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  1. Article ; Online: Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study.

    Sparsa, Agnès / Blaise, Sophie / Tack, Brigitte / Dalmay, François / Leroy, Dominique / Bonnetblanc, Jean-Marie / Béani, Jean-Claude / Bédane, Christophe

    Photochemistry and photobiology

    2012  Volume 88, Issue 4, Page(s) 1023–1026

    Abstract: Many studies have been conducted showing that aminolevulinic acid (ALA)-photodynamic therapy (PDT) can be an alternative treatment for recalcitrant warts. Recently, we performed a study evaluating methyl-aminolevulinic acid (MAL)-PDT for the treatment of ...

    Abstract Many studies have been conducted showing that aminolevulinic acid (ALA)-photodynamic therapy (PDT) can be an alternative treatment for recalcitrant warts. Recently, we performed a study evaluating methyl-aminolevulinic acid (MAL)-PDT for the treatment of hand warts in a population of renal transplant patients. Two symmetrical targets were selected on each hand and randomly assigned to chemical keratolytic treatment followed by three cycles of ALA-PDT (75 J cm(-2) red light). Patients were evaluated after 3 months and a second run of PDT was performed if the total area and number of warts decreased less than 50%, with evaluation every 3 months for 1 year. Twenty patients were included and 16 were evaluable (9 M, 7 F). After 6 months the reduction of warts' area was 48.4% on the treated side versus 18.4% in the control area (P = 0.021). The decrease in the total number of warts was 41%versus 19.4% (P = NS). The global tolerance of the treatment was good with acceptable pain during irradiation. These results suggest that ALA-PDT is a safe and efficient treatment for transplanted patient warts. The improvement between treated and control zone is 20% due to the decrease in untreated warts' area and number.
    MeSH term(s) Adult ; Aminolevulinic Acid/administration & dosage ; Aminolevulinic Acid/analogs & derivatives ; Female ; Hand/virology ; Humans ; Immunocompromised Host ; Kidney Transplantation/immunology ; Light ; Male ; Middle Aged ; Photochemotherapy ; Photosensitizing Agents/administration & dosage ; Prospective Studies ; Treatment Outcome ; Warts/drug therapy ; Warts/immunology ; Warts/virology
    Chemical Substances Photosensitizing Agents ; methyl 5-aminolevulinate (585NM85KYM) ; Aminolevulinic Acid (88755TAZ87)
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/j.1751-1097.2012.01114.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial.

    Morton, Colin / Horn, Michael / Leman, Joyce / Tack, Brigitte / Bedane, Christophe / Tjioe, Milan / Ibbotson, Sally / Khemis, Abdallah / Wolf, Peter

    Archives of dermatology

    2006  Volume 142, Issue 6, Page(s) 729–735

    Abstract: Objective: To compare the efficacy, tolerability, and cosmetic outcome of photodynamic therapy (PDT) using topical methyl aminolevulinate with cryotherapy or topical fluorouracil for treatment of squamous cell carcinoma in situ.: Design: Randomized, ... ...

    Abstract Objective: To compare the efficacy, tolerability, and cosmetic outcome of photodynamic therapy (PDT) using topical methyl aminolevulinate with cryotherapy or topical fluorouracil for treatment of squamous cell carcinoma in situ.
    Design: Randomized, placebo-controlled study, with follow-up at 3 and 12 months after last treatment.
    Setting: Forty outpatient dermatology centers in 11 European countries.
    Patients: Random sample of 225 patients with histologically confirmed squamous cell carcinoma in situ (lesion size, 6-40 mm) and no evidence of progression.
    Interventions: Treatment with PDT with methyl aminolevulinate (160 mg/g; n = 96) or matching placebo cream (n = 17), cryotherapy (n = 82), or topical fluorouracil (5% cream; n = 30). Methyl aminolevulinate or placebo cream was applied for 3 hours before illumination with broadband red light (75 J/cm2, 570-670 nm). Treatment was repeated 1 week later. Cryotherapy was performed with liquid nitrogen spray. Fluorouracil was applied for 4 weeks. Lesions with a partial response at 3 months were re-treated.
    Main outcome measures: Clinically verified complete response of lesions; blinded and on-site assessment of cosmetic outcome (4-point rating scale).
    Results: At 12 months, the estimated sustained lesion complete response rate with methyl aminolevulinate PDT was superior to that with cryotherapy (80% vs 67%; odds ratio, 1.77; 95% confidence interval, 1.01-3.12; P = .047), and better than that with fluorouracil (80% vs 69%; odds ratio, 1.64; 95% confidence interval, 0.78-3.45; P = .19). Cosmetic outcome at 3 months was good or excellent in 94% of patients treated with methyl aminolevulinate PDT vs 66% with cryotherapy and 76% with fluorouracil, and was maintained at 12 months.
    Conclusion: Methyl aminolevulinate PDT is an effective treatment option for squamous cell carcinoma in situ, with excellent cosmesis.
    MeSH term(s) Administration, Cutaneous ; Adult ; Aged ; Aged, 80 and over ; Aminolevulinic Acid/administration & dosage ; Antimetabolites, Antineoplastic/administration & dosage ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Cryotherapy ; Double-Blind Method ; Europe ; Female ; Fluorouracil/administration & dosage ; Humans ; Male ; Middle Aged ; Photochemotherapy ; Photosensitizing Agents/administration & dosage ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Treatment Outcome
    Chemical Substances Antimetabolites, Antineoplastic ; Photosensitizing Agents ; Aminolevulinic Acid (88755TAZ87) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2006-06
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 212139-6
    ISSN 1538-3652 ; 0003-987X
    ISSN (online) 1538-3652
    ISSN 0003-987X
    DOI 10.1001/archderm.142.6.729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.32: Show issues Location:
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