LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Article ; Online: Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Renal Replacement Therapy.

Kaewdoungtien, Piyanut / Tachaboon, Sasipha / Kangsumrith, Natamon / Srisawat, Nattachai

2023 Volume 52, Issue 5, Page(s) 474–482

Abstract: Introduction: Acute kidney injury (AKI) is a common syndrome in critically ill patients. Continuous renal replacement therapy (CRRT) is the standard treatment for patients with AKI. Research on the immunomodulating effects of regional citrate ... ...

Abstract	Introduction: Acute kidney injury (AKI) is a common syndrome in critically ill patients. Continuous renal replacement therapy (CRRT) is the standard treatment for patients with AKI. Research on the immunomodulating effects of regional citrate anticoagulation (RCA) remains limited in patients with AKI receiving CRRT. We aimed to evaluate the immunomodulating effects of RCA in patients with AKI receiving CRRT. Methods: A randomized controlled trial study on critically ill adult patients with AKI undergoing CRRT was undertaken. Participants were randomized into either a regional citrate group or control group (either heparin anticoagulant or normal saline). Measurements were taken at baseline, 6 and 24 h after commencing CRRT for CD11b expression, C3a, C5a, and plasminogen activator inhibitor-1 (PAI-1) levels. Clinical outcomes assessed were 28-day survival rate, length of ICU stay, renal support duration, and renal function at discharge. Results: Thirty patients were recruited and randomized into 2 groups of 15 subjects. Baseline demographic and clinical data were comparable between groups. In the citrate group, CD11b expression was significantly decreased at 24 h compared to the control group (1.84% [1.18-3.32] versus 4.92% [2.63-6.93], p < 0.01). The complement level, including c3b and c5a, was stable during CRRT. Additionally, the PAI-1 levels were significantly decreased at 24 h compared to the control group (114 ng/mL [19-193] versus 359 ng/mL [264-491], p < 0.01). No significant difference in survival rate was observed. Conclusions: RCA may have the potential to mitigate the inflammatory response by decreasing CD11b expression of neutrophil and improve fibrinolysis activity through a reduction of PAI-1 levels. Larger clinical trials are warranted to test this immunomodulation effect of RCA.
MeSH term(s)	Adult ; Humans ; Citric Acid/therapeutic use ; Continuous Renal Replacement Therapy ; Plasminogen Activator Inhibitor 1/therapeutic use ; Critical Illness ; Anticoagulants/therapeutic use ; Renal Replacement Therapy ; Citrates/therapeutic use ; Acute Kidney Injury
Chemical Substances	Citric Acid (2968PHW8QP) ; Plasminogen Activator Inhibitor 1 ; Anticoagulants ; Citrates
Language	English
Publishing date	2023-03-14
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000529350
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comparison of circulating bacterial profiles between mild and severe COVID-19 patients.

Sivapornnukul, Pavaret / Chitcharoen, Suwalak / Sawaswong, Vorthon / Tachaboon, Sasipha / Dinhuzen, Janejira / Srisawat, Nattachai / Payungporn, Sunchai

Experimental biology and medicine (Maywood, N.J.)

2023 Volume 248, Issue 10, Page(s) 866–873

Abstract: Recent reports revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients can develop bacteremia; however, the circulating bacterial profile is not well studied. Therefore, this study has aimed to investigate circulating ...

Abstract	Recent reports revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients can develop bacteremia; however, the circulating bacterial profile is not well studied. Therefore, this study has aimed to investigate circulating bacterial profile in mild (
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/genetics ; RNA, Ribosomal, 16S/genetics ; Bacteria/genetics ; DNA, Ribosomal
Chemical Substances	RNA, Ribosomal, 16S ; DNA, Ribosomal
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702231157931
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.111: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The combination of RPA-CRISPR/Cas12a and Leptospira IgM RDT enhances the early detection of leptospirosis.

