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  1. Article: The Programmed Cell Death Ligand 1 and Lipocalin 2 Expressions in Primary Breast Cancer and Their Associations with Molecular Subtypes and Prognostic Factors.

    Ekemen, Suheyla / Bilir, Ebru / Soultan, Hagar Elsayed Akram / Zafar, Sadia / Demir, Figen / Tabandeh, Babek / Toprak, Sadik / Yapicier, Ozlem / Coban, Cevayir

    Breast cancer (Dove Medical Press)

    2024  Volume 16, Page(s) 1–13

    Abstract: Purpose: Breast cancers exhibit molecular heterogeneity, leading to diverse clinical outcomes and therapeutic responses. Immune checkpoint inhibitors targeting PD-L1 have shown promise in various malignancies, including breast cancer. Lipocalin 2 (LCN2) ...

    Abstract Purpose: Breast cancers exhibit molecular heterogeneity, leading to diverse clinical outcomes and therapeutic responses. Immune checkpoint inhibitors targeting PD-L1 have shown promise in various malignancies, including breast cancer. Lipocalin 2 (LCN2) has also been associated with tumor aggressiveness and prognostic potential in breast cancers. However, the expression of PD-L1 and LCN2 in breast cancer subtypes and their prognostic implications remains poorly investigated.
    Methods: A retrospective analysis of 89 primary breast cancer cases was conducted to assess PD-L1 and LCN2 expressions using immunohistochemistry. Cases were classified into four different molecular subtypes based on ER, PR, HER2, and Ki-67 status. Associations between PD-L1 and LCN2 expressions and various prognostic factors were examined.
    Results: Although low expression of LCN2 (Allred score of <3) was observed even in normal breast tissue, LCN2 expression with increasing Allred score (≥3) positively correlated with the histological grade, high Ki-67 proliferation index, and ER/PR negativity. Significant elevations of LCN2 and PD-L1 expressions were observed in triple-negative and HER2-positive breast cancers.
    Conclusion: The results of the study highlight the association of LCN2 with known prognostic factors and molecular subtypes. To identify potential immunotherapy recipients, it would be useful to evaluate LCN2 as well as PD-L1 immune targets in different subgroups of breast cancer patients. Further studies with larger patient numbers are warranted to validate these observations and establish standardized scoring criteria for LCN2 expression assessment.
    Language English
    Publishing date 2024-01-03
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520722-2
    ISSN 1179-1314
    ISSN 1179-1314
    DOI 10.2147/BCTT.S444077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Deficiency of epithelial-mesenchymal transition causes child indirect inguinal hernia.

    Somuncu, Salih / Somuncu, Özge Sezin / Ballıca, Başak / Tabandeh, Babek

    Journal of pediatric surgery

    2019  Volume 55, Issue 4, Page(s) 665–671

    Abstract: Introduction: Epithelial-mesenchymal transition (EMT) describes rapid changes in cellular phenotype. During EMT, epithelial cells down-modulate cell-cell adhesion, alter polarity, reorganize cytoskeleton, become isolated, motile, and resistant to ... ...

    Abstract Introduction: Epithelial-mesenchymal transition (EMT) describes rapid changes in cellular phenotype. During EMT, epithelial cells down-modulate cell-cell adhesion, alter polarity, reorganize cytoskeleton, become isolated, motile, and resistant to anoikis. Epithelial breakdown and epithelial cell migration are the key processes involved in the obliteration of processus vaginalis. The great majority of abnormalities are because of nonobliteration or incomplete fusion of PV. We aimed to analyze the quantitative changes of epithelial genes in adult/child patients and their controls to examine differences of the genesis of these hernias. We also aimed to investigate the potential epigenetic causes of indirect inguinal hernia in adult patients.
    Methods: Ten adult, ten child indirect inguinal hernia sacs and ten adult, ten child parietal peritonea were used. Hernial sac samples were obtained from indirect inguinal hernia surgeries. Peritonea of adult patients who underwent open cholecystectomy for cholelithiasis via subcostal incision were included in the study as the healthy control groups. Ages of the children were selected to be between 0 and 5 whereas the age of adults was chosen as 35-55, respectively. Total RNA isolation and cDNA synthesis were made from hernia sacs and peritoneum samples. Relative Keratin 1, Keratin 15, Filaggrin2 and STAT3 expressions were analyzed via qPCR. Indirect inguinal hernia sac cells were seeded and grown in vitro. Child diseased cells were employed in immunocytochemistry (ICC) analysis for Cytokeratin 15, Filaggrin2 and Bcl-2. Adult indirect inguinal hernia cells were examined for H3 modifications through ICC.
    Results: In child indirect inguinal hernia, Keratin expressions were found higher than their controls. They were meaningfully lower than the healthy group in adult indirect inguinal hernia. Keratin 15, Keratin 1 and Filaggrin2 expressions were all correlating since they are members of related pathways. STAT3 expressions were opposite to Keratin and Filaggrin expressions suggesting that adult cells might have a switch to the mesenchymal state from the epithelial state. Adult indirect inguinal hernia samples have switched to the mesenchymal state whereas child indirect inguinal hernia samples have shown lack of transition.
    Conclusion: Irregular changes of EMT associated genes act in the progression of indirect inguinal hernia. Hence, the information on the epigenetic regulation of EMT in patients with primary inguinal hernia can aid to comprehend the pathogenesis in adults and infers new therapeutic approaches for this disease.
    Type of study: Prognosis study.
    Level of evidence: Level 2.
    MeSH term(s) Adult ; Case-Control Studies ; Child, Preschool ; Epigenesis, Genetic ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition/physiology ; Female ; Hernia, Inguinal/etiology ; Humans ; Immunohistochemistry ; Infant ; Infant, Newborn ; Inguinal Canal/pathology ; Keratins/metabolism ; Male ; Middle Aged ; Peritoneum
    Chemical Substances Keratins (68238-35-7)
    Language English
    Publishing date 2019-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2019.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 607: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Successful Endovascular Management of a Transplant Renal Artery Pseudoaneurysm Complicated With Arterioureteral Fistula.

