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Article ; Online: Roles for eosinophils and basophils in COVID-19?

Tabachnikova, Alexandra / Chen, Steven T

2020 Volume 20, Issue 8, Page(s) 461

Keywords	covid19
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-0379-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Roles for eosinophils and basophils in COVID-19?

Tabachnikova, Alexandra / Chen, Steven T

Nat Rev Immunol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #611260
Database	COVID19

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Article ; Online: Roles for eosinophils and basophils in COVID-19?

Tabachnikova, Alexandra / Chen, Steven T.

Nature Reviews Immunology

2020 Volume 20, Issue 8, Page(s) 461–461

Keywords	Immunology ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-0379-1
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Sex differences in symptomatology and immune profiles of Long COVID.

medRxiv : the preprint server for health sciences

2024

Abstract: Strong sex differences in the frequencies and manifestations of Long COVID (LC) have been reported with females significantly more likely than males to present with LC after acute SARS-CoV-2 ... ...

Abstract	Strong sex differences in the frequencies and manifestations of Long COVID (LC) have been reported with females significantly more likely than males to present with LC after acute SARS-CoV-2 infection
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.29.24303568
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.

Grady, Connor B / Bhattacharjee, Bornali / Silva, Julio / Jaycox, Jillian / Lee, Lik Wee / Monteiro, Valter Silva / Sawano, Mitsuaki / Massey, Daisy / Caraballo, César / Gehlhausen, Jeff R / Tabachnikova, Alexandra / Mao, Tianyang / Lucas, Carolina / Peña-Hernandez, Mario A / Xu, Lan / Tzeng, Tiffany J / Takahashi, Takehiro / Herrin, Jeph / Güthe, Diana Berrent /

Akrami, Athena / Assaf, Gina / Davis, Hannah / Harris, Karen / McCorkell, Lisa / Schulz, Wade L / Grffin, Daniel / Wei, Hannah / Ring, Aaron M / Guan, Leying / Cruz, Charles Dela / Iwasaki, Akiko / Krumholz, Harlan M

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in ... ...

Abstract	Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-β and CNTF, among soluble analytes. Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.11.24300929
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination.

Lu-Culligan, Alice / Tabachnikova, Alexandra / Pérez-Then, Eddy / Tokuyama, Maria / Lee, Hannah J / Lucas, Carolina / Silva Monteiro, Valter / Miric, Marija / Brache, Vivian / Cochon, Leila / Muenker, M Catherine / Mohanty, Subhasis / Huang, Jiefang / Kang, Insoo / Dela Cruz, Charles / Farhadian, Shelli / Campbell, Melissa / Yildirim, Inci / Shaw, Albert C /

Ma, Shuangge / Vermund, Sten H / Ko, Albert I / Omer, Saad B / Iwasaki, Akiko

PLoS biology

2022 Volume 20, Issue 5, Page(s) e3001506

Abstract: The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice ... ...

Abstract	The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic of public interest. We investigated 2 of the most widely propagated claims to determine (1) whether COVID-19 mRNA vaccination of mice during early pregnancy is associated with an increased incidence of birth defects or growth abnormalities; and (2) whether COVID-19 mRNA-vaccinated human volunteers exhibit elevated levels of antibodies to the human placental protein syncytin-1. Using a mouse model, we found that intramuscular COVID-19 mRNA vaccination during early pregnancy at gestational age E7.5 did not lead to differences in fetal size by crown-rump length or weight at term, nor did we observe any gross birth defects. In contrast, injection of the TLR3 agonist and double-stranded RNA mimic polyinosinic-polycytidylic acid, or poly(I:C), impacted growth in utero leading to reduced fetal size. No overt maternal illness following either vaccination or poly(I:C) exposure was observed. We also found that term fetuses from these murine pregnancies vaccinated prior to the formation of the definitive placenta exhibit high circulating levels of anti-spike and anti-receptor-binding domain (anti-RBD) antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) consistent with maternal antibody status, indicating transplacental transfer in the later stages of pregnancy after early immunization. Finally, we did not detect increased levels of circulating anti-syncytin-1 antibodies in a cohort of COVID-19 vaccinated adults compared to unvaccinated adults by ELISA. Our findings contradict popular claims associating COVID-19 mRNA vaccination with infertility and adverse neonatal outcomes.
MeSH term(s)	Animals ; Antibodies, Viral ; COVID-19/prevention & control ; Female ; Fetus ; Gene Products, env ; Humans ; Mice ; Placenta/metabolism ; Pregnancy ; Pregnancy Proteins ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies, Viral ; Gene Products, env ; Pregnancy Proteins ; RNA, Messenger ; syncytin
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3001506
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID

Grady, Connor B / Bhattacharjee, Bornali / Silva, Julio / Jaycox, Jillian / Lee, Lik Wee / Monteiro, Valter Silva / Sawano, Mitsuaki / Massey, Daisy / Caraballo, César / Gehlhausen, Jeff R. / Tabachnikova, Alexandra / Mao, Tianyang / Lucas, Carolina / Peña-Hernandez, Mario A. / Xu, Lan / Tzeng, Tiffany J. / Takahashi, Takehiro / Herrin, Jeph / Güthe, Diana Berrent /

medRxiv

Abstract	Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-β and CNTF, among soluble analytes. Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.
Keywords	covid19
Language	English
Publishing date	2024-01-12
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.01.11.24300929
Database	COVID19

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Article ; Online: Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity.