Jirawannaporn, Sirawit / Limothai, Umaporn / Tachaboon, Sasipha / Dinhuzen, Janejira / Kiatamornrak, Patcharakorn / Chaisuriyong, Watchadaporn / Srisawat, Nattachai

PLoS neglected tropical diseases

2023 Volume 17, Issue 8, Page(s) e0011596

Abstract: Background: Lack of available sensitive point-of-care testing is one of the primary obstacles to the rapid diagnosis of leptospirosis. The purpose of this study was to test the performance of two point-of-care tests, a clustered regularly interspaced ... ...

Abstract	Background: Lack of available sensitive point-of-care testing is one of the primary obstacles to the rapid diagnosis of leptospirosis. The purpose of this study was to test the performance of two point-of-care tests, a clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 12a (CRISPR/Cas12a) fluorescence-based diagnostic assay (FBDA), a Leptospira immunoglobulin M (IgM) rapid diagnostic test (RDT), and the two tests combined. Methodology/principal findings: For the diagnosis of 171 clinical samples, a recombinase polymerase amplification (RPA)-CRISPR/Cas12a FBDA for whole blood and Leptospira IgM RDT (Medical Science Public Health, Thailand) for serum were used. The confirmed cases were determined by using any positive qPCR, microscopic agglutination test (MAT), and culture results. Diagnostic accuracy was assessed on the first day of enrollment and stratified by the day after symptom onset. The overall sensitivity of the Leptospira IgM RDT and RPA-CRISPR/Cas12a FBDA was 55.66% and 60.38%, respectively. When the two tests were combined, the sensitivity rose to 84.91%. The specificity of each test was 63.08% and 100%, respectively, and 63.08% when combined. The sensitivity of the Leptospira IgM RDT rose on days 4-6 after the onset of fever, while the RPA-CRISPR/Cas12a FBDA continued to decrease. When the two tests were combined, the sensitivity was over 80% at different days post-onset of fever. Conclusions/significance: The combination of Leptospira IgM RDT and RPA-CRISPR/Cas12 FBDA exhibited significant sensitivity for the detection of leptospires at various days after the onset of fever, thereby reducing the likelihood of misdiagnosis. The combination of these assays may be suitable for early leptospirosis screening in situations with limited resources.
MeSH term(s)	Humans ; Recombinases ; Leptospira/genetics ; CRISPR-Cas Systems ; Leptospirosis/diagnosis ; Antibodies, Bacterial ; Fever ; Immunoglobulin M
Chemical Substances	Recombinases ; Antibodies, Bacterial ; Immunoglobulin M
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011596
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Rapid and sensitive point-of-care detection of Leptospira by RPA-CRISPR/Cas12a targeting lipL32.

Jirawannaporn, Sirawit / Limothai, Umaporn / Tachaboon, Sasipha / Dinhuzen, Janejira / Kiatamornrak, Patcharakorn / Chaisuriyong, Watchadaporn / Bhumitrakul, Jom / Mayuramart, Oraphan / Payungporn, Sunchai / Srisawat, Nattachai

PLoS neglected tropical diseases

2022 Volume 16, Issue 1, Page(s) e0010112

Abstract: Background: One of the key barriers preventing rapid diagnosis of leptospirosis is the lack of available sensitive point-of-care testing. This study aimed to develop and validate a clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR- ...

