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  1. Article: Two-way traffic: aligning expectations with current realities in oncology. Mid-term ESMO Presidency considerations.

    Tabernero, Josep

    ESMO open

    2019  Volume 4, Issue 1, Page(s) e000494

    Language English
    Publishing date 2019-01-31
    Publishing country England
    Document type Editorial
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2019-000494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: All change: closing the gender gap in oncology.

    Tabernero, Josep

    ESMO open

    2018  Volume 3, Issue 7, Page(s) e000448

    Language English
    Publishing date 2018-11-15
    Publishing country England
    Document type Editorial
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2018-000448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Biosimilars in oncology.

    Tabernero, Josep

    ESMO open

    2018  Volume 3, Issue 6, Page(s) e000456

    Language English
    Publishing date 2018-10-24
    Publishing country England
    Document type Journal Article
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2018-000456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Circulating tumor DNA as a novel prognostic indicator.

    Vivancos, Ana / Tabernero, Josep

    Nature medicine

    2022  Volume 28, Issue 11, Page(s) 2255–2256

    MeSH term(s) Humans ; Circulating Tumor DNA/genetics ; Prognosis ; Neoplastic Cells, Circulating/pathology ; Biomarkers, Tumor/genetics
    Chemical Substances Circulating Tumor DNA ; Biomarkers, Tumor
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-02068-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4212: Show issues Location:
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  5. Article ; Online: Third-Line Therapy in Metastatic Colorectal Cancer. Reply.

    Tabernero, Josep / Fakih, Marwan / Prager, Gerald W

    The New England journal of medicine

    2023  Volume 389, Issue 2, Page(s) 190–191

    MeSH term(s) Humans ; Trifluridine ; Bevacizumab ; Colorectal Neoplasms/drug therapy
    Chemical Substances tipiracil (NGO10K751P) ; Trifluridine (RMW9V5RW38) ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2306486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Seeking therapeutic synergy in BRAF mutant colorectal cancer.

    Elez, Elena / Ros, Javier / Tabernero, Josep

    Nature medicine

    2023  Volume 29, Issue 2, Page(s) 307–308

    MeSH term(s) Humans ; Proto-Oncogene Proteins B-raf/genetics ; Mutation ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-02192-5
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    Zs.A 4212: Show issues Location:
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  7. Article ; Online: Quantifying the Long-term Survival Benefit of Pembrolizumab for Patients With Advanced Gastric Cancer-Reply.

    Shitara, Kohei / Tabernero, Josep

    JAMA oncology

    2021  Volume 7, Issue 4, Page(s) 633

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Carcinoma, Non-Small-Cell Lung ; Humans ; Lung Neoplasms ; Stomach Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2020.8011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Evolving Treatment Landscape in

    Tabernero, Josep / Ros, Javier / Élez, Elena

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2022  Volume 42, Page(s) 1–10

    Abstract: Between 8% and 12% of patients with metastatic colorectal cancer (mCRC) harbor ... ...

    Abstract Between 8% and 12% of patients with metastatic colorectal cancer (mCRC) harbor a
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Cetuximab/genetics ; Cetuximab/therapeutic use ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; ErbB Receptors/genetics ; Humans ; Microsatellite Instability ; Mutation ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins B-raf/genetics
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_349561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Chemorefractory Gastric Cancer: The Evolving Terrain of Third-Line Therapy and Beyond.

    Alsina, Maria / Tabernero, Josep / Diez, Marc

    Cancers

    2022  Volume 14, Issue 6

    Abstract: Gastric and gastro-oesophageal junction cancer (GC) represent a global healthcare problem being the fifth most common tumour type and the fourth cause of cancer mortality. Extremely poor median survival of approximately 10 months is normally reported ... ...

    Abstract Gastric and gastro-oesophageal junction cancer (GC) represent a global healthcare problem being the fifth most common tumour type and the fourth cause of cancer mortality. Extremely poor median survival of approximately 10 months is normally reported within advanced GC patients, mainly secondary to two factors, i.e., the fragility of these patients and the aggressiveness of this disease. In this context, the correct treatment of GC patients requires not only a multidisciplinary team with special attention to palliative and nutritional care but also a close follow-up with regular monitoring of disease symptoms and tumour evaluation. Sequential treatment lines with few toxic adverse events have emerged as the best therapeutic approach, and a third line of therapy could further improve survival and quality of life of GC patients. Chemotherapy, immunotherapy, and targeted agents -when indicated- constitute the treatment armamentarium of these patients. In this review, we discuss treatment options in the refractory setting as well as novel approaches to overcome the poor prognosis of GC.
    Language English
    Publishing date 2022-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14061408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Current developments in gastric cancer: from molecular profiling to treatment strategy.

    Alsina, Maria / Arrazubi, Virginia / Diez, Marc / Tabernero, Josep

    Nature reviews. Gastroenterology & hepatology

    2022  Volume 20, Issue 3, Page(s) 155–170

    Abstract: Gastric cancer and gastro-oesophageal junction cancer represent a global health-care challenge. Despite the efficacy of improved chemotherapy and surgical options, these patients still have a poor prognosis. In advanced disease, only trastuzumab and some ...

    Abstract Gastric cancer and gastro-oesophageal junction cancer represent a global health-care challenge. Despite the efficacy of improved chemotherapy and surgical options, these patients still have a poor prognosis. In advanced disease, only trastuzumab and some immune checkpoint inhibitors, such as nivolumab and pembrolizumab in addition to chemotherapy, have demonstrated consistent and reliable efficacy in patients with HER2-positive and PDL1-positive tumours, respectively. In this Review, we discuss the intrinsic characteristics of gastric and gastro-oesophageal cancer from the molecular and clinical perspectives and provide a comprehensive review of previously reported and ongoing phase II and III clinical trials with targeted agents and immunotherapy in advanced and localized settings. Finally, we suggest alternative strategies to help overcome current challenges in precision medicine and to improve outcomes for these patients.
    MeSH term(s) Humans ; Stomach Neoplasms/genetics ; Stomach Neoplasms/therapy ; Trastuzumab/therapeutic use ; Antineoplastic Agents/therapeutic use ; Nivolumab/therapeutic use ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Trastuzumab (P188ANX8CK) ; Antineoplastic Agents ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-022-00703-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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