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  1. Article: Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice.

    Yallampalli, Chandra / Betancourt, Ancizar / Mishra, Akansha / Pennington, Kathleen A / Ruano, Simone Hernandez / Tacam, Moises / Chauhan, Madhu

    Frontiers in physiology

    2023  Volume 14, Page(s) 1116042

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1116042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of polycyclic aromatic hydrocarbon intake in the US adult population from NHANES 2005-2014 identifies vulnerable subpopulations, suggests interaction between tobacco smoke exposure and sociodemographic factors.

    Gearhart-Serna, Larisa M / Tacam, Moises / Slotkin, Theodore A / Devi, Gayathri R

    Environmental research

    2021  Volume 201, Page(s) 111614

    Abstract: Polycyclic aromatic hydrocarbons (PAHs) are a toxic and ubiquitous class of environmental chemicals, products of fuel combustion from human and natural sources. The objective of this study was to identify vulnerable populations for high PAH exposure and ... ...

    Abstract Polycyclic aromatic hydrocarbons (PAHs) are a toxic and ubiquitous class of environmental chemicals, products of fuel combustion from human and natural sources. The objective of this study was to identify vulnerable populations for high PAH exposure and variability, to better understand where to target PAH exposure reduction initiatives. Urinary metabolite data were collected from 9517 individuals from the U.S. CDC National Health and Nutrition Examination Survey years 2005-2014 for four parental PAHs naphthalene, fluorene, phenanthrene, and pyrene. We utilized these urinary biomarkers to estimate PAH intake, and regression models were fit for multiple demographic and lifestyle variables, to determine variable effects, interactions, odds of high versus low PAH intake. Smoking and secondhand smoke exposure accounted for the largest PAH intake rate variability (25.62%), and there were strongest interactions between race/ethnicity and smoking or SHS exposure, reflected in a much greater contribution of smoking to PAH intake in non-Hispanic Whites as compared to other races/ethnicities. Increased odds of high PAH intake were seen in older age groups, obese persons, college graduates, midrange incomes, smokers, and those who were SHS exposed. Among the non-smoking population, effects of other demographic factors lessened, suggesting a highly interactive nature. Our results suggest that there are demographic subpopulations with high PAH intake as a result of different smoking behaviors and potentially other exposures. This has human health, environmental justice, and regulatory implications wherein smoking cessation programs, SHS exposure regulations, and public health initiatives could be better targeted towards vulnerable subpopulations to meaningfully reduce PAH exposures.
    MeSH term(s) Adult ; Aged ; Humans ; Life Style ; Nutrition Surveys ; Polycyclic Aromatic Hydrocarbons ; Tobacco Smoke Pollution/adverse effects ; Vulnerable Populations
    Chemical Substances Polycyclic Aromatic Hydrocarbons ; Tobacco Smoke Pollution
    Language English
    Publishing date 2021-07-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2021.111614
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  3. Article ; Online: Correction: Maternal Embryonic Leucine Zipper Kinase Is Associated with Metastasis in Triple-negative Breast Cancer.

    Xie, Xuemei / Chauhan, Gaurav B / Edupuganti, Ramakrishna / Kogawa, Takahiro / Park, Jihyun / Tacam, Moises / Tan, Alex W / Mughees, Mohd / Vidhu, Fnu / Liu, Diane D / Taliaferro, Juliana M / Pitner, Mary Kathryn / Browning, Luke S / Lee, Ju-Hyeon / Bertucci, François / Shen, Yu / Wang, Jian / Ueno, Naoto T / Krishnamurthy, Savitri /
    Hortobagyi, Gabriel N / Tripathy, Debu / Van Laere, Steven J / Bartholomeusz, Geoffrey / Dalby, Kevin N / Bartholomeusz, Chandra

    Cancer research communications

    2024  Volume 4, Issue 1, Page(s) 236

    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Published Erratum
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-24-0046
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  4. Article ; Online: Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations.