Abstract	Background: One of the key barriers preventing rapid diagnosis of leptospirosis is the lack of available sensitive point-of-care testing. This study aimed to develop and validate a clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 12a (CRISPR/Cas12a) platform combined with isothermal amplification to detect leptospires from extracted patient DNA samples. Methodology/principal findings: A Recombinase Polymerase Amplification (RPA)-CRISPR/Cas12a-fluorescence assay was designed to detect the lipL32 gene of pathogenic Leptospira spp. The assays demonstrated a limit of detection (LOD) of 100 cells/mL, with no cross-reactivity against several other acute febrile illnesses. The clinical performance of the assay was validated with DNA extracted from 110 clinical specimens and then compared to results from qPCR detection of Leptospira spp. The RPA-CRISPR/Cas12a assay showed 85.2% sensitivity, 100% specificity, and 92.7% accuracy. The sensitivity increased on days 4-6 after the fever onset and decreased after day 7. The specificity was consistent for several days after the onset of fever. The overall performance of the RPA-CRISPR/Cas12a platform was better than the commercial rapid diagnostic test (RDT). We also developed a lateral flow detection assay (LFDA) combined with RPA-CRISPR/Cas12a to make the test more accessible and easier to interpret. The combined LFDA showed a similar LOD of 100 cells/mL and could correctly distinguish between known positive and negative clinical samples in a pilot study. Conclusions/significance: The RPA-CRISPR/Cas12 targeting the lipL32 gene demonstrated acceptable sensitivity and excellent specificity for detection of leptospires. This assay might be an appropriate test for acute leptospirosis screening in limited-resource settings.
MeSH term(s)	Bacterial Outer Membrane Proteins/genetics ; CRISPR-Cas Systems/genetics ; Female ; Humans ; Leptospira/genetics ; Leptospira/isolation & purification ; Leptospirosis/diagnosis ; Limit of Detection ; Lipoproteins/genetics ; Male ; Mass Screening/methods ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Nucleic Acid Amplification Techniques/methods ; Point-of-Care Testing ; Real-Time Polymerase Chain Reaction ; Sensitivity and Specificity
Chemical Substances	Bacterial Outer Membrane Proteins ; LipL32 protein, Leptospira ; Lipoproteins
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0010112
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Citrate pharmacokinetics in critically ill liver failure patients receiving CRRT.

Thanapongsatorn, Peerapat / Chaijamorn, Weerachai / Sirivongrangson, Phatadon / Tachaboon, Sasipha / Peerapornratana, Sadudee / Lumlertgul, Nuttha / Lucksiri, Aroonrut / Srisawat, Nattachai

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1815

Abstract: Citrate has been proposed as anticoagulation of choice in continuous renal replacement therapy (CRRT). However, little is known about the pharmacokinetics (PK) and metabolism of citrate in liver failure patients who require CRRT with regional citrate ... ...

Abstract	Citrate has been proposed as anticoagulation of choice in continuous renal replacement therapy (CRRT). However, little is known about the pharmacokinetics (PK) and metabolism of citrate in liver failure patients who require CRRT with regional citrate anticoagulation (RCA). This prospective clinical PK study was conducted at King Chulalongkorn Memorial Hospital between July 2019 to April 2021, evaluating seven acute liver failure (ALF) and seven acute-on-chronic liver failure (ACLF) patients who received CRRT support utilizing RCA as an anticoagulant at a citrate dose of 3 mmol/L. For evaluation of the citrate PK, we delivered citrate for 120 min and then stopped for a further 120 min. Total body clearance of citrate was 152.5 ± 50.9 and 195.6 ± 174.3 mL/min in ALF and ACLF, respectively. The ionized calcium, ionized magnesium, and pH slightly decreased after starting citrate infusion and gradually increased to baseline after stopping citrate infusion. Two of the ACLF patients displayed citrate toxicity during citrate infusion, while, no ALF patient had citrate toxicity. In summary, citrate clearance was significantly decreased in critically ill ALF and ACLF patients receiving CRRT. Citrate use as an anticoagulation in these patients is of concern for the risk of citrate toxicity.
MeSH term(s)	Acute-On-Chronic Liver Failure/blood ; Acute-On-Chronic Liver Failure/diagnosis ; Acute-On-Chronic Liver Failure/physiopathology ; Acute-On-Chronic Liver Failure/therapy ; Adult ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/pharmacokinetics ; Citric Acid/administration & dosage ; Citric Acid/adverse effects ; Citric Acid/pharmacokinetics ; Continuous Renal Replacement Therapy/adverse effects ; Critical Illness ; Female ; Humans ; Kidney Diseases/blood ; Kidney Diseases/diagnosis ; Kidney Diseases/physiopathology ; Kidney Diseases/therapy ; Liver/metabolism ; Liver/physiopathology ; Liver Failure, Acute/blood ; Liver Failure, Acute/diagnosis ; Liver Failure, Acute/physiopathology ; Liver Failure, Acute/therapy ; Male ; Metabolic Clearance Rate ; Middle Aged ; Prospective Studies ; Treatment Outcome
Chemical Substances	Anticoagulants ; Citric Acid (2968PHW8QP)
Language	English
Publishing date	2022-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05867-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Circulating microtranscriptome profiles reveal distinct expression of microRNAs in severe leptospirosis.