    Turunç, Volkan / Eroğlu, Aşkın / Tabandeh, Babek / Dheir, Hamad / Soylu, Özer / Demir, Mustafa K

    Progress in transplantation (Aliso Viejo, Calif.)

    2017  Volume 28, Issue 1, Page(s) 93–94

    Abstract: We report a case of renal artery pseudoaneurysm at the anastomosis site complicated with arterioureteral fistula (AUF) in a 57-year-old kidney transplant recipient who presented with intermittent massive hematuria at one month post-transplant. We ... ...

    Abstract We report a case of renal artery pseudoaneurysm at the anastomosis site complicated with arterioureteral fistula (AUF) in a 57-year-old kidney transplant recipient who presented with intermittent massive hematuria at one month post-transplant. We successfully treated the pseudoaneurysm and AUF with endovascular covered stent implantation. The diagnosis of AUF is rare and it is a condition that occurs in patients with previous pelvic or vascular surgery, chronic ureteral catheterization and radiotherapy. This diagnosis requires the expertise of the urologist, vascular surgeon and interventional radiologist. The fistula most often occur in the iliac arteries and are often associated with pseudoaneurysms or abscesses. Angiography and ureteral contrast studies (antegrade or retrograde pyelography) are the most valuable diagnostic tools. Treatment of AUF via endovascular approach using covered stents is effective and safe, and is becoming the reference treatment in AUFs.
    MeSH term(s) Aneurysm, False/physiopathology ; Aneurysm, False/surgery ; Endovascular Procedures ; Hematuria/surgery ; Humans ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Renal Artery/physiopathology ; Renal Artery/surgery ; Treatment Outcome ; Urinary Fistula/surgery ; Vascular Fistula/surgery
    Language English
    Publishing date 2017-12-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2019786-X
    ISSN 1526-9248
    ISSN 1526-9248
    DOI 10.1177/1526924817746913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3403: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Imaging Findings of the Unusual Presentations, Associations and Clinical Mimics of Acute Appendicitis.

    Demir, Mustafa Kemal / Savas, Yildiray / Furuncuoglu, Yavuz / Cevher, Tarik / Demiral, Serdar / Tabandeh, Babek / Aslan, Melisa

    The Eurasian journal of medicine

    2017  Volume 49, Issue 3, Page(s) 198–203

    Abstract: There are many kinds of unusual presentations or associations and clinical mimics of acute appendicitis, and definitive diagnosis requires knowledge of the imaging findings in some cases. The unusual presentations and associations of acute appendicitis ... ...

    Abstract There are many kinds of unusual presentations or associations and clinical mimics of acute appendicitis, and definitive diagnosis requires knowledge of the imaging findings in some cases. The unusual presentations and associations of acute appendicitis included in this study are perforated appendicitis, acute appendicitis occurring in hernias, acute appendicitis with cystic endosalpingiosis, intussusception of appendix, and acute appendicitis with pregnancy. We also present uncommon gastrointestinal, urinary and gynecologic clinical mimics of acute appendicitis including anomalous congenital band, duplication cysts, giant Meckel's diverticulitis, inflammatory fibroid polyp, renal artery thrombosis, spontaneous urinary extravasation and OHVIRA syndrome. Familiarity with these entities may improve diagnostic accuracy and enable the quickest and most appropriate clinical management.
    Language English
    Publishing date 2017-06-05
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2577670-8
    ISSN 1308-8742 ; 1308-8734
    ISSN (online) 1308-8742
    ISSN 1308-8734
    DOI 10.5152/eurasianjmed.2017.17218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Large abdominal cystic masses: Report of seven cases.