Nature

2021 Volume 600, Issue 7889, Page(s) 523–529

Abstract: The emergence of SARS-CoV-2 variants with mutations in major neutralizing antibody-binding sites can affect humoral immunity induced by infection or ... ...

Abstract	The emergence of SARS-CoV-2 variants with mutations in major neutralizing antibody-binding sites can affect humoral immunity induced by infection or vaccination
MeSH term(s)	2019-nCoV Vaccine mRNA-1273/immunology ; Adult ; Aged ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; BNT162 Vaccine/immunology ; COVID-19/epidemiology ; COVID-19/virology ; Female ; Health Personnel/statistics & numerical data ; Humans ; Immunity, Humoral ; Male ; Middle Aged ; Mutation ; Retrospective Studies ; SARS-CoV-2/classification ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology ; Vaccines, Synthetic/immunology ; mRNA Vaccines/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; Vaccines, Synthetic ; mRNA Vaccines ; spike protein, SARS-CoV-2 ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2021-10-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-04085-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 244: Show issues

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Article: Distinguishing features of Long COVID identified through immune profiling.

Klein, Jon / Wood, Jamie / Jaycox, Jillian / Lu, Peiwen / Dhodapkar, Rahul M / Gehlhausen, Jeff R / Tabachnikova, Alexandra / Tabacof, Laura / Malik, Amyn A / Kamath, Kathy / Greene, Kerrie / Monteiro, Valter Silva / Peña-Hernandez, Mario / Mao, Tianyang / Bhattacharjee, Bornali / Takahashi, Takehiro / Lucas, Carolina / Silva, Julio / Mccarthy, Dayna /

Breyman, Erica / Tosto-Mancuso, Jenna / Dai, Yile / Perotti, Emily / Akduman, Koray / Tzeng, Tiffany J / Xu, Lan / Yildirim, Inci / Krumholz, Harlan M / Shon, John / Medzhitov, Ruslan / Omer, Saad B / van Dijk, David / Ring, Aaron M / Putrino, David / Iwasaki, Akiko

medRxiv : the preprint server for health sciences

2022

Abstract: SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long ... ...

Abstract	SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long COVID
Language	English
Publishing date	2022-08-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.08.09.22278592
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain.

Fernández-Castañeda, Anthony / Lu, Peiwen / Geraghty, Anna C / Song, Eric / Lee, Myoung-Hwa / Wood, Jamie / Yalçın, Belgin / Taylor, Kathryn R / Dutton, Selena / Acosta-Alvarez, Lehi / Ni, Lijun / Contreras-Esquivel, Daniel / Gehlhausen, Jeff R / Klein, Jon / Lucas, Carolina / Mao, Tianyang / Silva, Julio / Peña-Hernández, Mario A / Tabachnikova, Alexandra /

Takahashi, Takehiro / Tabacof, Laura / Tosto-Mancuso, Jenna / Breyman, Erica / Kontorovich, Amy / McCarthy, Dayna / Quezado, Martha / Hefti, Marco / Perl, Daniel / Folkerth, Rebecca / Putrino, David / Nath, Avi / Iwasaki, Akiko / Monje, Michelle

bioRxiv : the preprint server for biology

2022

Abstract: Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in attention, concentration, speed of information processing and memory. This long-COVID ... ...

Abstract	Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in attention, concentration, speed of information processing and memory. This long-COVID cognitive syndrome shares many features with the syndrome of cancer therapy-related cognitive impairment (CRCI). Neuroinflammation, particularly microglial reactivity and consequent dysregulation of hippocampal neurogenesis and oligodendrocyte lineage cells, is central to CRCI. We hypothesized that similar cellular mechanisms may contribute to the persistent neurological symptoms associated with even mild SARS-CoV-2 respiratory infection. Here, we explored neuroinflammation caused by mild respiratory SARS-CoV-2 infection - without neuroinvasion - and effects on hippocampal neurogenesis and the oligodendroglial lineage. Using a mouse model of mild respiratory SARS-CoV-2 infection induced by intranasal SARS-CoV-2 delivery, we found white matter-selective microglial reactivity, a pattern observed in CRCI. Human brain tissue from 9 individuals with COVID-19 or SARS-CoV-2 infection exhibits the same pattern of prominent white matter-selective microglial reactivity. In mice, pro-inflammatory CSF cytokines/chemokines were elevated for at least 7-weeks post-infection; among the chemokines demonstrating persistent elevation is CCL11, which is associated with impairments in neurogenesis and cognitive function. Humans experiencing long-COVID with cognitive symptoms (48 subjects) similarly demonstrate elevated CCL11 levels compared to those with long-COVID who lack cognitive symptoms (15 subjects). Impaired hippocampal neurogenesis, decreased oligodendrocytes and myelin loss in subcortical white matter were evident at 1 week, and persisted until at least 7 weeks, following mild respiratory SARS-CoV-2 infection in mice. Taken together, the findings presented here illustrate striking similarities between neuropathophysiology after cancer therapy and after SARS-CoV-2 infection, and elucidate cellular deficits that may contribute to lasting neurological symptoms following even mild SARS-CoV-2 infection.
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.01.07.475453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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