Limothai, Umaporn / Dinhuzen, Janejira / Payongsri, Titipon / Tachaboon, Sasipha / Tangkijvanich, Pisit / Chuaypen, Natthaya / Srisawat, Nattachai

PLoS neglected tropical diseases

2020 Volume 14, Issue 11, Page(s) e0008809

Abstract: Biomarkers to predict the severity of leptospirosis are still lacking. This study aimed to identify and validate microRNAs in patients with severe leptospirosis, that could potentially be used as biomarkers for predicting an unfavorable outcome. Serum ... ...

Abstract	Biomarkers to predict the severity of leptospirosis are still lacking. This study aimed to identify and validate microRNAs in patients with severe leptospirosis, that could potentially be used as biomarkers for predicting an unfavorable outcome. Serum samples were collected from participants with definite diagnosis of leptospirosis. The participants were divided into two groups, non-severe and severe leptospirosis, as defined by the Specific Organ Sequential Organ Failure (SOFA) Score of more than two in any organ. Microtranscriptome analysis was performed using the NanoString miRNA Expression Assay. The expression level of candidate miRNAs was then validated by quantitative RT-PCR. Based on the NanoString, the microtranscriptome profile of the severe group was significantly different from that of the non-severe group. Upregulation of miR155-5p, miR362-3p, miR502-5p, miR601, miR1323, and miR630 in the severe group were identified, and further investigated. A total of 119 participants were enrolled in the validation cohort. Serum miR155-5p and miR630 levels were significantly higher in the severe group compared to the non-severe group. The combined use of miR155-5p or miR-630 with serum bicarbonate levels had an AUC of 0.79 (95%CI; 0.69-0.89, p<0.001) in identifying the severity of the disease. This data provides the first evidence that the microtranscriptome profiles of patients with severe leptospirosis were different from the non-severe group. Serum miR155-5p and miR630 levels might be novel biomarkers for identifying severe leptospirosis.
MeSH term(s)	Biomarkers/blood ; Female ; Gene Expression Profiling ; Humans ; Leptospira/isolation & purification ; Leptospirosis/diagnosis ; Leptospirosis/pathology ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; Middle Aged ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; Severity of Illness Index ; Transcriptome/genetics
Chemical Substances	Biomarkers ; MIRN155 microRNA, human ; MicroRNAs
Language	English
Publishing date	2020-11-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0008809
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Serum Cortisol as a Biomarker of Severe Dengue.

Bongsebandhu-Phubhakdi, Chansuda / Supornsilchai, Vichit / Aroonparkmongkol, Suphab / Limothai, Umaporn / Tachaboon, Sasipha / Dinhuzen, Janejira / Chaisuriyong, Watchadaporn / Trongkamolchai, Supachoke / Wanpaisitkul, Mananya / Chulapornsiri, Chatchai / Tiawilai, Anongrat / Tiawilai, Thawat / Tantawichien, Terapong / Thisyakorn, Usa / Srisawat, Nattachai

Tropical medicine and infectious disease

2023 Volume 8, Issue 3

Abstract: Dengue infection presents a wide range of clinical symptoms. Serum cortisol is known as a severity predictor of serious infection but is not yet clearly understood in dengue infection. We aimed to investigate the pattern of cortisol response after dengue ...