    Bolukbas, Filiz Fusun / Bolukbas, Cengiz / Furuncuoglu, Yavuz / Tabandeh, Babek / Saglam, Filiz Yarimcam / Iyigun, Gokmen / Orug, Taner / Ozcan, Ali / Yapicier, Ozlem

    JPMA. The Journal of the Pakistan Medical Association

    2016  Volume 66, Issue 2, Page(s) 226–228

    Abstract: Cystic abdominal tumours are encountered quite often and are diagnosed more frequently due to the availability of better imaging possibilities. Presentation of huge cysts has become rare as most of them are diagnosed and treated early. But we still have ... ...

    Abstract Cystic abdominal tumours are encountered quite often and are diagnosed more frequently due to the availability of better imaging possibilities. Presentation of huge cysts has become rare as most of them are diagnosed and treated early. But we still have patients with enlarged abdominal cysts; majority with cases of serous cystadenomas of the ovary. Absolute diagnosis is only possible with laparotomy and histopathological findings. In this report, seven patients with enlarged gynaecological or mesenteric cystic masses and gastroenterological symptoms are reported. Four of these cases were serous cystadenoma, two were mucinous cystadenoma and one was a paratubal cyst. Gynaecological tumours and mesenteric cysts should not be missed in female patients showing gastrointestinal symptoms.
    MeSH term(s) Abdominal Cavity/diagnostic imaging ; Abdominal Cavity/pathology ; Abdominal Pain/diagnosis ; Adult ; Asymptomatic Diseases ; Diagnosis, Differential ; Female ; Genital Neoplasms, Female/diagnosis ; Gynecologic Surgical Procedures/methods ; Humans ; Magnetic Resonance Imaging/methods ; Mesenteric Cyst/diagnosis ; Mesenteric Cyst/physiopathology ; Middle Aged ; Ovarian Cysts/diagnosis ; Ovarian Cysts/physiopathology ; Treatment Outcome ; Tumor Burden ; Ultrasonography/methods
    Language English
    Publishing date 2016-02
    Publishing country Pakistan
    Document type Case Reports ; Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  6. Article ; Online: Anatomical variations of donor portal vein in right lobe living donor liver transplantation: the safe use of variant portal veins.

    Guler, Necdet / Dayangac, Murat / Yaprak, Onur / Akyildiz, Murat / Gunay, Yusuf / Taskesen, Fatih / Tabandeh, Babek / Bulutcu, Fisun / Yuzer, Yildiray / Tokat, Yaman

    Transplant international : official journal of the European Society for Organ Transplantation

    2013  Volume 26, Issue 12, Page(s) 1191–1197

    Abstract: In right lobe (RL) living donor liver transplantation (LDLT), portal vein (PV) variations are of immense clinical significance. In this study, we describe in detail our PV reconstruction techniques in RL grafts with variant PV anatomy and evaluate the ... ...

    Abstract In right lobe (RL) living donor liver transplantation (LDLT), portal vein (PV) variations are of immense clinical significance. In this study, we describe in detail our PV reconstruction techniques in RL grafts with variant PV anatomy and evaluate the impact of accompanying biliary variations on the recipient outcomes. In a total of 386 RL LDLTs performed between July 2004 and July 2012, the clinical data on 52 (13%) transplants using RL grafts with variant PV anatomy were retrospectively analyzed. Portal vein anatomy was classified as type 2 in 20 patients, type 3 in 24 patients, and type 4 in eight patients. The PV reconstruction techniques utilized included back-wall plasty (n = 21), back-wall plasty with saphenous vein graft interposition (n = 6), saphenous vein graft interposition (n = 5), cryopreserved iliac vein Y-graft interposition (n = 6), and quiltplasty (n = 3). There was no donor mortality. In a median follow-up of 29 months, none of the recipients had vascular complications. Anomalous PV anatomy was associated with a high (54%) incidence of biliary variations; however, these variations did not result in increased biliary complication rate. Overall, the 1- and 3-year patient survival rates of recipients were 91% and 81%, respectively. Vascular and biliary variations in RL grafts render LDLT technically more challenging. By employing appropriate reconstruction techniques, it is possible to successfully use RL grafts with PV variations without endangering recipient and donor safety.
    MeSH term(s) Adult ; Anastomosis, Surgical ; Female ; Humans ; Iliac Vein/surgery ; Liver/surgery ; Liver Transplantation/methods ; Living Donors ; Male ; Middle Aged ; Portal Vein/abnormalities ; Portal Vein/surgery ; Retrospective Studies ; Saphenous Vein/surgery ; Vascular Surgical Procedures
    Language English
    Publishing date 2013-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.12190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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