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  1. Article ; Online: QT Changes of Unforeseen Implications and Bedaquiline

    Samya Dutta / Chitrita Ghosh / Sandip Mukhopadhyay / Ta Rupam Kumar

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 2, Pp OC24-OC

    An Observational Study

    2022  Volume 28

    Abstract: Introduction: Bedaquiline (BDQ), a diarylquinoline class of antimicrobial, is one of the latest anti-mycobacterial agents to be developed in several decades. Despite the drug being a great hope for the Drug Resistant Tuberculosis (DR-TB) patients, ... ...

    Abstract Introduction: Bedaquiline (BDQ), a diarylquinoline class of antimicrobial, is one of the latest anti-mycobacterial agents to be developed in several decades. Despite the drug being a great hope for the Drug Resistant Tuberculosis (DR-TB) patients, previous studies have raised alarm about BDQ-induced QT prolongations of serious clinical implication. Unfortunately, knowledge about adverse drug reaction of BDQ on Indian patients remains limited. Therefore, dedicated research focused on safety of BDQ in Indian population can provide valuable insight. Aim: To assess the short-term safety of BDQ on Indian DR-TB patients. Materials and Methods: This prospective observational study was conducted over a period of one year on 49 DR-TB patients under BDQ therapy. Data of all the DR-TB patients from the first 14 days of BDQ therapy were enrolled in the study. All adverse events during this period were closely observed and recorded. Electrocardiography (ECG) were recorded daily during this period. From the observed QT value, a ‘corrected QT’ (QTc) value was calculated using Fridericia’s formula (QTcF). Values above 440 ms were noted as prolonged QTcF and values >500 ms were given a special consideration. Results: Total 49 patients were recruited in the present study, with mean age of 38.63±1.63 years. A total of 124 reports of adverse events or symptoms were recorded during the 14 days in-hospital period. Nausea was the most commonly reported complaint (n=33) followed by headache (n=30) and arthralgia (n=28). A total of 278 observations of prolonged QTcF values (>440 ms) was noted out of 686 ECG recordings. The mean QTcF values among day 1, day 7 and day 14 showed statistically significant difference {p=0.01, 95% CI (Confidence Interval)}. Moreover, a mean increase of 14.2% was observed in the QTcF values between day 1 and day 14. There were a total of 69 observations of QTcF value more than 500 ms. The incidence of such value was maximum on day 14 (n=9). The QTcF values were found to follow three distinct trends: a) ...
    Keywords drug-resistant tuberculosis ; qt prolongation ; qt reduction ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Ocular Manifestations among Newly Diagnosed Tuberculosis Patients Receiving Anti-Tubercular Therapy under Revised National Tuberculosis Control Programme

    SOUMYA RAY / Ta RUPAM KUMAR / PALLABI RAYCHAUDHURI / UTTAM BISWAS / MOUSUMI BANDYOPADHYAY

    Journal of Clinical and Diagnostic Research, Vol 15, Iss 12, Pp 34-

    A Prospective Cohort Study

    2021  Volume 38

    Abstract: Introduction: Ocular tuberculosis has diverse presentations. As microbiological confirmation is difficult, a high index of suspicion is required. The present study replenishes the gap of existing knowledge regarding ocular tuberculosis and facts related ... ...

    Abstract Introduction: Ocular tuberculosis has diverse presentations. As microbiological confirmation is difficult, a high index of suspicion is required. The present study replenishes the gap of existing knowledge regarding ocular tuberculosis and facts related to antitubercular drug related toxicity. Aim: To evaluate the magnitude and outcome of ocular tuberculosis along with antitubercular drug related ocular toxicity, with special reference to ethambutol toxicity. Materials and Methods: This cohort study was conducted from May 2018 to April 2019 at Outpatient Department of Ophthalmology, Burdwan Medical College and Hospital, West Bengal, India. Total 170 newly diagnosed tuberculosis patients underwent comprehensive ophthalmic examination for any signs of ocular tuberculosis or development of antitubercular drug related ocular toxicity. They were treated and followed up to the completion of Anti-Tubercular Therapy (ATT). The statistical software Statistical Package for the Social Sciences (SPSS) version 20.0 was used for the analysis. Results: Out of total 170 study participants, 110 (64.7%) were male, mean age was 35.65±15.49 years. Ocular tuberculosis was found in 12 (7.05%) patients. Four patients had choroidal tuberculoma, two had Eales disease, four had choroiditis, two had anterior and intermediate uveitis. All the ocular tubercular lesions responded to ATT. Total 7 (4.1%) patients developed ethambutol-induced ocular toxicity. Following stoppage of ethambutol and treatment with corticosteroids there was significant improvement in colour vision, perimetry and Visual Evoked Potential (VEP) findings in 3 (42.9%) patients. Unfortunately, 4 (57.1%) patients developed optic atrophy. Conclusion: Comprehensive ophthalmic examination should to be done in all tuberculosis patients to detect and treat co-existing ocular tuberculosis as well as early detection of antitubercular drug toxicity. Withholding of the offender can result in visual recovery
    Keywords choroidal tuberculoma ; ethambutol toxicity ; eales disease ; ocular tuberculosis ; uveitis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Rapidly Fatal Silicosis Among Jewellery Workers Attending a District Medical College of West Bengal, India.

    Panchadhyayee, Prabodh / Saha, Kaushik / Saha, Indranil / Ta, Rupam Kumar / Ghosh, Santanu / Saha, Arnab / Barma, Pratik / Mitra, Mrinmoy

    The Indian journal of chest diseases & allied sciences

    2015  Volume 57, Issue 3, Page(s) 165–171

    Abstract: Background: Silicosis is a slowly progressive chronic occupational lung disease, developed after a prolong period of exposure to high concentration of silica dust.: Methods: In this longitudinal study, we enrolled old and new silicosis patients (n=19; ...

    Abstract Background: Silicosis is a slowly progressive chronic occupational lung disease, developed after a prolong period of exposure to high concentration of silica dust.
    Methods: In this longitudinal study, we enrolled old and new silicosis patients (n=19; 8 jewellery polishers, 11 from other occupations) seen at our Pulmonary Medicine Department from June 2009 to December 2012 to document the course of illness as per their occupational exposure.
    Results: Six of the eight jewellery polishing workers had developed silicosis within five years of exposure, while six of the 11 other workers with other occupational exposure had developed silicosis after exposure of 10 years or more. Mean duration of exposure was significantly less among jewellery polishing workers compared to other workers (3.4 +/- 1.7 versus 9.3 +/- 4.1; p=0.001). Mean duration of illness (months) (14.9 +/- 5.8 versus 28.5 +/- 16.5; p=0.040) were significantly less among the jewellery polishing workers compared to other workers. At the end of the study period, all eight jewellery polishing workers with silicosis had died while four of the 11 patients with other occupational exposure had died.
    Conclusion: Silicosis among jewellery polishing workers was found to be more severe and progressive compared to silicosis due to other occupational exposures, in our study.
    MeSH term(s) Adolescent ; Adult ; Humans ; India ; Jewelry ; Longitudinal Studies ; Male ; Occupational Exposure/adverse effects ; Silicosis/diagnosis ; Silicosis/mortality ; Survival Analysis ; Time Factors ; Young Adult
    Language English
    Publishing date 2015-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 416066-6
    ISSN 0377-9343 ; 0019-5111
    ISSN 0377-9343 ; 0019-5111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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