Abstract	Dengue infection presents a wide range of clinical symptoms. Serum cortisol is known as a severity predictor of serious infection but is not yet clearly understood in dengue infection. We aimed to investigate the pattern of cortisol response after dengue infection and evaluate the possibility of using serum cortisol as the biomarker to predict the severity of dengue infection. This prospective study was conducted in Thailand during 2018. Serum cortisol and other laboratory tests were collected at four time points: day 1 at hospital admission, day 3, day of defervescence (DFV) (4-7 days post-fever onset), and day of discharge (DC). The study recruited 265 patients (median age (IQR) 17 (13, 27.5)). Approximately 10% presented severe dengue infection. Serum cortisol levels were highest on the day of admission and day 3. The best cut-off value of serum cortisol level for predicting severe dengue was 18.2 mcg/dL with an AUC of 0.62 (95% CI, 0.51, 0.74). The sensitivity, specificity, PPV and NPV were 65.4, 62.3, 16 and 94%, respectively. When we combined serum cortisol with persistent vomiting and day of fever, the AUC increased to 0.76. In summary, serum cortisol at day of admission was likely to be associated with dengue severity. Further studies may focus on the possibility of using serum cortisol as one of the biomarkers for dengue severity.
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed8030146
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Seroprevalence of leptospirosis among blood donors in an endemic area.

Limothai, Umaporn / Tachaboon, Sasipha / Dinhuzen, Janejira / Singh, Jasleen / Jirawannaporn, Sirawit / Leewongworasingh, Akarathep / Thongpin, Matsaya / Brameld, Suppalak / Watanaboonyongcharoen, Phandee / Sitprija, Visith / Tantawichien, Terapong / Thisyakorn, Usa / Srisawat, Nattachai

Scientific reports

2023 Volume 13, Issue 1, Page(s) 12336

Abstract: Thailand is known to be endemic for leptospirosis. This bacterium may pose a potential risk to transfusion safety. This study was a cross-sectional study examining the seroprevalence of leptospirosis among Thai blood donors. A total of 1053 serum ... ...

Abstract	Thailand is known to be endemic for leptospirosis. This bacterium may pose a potential risk to transfusion safety. This study was a cross-sectional study examining the seroprevalence of leptospirosis among Thai blood donors. A total of 1053 serum specimens collected from blood donors residing in 5 regions of Thailand during March to September 2020 were included in this study. All samples were tested for the presence of antibodies to 22 leptospiral serovars using the microscopic agglutination test (MAT) and anti-Leptospira IgG antibodies using commercially available enzyme immunoassay. We found no evidence of recent exposure to Leptospira spp. in sera of healthy Thai blood donors by MAT, including those in higher-risk areas. However, in this same group, we did find small numbers of past exposure (1.7%) to Leptospira spp. by IgG ELISA. According to the findings of this study, there is currently no evidence for implementing new blood banking procedures to identify possible carriers in Thailand, however these should be continually monitored and revised according to the infectious disease burden in each country. It should be noted that there was a difference in the occupation rate between the general population reported in Thailand and blood donors in this study; it may not reflect the actual situation in the country.
MeSH term(s)	Humans ; Seroepidemiologic Studies ; Blood Donors ; Cross-Sectional Studies ; Leptospirosis/microbiology ; Leptospira ; Antibodies, Bacterial
Chemical Substances	Antibodies, Bacterial
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-39461-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Long-term kidney outcomes after leptospirosis: a prospective multicentre cohort study in Thailand.

Phannajit, Jeerath / Lertussavavivat, Tanat / Limothai, Umaporn / Tachaboon, Sasipha / Avihingsanon, Yingyos / Praditpornsilpa, Kearkiat / Eiam-Ong, Somchai / Tungsanga, Kriang / Sitprija, Visith / Srisawat, Nattachai

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 38, Issue 10, Page(s) 2182–2191

Abstract: Background: Leptospirosis is one of the most important public-health zoonotic diseases in the tropics that can cause severe organ dysfunction and death. Currently there are insufficient data on long-term renal dysfunction in patients after leptospirosis ...

