, PhD / Uday Mohan, MD / Suman Sundar Mohanty, PhD / Subarna Roy, PhD / Vivek Sagar, PhD / Deepali Savargaonkar, MBBS / Babasaheb V Tandale, MD / Roshan Kamal Topno, MBBS / Gajanan Sapkal, PhD / C P Girish Kumar, PhD / R Sabarinathan, BE / Velusamy Saravana Kumar, PhD /
    Sailaja Bitragunta, MAE / Gagandeep Singh Grover, MD / P V M Lakshmi, MD / Chandra Mauli Mishra, MBBS / Provash Sadhukhan, PhD / Prakash Kumar Sahoo, PhD / S K Singh, MD / Chander Prakash Yadav, PhD / Asha Bhagat, MSc / Rashi Srivastava, MSc / E Ramya Dinesh, MSc / T Karunakaran, MSc / C Govindhasamy, MSc / T Daniel Rajasekar, MSc / A Jeyakumar, MPhil / A Suresh, MA / D Augustine, BA / P Ashok Kumar, BA / Rajesh Kumar, MD / Shanta Dutta, PhD / G S Toteja, PhD / Nivedita Gupta, PhD / Sanjay M Mehendale, MD

    The Lancet Global Health, Vol 7, Iss 8, Pp e1065-e

    a cross-sectional population based serosurvey

    2019  Volume 1073

    Abstract: Summary: Background: The burden of dengue virus (DENV) infection across geographical regions of India is poorly quantified. We estimated the age-specific seroprevalence, force of infection, and number of infections in India. Methods: We did a community- ... ...

    Abstract Summary: Background: The burden of dengue virus (DENV) infection across geographical regions of India is poorly quantified. We estimated the age-specific seroprevalence, force of infection, and number of infections in India. Methods: We did a community-based survey in 240 clusters (118 rural, 122 urban), selected from 60 districts of 15 Indian states from five geographical regions. We enumerated each cluster, randomly selected (with an Andriod application developed specifically for the survey) 25 individuals from age groups of 5–8 years, 9–17 years, and 18–45 years, and sampled a minimum of 11 individuals from each age group (all the 25 randomly selected individuals in each age group were visited in their houses and individuals who consented for the survey were included in the study). Age was the only inclusion criterion; for the purpose of enumeration, individuals residing in the household for more than 6 months were included. Sera were tested centrally by a laboratory team of scientific and technical staff for IgG antibodies against the DENV with the use of indirect ELISA. We calculated age group specific seroprevalence and constructed catalytic models to estimate force of infection. Findings: From June 19, 2017, to April 12, 2018, we randomly selected 17 930 individuals from three age groups. Of these, blood samples were collected and tested for 12 300 individuals (5–8 years, n=4059; 9–17 years, n=4265; 18–45 years, n=3976). The overall seroprevalence of DENV infection in India was 48·7% (95% CI 43·5–54·0), increasing from 28·3% (21·5–36·2) among children aged 5–8 years to 41·0% (32·4–50·1) among children aged 9–17 years and 56·2% (49·0–63·1) among individuals aged between 18–45 years. The seroprevalence was high in the southern (76·9% [69·1–83·2]), western (62·3% [55·3–68·8]), and northern (60·3% [49·3–70·5]) regions. The estimated number of primary DENV infections with the constant force of infection model was 12 991 357 (12 825 128–13 130 258) and for the age-dependent force of infection model was 8 655 ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 950
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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