    Gearhart-Serna, Larisa M / Jayasundara, Nishad / Tacam, Moises / Di Giulio, Richard / Devi, Gayathri R

    Journal of environmental and public health

    2018  Volume 2018, Page(s) 5610462

    Abstract: Polycyclic aromatic hydrocarbon (PAH) exposure is widespread, and many PAHs are considered carcinogenic. The PAH-contaminated AWI Superfund site in Virginia provides a model for studying a complex PAH mixture and its extrapolation to cancer risk and PAH ... ...

    Abstract Polycyclic aromatic hydrocarbon (PAH) exposure is widespread, and many PAHs are considered carcinogenic. The PAH-contaminated AWI Superfund site in Virginia provides a model for studying a complex PAH mixture and its extrapolation to cancer risk and PAH exposure in the general population. We examined cancer risk at the Superfund site due to sediment-derived PAHs and then evaluated PAH sources in the general population and potentially vulnerable subpopulations upon PAH mixture exposure. The PAH mixture was assessed for potential carcinogenicity using the US EPA's OncoLogic™ ranking tool and the US EPA list of priority PAHs. Cancer risk due to PAH exposure was calculated for Superfund site users and compared to the US EPA assessment. Human intake and health endpoints of PAHs within the mixture were extracted from USEtox® chemical fate database, while mean intake exposure was calculated for U.S. adults for select PAHs using NHANES database urinary biomarkers. Eleven PAH compounds within the mixture were of carcinogenic concern, and seven PAHs conveyed significant excess cancer risk at the Superfund site and in the general population, wherein PAH-contaminated seafood ingestion was a main contributor. Other dietary sources of PAHs derived from PAH-contaminated soil or water could also play a role in total exposure. Vulnerable populations to PAH exposure and coinciding increased cancer risk may include, in addition to smokers, children and non-Hispanic blacks, which is a public health concern.
    MeSH term(s) Diet ; Environmental Exposure ; Geologic Sediments/chemistry ; Humans ; Models, Theoretical ; Neoplasms/chemically induced ; Neoplasms/epidemiology ; Polycyclic Aromatic Hydrocarbons/adverse effects ; Risk Assessment ; Virginia/epidemiology ; Vulnerable Populations/statistics & numerical data ; Water Pollutants, Chemical/adverse effects
    Chemical Substances Polycyclic Aromatic Hydrocarbons ; Water Pollutants, Chemical
    Language English
    Publishing date 2018-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2526611-1
    ISSN 1687-9813 ; 1687-9813
    ISSN (online) 1687-9813
    ISSN 1687-9813
    DOI 10.1155/2018/5610462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.

    Xie, Xuemei / Chauhan, Gaurav B / Edupuganti, Ramakrishna / Kogawa, Takahiro / Park, Jihyun / Tacam, Moises / Tan, Alex W / Mughees, Mohd / Vidhu, Fnu / Liu, Diane D / Taliaferro, Juliana M / Pitner, Mary Kathryn / Browning, Luke S / Lee, Ju-Hyeon / Shen, Yu / Wang, Jian / Ueno, Naoto T / Krishnamurthy, Savitri / Hortobagyi, Gabriel N /
    Tripathy, Debu / Van Laere, Steven J / Bartholomeusz, Geoffrey / Dalby, Kevin N / Bartholomeusz, Chandra

    Cancer research communications

    2023  Volume 3, Issue 6, Page(s) 1078–1092

    Abstract: Triple-negative breast cancer (TNBC) has high relapse and metastasis rates and a high proportion of cancer stem-like cells (CSC), which possess self-renewal and tumor initiation capacity. MELK (maternal embryonic leucine zipper kinase), a protein kinase ... ...

    Abstract Triple-negative breast cancer (TNBC) has high relapse and metastasis rates and a high proportion of cancer stem-like cells (CSC), which possess self-renewal and tumor initiation capacity. MELK (maternal embryonic leucine zipper kinase), a protein kinase of the Snf1/AMPK kinase family, is known to promote CSC maintenance and malignant transformation. However, the role of MELK in TNBC metastasis is unknown; we sought to address this in the current study. We found that
    Significance: These findings indicate that MELK is a driver of aggressiveness and metastasis in TNBC.
    MeSH term(s) Humans ; Animals ; Mice ; Triple Negative Breast Neoplasms/genetics ; Mice, Nude ; Leucine Zippers ; Cell Proliferation/physiology ; Neoplasm Recurrence, Local ; Protein Serine-Threonine Kinases/genetics
    Chemical Substances MELK protein, human (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2767-9764
    ISSN (online) 2767-9764
    DOI 10.1158/2767-9764.CRC-22-0330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression.

    Park, Jihyun / Tacam, Moises J / Chauhan, Gaurav / Cohen, Evan N / Gagliardi, Maria / Iles, Lakesla R / Ueno, Naoto T / Battula, Venkata L / Sohn, Yoo-Kyoung / Wang, Xiaoping / Kim, Hak-Sung / Krishnamurthy, Savitri / Fowlkes, Natalie W / Green, Morgan M / Bartholomeusz, Geoffrey A / Tripathy, Debu / Reuben, James M / Bartholomeusz, Chandra

    Breast cancer research and treatment

    2021  Volume 189, Issue 2, Page(s) 333–345

    Abstract: Background: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks targeted therapies. Patients with TNBC have a very poor prognosis because the disease often metastasizes. New treatment approaches addressing drivers of ... ...

    Abstract Background: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks targeted therapies. Patients with TNBC have a very poor prognosis because the disease often metastasizes. New treatment approaches addressing drivers of metastasis and tumor growth are crucial to improving patient outcomes. Developing targeted gene therapy is thus a high priority for TNBC patients. PEA15 (phosphoprotein enriched in astrocytes, 15 kDa) is known to bind to ERK, preventing ERK from being translocated to the nucleus and hence blocking its activity. The biological function of PEA15 is tightly regulated by its phosphorylation at Ser104 and Ser116. However, the function and impact of phosphorylation status of PEA15 in the regulation of TNBC metastasis and in epithelial-to-mesenchymal transition (EMT) are not well understood.
    Methods: We established stable cell lines overexpressing nonphosphorylatable (PEA15-AA) and phospho-mimetic (PEA15-DD) mutants. To dissect specific cellular mechanisms regulated by PEA15 phosphorylation status, we performed RT-PCR immune and metastasis arrays. In vivo mouse models were used to determine the effects of PEA15 phosphorylation on tumor growth and metastasis.
    Results: We found that the nonphosphorylatable mutant PEA15-AA prevented formation of mammospheres and expression of EMT markers in vitro and decreased tumor growth and lung metastasis in in vivo experiments when compared to control, PEA15-WT and phosphomimetic PEA15-DD. However, phosphomimetic mutant PEA15-DD promoted migration, mesenchymal marker expression, tumorigenesis, and lung metastasis in the mouse model. PEA15-AA-mediated inhibition of breast cancer cell migratory capacity and tumorigenesis was the partial result of decreased expression of interleukin-8 (IL-8). Further, we identified that expression of IL-8 was possibly mediated through one of the ERK downstream molecules, Ets-1.
    Conclusions: Our results show that PEA15 phosphorylation status serves as an important regulator for PEA15's dual role as an oncogene or tumor suppressor and support the potential of PEA15-AA as a therapeutic strategy for treatment of TNBC.
    MeSH term(s) Animals ; Apoptosis Regulatory Proteins/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-8 ; Mice ; Triple Negative Breast Neoplasms/genetics
    Chemical Substances Apoptosis Regulatory Proteins ; Interleukin-8 ; PEA15 protein, human
    Language English
    Publishing date 2021-07-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-021-06316-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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