Abstract	Background: Leptospirosis is one of the most important public-health zoonotic diseases in the tropics that can cause severe organ dysfunction and death. Currently there are insufficient data on long-term renal dysfunction in patients after leptospirosis infection. Methods: A prospective multicentre cohort study was conducted at 15 hospitals in the Sisaket province of Thailand. Confirmed leptospirosis patients admitted from 1 December 2015 to 30 November 2018 were followed between 1 February 2020 and 31 October 2020 (median 4.1 years after hospital discharge). The primary outcome was a composite of major kidney adverse events (MAKEs) including all-cause mortality, dialysis and new-onset chronic kidney disease (CKD). Results: Of the 217 confirmed leptospirosis cases enrolled, 32.7% were classified as having severe leptospirosis. Fifteen cases (6.9%) were deceased at the time of hospital admission. After a median follow-up time of 4.18 years, 30 patients had died and 33 patients developed CKD. Patients with severe leptospirosis had a significantly higher risk of MAKEs {adjusted hazard ratio 2.45 [95% confidence interval (CI) 1.44-4.18]}. Patients with intensive care unit admission, pulmonary haemorrhage and acute kidney injury also had a higher risk of MAKEs and all-cause mortality. Participants with severe leptospirosis in the follow-up cohort showed a higher risk of developing CKD compared with non-severe leptospirosis [adjusted odds ratio 3.22 (95% CI 1.04-9.96)], especially renal magnesium and phosphate wasting. Conclusion: Leptospirosis patients, especially severe leptospirosis, are associated with long-term kidney sequelae. Our finding reflects the importance of long-term follow-up and the urgent need for specific interventions.
MeSH term(s)	Humans ; Cohort Studies ; Prospective Studies ; Thailand/epidemiology ; Renal Dialysis/adverse effects ; Kidney ; Leptospirosis/complications ; Leptospirosis/epidemiology ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Renal Insufficiency, Chronic/complications ; Risk Factors
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad030
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A prospective study to evaluate the accuracy of rapid diagnostic tests for diagnosis of human leptospirosis: Result from THAI-LEPTO AKI study.

Dinhuzen, Janejira / Limothai, Umaporn / Tachaboon, Sasipha / Krairojananan, Panadda / Laosatiankit, Bangon / Boonprasong, Sakarin / Lumlertgul, Nuttha / Peerapornratana, Sadudee / Srisawat, Nattachai

PLoS neglected tropical diseases

2021 Volume 15, Issue 2, Page(s) e0009159

Abstract: Background: Rapid diagnostic tests (RDTs) have become widely used in low-resource settings for leptospirosis diagnostic. This study aims to evaluate the diagnostic performance of the five commercially available RDTs to detect human IgM against ... ...

Abstract	Background: Rapid diagnostic tests (RDTs) have become widely used in low-resource settings for leptospirosis diagnostic. This study aims to evaluate the diagnostic performance of the five commercially available RDTs to detect human IgM against Leptospira spp. in Thai population. Methodology/principal findings: Ninety-nine serum samples from Leptospirosis suspicious patients were tested with five RDTs, including Medical Science Public Health, Leptocheck-WB, SD bioline, TRUSTline, and J.Mitra. The case definition was based on MAT, qPCR, and culture results. Diagnostic accuracy was determined based on the first day of enrollment in an overall analysis and stratified according to days post-onset of fever. The five RDTs had overall sensitivity ranging from 1.8% to 75% and specificity ranging from 52.3% to 97.7%. Leptocheck-WB had high sensitivity of 75.0%. The sensitivity of five RDTs increased on days 4-6 post-onset of fever, while the specificity of all tests remained relatively stable at different days post-onset of fever. Conclusions/significance: The tested RDTs showed low sensitivity. Therefore, based on the present study, five commercially available RDTs might not be an appropriate test for acute leptospirosis screening in the Thai population.
MeSH term(s)	Acute Kidney Injury ; Adult ; Aged ; Antibodies, Bacterial/blood ; Diagnostic Tests, Routine/methods ; Female ; Humans ; Immunoglobulin M/blood ; Leptospirosis/diagnosis ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity ; Thailand
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin M
Language	English
Publishing date	2021-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0009159
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito